Abstract: A medical device, comprising a fastening assembly, wherein the fastening assembly includes an adapter defining an opening therethrough, a fastener releasably coupled to the adapter, wherein the fastener includes at least two jaws pivotable relative to one another, the fastener having a first configuration wherein the jaws are open and a second configuration wherein the jaws are closed, and at least one cable coupled to the fastener and the adapter, the at least one cable being configured to apply tension to the fastener to transition between the first configuration and the second configuration while the fastener is coupled to the adapter, and to control release of the fastener from the adapter.

Abstract: A boat lift controller may include a digital switch, a power-isolation relay, and a motor-direction-select relay, together which control a motor. The digital switch may provide power to the power-isolation relay. The power-isolation relay may provide power to the motor-direction-select relay and to the motor. The motor-direction-select relay may control the direction in which the shaft of the motor turns.

Abstract: Disclosed is a cyber-security system that is configured to aggregate and unify data from multiple components and platforms on a network. The system allows security administrators to design and implement a workflow of device-actions taken by security individuals in response to a security incident. Based on the nature of a particular threat, the cyber-security system may initiate an action plan that is tailored to the security operations center and their operating procedures to protect potentially impacted components and network resources.

Abstract: Stent delivery systems and methods for making and using stent delivery systems are disclosed. An example stent delivery system may include an inner member having a stent receiving region, a stent disposed along the stent receiving region, a deployment sheath axially slidable relative to the inner member, the deployment sheath having a proximal end region, a handle coupled to the deployment sheath, a rod coupled to the handle, the rod having a distal end region, a proximal end region and a first threaded portion extending from the distal end region to the proximal end region and a coupling member configured to couple the rod to the deployment sheath, the coupling member having an engagement portion. Additionally, the first threaded portion of the rod is designed to engage the engagement portion of coupling member and rotation of the rod is designed to translate the coupling member along the rod.

Abstract: The present disclosure is directed to a wheel cover that is coupled to a wheel of a vehicle utilizing a mounting assembly that has a bearing block. A retainer assembly in combination with the bearing block of the mounting assembly allows the wheel cover to be coupled to the wheel in a manner such that the wheel cover does not rotate with the forward and backward rotation of the wheel when the vehicle is being driven. The wheel cover covers the wheel and partially covers a gap or space between a tire of the wheel and a fender of the vehicle, which increases the aerodynamic performance of the vehicle. The retainer assembly provides at least one degree of freedom such that the wheel cover may move with the wheel when steering the vehicle in a leftward direction and a rightward direction.

Abstract: A body support structure includes a structural lattice structure having a first stiffness, and a compressive lattice structure supported by the structural lattice structure and having a second stiffness less than the first stiffness. A skin lattice structure is supported by the compressive lattice structure, wherein the skin lattice structure is resistant to shear deformation in response to a normal force and is expandable in a direction transverse to the normal force.

Abstract: The present disclosure relates methods for treating skin disorders caused by an immune deficiency with topical formulations comprising ethyl (R)-4-((1-(2-cyanoacetyl)piperidin-3-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (Compound I) or pharmaceutically acceptable derivative thereof. In particular, the topical formulations described herein may be used to treat atopic dermatitis, alopecia areata, or vitiligo.

Abstract: The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for detection of multiple different nucleotides in a sample utilizing fewer detection moieties than the number of nucleotides being detected and/or fewer imaging events than the number of nucleotides being detected.

Abstract: Devices used to deploy transvascular medical device systems and methods for using such devices are described in this document. For example, this document describes dilating introducer devices used for the percutaneous vascular deployment of catheter-based medical devices such as structural heart medical devices. Such dilating introducer devices can facilitate the percutaneous vascular deployment of catheter-based medical devices without an additional introducer sheath.

Abstract: A clipping system includes an adapter configured to be mounted over an insertion device and a clip including first and second jaws movable between an insertion configuration and an initial deployed configuration. A first extending member is releasably coupled to the clip and movably connected to the adapter to permit a movement of the clip relative to the adapter from the insertion configuration to the initial deployed configuration. The first extending member is configured to permit withdrawal of the adapter away from the clip to place the system in a review configuration to enhance a visual observation of the clip. The first extending member is operable to retract the clip over the adapter so that the clip is forced open, freeing the clip from tissue on which it has been clipped. The first extending member is configured to release the clip therefrom in a final deployed configuration.

Abstract: Presented are methods and compositions for using immobilized transposase and a transposon end for generating an immobilized library of 5?-tagged double-stranded target DNA on a surface. The methods are useful for generating 5?- and 3?-tagged DNA fragments for use in a variety of processes, including massively parallel DNA sequencing.

Abstract: A firearm with a slide and a frame. The slide has a slide rail. The frame has a frame rail. The frame rail interfaces with the slide rail. The frame rail has a lubrication groove and a debris removal port. The lubrication groove extends along a surface of the frame rail that bears against the slide rail during operation of the firearm. The debris removal port has gap within the frame rail proximate to an end of the lubrication groove.

Abstract: An expansion joint system for bridging a gap between spaced apart structural members and capable of self-cleaning. The expansion joint system includes first and second base members, at least one upwardly sloped base plate engaged with one of the first and second base members, and at least one substantially horizontal movable plate engaged with at least one of the first and second base members. Also disclosed is an expansion joint including a first structural member and a second structural member, first and second base members, at least one upwardly sloped base plate engaged with one of the first and second base members, and at least one substantially horizontal movable plate engaged with at least one of the first and second base members.

Abstract: Methods and systems for implementing a traditional computer vision algorithm as a neural network. The method includes: receiving a definition of the traditional computer vision algorithm that identifies a sequence of one or more traditional computer vision algorithm operations; mapping each of the one or more traditional computer vision algorithm operations to a set of one or more neural network primitives that is mathematically equivalent to that traditional computer vision algorithm operation; linking the one or more network primitives mapped to each traditional computer vision algorithm operation according to the sequence to form a neural network representing the traditional computer vision algorithm; and configuring hardware logic capable of implementing a neural network to implement the neural network that represents the traditional computer vision algorithm.

Abstract: Automatic neighbor relationships (ANR) can be implemented within a radio access network intelligent controller (RIC), which receives load information from network nodes and user equipment measurements from user equipment. The RIC can create and maintain real-time load information and leverage slicing knowledge of neighbor cells during mobility to direct the user equipment to various network slices. Thus, an enhanced radio access network (RAN) neighbor relationship that utilizes slicing information can provide slice level RAN neighbor visibility on top of physical ANR relationships to enable enhancements for mobility management optimization.

Abstract: A graph database for outbreak tracking and management is disclosed. In an example embodiment, an outbreak management system includes a memory device storing instructions that define a graph database for disease outbreak tracking. The instructions specify for a given host that a host node is created and an episode node is connected to the host node via a ‘case’ link. The episode node is associated with episode parameters that are related to a disease classification of the host. In addition, the instructions specify that an outbreak node is connected to the episode node via a ‘part of’ link to indicate that the host has become part of an outbreak of the disease. The outbreak node is connected to a definition node via a ‘defined as’ link. The definition node specifies disease parameters of the disease that is related to the outbreak node.

Abstract: Foldable apparatus comprise a foldable substrate comprising a substrate thickness. The second major surface of the foldable substrate faces an end portion of a first inner surface area of a first housing member extending along a first plane. The second surface faces an end portion of a second inner surface area of a second housing member extending along a second plane. A support is attached to at least the second housing member. The support contacts the second major surface when an angle between the first plane and the second plane ranges from about 80° to about 135°. The support is spaced from the second major surface when an angle between the first plane and the second plane ranges from about 0° to about 30°. In some embodiments, the foldable substrate comprises a neutral stress configuration at a parallel plate distance ranging from about 20 millimeters to about 200 millimeters.

Abstract: The present invention relates to treatments of hereditary angioedema (HAE). In particular, the present invention provides on-demand treatments of hereditary angioedema (HAE) by orally administering a plasma kallikrein inhibitor to a patient in need thereof on-demand.

Abstract: A medical device, comprising a handle, wherein the handle includes a movable body and a stationary body; an end cap, the end cap comprising an inner cap and an outer cap, wherein the inner cap is coupled to the movable body by a control element such that movement of the movable body relative to the stationary body extends the inner cap relative to the outer cap; and a patch disposed between the inner cap and the outer cap such that movement of the inner cap relative to the outer cap at least partially deploys the patch.