Abstract: A compound, as represented by formula I, as a TLR7 agonist, a method for preparing the compound, and the use of the compound in treating diseases mediated by the TLR7 agonist are provided. Studies on the activity of a human-derived receptor, a TLR7 agonist, show that compounds have a strong agonistic effect on the human-derived receptor, TLR7, and can be used as a foreground compound for treating diseases mediated by the TLR7 agonist.

Abstract: The present invention provides a multi-modal data prediction method based on a causal Markov model, belonging to the technical field of intelligent traffic technology; the method of the present invention includes: collecting regional data and multi-modal traffic data of a research region; taking the time position, the regional point of interest and the weather information as conditional feature variables; taking the regional attraction factor, the bicycle demand factor, the taxi demand factor, the bus demand factor and the traffic speed factor as physical concept variables; taking the bicycle traffic flow, the taxi traffic flow, the bus traffic flow and the regional speed as multi-modal traffic data observation variables, and describing the generation process of the multi-modal traffic flow by using a causal Markov process; solving the causal Markov process by using a neural network, and training a built neural network for the multi-modal traffic data observation.

Abstract: The present invention relates to the use of hypoxia-inducible factor (HIF) inhibitors in cancer immunotherapy. Specifically, the disclosure provides methods of treating a cancer in a subject in need of cancer immunotherapy, comprising administering a HIF-1a inhibitor to the subject and a second cancer immunotherapeutic agent to the subject, wherein the HIF-1a inhibitor comprising echinomycin, and wherein the second cancer immunotherapeutic agent comprising an anti-CTLA-4 antibody including Ipilimumab or Tremelimumab.

Abstract: A computer device obtains a block proposal message and obtains a first block from the block proposal message. In accordance with a determination that a current consensus node of the computer device has a second block in a locked state and a block height of the first block is the same as a block height of the second block, the computer device deletes the block proposal message and obtains block voting information of the second block in a first consensus stage. The locked state is a state of a block that has passed the first consensus stage and has not passed a second consensus stage. The computer device obtains block submission voting information of the second block in the second consensus stage according to the block voting information, and determines a consensus result corresponding to the second block according to the block submission voting information.

Abstract: An automatic cleaning apparatus includes: a mobile platform configured to automatically move on an operating surface; a cleaning module disposed on the mobile platform and including: a wet cleaning module configured to clean at least a part of the operating surface by means of wet cleaning; a lifting and lowering structure connected with the wet cleaning module and configured to enable the wet cleaning module to move vertically relative to the mobile platform; and a cleaning liquid module for providing cleaning liquid for the wet cleaning module; and a driving mechanism, including a first driving component and a second driving component.

Abstract: A base station may include a base body, a landing pad, and a base station opening and closing structure. The base station opening and closing structure may include an open state and a closed state. In the open state, the base station opening and closing structure may provide a landing space for an aerial vehicle to land on the landing pad, and in the closed state, the base station opening and closing structure may provide an accommodating space to accommodate the aerial vehicle. During a process of the base station opening and closing structure transitioning from the open state to the closed state, the base station opening and closing structure may be configured to propel some blades of the aerial vehicle partially protruding out of the accommodating space to fold or retract so as to accommodate the aerial vehicle within the accommodating space.

Abstract: The present application provides a compound dry powder inhalant, comprising baicalin, ambroxol hydrochloride, L-leucine and phosphate, wherein based on a mass of the compound dry powder inhalant, L-leucine accounts for 0-50%, phosphate accounts for 15-35%, and a total mass of baicalin and ambroxol hydrochloride accounts for 15-85%, and wherein a mass ratio of baicalin to ambroxol hydrochloride is 1:0.2 to 2. The compound dry powder inhalant has a Dv90?5 ?m. The drug combination of baicalin and ambroxol hydrochloride can effectively reduce inflammation and oxidative damage in lung tissue, alleviate pulmonary edema and histopathological changes, and reduce pulmonary dysfunction and pulmonary fibrosis.

Abstract: Mechanisms are provided for compartmental epidemiological computer modeling based on mobility data. Machine learning training of an isolation rate prediction computer model is performed to generate a trained isolation rate prediction model that predicts an isolation rate of a biological population. Isolation data is received which comprises data indicating a measure of mobility of the biological population. The trained isolation rate prediction model is executed on input features extracted from the isolation data to generate a predicted isolation rate. A compartmental epidemiological computer model, comprising a plurality of compartments representing states of a population with regard to an infectious disease, is executed to simulate a progression of the infectious disease and flows of portions of the population from between compartments in the compartmental epidemiological computer model are controlled based on the predicted isolation rate.

Abstract: A tunnel operation robot includes a robot body, a walking module, a fixed wing module and a plurality of rotatable wing modules. Both sides of the robot body are provided with cantilever parts, which are collinearly arranged. The walking module is arranged on the robot body. The fixed wing module includes a fixed fan, is fixedly arranged on the robot body, and is configured to provide a pressure for the walking module to be attached to and pressed against the tunnel wall surface. The plurality of rotatable wing modules are respectively arranged on the cantilever parts on both sides of the robot body, and include a rotatable rotating fan and a wind direction adjustment driver. Each rotating fan has a rotation axis parallel to the cantilever parts and an air outlet direction perpendicular to the cantilever parts, and the wind direction adjustment driver is connected to the rotating fan.

Abstract: A lost circulation detection device includes a first detection member and a second detection member, a first signal transmitter and a first signal receiver are disposed on the first detection member, and the first signal transmitter transmits a signal along an axial direction of a rockshaft so that the first signal receiver acquires data information of drilling fluid in the axial direction of the rockshaft; a fluid channel penetrating through the second detection member is disposed in the second detection member, and the fluid channel is configurable to be in communication with the rockshaft; a second signal transmitter and a second signal receiver are disposed oppositely on two sides of the fluid channel, and the second signal transmitter transmits a signal along a center line of a second accommodating groove, so that the second signal receiver acquires data information of drilling fluid in a circumferential direction of the rockshaft.

Abstract: A discharge unit is connected to a power pad, a ground pad, and an I/O pad, and can discharge an electrostatic charge when an electrostatic pulse appears on any of the power pad, the ground pad, and the I/O pad. The discharge unit includes a first discharge unit and a second discharge unit, the first discharge unit is connected to the second discharge unit, the power pad, and the I/O pad, and the second discharge unit is connected to the ground pad and the I/O pad. The first discharge unit and/or the second discharge unit can discharge electrostatic charges on different pads, respectively.

Abstract: A curved display apparatus is provided, including one or more bending portions where the curved display apparatus is bent. At least the one or more bending portions of the curved display apparatus including a stacked structure, which includes a support layer; a display panel on the support layer; and N number of pressure sensitive adhesive layers and M number of flexible base layers between the support layer and the display panel, N is an integer equal to or greater than 3, M is an integer equal to or greater than 2. A first one of the N number of pressure sensitive adhesive layers adheres the support layer and a first one of the M number of flexible base layers together. A last one of the N number of pressure sensitive adhesive layers adheres the display panel and a last one of the M number of flexible base layers together.

Abstract: A computer-implemented method, an apparatus, and a computer program product for edge node autonomy. For a first edge node of a plurality of edge nodes in a federation in a distributed computing framework, one or more processors receive a request to be sent to a central node in the distributed computing framework. The one or more processors determine whether the federation is connected to the central node. In response to determining that the federation is not connected to the central node, the one or more processors determine whether a controller capable of processing the request is available in the federation. In response to determining that the controller capable of processing the request is available in the federation, the one or more processors notify the controller to process the request.

Abstract: A computing device transmits, to a second node, first consensus voting information for a target block. The device receives, from the second node, second consensus voting information for the target block. The device determines a consensus result for the target block according to the first and second consensus voting information. In accordance with a determination that the consensus result is a consensus success result, the device activates an accounting duration window. The device performs accounting processing on the target block in the predetermined time duration of the accounting duration window. The device receives, from the second node, a first accounting completion message for the target block transmitted by the second node in the accounting duration window. In accordance with a determination that accounting processing on the target block is completed in the accounting duration window, the device transmits a second accounting completion message to the second node.

Abstract: An urban data prediction method based on a generative causal interpretation model is provided. The generative causal interpretation model includes exogenous variables, spatio-temporal conditional parent variables, controlled causal transition functions, and spatio-temporal mixing functions. By inferring the model's exogenous variables, causal descriptors, spatio-temporal conditional parent variables, and other causal latent variables from the observation data and fitting the corresponding functions such as the controlled causal transfer function and the spatio-temporal mixing function, the invention can predict the spatio-temporal data in city level based on the model. The observation data of the urban complex system can be decomposed into causal descriptors with physical meanings. Under the influence of stable causal structure, the robustness and applicability of the model can be improved, so that the prediction results are more in line with the operation of urban complex systems.

Abstract: The present invention relates to the use of a CD24 protein for preventing or treating relapse of a cancer in a subject. The present invention also relates to the use of a CD24 protein for reducing cancer stem cell activity.

Abstract: A method for processing information includes: while performing, by a target consensus node, consensus validation on a first block, in accordance with a determination that a target consensus validation message for performing consensus validation on a second block is received: in accordance with a determination that the target consensus validation message meets a cache condition according to block attribute information of the second block, storing the target consensus validation message into a message cache pool corresponding to the target consensus node; and in accordance with a determination that the consensus validation on the first block is completed, performing consensus validation on the second block based on the target consensus validation message in the message cache pool.

Abstract: A blockchain-based data synchronization method, executed by a first service node, includes: acquiring target block data having a minimum block height that is greater than a first local block height, the first local block height being a maximum block height of local block data of the first service node before the first service node acquires the target block data; determining a block height of missing block data according to a block height of the target block data and the first local block height, the block height of the missing block data being less than the minimum block height of the target block data and greater than the first local block height; and requesting a target service node to synchronize the missing block data according to the block height of the missing block data.

Abstract: A blockchain network includes a service sub-network, a consensus sub-network, and a routing layer configured to isolate the service sub-network from the consensus sub-network. A data processing method in the blockchain network includes: receiving a data processing request transmitted by a service node in the service sub-network; performing identity verification on the service node according to the data processing request; obtaining a running load of each consensus node in the consensus sub-network when the verification succeeds; determining, from the consensus sub-network according to the running load, a target consensus node configured to process the data processing request; and forwarding the data processing request to the target consensus node, and performing corresponding data processing on the data processing request by using the target consensus node.