Patents by Inventor Patrick Pfister
Patrick Pfister has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240117001Abstract: Provided herein are polypeptides that bind to the malodour-causing substance DMTS. Also provided are nucleic acid sequences that encode for the polypeptides. Further provided herein is a method for identifying a compound that binds, suppresses, blocks, inhibits, and/or modulates the activity of one or more olfactory receptor that is activated by the malodor-causing substance DMTS comprising a) contacting the receptor, or a chimera or fragment thereof with a compound and b) determining whether the compound has an effect on the activity of the receptor. Further provided is an expression vector comprising the nucleic acid encoding the polypeptides described as well as a non-human organism or a host cell modified to express a receptor that is activated by DMTS. Also provided is the use of the polypeptides for identifying malodor modulating compounds.Type: ApplicationFiled: October 13, 2023Publication date: April 11, 2024Applicant: FIRMENICH SAInventors: Patrick Pfister, Matthew Rogers, Huey-Ling Kao, Claude Ayome Abibi
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Patent number: 11951197Abstract: Described herein are compositions and/or ingredients that increase a subject's perception of floral muguet compounds, methods for intensifying a subject's perception of floral muguet compounds, as well as perfumed articles or perfuming compositions including as an active ingredient, at least one compound selected from octanal; (E)-dec-2-enal, 2-phenylpropanal; (E)-but-2-enal; 3-methylbenzaldehyde; 3-(1,3-benzodioxol-5-yl)-2-methylpropanal; (±)-3-(4-methyl-3-penten-1-yl)-3-cyclohexene-1-carbaldehyde, (±)-4-(4-methyl-3-penten-1-yl)-3-cyclohexene-1-carbaldehyde, and mixtures thereof; heptanal, 4-Propan-2-ylbenzaldehyde; (3R)-3,7-dimethyloct-6-enal; (+)-(3S)-3-[(1R)-4-methyl-3-cyclohexen-1-yl]butanal, (+)-(3R)-3-[(1R)-4-methyl-3-cyclohexen-1-yl]butanal, and mixtures thereof; hexanal; 2,6-dimethylhept-5-enal; benzaldehyde; 2-methyl-3-(4-methylphenyl)propanal; 3,5,6-trimethyl-3-cyclohexene-1-carbaldehyde, 2,4,6-trimethyl-3-cyclohexene-1-carbaldehyde, and mixtures thereof; 4-ethylbenzaldehyde; 6-methoxy-2,6-dimethylType: GrantFiled: December 17, 2019Date of Patent: April 9, 2024Assignee: FIRMENICH SAInventors: Patrick Pfister, Christie Delaura, Casey Trimmer, Lily Wu, Aleksey Dumer, Florian De Nanteuil
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Patent number: 11921105Abstract: The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to assays and methods for screening and identifying compositions and/or ingredients that intensify a subject's perception of target odorant compounds based on the use of particular olfactory receptors activated by the target odorant compound.Type: GrantFiled: December 20, 2018Date of Patent: March 5, 2024Inventors: Patrick Pfister, Matthew Rogers, Lily Wu, Christian Margot
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Patent number: 11787847Abstract: Provided herein are polypeptides that bind to the malodour-causing substance DMTS. Also provided are nucleic acid sequences that encode for the polypeptides. Further provided herein is a method for identifying a compound that binds, suppresses, blocks, inhibits, and/or modulates the activity of one or more olfactory receptor that is activated by the malodor-causing substance DMTS comprising a) contacting the receptor, or a chimera or fragment thereof with a compound and b) determining whether the compound has an effect on the activity of the receptor. Further provided is an expression vector comprising the nucleic acid encoding the polypeptides described as well as a non-human organism or a host cell modified to express a receptor that is activated by DMTS. Also provided is the use of the polypeptides for identifying malodor modulating compounds.Type: GrantFiled: March 8, 2018Date of Patent: October 17, 2023Assignee: FIRMENICH SAInventors: Patrick Pfister, Matthew Rogers, Huey-Ling Kao, Claude Ayome Abibi
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Patent number: 11744785Abstract: The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to the use of volatile compositions to limit, decrease or eliminate the perception of malodor. Such compositions include at least one malodor antagonist optionally combined with perfuming ingredients. Such compositions, their use in combination with delivery systems and their applications in consumer products are also objects of the present disclosure.Type: GrantFiled: November 21, 2018Date of Patent: September 5, 2023Assignee: FIRMENICH SAInventors: Huey-Ling Kao, Stefan Alexander Ruider, Ben Smith, Gary Marr, Matthew Rogers, Mushhood Sheikh, Zhenan Wu, Patrick Pfister, Anthony Alexander Birkbeck, Julien Coulomb
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Publication number: 20230233425Abstract: The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to the use of volatile compositions to limit, decrease or eliminate the perception of malodor. Such compositions include at least one malodor antagonist optionally combined with perfuming ingredients. Such compositions, their use in combination with delivery systems and their applications in consumer products are also objects of the present disclosure.Type: ApplicationFiled: December 16, 2022Publication date: July 27, 2023Applicant: Firmenich SAInventors: Huey-Ling KAO, Stefan Alexander RUIDER, Ben SMITH, Gary MARR, Matthew ROGERS, Mushhood SHEIKH, Zhenan WU, Patrick PFISTER, Anthony Alexander BIRKBECK, Julien COULOMB
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Publication number: 20230125249Abstract: The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to compositions and/or ingredients that increase a subject's perception of musk compounds, methods for intensifying a subject's perception of musk compounds, as well as to the perfumed articles or perfuming compositions comprising as an active ingredient, a compound of Formula (I).Type: ApplicationFiled: November 17, 2022Publication date: April 27, 2023Inventors: Patrick PFISTER, Matthew ROGERS, Jana PIKA, Florian DE NANTEUIL, Nicholas O'LEARY, Christie DELAURA
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Publication number: 20230065799Abstract: The present invention relates to the perfumery industry. More particularly, the present invention relates to assays and methods for screening and identifying compositions and/or ingredients that intensify a subjects perception of target odorant compounds based on the use of particular olfactory receptors activated by the target odorant compound.Type: ApplicationFiled: October 2, 2020Publication date: March 2, 2023Inventors: Ben SMITH, Patrick PFISTER, Lily WU, Hyo Young JEONG, Daniel RAPS
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Patent number: 11530366Abstract: The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to compositions and/or ingredients that increase a subjects perception of musk compounds, methods for intensifying a subjects perception of musk compounds, as well as to the perfumed articles or perfuming compositions comprising as an active ingredient, a compound of Formula (I).Type: GrantFiled: December 20, 2018Date of Patent: December 20, 2022Assignee: Firmenich SAInventors: Patrick Pfister, Matthew Rogers, Jana Pika, Florian De Nanteuil, Nicholas O'Leary, Christie Delaura
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Publication number: 20220375548Abstract: The composition tonality determination method includes: inputting at least one volatile molecule digital identifier, the volatile molecule digital identifier representative of a fragrant volatile molecule, the input defining a formula, calculating, by a computing system, for at least one volatile molecule digital identifier of the formula, a value representative of an impact of each molecule on an activity level of an odorant receptor, represented by an odorant receptor digital identifier, each volatile molecule digital identifier being associated with at least one odorant receptor digital identifier, the association being a many-to-many association, and determining, by a computing system, for the formula and as a function of at least one odorant receptor activity level impact calculated and a value representative of an odorant receptor activation threshold, a value representative of at least one tonality forming a composition, each odorant receptor digital identifier being associated with one tonality digitaType: ApplicationFiled: October 2, 2020Publication date: November 24, 2022Inventors: Ben SMITH, Patrick PFISTER, Lily WU, Hyo Young JEONG, Daniel RAPS, Maria BORISOVSKA
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Patent number: 11267852Abstract: Provided herein is a cell line with improved odorant receptor function comprising an activated endogenous RTP1 gene, which further expresses an RTP1 protein. Further provided herein is a method for specifically activating an endogenous RTP1 gene in a eukaryotic cell using a CRISPR/Cas9 derived technique. Also provided herein is a method for identifying compounds with desired effects such as perfume or aroma modulators in said cell line.Type: GrantFiled: June 9, 2016Date of Patent: March 8, 2022Assignee: FIRMENICH SAInventors: Hyo-Young Jeong, Patrick Pfister, Matthew Rogers
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Publication number: 20220008302Abstract: Described herein are compositions and/or ingredients that increase a subject's perception of floral muguet compounds, methods for intensifying a subject's perception of floral muguet compounds, as well as perfumed articles or perfuming compositions including as an active ingredient, at least one compound selected from octanal; (E)-dec-2-enal, 2-phenylpropanal; (E)-but-2-enal; 3-methylbenzaldehyde; 3-(1,3-benzodioxol-5-yl)-2-methylpropanal; (±)-3-(4-methyl-3-penten-1-yl)-3-cyclohexene-1-carbaldehyde, (±)-4-(4-methyl-3-penten-1-yl)-3-cyclohexene-1-carbaldehyde, and mixtures thereof; heptanal, 4-Propan-2-ylbenzaldehyde; (3R)-3,7-dimethyloct-6-enal; (+)-(3S)-3-[(1R)-4-methyl-3-cyclohexen-1-yl]butanal, (+)-(3R)-3-[(1R)-4-methyl-3-cyclohexen-1-yl]butanal, and mixtures thereof; hexanal; 2,6-dimethylhept-5-enal; benzaldehyde; 2-methyl-3-(4-methylphenyl)propanal; 3,5,6-trimethyl-3-cyclohexene-1-carbaldehyde, 2,4,6-trimethyl-3-cyclohexene-1-carbaldehyde, and mixtures thereof; 4-ethylbenzaldehyde; 6-methoxy-2,6-dimethylType: ApplicationFiled: December 17, 2019Publication date: January 13, 2022Inventors: Patrick Pfister, Christie Delaura, Casey Trimmer, Lily Wu, Aleksey Dumer, Florian De Nanteuil
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Patent number: 10913787Abstract: Provided herein are polypeptides that bind to Musk compounds. Also provided are nucleic acid sequences that encode for the polypeptides. Further provided herein is a method for identifying a compound that activates, mimics, blocks, inhibits, modulates, and/or enhances the activity of an olfactory receptor that is activated by a polycyclic Musk or a nitro Musk wherein the receptor is a polypeptide having an amino acid sequence that is at least 75% identical to Olfr96 or OR11A1, wherein the method includes a) contacting the receptor, or a chimera or fragment thereof with a compound and b) determining whether the compound has an effect on the activity of the receptor.Type: GrantFiled: June 9, 2016Date of Patent: February 9, 2021Assignee: Firmenich SAInventors: Patrick Pfister, Matthew Rogers
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Publication number: 20210003553Abstract: The present disclosure relates to a method for identifying a compound that binds, suppresses, blocks, inhibits, and/or modulates the activity of an olfactory receptor that is activated by a laundry malodor causing substance, a moldy malodour causing substance and/or a sweat malodor-causing substance. The method includes contacting a test substance and the laundry malodor and/or sweat malodor-causing substance to an olfactory receptor polypeptide.Type: ApplicationFiled: November 21, 2018Publication date: January 7, 2021Inventors: Huey-Ling KAO, Mushhood SHEIKH, Patrick PFISTER, Cristinel SANDU, Barry EVANS, Nicholas O'LEARY, Ben SMITH
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Publication number: 20200408738Abstract: The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to assays and methods for screening and identifying compositions and/or ingredients that intensify a subject's perception of target odorant compounds based on the use of particular olfactory receptors activated by the target odorant compound.Type: ApplicationFiled: December 20, 2018Publication date: December 31, 2020Inventors: Patrick PFISTER, Matthew ROGERS, Lily WU, Christian MARGOT
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Publication number: 20200385648Abstract: The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to compositions and/or ingredients that increase a subjects perception of musk compounds, methods for intensifying a subjects perception of musk compounds, as well as to the perfumed articles or perfuming compositions comprising as an active ingredient, a compound of Formula (I).Type: ApplicationFiled: December 20, 2018Publication date: December 10, 2020Applicant: Firmenich, SAInventors: Patrick PFISTER, Matthew ROGERS, Jana PIKA, Florian DE NANTEUIL, Nicholas O'LEARY, Christie DELAURA
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Publication number: 20200345601Abstract: The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to the use of volatile compositions to limit, decrease or eliminate the perception of malodor. Such compositions include at least one malodor antagonist optionally combined with perfuming ingredients. Such compositions, their use in combination with delivery systems and their applications in consumer products are also objects of the present disclosure.Type: ApplicationFiled: November 21, 2018Publication date: November 5, 2020Applicant: Firmenich SAInventors: Huey-Ling KAO, Stefan Alexander RUIDER, Ben SMITH, Gary MARR, Matthew ROGERS, Mushhood SHEIKH, Anna WU, Patrick PFISTER, Anthony Alexander BIRKBECK, Julien COULOMB
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Publication number: 20200048326Abstract: Provided herein are polypeptides that bind to Musk compounds. Also provided are nucleic acid sequences that encode for the polypeptides. Further provided herein is a method for identifying a compound that activates, mimics, blocks, inhibits, modulates, and/or enhances the activity of an olfactory receptor that is activated by a polycyclic Musk or a nitro Musk wherein the receptor is a polypeptide having an amino acid sequence that is at least 75% identical to Olfr96 or OR11A1, wherein the method includes a) contacting the receptor, or a chimera or fragment thereof with a compound and b) determining whether the compound has an effect on the activity of the receptor.Type: ApplicationFiled: June 9, 2016Publication date: February 13, 2020Applicant: Firmenich SAInventors: Patrick PFISTER, Matthew ROGERS
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Publication number: 20200002399Abstract: Provided herein are polypeptides that bind to the malodour-causing substance DMTS. Also provided are nucleic acid N sequences that encode for the polypeptides. Further provided herein is a method for identifying a compound that binds, suppresses, blocks, inhibits, and/or modulates the activity of one or more olfactory receptor that is activated by the malodor-causing substance DMTS comprising a) contacting the receptor, or a chimera or fragment thereof with a compound and b) determining whether the compound has an effect on the activity of the receptor. Further provided is an expression vector comprising the nucleic acid encoding the polypeptides described as well as a non-human organism or a host cell modified to express a receptor that is activated by DMTS. Also provided is the use of the polypeptides for identifying malodor modulating compounds.Type: ApplicationFiled: March 8, 2018Publication date: January 2, 2020Inventors: Patrick Pfister, Matthew Rogers, Huey-Ling Kao, Claude Ayome Abibi
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Publication number: 20180298069Abstract: Provided herein is a cell line with improved odorant receptor function comprising an activated endogenous RTP1 gene, which further expresses an RTP1 protein. Further provided herein is a method for specifically activating an endogenous RTP1 gene in a eukaryotic cell using a CRISPR/Cas9 derived technique. Also provided herein is a method for identifying compounds with desired effects such as perfume or aroma modulators in said cell line.Type: ApplicationFiled: June 9, 2016Publication date: October 18, 2018Applicant: Firmenich SAInventors: Hyo-Young JEONG, Patrick PFISTER, Matthew ROGERS