Patents by Inventor Olaf Ritzeler

Olaf Ritzeler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-AMINO-3-(IMIDAZOL-2-YL)-PYRIDIN-4-ONE DERIVATIVES AND THEIR USE AS VEGF RECEPTOR KINASE INHIBITORS
    Publication number: 20140094488
    Abstract: The invention relates to the compounds of general formula (I): Preparation process and therapeutic use.
    Type: Application
    Filed: May 16, 2012
    Publication date: April 3, 2014
    Applicant: SANOFI
    Inventors: Alain BRAUN, Olivier DUCLOS, Gilbert LASSALLE, Franz LORGE, Valerie MARTIN, Olaf RITZELER, Aurelie STRUB
  • SUBSTITUTED 2-(CHROMAN-6-YLOXY)-THIAZOLES AND THEIR USE AS PHARMACEUTICALS
    Publication number: 20130065859
    Abstract: The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I, in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula I are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.
    Type: Application
    Filed: September 12, 2011
    Publication date: March 14, 2013
    Applicant: SANOFI
    Inventors: Werngard CZECHTIZKY, John WESTON, Nils RACKELMANN, Michael PODESCHWA, Petra ARNDT, Klaus WIRTH, Heinz GOEGELEIN, Olaf RITZELER, Volker KRAFT, Patrice BELLEVERGUE, Gary MCCORT
  • Phenyl-alkyl piperazines having TNF-modulating activity, preparation method, and therapeutic use thereof
    Patent number: 8153637
    Abstract: The present invention relates to phenyl-alkyl piperazines of formula (I): in which A, R1, R2 and R3 are as defined herein, having TNF-modulating activity. The invention also relates to the preparation thereof, pharmaceutical compositions thereof, and to the therapeutic use thereof.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: April 10, 2012
    Assignee: Sanofi
    Inventors: Marco Baroni, Olaf Ritzeler, Marco Zanchet
  • PHENYL-ALKYL PIPERAZINES HAVING TNF-MODULATING ACTIVITY, PREPARATION METHOD, AND THERAPEUTIC USE THEREOF
    Publication number: 20110144120
    Abstract: The present invention relates to phenyl-alkyl piperazines of formula (I): in which A, R1, R2 and R3 are as defined herein, having TNF-modulating activity. The invention also relates to the preparation thereof, pharmaceutical compositions thereof, and to the therapeutic use thereof.
    Type: Application
    Filed: December 16, 2010
    Publication date: June 16, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Marco BARONI, Olaf RITZELER, Marco ZANCHET
  • Use of IKappaB-Kinase Inhibitors in Pain Therapy
    Publication number: 20090069358
    Abstract: The present invention relates to the use of I?B-kinase Inhibitors and methods for the prophylaxis and therapy for treating pain comprising administering such compounds.
    Type: Application
    Filed: November 6, 2008
    Publication date: March 12, 2009
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Martin MICHAELIS, Olaf RITZELER, Gerhard JAEHNE, Karl RUDOLPHI, Gerd GEISSLINGER, Hans-Georg SCHAIBLE
  • Use of I?B-kinase inhibitors in pain therapy
    Patent number: 7462638
    Abstract: The present invention relates to the use of I?B-kinase Inhibitors and methods for the prophylaxis and therapy for treating pain comprising administering such compounds.
    Type: Grant
    Filed: August 18, 2003
    Date of Patent: December 9, 2008
    Assignee: SANOFI-AVENTIS Deutschland GmbH
    Inventors: Martin Michaelis, Olaf Ritzeler, Gerhard Jaehne, Karl Rudolphi, Gerd Geisslinger, Hans-Georg Schaible
  • Substituted ?-carbolines
    Patent number: 7348336
    Abstract: The subject matter of the present invention is directed to novel substituted ?-carbolines, and specifically compounds of the formula I, which are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of I?B kinase is involved.
    Type: Grant
    Filed: March 28, 2006
    Date of Patent: March 25, 2008
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Olaf Ritzeler, Alfredo Castro, Louis Grenier, Francois Soucy, Wayne W. Hancock, Hormoz Mazdiyasni, Vito Palombella, Julian Adams
  • Substituted indoles
    Patent number: 7342029
    Abstract: Compounds of the formula I are suitable for preparing pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NF?B is involved.
    Type: Grant
    Filed: July 22, 2005
    Date of Patent: March 11, 2008
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Olaf Ritzeler, Hans Ulrich Stilz, Bernhard Neises, Gerhard Jaehne, Joerg Habermann
  • Indole derivatives or benzimidazole derivatives for modulating I?B kinase
    Patent number: 7285560
    Abstract: The present invention relates to indole derivatives or benzimidazole derivatives, to processes for preparing such compounds, to pharmaceutical compositions comprising such compounds, and methods for the prophylaxis and therapy of a disease associated with an increased activity of I?B kinase comprising administering such compounds.
    Type: Grant
    Filed: August 18, 2003
    Date of Patent: October 23, 2007
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Olaf Ritzeler, Gerhard Jaehne
  • Indole Derivatives or Benzimidazole Derivatives for Modulating IkB Kinase
    Publication number: 20070244139
    Abstract: The present invention relates to indole derivatives or benzimidazole derivatives, to processes for preparing such compounds, to pharmaceutical compositions comprising such compounds, and methods for the prophylaxis and therapy of a disease associated with an increased activity of I?B kinase comprising administering such compounds.
    Type: Application
    Filed: June 6, 2007
    Publication date: October 18, 2007
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Olaf RITZELER, Gerhard JAEHNE
  • Substantially Pure 2-{[2-(2-Methylamino-Pyrimidin-4-YL)-1H-Indole-5-Carbonyl]-Amino}-3-Phenylpyridin-2-YL-Amino)-Propionic Acid as an IkB Kinase Inhibitor
    Publication number: 20070142417
    Abstract: The present invention is directed to the substantially pure compound of formula (A), or pharmaceutically acceptable salt, or solvate of said compound; to a pharmaceutical composition comprising a pharmaceutically effective amount of the compound of formula (A), and a pharmaceutically acceptable carrier; and the use of a compound of formula (A) having activity as an inhibitor, preferably a selective inhibitor, of I?B (IKK), particularly IKK-2, and methods related thereto.
    Type: Application
    Filed: November 13, 2006
    Publication date: June 21, 2007
    Applicant: AVENTIS PHARMACEUTICALS INC
    Inventors: El-Bdaoui HADDAD, Olaf Ritzeler, David Aldous, Paul Cox
  • Substituted beta carbolines
    Publication number: 20060166978
    Abstract: The subject matter of the present invention is directed to novel substituted beta-carbolines, and specifically compounds of the formula I, which are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of I?B kinase is involved.
    Type: Application
    Filed: March 28, 2006
    Publication date: July 27, 2006
    Inventors: Olaf Ritzeler, Alfredo Castro, Louis Grenier, Francois Soucy, Wayne Hancock, Hormoz Mazdiyasni, Vito Palombella, Julian Adams
  • Substituted beta-carbolines
    Patent number: 7026331
    Abstract: The subject matter of the present invention is directed to novel substituted beta-carbolines, and specifically compounds of the formula I, which are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of I?B kinase is involved.
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: April 11, 2006
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Olaf Ritzeler, Alfredo Castro, Louis Grenier, Francois Soucy, Wayne W. Hancock, Hormoz Mazdiyasni, Vito Palombella, Julian Adams
  • Substituted indoles
    Publication number: 20050282866
    Abstract: Compounds of the formula I are suitable for preparing pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NF?B is involved.
    Type: Application
    Filed: July 22, 2005
    Publication date: December 22, 2005
    Applicant: AVENTIS PHARMA DEUTSCHLAND GMBH
    Inventors: Olaf Ritzeler, Hans Stilz, Bernhard Neises, Gerhard Jaehne, Joerg Habermann
  • Indole derivatives or benzimidazole derivatives for modulating IkB kinase
    Publication number: 20050197353
    Abstract: The present invention relates to indole derivatives or benzimidazole derivatives, to processes for preparing such compounds, to pharmaceutical compositions comprising such compounds, and methods for the prophylaxis and therapy of a disease associated with an increased activity of I?B kinase comprising administering such compounds.
    Type: Application
    Filed: August 18, 2003
    Publication date: September 8, 2005
    Applicant: AVENTIS PHARMA DEUTSCHLAND GMBH
    Inventors: Olaf Ritzeler, Gerhard Jaehne
  • Substituted indoles
    Publication number: 20040209868
    Abstract: Compounds of the formula I 1
    Type: Application
    Filed: May 11, 2004
    Publication date: October 21, 2004
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Olaf Ritzeler, Hans Ulrich Stilz, Bernhard Neises, Gerhard Jaehne, Jorg Habermann
  • Use of IkappaB-kinase inhibitors in pain therapy
    Publication number: 20040116494
    Abstract: The present invention relates to the use of I&kgr;B-kinase Inhibitors and methods for the prophylaxis and therapy for treating pain comprising administering such compounds.
    Type: Application
    Filed: August 18, 2003
    Publication date: June 17, 2004
    Applicant: AVENTIS PHARMA DEUTSCHLAND GMBH
    Inventors: Martin Michaelis, Olaf Ritzeler, Gerhard Jaehne, Karl Rudolphi, Gerd Geisslinger, Hans-Georg Schaible
  • Substituted beta carbolines
    Publication number: 20040110759
    Abstract: The subject matter of the present invention is directed to novel substituted beta-carbolines, and specifically compounds of the formula I, 1
    Type: Application
    Filed: July 28, 2003
    Publication date: June 10, 2004
    Applicant: AVENTIS PHARMA DEUTSCHLAND GMBH
    Inventors: Olaf Ritzeler, Alfredo Castro, Louis Grenier, Francois Soucy, Wayne W. Hancock, Hormoz Mazdiyasni, Vito Palombella, Julian Adams
  • Substituted beta carbolines
    Patent number: 6627637
    Abstract: The subject matter of the present invention is directed to novel substituted beta-carbolines, and specifically compounds of the formula I, which are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of I&kgr;B kinase is involved.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: September 30, 2003
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Olaf Ritzeler, Alfredo Castro, Louis Grenier, Francois Soucy, Wayne W. Hancock, Hormoz Mazdiyashi, Vito Palombella, Julian Adams
  • Substituted indoles
    Publication number: 20030119820
    Abstract: Compounds of the formula I 1
    Type: Application
    Filed: October 4, 2002
    Publication date: June 26, 2003
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Olaf Ritzeler, Hans Ulrich Stilz, Bernhard Neises, Gerhard Jaehne, Jorg Habermann