Abstract: The object of this invention is a method for attaching a pipette tip and an apparatus for such method. The method comprises the following steps: opening the interlocking which attaches the replaceable part with the help of electronically controlled interlocking mechanism for detaching or receiving the replaceable part; saving the information of the opening of the interlocking mechanism to the control electronics of the pipette; closing the interlocking which attaches the replaceable part with the help of the electronically controlled interlocking mechanism for attaching the replaceable part; saving the information of the closing of the interlocking mechanism to the control electronics of the pipette; providing the dispensing parameters and/or type and/or size of the replaceable part with the help of a keyboard to the control electronics to ensure the attachment of a desired replaceable part and to achieve pipetting readiness.

Abstract: This invention relates to a method for selecting a plunger-cylinder tip of a pipette and a device for carrying out the method. In the method, the dose size is entered into the control electronics of the pipetting device; the dose size is stored in the control electronics; the amount of doses is entered; and on the basis of the dose size and the amount of doses, the control electronics indicates suitable available interchangeable components on the display.

Abstract: This invention relates to plunger operated liquid dispensers, such as hand held pipettors, which are used to portion liquids. Specifically the invention relates to a reliable removal of a liquid from the liquid dispenser. According to the invention the plunger of the liquid dispenser is arranged into a speeded up movement while removing the liquid. This change in speed is preferably sudden.

Abstract: The object of the invention comprises food compositions, to which one or more acetaldehyde-binding compounds are added. The purpose of the compositions is to reduce the amount of detrimental acetaldehyde in the area of the mouth, the pharynx, the oesophagus, the stomach, and the small and large intestines, and through this, to reduce the risk of developing cancers in these areas.

Abstract: The present invention is directed to a method for assessing or predicting the state of the gastric mucosa in a subject by determining, in said subject, the probability for the gastric mucosa belonging to at least one gastric mucosa class, the method comprising: measuring, from a sample of said subject, the pepsinogen I (PGI) and gastrin-17 (G-17) analyte concentrations, as well as determining the presence or concentration of a marker for Helicobacter pylori; entering the data so obtained in a data processing system comprising an operating system, a database and means for transceiving and processing data, the said data processing system being adapted to determine the probability for the gastric mucosa belonging to the at least one gastric mucosa class, based on the data entered as well as on predefined clinical data in the database, the information so generated being indicative of the state of the gastric mucosa in said subject.

Abstract: The press device for a paper web, such as a calender, contains a flexible moving element (1a) forming an endless structure, said element forming the shell (1) of a roll, the press device including further a counter roll. Inside the moving element (1a) there is a shoe element (3) that is arranged to support the shell (1a) against the counter roll to form a nip (N). The width and/or the surface contour of the supporting surface of the shoe element (3) guiding the shell of the roll in the nip contact varies in the machine direction and the shoe element is positionable in the machine direction to adjust the nip width and/or length.

Abstract: The object of the invention is the use of compounds comprising one or more free sulphlydryl or amino groups for preparing a pharmaceutical composition for locally binding acetaldehyde in saliva, the stomach or the large intestine, and pharmaceutical compositions comprising the said compounds.

Abstract: The present invention is directed to the use of DMSO for the stabilization of temperature sensitive proteins and peptides, such as gastrin, against degradation in a mammalian biological sample, such as a serum or plasma sample.

Abstract: The object of this invention is a method for attaching a pipette tip and an apparatus for such method. The method comprises the following steps: opening the interlocking which attaches the replaceable part with the help of electronically controlled interlocking mechanism for detaching or receiving the replaceable part; saving the information of the opening of the interlocking mechanism to the control electronics of the pipette; closing the interlocking which attaches the replaceable part with the help of the electronically controlled interlocking mechanism for attaching the replaceable part; saving the information of the closing of the interlocking mechanism to the control electronics of the pipette; providing the dispensing parameters and/or type and/or size of the replaceable part with the help of a keyboard to the control electronics to ensure the attachment of a desired replaceable part and to achieve pipetting readiness.

Abstract: The present invention concerns a method for assessing the risk of peptic ulcer by determining the presence and topographic phenotype of gastritis in an individual, by determining quantitatively the pepsinogen I and gastin-17 concentrations in a serum sample from the said individual, selecting a method-specific reference value and cut-off value for respective analyte, assessing the topography and phenotype of gastritis based on a comparison of the pepsinogen I and gastrin-17 concentrations so determined with their respective method-specific reference and cut-off values, and correlating the so assessed gastritis phenotype with the risk for peptic ulcer. Preferably also Helicobacter antibodies are determined in the sample.

Abstract: A method for detaching a barrier means adapted to the end part of the suction device for closing an opening in the end part by the movement of a plunger intended for changing the volume of a cylindrical space provided in the end part whereby the barrier means is removed by bringing means for limiting the movement of the plunger in the cylindrical space, e.g. means intended for removing the disposable tip, in such a position that the plunger can be brought into contact with the barrier means for detaching the barrier means from the end part of the suction device.

Abstract: The present invention relates to a method and reagents for determining extension products in reactions involving nucleic acid chain extension, e.g., in cyclic minisequencing, and to the use of this method when identifying specific point mutations and genetic variations. Three standard unmodified primers are needed and a non-specific fluorescent reagent (e.g. a ssDNA-binding dye) can be used as one of the fluorophores in the FRET assay used. The invention is also related to vertical light beam fluorometry.

Abstract: The press device for a paper web, such as a calender, contains a flexible moving element (1a) forming an endless structure, said element forming the shell (1) of a roll, the press device including further a counter roll. Inside the moving element (1a) there is a shoe element (3) that is arranged to support the shell (1a) against the counter roll to form a nip (N). The width and/or the surface contour of the supporting surface of the shoe element (3) guiding the shell of the roll in the nip contact varies in the machine direction and the shoe element is positionable in the machine direction to adjust the nip width and/or length.

Abstract: A pipette for use with disposable tips and having ejector and actuating devices for detaching the disposable tips from the pipette. The actuating device includes at least one cam element for interacting with the ejector, connected to the pipette body by a pivotal joint. The mechanism makes it possible to vary the torque conversion ratio of the cam element throughout the operation cycle of the actuator. It is particularly well suited for use with a multi-tip device in which the force required for tip ejection is larger than in single tip devices.

Abstract: A top with a mantle wall defining a sample space, for receiving a liquid sample, the tip having first open end to be inserted into a liquid and a second open end for attaching the top to a suction device intended for dispensing, which tip is provided with a membrane device closing the gas and liquid passage in a gas and liquid tight manner from the first end of the tip to the suction device, when the tip is attached to the suction device, the membrane of the membrane device being made of a gas and liquid impermeable, flexible, reversibly deformable material.

Abstract: A suction device for dispensing a liquid having a membrane device mounted in a gastight manner in the air space jointly formed by the cylindrical space of its end part and the sample space of a tip to be mounted onto the end part, the membrane device comprising a membrane, made of a liquid and gas impermeable, flexible, reversibly deformable material, with which membrane the reciprocating device in the cylindrical space can be brought into contact for taking a liquid sample into the sample space of the tip and/or removing it therefrom.

Abstract: The object of the invention is a method for adjusting the dispensing volume in a pipette having a spring for returning a plunger to its initial position. The invention is characterized in that when the pipetting volume is adjusted, the spring moves in accordance with the adjustment together with the adjustment members, preserving its length and/or pretension, whereby the tension of the spring does not change when the pipetting volume is adjusted. The object of the invention is also a pipette for implementing the method.

Abstract: A method for removing a replaceable tip used with a suction device for dispensing a liquid removes the tip by bringing a removal device, arranged in an air space formed jointly by a sample space of a replaceable tip and a cylindrical space of an end part of a suction device, movable between its two extreme positions, namely an inner home position and an outer removal position, into cooperation with an inside surface of the replaceable tip mounted on the end part whereby the movement of the removal device into its removal position causes the replaceable tip to be detached from the end part. A suction device is provided for using the method.

Abstract: The object of the invention is a method for correcting a temperature dependent dispensing error occurring during liquid dispensing, such as pipetting, as well as a liquid dispensing device, such as a pipette, having a higher degree of accuracy. According to the method the dispensing takes place by means of two chambers connected to each other over a gas passage. The first chamber communicates, in addition to the gas passage, with the liquid to be dispensed, and the second chamber is gas tight except for the gas passage. In order to receive liquid in the dispensing device, the volume of the second chamber is increased, resulting in gas flowing therein from the first chamber, and in turn, liquid to be dispensed flowing into the first chamber until a pressure equilibrium between the chambers has been reached.

Abstract: A pipette, comprising: a cylinder (1) with liquid passage (3), a plunger (4), and a plunger operating assembly (5) for moving the plunger in the cylinder; the operating assembly comprising a body (6), a threaded rod (7), an operating member (8) cooperating by mediation of threads with the threaded rod, and a power unit (9) for rotating the threaded rod and the operating member relative to each other for moving the plunger by mediation of the threaded rod and the operating member when the threaded rod and the operating member are rotated relative to each other with the aid of the power unit; the thread of the threaded rod (7) or alternatively that of the operating member (8) being non-linear locally over a certain transition range.