Abstract: According to one aspect, a tissue fastening device may comprise a body configured to include a plurality of fasteners; an anvil rotatable relative to the body; and a tissue cutting device. The body may define a longitudinal channel configured to receive the tissue cutting device. The tissue fastening device may further comprise a fastener actuator configured to move proximally relative to the body to deploy the plurality of fasteners from the body; and an actuation wire coupled to the tissue cutting device and the fastener actuator. The actuation of the actuation wire may cause the fastener actuator to deploy at least one of the plurality of fasteners into tissue distally of tissue cut by the tissue cutting device.

Abstract: A medical device that includes: a first handle coupled to a first sheath; a second handle coupled to a second sheath, wherein at least a portion of the first sheath is disposed within a lumen of the second sheath; and a patch. In a first configuration, the first handle and the second handle may be separated by a first distance, and the patch may be disposed between a distal portion of the first sheath and a distal portion of the second sheath. In a second configuration, the first handle and the second handle may contact one another or may be separated by a second distance, wherein the second distance is smaller than the first distance, and wherein a distalmost end of the second sheath is proximal of a proximal end of the patch.

Abstract: A medical device comprising a shaft, a handle including a proximal portion and a distal portion, wherein the distal portion is fixed to a proximal portion of the shaft, and a channel extending from the handle into the shaft, wherein the channel includes a proximal channel and a distal channel, the proximal channel being rotatable relative to the distal channel and aligned with the distal channel throughout rotation of the proximal channel, wherein the proximal portion includes the proximal channel and the distal portion includes the distal channel, wherein the distal portion is rotatable relative to the proximal portion of the handle, and the shaft is configured to rotate with the distal portion of the handle.

Abstract: According to one aspect, a fastening device may include a coupling body having (1) a portion configured to couple to a distal end of a medical device, (2) a cartridge holder, and (3) an anvil pivotably coupled to the cartridge holder. The cartridge holder and the anvil may extend distally from the portion and may be configured to extend distally of a distalmost face of the medical device when the portion is coupled to the distal end of the medical device. A flexible member may be configured to extend through a channel of the medical device. A fastener cartridge may be coupled to a distal end of the flexible member, including at least one fastener, and may be configured for releasable coupling to the cartridge holder.

Abstract: A pouring attachment device for a disposable package of nitrogenated beverage, e.g. an aluminium can P, that achieves a desirable foam head when the beverage is poured into a glass. The attachment comprises a main body or housing (11), an ultrasonic wave generator (27) and a means to couple the device to the package, such as a rim seal (2)0. A flow channel has a contoured inlet (26) configured for communicating beverage from the package to an outlet (21), via a resonance chamber (28), and is particularly configured for minimising turbulence.

Abstract: A tissue fastening device includes a body including a plurality of sidewalls defining a channel, an anvil having a proximal end and a distal end and pivotally coupled to the body and the anvil moves between an open position and a closed position, and a locking mechanism to lock the anvil in the closed position.

Abstract: A space active optical cable (SAOC) includes a cable including one or more optical fibers, and two or more electrical transceivers on opposing ends of the cable and interconnected by the cable. Each of the electrical transceivers includes an enclosure that encloses one or more light sources, one or more light detectors, and control electronics. Also included in the enclosure are a coupling medium to couple light into and out of the one or more optical fibers. The coupling medium can be reflecting surface or an on-axis mount. The enclosure provides a suitable heat propagation and electromagnetic interference (EMI) shielding, and the cable and the two or more electrical transceivers are radiation resistant. SAOC features optionally support a health check algorithm that allows trending optical performance in the absence of an optical connector and a potential surface treatment to increase nominally low emissivity of an EMI conductive surface.

Abstract: This disclosure relates to ruxolitinib, or a pharmaceutically acceptable salt thereof, and its use in treating prurigo nodularis.

Abstract: A composition comprises one or more trimesic acid derivatives of Formula (I) in which R1, R2, and R3 are independently selected from the group consisting of alkyl groups. A polymer composition comprises a composition as described above and a polyolefin polymer. The polymer compositions containing a trimesic acid derivative of Formula (I) exhibit very low haze levels and minimal extraction of the trimesic acid derivative.

Abstract: A system for determining biological entities of interest is described. The system comprises a user input module configured to receive a search term comprising a representation of a biological entity; a search module configured to determine which biological entities of a set have a known association with the biological entity of the search term, those having a known association being results and those not having a known association being non-results, wherein biological entities of the set are related to each other by parent-child relationships in a relationship tree; and an analysis module configured to determine biological entities of interest by identifying non-results that have one or more results within a boundary in the relationship tree.

Abstract: Medical devices and methods of using medical devices are disclosed. An example tissue retraction device includes a first engagement member having a first end and a second end, a second engagement member having a first end and a second end, a first elastic member attached to the second end of the first engagement member, and a first alignment member having a first end, a second end and a lumen extending therethrough. Further, the tissue retraction device has a first length, the first alignment member has a second length, the first elastic member extends within the lumen of the first alignment member and the second length of the first alignment member is less than or equal to the first length of the tissue retraction device.

Abstract: A device for treating tissue includes a capsule extending longitudinally from a proximal end to a distal end and including a channel extending therethrough, the capsule releasably coupled to a proximal portion of the device and clip jaws, proximal ends of which are slidably received within the channel of the capsule so that the clip jaws are movable between an open configuration and a closed configuration. Clip jaws are configured so that a distance between the distal ends of the clip jaws in an open configuration is between 15 and 18 millimeters. Clip jaws further include barbs extending from a distal portion thereof.

Abstract: Methods and systems for redirecting a flow of air/gas to flush fluid channels. An illustrative container and tube set for redirecting a flow of air may include a container, a water supply tube including a first lumen extending therethrough, a gas supply tube including a second lumen extending therethrough, a manifold including a first inlet for receiving air, a second inlet for receiving fluid from the container, a first air outlet, and a second fluid outlet, and a valve positioned within the manifold. When the valve is in a first configuration, the first inlet is in fluid communication with the first air outlet, and the second inlet is in fluid communication the second fluid outlet and when the valve is in a second configuration, the first inlet is in fluid communication with the second fluid outlet.

Abstract: Methods and systems for coupling a tube set to an endoscope. An illustrative adaptor for coupling a tube set to an endoscope may include a planar head portion having at least one aperture, at least one floating cylinder extending from a proximal end at least partially disposed within the at least one aperture of the planar head portion to a distal tip and having a first lumen extending therethrough, at least one O-ring positioned at the distal tip of the at least one floating cylinder, and at least one biasing element disposed about an outer surface of the at least one floating cylinder and extending from a first end adjacent the at least one aperture of the planar head portion to a second end proximal to the distal tip of the at least one floating cylinder.

Abstract: Methods and systems for refilling a container during an endoscopic procedure. An illustrative container may comprise a container configured to contain a fluid, a water supply tube including a first end, a second end, and a first lumen extending therethrough and in fluid communication with the bottom portion of the container, a gas supply tube including a first end, a second end, and a second lumen extending therethrough and in operative fluid communication with container, a manifold configured to couple the water supply tube and the gas supply tube to the container and including a first end positioned interior to the container and a second end positioned exterior to the container, and a port positioned adjacent to the top portion of the container. The port may be configured to be in selective fluid communication with an interior of the container.

Abstract: Methods and systems for refilling a container during an endoscopic procedure. An illustrative container may comprise a container configured to contain a fluid within a first receptacle thereof, the container movable between a collapsed storage configuration and an expanded use configuration, a lens water supply tube including a first lumen extending therethrough, the first lumen is in fluid communication with the first receptacle of the container, a gas supply tube including a second lumen extending therethrough, the second lumen is in operative fluid communication with the first receptacle, and a port positioned adjacent to the top portion of the container. The port may be configured to be in selective fluid communication with the first receptacle of the container.

Abstract: Rotary position sensors are provided. In one example implementation, a rotary position sensor can include a first member and a second member, one of the first and second members having a transmit aerial and a receive aerial and the other of the first and second members having an intermediate coupling element. The receive aerial has at least one receive conductive winding arranged to form a first set of current loops and a second set of current loops. The intermediate coupling element comprises a conductive material arranged in a pattern. The pattern of the intermediate coupling element and the layout of the first and second set of current loops are mutually arranged such that any electromotive force induced in the first set of current loops by a background magnetic field is substantially balanced by an electromotive force induced in the second set of current loops by the background magnetic field.

Abstract: A fuel oxygen reduction unit assembly for a fuel system is provided. The fuel oxygen reduction unit assembly includes: a fuel oxygen reduction unit located downstream from the fuel source and defining a stripping gas flowpath and a liquid fuel flowpath, the fuel oxygen reduction unit comprising a means for transferring an amount of oxygen from a liquid fuel flow through the liquid fuel flowpath to a gas flow through the stripping gas flowpath; and an oxygen conversion unit in flow communication with the stripping gas flowpath configured to extract a flow of oxygen from a gas flow through the stripping gas flowpath, the oxygen conversion unit defining an oxygen outlet configured to provide the extracted flow of oxygen to an external system.

Abstract: A process for polymerizing at least one fluoromonomer in an aqueous medium containing initiator and hydrocarbon dispersing agent to form an aqueous dispersion of particles of fluoropolymer. The hydrocarbon dispersing agent comprises a compound of formula I: R—(XZ)n??I wherein R is a hydrophobic hydrocarbon moiety that comprises one or more saturated or unsaturated, non-cyclic or cyclic aliphatic groups, the percentage of total CH3 groups in relation to the total of CH3, CH2 and CH groups in said one or more aliphatic groups being at least about 70%, said hydrophobic moiety being free of siloxane units; wherein each X may be the same or different and represents an ionic hydrophilic moiety; wherein each Z may be a same or different and represents one or more counter ions for said ionic hydrophilic moiety; and wherein n is 1 to 3.