Patents by Inventor Oliver Lange
Oliver Lange has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110156973Abstract: An antenna has an antenna body having a plurality of first antenna elements situated along a first straight line. The antenna body includes a first conductive grounded surface and a second conductive grounded surface, the first and second grounded surfaces being situated essentially parallel to one another. A dielectric is situated between the first and second grounded surfaces. A signal conductor is also situated between the first and second grounded surfaces. The first antenna elements are designed as apertures situated above the signal conductor in the first grounded surface. Furthermore, the antenna is designed to emit a signal in a direction in space, depending on a frequency of the signal. At least two of the first antenna elements differ from one another in such a way that their power emissions are different.Type: ApplicationFiled: December 13, 2010Publication date: June 30, 2011Inventors: Thomas Focke, Joerg Hilsebecher, Oliver Lange, Reinhard Meschenmoser, Arne Zender, Thomas Schoeberl, Thomas Hansen, Joachim Selinger, Karl Schneider
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Publication number: 20110147582Abstract: This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analysed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analysed; accumulating in the ion store a sample of another type of ions to be analysed; and mass analysing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.Type: ApplicationFiled: January 18, 2011Publication date: June 23, 2011Inventors: Alexander Alekseevich MAKAROV, Oliver LANGE, Stevan Roy HORNING
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Patent number: 7962301Abstract: A data compression technique is disclosed for Fourier Transform Mass Spectrometry (FTMS). A statistical analysis is applied to the data in the frequency domain since most of this data is a result of randomly distributed electronic noise. A fit of the whole frequency dataset to the distribution is made to determine preliminary moments of the distribution. The data in the tail of that distribution (which is mainly the peak data) is then removed and the remaining data points are re-fitted to the distribution, to identify the moments of distribution of that remaining noise data. A noise threshold for the mass spectrum is then applied using the calculated moments. The data above the threshold is kept. The whole spectrum can be reconstituted by storing the moments of distribution along with the peak data and then regenerating the noise from those moments and adding it to the peak data.Type: GrantFiled: December 16, 2009Date of Patent: June 14, 2011Assignee: Thermo Finnigan LLCInventors: Robert Malek, Oliver Lange
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Publication number: 20110057099Abstract: This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.Type: ApplicationFiled: November 11, 2010Publication date: March 10, 2011Inventors: Alexander Alekseevich MAKAROV, Eduard V. Denisov, Gerhard Jung, Robert Malek, Oliver Lange
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Patent number: 7880136Abstract: This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analysed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analysed; accumulating in the ion store a sample of another type of ions to be analysed; and mass analysing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.Type: GrantFiled: May 31, 2006Date of Patent: February 1, 2011Assignee: Thermo Finnigan LLCInventors: Alexander Alekseevich Makarov, Oliver Lange, Stevan Roy Horning
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Patent number: 7847243Abstract: This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.Type: GrantFiled: March 29, 2006Date of Patent: December 7, 2010Assignee: Thermo Finnigan LLCInventors: Alexander Alekseevich Makarov, Eduard V. Denisov, Gerhard Jung, Robert Malek, Oliver Lange
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Publication number: 20100193680Abstract: This invention relates to a mass spectrometer including a reaction cell and to a method of using such a mass spectrometer. In particular, although not exclusively, this invention relates to a tandem mass spectrometer and to tandem mass spectrometry. The invention provides a method of mass spectrometry using a mass spectrometer having a longitudinal axis, comprising guiding ions to travel along the longitudinal axis of the mass spectrometer in a forwards direction to pass through an intermediate ion store and then to enter a reaction cell, to process the ions within the reaction cell, to eject the processed ions to travel back along the longitudinal axis to enter the intermediate ion store once more, and to eject one or more pulses of the processed ions in an off-axis direction to a mass analyser.Type: ApplicationFiled: April 16, 2010Publication date: August 5, 2010Inventors: Alexander Alekseevich MAKAROV, Eduard V. Denisov, Gerhard Jung, Alexander Kholomeev, Oliver Lange
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Patent number: 7728288Abstract: This invention relates to a mass spectrometer including a reaction cell and to a method of using such a mass spectrometer. In particular, although not exclusively, this invention relates to a tandem mass spectrometer and to tandem mass spectrometry. The invention provides a method of mass spectrometry using a mass spectrometer having a longitudinal axis, comprising guiding ions to travel along the longitudinal axis of the mass spectrometer in a forwards direction to pass through an intermediate ion store and then to enter a reaction cell, to process the ions within the reaction cell, to eject the processed ions to travel back along the longitudinal axis to enter the intermediate ion store once more, and to eject one or more pulses of the processed ions in an off-axis direction to a mass analyser.Type: GrantFiled: March 29, 2006Date of Patent: June 1, 2010Assignee: Thermo Finnigan LLCInventors: Alexander Alekseevich Makarov, Eduard V. Denisov, Gerhard Jung, Alexander Kholomeev, Oliver Lange
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Publication number: 20100096545Abstract: A data compression technique is disclosed for Fourier Transform Mass Spectrometry (FTMS). A statistical analysis is applied to the data in the frequency domain since most of this data is a result of randomly distributed electronic noise. A fit of the whole frequency dataset to the distribution is made to determine preliminary moments of the distribution. The data in the tail of that distribution (which is mainly the peak data) is then removed and the remaining data points are re-fitted to the distribution, to identify the moments of distribution of that remaining noise data. A noise threshold for the mass spectrum is then applied using the calculated moments. The data above the threshold is kept. The whole spectrum can be reconstituted by storing the moments of distribution along with the peak data and then regenerating the noise from those moments and adding it to the peak data.Type: ApplicationFiled: December 16, 2009Publication date: April 22, 2010Inventors: Robert MALEK, Oliver Lange
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Patent number: 7657387Abstract: A data compression technique is disclosed for Fourier Transform Mass Spectrometry (FTMS). A statistical analysis is applied to the data in the frequency domain since most of this data is a result of randomly distributed electronic noise. A fit of the whole frequency dataset to the distribution is made to determine preliminary moments of the distribution. The data in the tail of that distribution (which is mainly the peak data) is then removed and the remaining data points are re-fitted to the distribution, to identify the moments of distribution of that remaining noise data. A noise threshold for the mass spectrum is then applied using the calculated moments. The data above the threshold is kept. The whole spectrum can be reconstituted by storing the moments of distribution along with the peak data and then regenerating the noise from those moments and adding it to the peak data.Type: GrantFiled: September 23, 2004Date of Patent: February 2, 2010Assignee: Thermo Finnigan LLCInventors: Robert Malek, Oliver Lange
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Patent number: 7576318Abstract: The present invention relates to mass spectrometry and, more particularly, to the scheduling of the steps involved in performing mass spectrometry. The present invention will be of particular benefit to types of mass spectrometry that generate large quantities of data and hence give rise to lengthy data-processing. The present invention provides a method of mass spectrometry comprising a plurality of cycles, each cycle comprising the steps of (a) preparing ions to be analysed by a mass spectrometer; (b) using a detector of the mass spectrometer to collect data from the ions prepared in step (a); and (c) processing the data collected in step (b) with processing means; wherein at least a part of step (a) and/or a part of step (b) of a cycle is performed concurrently with part (c) of a previous cycle.Type: GrantFiled: September 24, 2004Date of Patent: August 18, 2009Assignee: Thermo Finnigan LLCInventors: Robert Malek, Oliver Lange, Reinhold Pesch, Stevan Horning
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Publication number: 20090202184Abstract: The elastomeric bush bearing is constructed of a metallic inner part (1) which is symmetric in relation to a bearing axis (a), an outer sleeve (3) arranged concentric with respect to the inner part (1), an elastomeric bearing body (2) arranged between the inner part (1) and the outer sleeve (3) and connected with the inner part (1) by vulcanization. At least one intermediate sheet (4) is vulcanized into the bearing body (2) which forms a support spring. The inner part (1) and the at least one intermediate sheet (4) are bulgedly expanded in a center axial region (5, 5?).Type: ApplicationFiled: January 27, 2009Publication date: August 13, 2009Applicant: ZF FRIEDRICHSHAFEN AGInventors: Tim-Malte FRANKE, Torsten BALTES, Oliver LANGE, Claudia HOPING
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Patent number: 7513794Abstract: A clamp/plug connector for through-wall connection includes a clamp housing of an insulating material. A locking element is provided for attaching the clamp housing to a wall. A pivotable actuation wedge is connected as a single piece to the locking element.Type: GrantFiled: March 4, 2004Date of Patent: April 7, 2009Assignee: Phoenix Contact GmbH & Co. KGInventor: Oliver Lange
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Patent number: 7482581Abstract: A method of generating a mass spectrum from an FTMS is disclosed. A first quantity of ions from a source, having a first m/z range, is captured and detected in the FTMS measurement cell to produce a first output. A second quantity of ions, having a second m/z range which at least partially does not overlap with the first m/z range, is then captured and detected so as to produce a second output. The two outputs are then combined using a processor so as to “stitch” together the outputs, which may be FTMS transients or may first be Fourier Transformed into the frequency mass domain, into a composite output from which a composite mass spectrum covering the full range of m/z ratios included by the first and second ranges can be produced.Type: GrantFiled: March 24, 2005Date of Patent: January 27, 2009Assignee: Thermo Finnigan LLCInventors: Oliver Lange, Andreas Wieghaus
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Publication number: 20080270083Abstract: A method of processing Fourier Transform Mass Spectrometry (FTMS) data comprises carrying out a Fourier Trans-form of a part of a time domain transient and identifying from that transformed data signal peaks representative of the presence of ions. Once the peaks have been identified, the full transient is then transformed, and the peaks identified in the partial transient transform are used to locate true peaks in the transformed full transient. The number of ‘false’ peaks resulting from random noise has been found to correlate to the resolution, so that using a partial transient to identify true peaks reduces the risk of false peaks being included; nevertheless this information can then be applied to the full data set when transformed. As an alternative, different parts of the full data set can be transformed and then correlated; because any noise will be random, false peaks should occur at different places in the two partial transforms.Type: ApplicationFiled: November 23, 2005Publication date: October 30, 2008Inventors: Oliver Lange, Michael W. Senko
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Publication number: 20080203288Abstract: This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analysed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analysed; accumulating in the ion store a sample of another type of ions to be analysed; and mass analysing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.Type: ApplicationFiled: May 31, 2006Publication date: August 28, 2008Inventors: Alexander Alekseevich Makarov, Oliver Lange, Steven Roy Horning
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Publication number: 20080191129Abstract: This invention relates to a mass spectrometer including a reaction cell and to a method of using such a mass spectrometer. In particular, although not exclusively, this invention relates to a tandem mass spectrometer and to tandem mass spectrometry. The invention provides a method of mass spectrometry using a mass spectrometer having a longitudinal axis, comprising guiding ions to travel along the longitudinal axis of the mass spectrometer in a forwards direction to pass through an intermediate ion store and then to enter a reaction cell, to process the ions within the reaction cell, to eject the processed ions to travel back along the longitudinal axis to enter the intermediate ion store once more, and to eject one or more pulses of the processed ions in an off-axis direction to a mass analyser.Type: ApplicationFiled: March 29, 2006Publication date: August 14, 2008Inventors: Alexander Alekseevich Makarov, Eduard V. Denisov, Gerhard Jung, Alexander Kholomeev, Oliver Lange
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Publication number: 20080156984Abstract: This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.Type: ApplicationFiled: March 29, 2006Publication date: July 3, 2008Inventors: Alexander Alekseevich Makarov, Eduard V. Denisov, Gerhard Jung, Robert Malek, Oliver Lange
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Publication number: 20080119755Abstract: A device and a method for evaluating a signal that can indicate the respiration of a person, particularly suitable for examining a patient with respect to the occurrence of sleep-related breathing disturbances. In one example, a device for evaluating a signal indicative of the temporal course of the respiration of a patient, in particular a respiratory flow signal, includes an electronic evaluation program or circuitry which is configured in such a manner that it evaluates the signal by continuously generating intermediate evaluation results for short signal periods and for longer signal periods being parallel thereto, and performs an identification of respiratory patterns in the time signal or in specific time periods on the basis of the position of the intermediate evaluation results of the short signal periods relative to the intermediate evaluation results of the longer signal periods.Type: ApplicationFiled: October 21, 2005Publication date: May 22, 2008Applicant: MAP Medizin-Technologie GmbHInventors: Stefan Schatzl, Jorg Meier, Aleksandra Dana-Mika, Thomas Betzl, Oliver Lange
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Publication number: 20070203652Abstract: The present invention provides a method of improving a mass spectrum collected from a mass spectrometer comprising a detector for collecting a mass spectrum from ions stored in or released from an ion trapping volume, wherein assignment of masses to peaks appearing in the mass spectrum is sensitive to an experimental parameter related to the mass spectrometer or the operation thereof, such as ion abundance, the method comprising: determining a positional value of a peak; determining the experimental parameter associated with the mass spectrum; comparing the determined positional value with positional values of peaks contained in a calibration dataset; and improving the determined positional value of the peak from adjacent peak positional values by interpolation thereby to provide a corrected mass assignment for the peak. The present invention also provides a method of calibrating such a mass spectrometer.Type: ApplicationFiled: March 24, 2005Publication date: August 30, 2007Inventors: Stevan Horning, Oliver Lange, Robert Malek, Andreas Wieghaus