Abstract: The present invention relates to human CCR8 (hCCR8) binders, wherein the hCCR8 binder is cross-reactive with a non-human primate CCR8. Such binders are particularly useful for the depletion of intra-tumoural regulatory T-cells and immunotherapy in general.

Abstract: A boring head is provided comprising a tool body (1) having a main rotation axis (R) about which the tool body (1) rotates during boring operations. The boring head further comprises a tool carrier (6) arranged in or on the tool body (1), a first motor (9) for displacing the tool carrier (6) relative to the tool body (1) and a clamping mechanism (26) with a clamping element (27, 55, 68, 81) for effecting a clamping force on the tool carrier (6), in order to prevent a displacement of the tool carrier (6) relative to the tool body (1) during boring operations. The clamping mechanism (26) is an active clamping mechanism which effects a clamping force that can be adjusted actively.

Abstract: A method includes receiving a request to assume control of a vehicle generated by a candidate operator via a first communication pathway. The method obtains a key from an onboard controller of the vehicle and communicates the key to the candidate operator via a second communication pathway that is different from the first communication pathway. The method determines the candidate operator to be a confirmed operator based at least in part on obtaining the key from the candidate operator via the first communication pathway.

Abstract: A method includes receiving a request to assume control of a vehicle generated by a candidate operator via a first communication pathway. The method obtains a key from an onboard controller of the vehicle and communicates the key to the candidate operator via a second communication pathway that is different from the first communication pathway. The method determines the candidate operator to be a confirmed operator based at least in part on obtaining the key from the candidate operator via the first communication pathway.

Abstract: In one aspect, a method of modulating transmission of ions in a mass spectrometer is disclosed, which comprises generating an ion beam comprising a plurality of ions, directing the ion beam to an ion optic positioned in the path of the ion beam, wherein the ion optic includes at least one opening through which the ions can pass, and applying one or more voltage pulses at a selected duty cycle to said ion optic so as to obtain a desired attenuation of brightness of the ion beam passing through the ion optic, where a pulse width of said voltage pulses at said selected duty cycle is determined by identifying a pulse width on a calibration normalized ion intensity versus pulse width relation for said ions that corresponds to said desired attenuation on an ideal normalized ion intensity versus pulse width relation for said ions.

Abstract: A vacuum pumping system includes a plurality of positive displacement vacuum pumps, and more particularly a plurality of positive displacement vacuum pumps working in parallel. The vacuum pumping system includes a management unit that carries out a synchronized control of all the positive displacement vacuum pumps of the vacuum pumping system and thus allows to check possible risk of contamination of the vacuum pumping system and carry out, if needed, the necessary corrective actions without requiring any modification to the construction of the vacuum pumping system.

Abstract: Apparatus and methods for controlling contamination of components contained within the high-vacuum chambers of mass spectrometer systems are provided. The apparatus and methods employ a beam of neutral gas injected in a contra-flow configuration to incoming particle stream from the ionization chamber. The contra-flow can be in the directly opposite counter-flow direction (e.g., 180 degrees) or at a cross-flow angle to the incoming ion stream (e.g., flowing at an angle between about 10 degrees and 170 degrees). The contra-flow disrupts the axial gas flow and diverts neutral molecules and other undesirable contaminants before they reach the high vacuum stages (e.g., beyond the IQ0 orifice) of the spectrometer. By reducing the transmission of contaminants into the sensitive components housed deep within the mass spectrometer, the present invention can increase throughput, improve robustness, and/or decrease the downtime typically required to vent/disassemble/clean the fouled components.

Abstract: The present invention concerns an airbag device comprising a security module (10) comprising a rigid body forming a casing (12) and a firing channel (20) comprising a top wall (21), two transverse guide flanges (22, 23) and two transverse walls (32B), said body comprising two transverse flanks having teeth (16) engaged in windows (30) provided on said transverse flanges (22, 23) and two side walls (17) in each of which an opening (17B) is provided, positioned close to the vertical of one of said transverse walls (32B) so as to allow two rods (T) that have been inserted through these openings (17B) to bear on these transverse walls (32B) so as to pivot in order to exert a lever effect causing said module (10) to move in translation and the teeth (16) situated on one of said transverse flanks to disengage from the corresponding windows (30).

Abstract: An electron multiplier is positioned relative to at least one dynode to direct a beam of secondary particles from the at least one dynode to a collector area of the electron multiplier and not to a channel area of the electron multiplier for a range of electron multiplier voltages applied by one or more voltage sources to the electron multiplier and for a dynode voltage applied by the one or more voltage sources to the at least one dynode. The electron multiplier includes an aperture with an entrance cone and walls of the entrance cone comprise the collector area and an apex of the entrance cone comprises the channel area. An electron multiplier voltage of the range of electron multiplier voltages is applied to the electron multiplier and the dynode voltage is applied to the at least one dynode using the one or more voltage sources.

Abstract: An electron multiplier is positioned relative to at least one dynode to direct a beam of secondary particles from the at least one dynode to a collector area of the electron multiplier and not to a channel area of the electron multiplier for a range of electron multiplier voltages applied by one or more voltage sources to the electron multiplier and for a dynode voltage applied by the one or more voltage sources to the at least one dynode. The electron multiplier includes an aperture with an entrance cone and walls of the entrance cone comprise the collector area and an apex of the entrance cone comprises the channel area. An electron multiplier voltage of the range of electron multiplier voltages is applied to the electron multiplier and the dynode voltage is applied to the at least one dynode using the one or more voltage sources.

Abstract: A device for manufacturing a reinforcing ply N by assembling lengths of strip cut at an angle, comprising: a feed means (300) for delivering a strip (B), an assembly belt (101), a transfer means (200) for conveying onto the assembly belt a given length of straight-grain strip in a direction (AA?) comprising a retaining wall (211), parallel to the planes of the assembly belt (101) and of the feed means, and a first face (211a) of which is intended to come into contact with the surface of the strip, in which device the feed means (300), the transfer means (200) and the assembly belt (101) are fitted with magnetic means.

Abstract: A system and method for determining characteristics of a trailer being towed by a vehicle. The trailer is coupled to the vehicle using a trailer hitch using at least one intelligent bolt or fastener. The intelligent fastener has structural characteristics similar to those of traditional bolts for fastening a trailer to a vehicle (e.g., shear strength, diameter, etc.), but the intelligent fastener is configured to sense forces at a junction between the trailer and the vehicle. An ESC system receives force readings from the intelligent fastener sensors along with signals from a plurality of other sensors and determines one or more characteristics of the trailer. The ESC system compensates the motion of the vehicle based on the forces sensed at the junction and the characteristics of the trailer.

Abstract: Device for manufacturing a reinforcement from a thread laid directly in its final place by casting lengths of the said thread onto a receiving surface, the said device comprising a feed means (200) for feeding the thread (1) from a source of thread (10), a rotary assembly comprising a rotary guide (2) of axis rr? fixed to a hollow shaft (20, 205) constituting the axis of rotation (RR?) of the said guide (2) so that the outer radial end (21) of the said guide (2) is directed substantially radially with respect to the axis of rotation of the hollow shaft (RR?), the said guide receiving the thread (1) that comes from the said feed means via its central end (22) that is the opposite end to the said outer radial end (21), the said thread leaving via the said outer radial end (21), the said feed means controlling the linear speed at which the thread advances inside the said rotary guide (2), means (13, 131) for rotating the hollow shaft, and means (31) for cutting the thread, acting on the thread in such a way as t

Abstract: A device for manufacturing a reinforcing ply N by assembling lengths of strip cut at an angle, comprising: a feed means (300) for delivering a strip (B), an assembly belt (101), a transfer means (200) for conveying onto the assembly belt a given length of straight-grain strip in a direction (AA?) comprising a retaining wall (211), parallel to the planes of the assembly belt (101) and of the feed means, and a first face (211a) of which is intended to come into contact with the surface of the strip, in which device the feed means (300), the transfer means (200) and the assembly belt (101) are fitted with magnetic means.

Abstract: The invention relates to an overpressure and bottoming detector for a shock-absorber or the like, the detector including a hollow body inside which a piston slides sealingly and that is designed to be subjected to a pressure via an inlet of the body that is in communication with an enclosure in which said pressure exists, the piston being retained in position against the pressure by threshold retaining means adapted to release the piston when the pressure reaches or exceeds said threshold in such a manner that the piston is pushed under the effect of the pressure towards an indication position, and wherein the piston is secured to a pin that projects from the inlet of the body so as to be capable of being pushed against the threshold retaining means.

Abstract: An apparatus for manufacturing a reinforcement from a thread laid down directly in its final location by projecting lengths of the thread onto a receiving surface (S). The apparatus has feed means for feeding thread from a source of thread, a rotary conduit (2) receiving the thread, thread-cutting device has a roller fixed with respect to the thread, and a moving cutter acting on the thread in collaboration with said roller so as, for each revolution of the rotary conduit, to release a length having a free end at the cutting means end. The apparatus also has a buffer positioned in the path of the free end so that, during the operation, the free end strikes the buffer before coming into contact with the receiving surface (S).

Abstract: The invention provides a system and method for determining characteristics of a trailer being towed by a vehicle that includes an electronic stability control (“ESC”) system. The trailer is coupled to the vehicle using a trailer hitch. The hitch is configured to fasten the trailer to the vehicle using at least one intelligent bolt or fastener. The intelligent fastener has structural characteristics similar to those of traditional bolts for fastening a trailer to a vehicle (e.g., shear strength, diameter, etc.), but the intelligent fastener is configured to sense forces at a junction between the trailer and the vehicle. The ESC system receives force readings from the intelligent fastener sensors and uses them in conjunction with signals from a plurality of other sensors connected to the ESC system to determine one or more characteristics of the trailer. The characteristics of the trailer include a trailer weight, a trailer sway, and a trailer center of gravity.

Abstract: A method for determining the operating parameters of a device for manufacturing a reinforcement from a thread (1) laid directly in its final position by projecting lengths of thread (10) onto a receiving surface (S).

Abstract: Device for manufacturing a reinforcement from a thread laid directly in its final position by spraying lengths of the thread onto a receiving surface. The thread lengths are delivered from a conduit to a guide as the conduit rotates about an axis. The guide includes deflectors forming therebetween a slot having a thread inlet orifice and a thread spray (discharge) orifice spaced apart along the guide's height. The separation between the deflectors narrows toward the spray orifice, wherein the deflectors form therebetween an angle in the range of 3° and 7° when measured at any point along the height of the slot.

Abstract: Device for manufacturing a reinforcement from a thread laid directly in its final place by casting lengths of the said thread onto a receiving surface, the said device comprising a feed means (200) for feeding the thread (1) from a source of thread (10), a rotary assembly comprising a rotary guide (2) of axis rr? fixed to a hollow shaft (20, 205) constituting the axis of rotation (RR?) of the said guide (2) so that the outer radial end (21) of the said guide (2) is directed substantially radially with respect to the axis of rotation of the hollow shaft (RR?), the said guide receiving the thread (1) that comes from the said feed means via its central end (22) that is the opposite end to the said outer radial end (21), the said thread leaving via the said outer radial end (21), the said feed means controlling the linear speed at which the thread advances inside the said rotary guide (2), means (13, 131) for rotating the hollow shaft, and means (31) for cutting the thread, acting on the thread in such a way as t