Patents by Inventor Paul A. Bottomley
Paul A. Bottomley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9482728Abstract: Featured are a device with localized sensitivity to magnetic resonance signals, an imaging system using such a device and MRI methods for performing internal MRI or MRI Endoscopy. Such an MRI method includes introducing an MRI antenna or probe into the specimen to be imaged, the antenna being configured in accordance with the devices described herein, so that the spatial coordinate frame of imaging is inherently locked or defined with respect to the introduced antenna thereby providing imaging of the specimen from the point of view of the antenna. Further such imaging is conducted so that the MRI signal is confined substantially to a volume with respect to a particular region of the antenna or probe.Type: GrantFiled: December 31, 2007Date of Patent: November 1, 2016Assignee: The Johns Hopkins UniversityInventors: Paul A. Bottomley, Shashank Sathyanarayana
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METHODS AND APPARATUS FOR FABRICATING LEADS WITH CONDUCTORS AND RELATED FLEXIBLE LEAD CONFIGURATIONS
Publication number: 20160220812Abstract: MRI/RF compatible leads include at least one conductor, a respective conductor having at least one segment with a multi-layer stacked coil configuration. The lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related leads and methods of fabricating leads are also described.Type: ApplicationFiled: February 1, 2016Publication date: August 4, 2016Inventors: Paul A. Bottomley, Parag V. Karmarkar, Justin M. Allen, William A. Edelstein, Peter Piferi, Brian Gore -
Publication number: 20160030290Abstract: A feeding apparatus includes a container, a flexible mouthpiece, and a partition. The container includes an open end and defines a main chamber. The flexible mouthpiece defines a secondary chamber in the container and includes a teat. The partition separates the main and secondary chambers and is part of a resiliently biased cartridge. When the flexible mouthpiece and partition are brought together, a flow restrictor is formed. A moveable part of the cartridge is configured to be biased towards a first position by a biasing element, and is moveable against the bias from the first position to a second position. The cartridge at least substantially closes a path for a flow of liquid feed through the flow restrictor and between the main and secondary chambers when the moveable part is in the first position, and opens the path when the moveable part is in the second position.Type: ApplicationFiled: October 16, 2015Publication date: February 4, 2016Applicant: Haberman Products LimitedInventors: Mandy Haberman, Paul Bottomley, Steve Reese, James Turner, Colin Jones
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Patent number: 9248270Abstract: MRI/RF compatible leads include at least one conductor, a respective conductor having at least one segment with a multi-layer stacked coil configuration. The lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related leads and methods of fabricating leads are also described.Type: GrantFiled: March 13, 2008Date of Patent: February 2, 2016Assignees: Boston Scientific Neuromodulation Corporation, MRI Interventions, Inc.Inventors: Parag V. Karmarkar, Paul A. Bottomley, Justin M. Allen, William A. Edelstein, Peter Piferi, Brian Gore
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Patent number: 9161886Abstract: Colic can be a particular problem for babies feeding on liquid feed from a feeder bottle. The colic can be formed by air from various sources in the liquid feed. Typically, there is less air in the liquid feed towards the bottom of the liquid feed container in the feeding position than towards the top of the liquid feed. The present invention provides apparatus for drawing milk from the bottom of the feeding apparatus chamber when the feeder is held in the operating position. This is achieved by positioning a flow restrictor for allowing the passage of liquid feed from a main chamber into a flexible feeding teat at a suitable location. The present invention also provides a resiliently-biased cartridge to assist in priming and/or draining of the flexible feeding teat. The present invention also provides a construction in which the flow restrictor is always provided in the correct position regardless of the relative angular orientation of the elements of the feeder.Type: GrantFiled: December 22, 2008Date of Patent: October 20, 2015Assignee: Haberman Products LimitedInventors: Mandy Haberman, Paul Bottomley, Steve Reese, James Turner, Colin Jones
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Publication number: 20150257675Abstract: A method of internal MRI employing at least one active internal MRI detector located within a sample of interest. The method includes applying an MRI pulse sequence to the sample of interest. The MRI pulse sequence includes spatial encoding projections. The method further includes receiving MRI signals at the active internal MRI detector and reconstructing at least one MRI image from the MRI signals using an error minimizing algorithm. The MRI pulse sequence provides an increase in an acquisition speed when reconstructing the at least one MRI image by sparsely under-sampling an image k-space in at least one dimension.Type: ApplicationFiled: September 20, 2013Publication date: September 17, 2015Inventors: Paul Bottomley, Yi Zhang, Shashank S. Hegde
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Patent number: 8717021Abstract: Featured is a dosimeter device that measures SAR deposited by RF power deposition during MRI of a specimen. Such a dosimeter device includes a transducer that is configured to present a load to the MRI scanner in which the transducer is located and to provide an output representative of signals induced in the transducer. The transducer also is configured so that the presented load is substantially equivalent to another load which would be presented by the specimen during MRI of the specimen. Such a transducer also is configured so as to generate an MRI signal that is sufficient to allow the MRI scanner to adjust the RF power to a value substantially equal to that of the specimen. Also featured are methods for measuring SAR deposited by RF power deposition and apparatuses or system embodying such a dosimeter device.Type: GrantFiled: September 8, 2008Date of Patent: May 6, 2014Assignee: The Johns Hopkins UniversityInventors: Paul A. Bottomley, John P. Stralka
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Patent number: 8688226Abstract: Some embodiments are directed to MRI/RF compatible medical interventional devices. A plurality of spaced apart high impedance circuit segments are configured to have a high impedance at a high range of radiofrequencies and a low impedance at a low range of frequencies. The high impedance circuit segments may comprise co-wound coiled inductors and can reduce, block or inhibit RJ-transmission along the lead system (20) during exposure to RF associated with a high-Held magnet MRI systems, while permuting passage of low frequency physiologic signals, treatments and/or stimuli. The devices can include at least one electrode.Type: GrantFiled: April 29, 2013Date of Patent: April 1, 2014Assignees: Boston Scientific Neuromodulation Corporation, MRI Interventions, Inc.Inventors: Ergin Atalar, Justin Allen, Paul Bottomley, William Edelstein, Parag V. Karmarkar
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Publication number: 20140015529Abstract: A method of performing spatially localized magnetic resonance spectroscopy includes receiving a magnetic resonance image of an object; identifying a plurality C of compartments that generate magnetic resonance spectroscopy signals in the object including at least one compartment of interest; segmenting in at least one spatial dimension the magnetic resonance image of the object into the C compartments; acquiring magnetic resonance spectroscopy signals from the compartments by applying a plurality of M? phase encodings applied in the at least one spatial dimension, wherein M??C; calculating a spatially localized magnetic resonance chemical shift spectrum from the at least one compartment of interest; and rendering a spatially localized magnetic resonance spectrum that is substantially equal to a spatial average of magnetic resonance chemical shift spectra from the at least one compartment of interest. A magnetic resonance spectroscopy and imaging system is configured to perform the above method.Type: ApplicationFiled: March 22, 2012Publication date: January 16, 2014Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Paul A. Bottomley, Refaat Gabr, Yi Zhang
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Publication number: 20140015547Abstract: A device with at least one channel for measuring high dynamic range, radio frequency (RF) power levels over broad-ranging duty cycles includes a power sensor circuit comprising at least one logarithmic amplifier; at least one directional RF coupler electrically connected to the at least one power sensor; at least one RF attenuator electrically connected to the at least one RF coupler; and at least one sampling circuit electrically connected to the at least one RF attenuator and the at least one RF coupler. The at least one sampling circuit performs analog-to-digital conversion of electrical signals received to provide digitals signals for measuring the RF power level in the at least one channel.Type: ApplicationFiled: March 22, 2012Publication date: January 16, 2014Applicant: The Johns Hopkins UniversityInventors: Paul A. Bottomley, William Edelstein, Abdel-Monem M. El-Sharkawy, Di Qian
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Publication number: 20130245741Abstract: Some embodiments are directed to MRI/RF compatible medical interventional devices. A plurality of spaced apart high impedance circuit segments are configured to have a high Impedance at a high range of radiofrequencies and a low impedance at a low range of frequencies. The high impedance circuit segments may comprise co-wound coiled inductors and can reduce, block or inhibit RJ-transmission along the lead system (20) during exposure to RF associated with a high-Held magnet MRI systems, while permuting passage of low frequency physiologic signals, treatments and/or stimuli. The devices can include at least one electrode.Type: ApplicationFiled: April 29, 2013Publication date: September 19, 2013Applicants: MRI Interventions, Inc., BOSTON SCIENTIFIC NEUROMODULATION CORPORATIONInventors: Ergin Atalar, Justin Allen, Paul Bottomley, William Edelstein, Parag V. Kamarkar
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Patent number: 8433421Abstract: Some embodiments are directed to MRI/RF compatible medical interventional devices. A plurality of spaced apart high impedance circuit segments are configured to have a high impedance at a high range of radiofrequencies and a low impedance at a low range of frequencies. The high impedance circuit segments may comprise co-wound coiled inductors and can reduce, block or inhibit RJ-transmission along the lead system (20) during exposure to RF associated with a high-Held magnet MRI systems, while permuting passage of low frequency physiologic signals, treatments and/or stimuli. The devices can include at least one electrode.Type: GrantFiled: November 7, 2011Date of Patent: April 30, 2013Assignees: Boston Scientific Neuromodulation Corporation, MRI Interventions, Inc.Inventors: Ergin Atalar, Justin Allen, Paul Bottomley, William Eldelstein, Parag V. Karmarkar
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Publication number: 20120071953Abstract: Some embodiments are directed to MRI/RF compatible medical interventional devices. A plurality of spaced apart high impedance circuit segments are configured to have a high impedance at a high range of radiofrequencies and a low impedance at a low range of frequencies. The high impedance circuit segments may comprise co-wound coiled inductors and can reduce, block or inhibit RJ-transmission along the lead system (20) during exposure to RF associated with a high-Held magnet MRI systems, while permuting passage of low frequency physiologic signals, treatments and/or stimuli. The devices can include at least one electrode.Type: ApplicationFiled: November 7, 2011Publication date: March 22, 2012Applicants: MRI Interventions, Inc., Boston Scientific Neuromodulation CorporationInventors: Ergin Atalar, Justin Allen, Paul Bottomley, William Eldelstein, Parag V. Karmarkar
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Patent number: 8055351Abstract: Some embodiments are directed to MRI/RF compatible medical interventional devices. A plurality of spaced apart high impedance circuit segments are configured to have a high impedance at a high range of radiofrequencies and a low impedance at a low range of frequencies The high impedance circuit segments may comprise co-wound coiled inductors and can reduce, block or inhibit RJ-transmission along the lead system (20) during exposure to RF associated with a high-Held magnet MRI systems, while permuting passage of low frequency physiologic signals, treatments and/or stimuli The devices can include at least one electrode.Type: GrantFiled: October 20, 2006Date of Patent: November 8, 2011Assignees: Boston Scientific Neuromodulation Corporation, MRI Interventions, Inc.Inventors: Ergin Atalar, Justin Allen, Paul Bottomley, William Eldelstein, Parag V. Karmarkar
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Patent number: 8004281Abstract: Featured is a device for NMR or MRI signals from excited nuclei as well as related apparatus, systems and methods. The device includes a strip array antenna including one or more conductor and N reactive tuning components, where N is an integer ?1 at least one of the N reactive components is electrically coupled to each of the one or more conductors as well as to ground/virtual ground. The apparent electrical length of the conductors is tuned with the reactive tuning components so it is equal to be about n?/4, where n is an integer ?1 and ? is the wavelength of the signal to be detected. The length of the strip also is such as to be substantially in the approximate range of 1.3 times the depth of interest. The strip conductors are also combined with loop coils to form quadrature detectors.Type: GrantFiled: September 10, 2010Date of Patent: August 23, 2011Assignee: The Johns Hopkins UniversityInventors: Paul A. Bottomley, Ananda Kumar
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Publication number: 20110148411Abstract: Featured is a dosimeter device that measures SAR deposited by RF power deposition during MRI of a specimen. Such a dosimeter device includes a transducer that is configured to present a load to the MRI scanner in which the transducer is located and to provide an output representative of signals induced in the transducer. The transducer also is configured so that the presented load is substantially equivalent to another load which would be presented by the specimen during MRI of the specimen. Such a transducer also is configured so as to generate an MRI signal that is sufficient to allow the MRI scanner to adjust the RF power to a value substantially equal to that of the specimen. Also featured are methods for measuring SAR deposited by RF power deposition and apparatuses or system embodying such a dosimeter device.Type: ApplicationFiled: September 8, 2008Publication date: June 23, 2011Applicant: Johns Hopkins UniversityInventors: Paul A. Bottomley, John Paul Stralka
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Patent number: 7909752Abstract: The use of stimuli in order to create association between training regimes subconsciously is known. Unfortunately, in highly noisy and other polluted environments it is difficult to provide ongoing reinforcement of previous behavior modification and training. By providing a stimulus phrase which comprises two or more stimuli in known combinations it is possible to provide keyed association with previous training regimes.Type: GrantFiled: September 21, 2005Date of Patent: March 22, 2011Assignee: Can-Do Corporation LimitedInventor: Paul Bottomley
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Publication number: 20110037468Abstract: Featured is a device for NMR or MRI signals from excited nuclei as well as related apparatus, systems and methods. The device includes a strip array antenna including one or more conductor and N reactive tuning components, where N is an integer?1 at least one of the N reactive components is electrically coupled to each of the one or more conductors as well as to ground/virtual ground. The apparent electrical length of the conductors is tuned with the reactive tuning components so it is equal to be about n?/4, where n is an integer?1 and ? is the wavelength of the signal to be detected. The length of the strip also is such as to be substantially in the approximate range of 1.3 times the depth of interest. The strip conductors are also combined with loop coils to form quadrature detectors.Type: ApplicationFiled: September 10, 2010Publication date: February 17, 2011Applicant: The Johns Hopkins UniversityInventors: Paul A. Bottomley, Ananda Kumar
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Publication number: 20100314347Abstract: Colic can be a particular problem for babies feeding on liquid feed from a feeder bottle. The colic can be formed by air from various sources in the liquid feed. Typically, there is less air in the liquid feed towards the bottom of the liquid feed container in the feeding position than towards the top of the liquid feed. The present invention provides apparatus for drawing milk from the bottom of the feeding apparatus chamber when the feeder is held in the operating position. This is achieved by positioning a flow restrictor for allowing the passage of liquid feed from a main chamber into a flexible feeding teat at a suitable location. The present invention also provides a resiliently-biased cartridge to assist in priming and/or draining of the flexible feeding teat. The present invention also provides a construction in which the flow restrictor is always provided in the correct position regardless of the relative angular orientation of the elements of the feeder.Type: ApplicationFiled: December 22, 2008Publication date: December 16, 2010Applicant: The Anywayup Company LimitedInventors: Mandy Haberman, Paul Bottomley, Steve Reese, James Turner, Colin Jones
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Patent number: D684426Type: GrantFiled: February 28, 2012Date of Patent: June 18, 2013Assignee: Haberman Products LimitedInventors: Paul Bottomley, Peter Fullagar, Mandy Haberman, Colin Jones, James Turner