Abstract: Disclosed herein are pyrazole pyrimidine compounds that modulate and/or inhibit hematopoietic progenitor kinase 1, as well as methods of making such compounds and therapeutic methods of using same.

Abstract: In one aspect, a power distribution enclosure is provided to supply DC power to a customer. The power distribution enclosure comprises an AC input section, a DC output section, a reconfigurable service entrance, a power converter section, and a DC distribution section. The AC input section is configured to receive AC power. The DC output section is configured to distribute the DC power to the customer. The reconfigurable service entrance is electrically coupled to the AC input section. The power converter section is electrically coupled to the AC input section and is configured to receive the AC power from the reconfigurable service entrance, and to generate the DC power. The DC distribution section is electrically coupled to the power converter section and is configured to receive the DC power from the power converter section, and to distribute the DC power to the DC output section.

Abstract: An optical connection identification assembly includes first and second connectors for conveying optical signals within and away from the optical connection identification assembly, first and second optical filters configured for conveying optical signals to and from the respective first and second connectors and between each other, and first and second photodiodes. The first photodiode is configured for receiving optical signals from the first optical filter to confirm the optical connection identification assembly is receiving optical signals. The second photodiode is configured for receiving optical signals from the second optical filter to confirm the optical connection identification assembly is receiving optical signals. The first and the second connectors are on opposite sides of each of the first and the second optical filters and each of the first and the second photodiodes.

Abstract: A connector assembly includes an adapter, a housing device, a ferrule assembly, and a sensor. The housing device is received by the adapter and has a bore, a front end, and a rear end opposite the front end. A ferrule of the ferrule assembly is within the bore of the housing device and has a mating end extending beyond the front end of the housing device. The sensor is mounted on the rear end of the housing, the rear end of the ferrule assembly, or on the adapter confronting and spaced apart from the housing device or the ferrule assembly. The sensor is configured for detecting a force applied by the housing device or the ferrule assembly, respectively. An electrical characteristic of the sensor changes to indicate a predetermined force has been applied by the housing device or the ferrule assembly, respectively.

Abstract: The present disclosure is directed to an optical device including at least one temperature-dependent tunable element for controlling a wavelength of an optical signal, a first temperature control circuit for controlling a temperature of a first region of the optical device; and a second temperature control circuit for controlling a temperature of a second region of the optical device. The second region may include a portion of the first region. The second region may be smaller than the first region. The tunable element may be positioned in the second region such that a temperature of the tunable element is controlled based on the second temperature control circuit controlling the temperature of the second region. The tunable element may be one of (i) a laser for transmitting an outgoing optical signal and (ii) an optical filter coupled to a photodetector for receiving an incoming optical signal.

Abstract: An optical system includes a connector, an optical filter, an optical receiving device, an optical transmission device, and a central processing and transmission unit. The connector is configured for routing optical signals. The optical filter is configured for routing optical signals to and from the connector. The optical receiving device is configured for receiving optical signals routed from the optical filter via the connector. The optical transmission device is configured for generating the optical signals routed from the optical filter via the connector. The central processing and transmission unit is in electrical communication with the optical receiving device.

Abstract: A connector assembly includes an adapter, a housing device, a ferrule assembly, and a sensor. The housing device is received by the adapter and has a bore, a front end, and a rear end opposite the front end. A ferrule of the ferrule assembly is within the bore of the housing device and has a mating end extending beyond the front end of the housing device. The sensor is mounted on the rear end of the housing, the rear end of the ferrule assembly, or on the adapter confronting and spaced apart from the housing device or the ferrule assembly. The sensor is configured for detecting a force applied by the housing device or the ferrule assembly, respectively. An electrical characteristic of the sensor changes to indicate a predetermined force has been applied by the housing device or the ferrule assembly, respectively.

Abstract: A non-geostationary satellite system and method for weather and climate monitoring, communications applications, scientific research, and similar tasks. The satellite system provides global coverage using a constellation of six satellites in two orthogonal, 24 sidereal hour orbits (geosynchronous) with inclinations of 70° to 90°, and eccentricities of 0.275-0.45. By placing three of the satellites in a first orbit with an apogee over the north pole, and three of the satellites in a second, orthogonal orbit with an apogee over the south pole, global coverage may be obtained. As well, the satellites in these orbits avoid most of the Van Allen Belts.

Abstract: A connector assembly includes an adapter, a housing device, a ferrule assembly, and a sensor. The housing device is received by the adapter and has a bore, a front end, and a rear end opposite the front end. A ferrule of the ferrule assembly is within the bore of the housing device and has a mating end extending beyond the front end of the housing device. The sensor is mounted on the rear end of the housing, the rear end of the ferrule assembly, or on the adapter confronting and spaced apart from the housing device or the ferrule assembly. The sensor is configured for detecting a force applied by the housing device or the ferrule assembly, respectively. An electrical characteristic of the sensor changes to indicate a predetermined force has been applied by the housing device or the ferrule assembly, respectively.

Abstract: The present invention provides a wavelength control method, a system thereof and a shutoff depth control circuit. The method includes: enabling a current temperature of TEC (6) to be rapidly stabilized at a target temperature through a closed loop control of hardware PID (8); allowing the shut-off depth control circuit (11) to operate when a burst driver (5) that drives a light emitting assembly (3) is standby or operating, providing an input to the light emitting assembly (3) through the shut-off depth control circuit (11) so that the light-emitting assembly (3) can emit the light that does not affect the normal operations of other ONU, the light emitted allows the light emitting assembly (3) to be warmed up, which enables the light emitting assembly (3) to quickly stabilize the emitted light within the bandwidth required by each channel of the system during the time period from a non-light emitting state to a light emitting state.

Abstract: The present invention provides a wavelength control method, a system thereof and a shutoff depth control circuit. The method includes: enabling a current temperature of TEC (6) to be rapidly stabilized at a target temperature through a closed loop control of hardware PID (8); allowing the shut-off depth control circuit (11) to operate when a burst driver (5) that drives a light emitting assembly (3) is standby or operating, providing an input to the light emitting assembly (3) through the shut-off depth control circuit (11) so that the light-emitting assembly (3) can emit the light that does not affect the normal operations of other ONU, the light emitted allows the light emitting assembly (3) to be warmed up, which enables the light emitting assembly (3) to quickly stabilize the emitted light within the bandwidth required by each channel of the system during the time period from a non-light emitting state to a light emitting state.

Abstract: A connector assembly includes an adapter, a housing, a ferrule, and a sensor. The housing is received by the adapter and has a bore. The ferrule is translatable within the bore of the housing. The sensor is mounted on the housing or on the adapter. The sensor is configured for detecting translation of the ferrule. An electrical characteristic of the sensor changes to indicate translation of the ferrule to a predetermined position.

Abstract: An optical connection identification assembly includes first and second connectors for conveying optical signals within and away from the optical connection identification assembly, first and second optical filters configured for conveying optical signals to and from the respective first and second connectors and between each other, and first and second photodiodes. The first photodiode is configured for receiving optical signals from the first optical filter to confirm the optical connection identification assembly is receiving optical signals. The second photodiode is configured for receiving optical signals from the second optical filter to confirm the optical connection identification assembly is receiving optical signals. The first and the second connectors are on opposite sides of each of the first and the second optical filters and each of the first and the second photodiodes.

Abstract: The present disclosure is directed to an optical device including at least one temperature-dependent tunable element for controlling a wavelength of an optical signal, a first temperature control circuit for controlling a temperature of a first region of the optical device; and a second temperature control circuit for controlling a temperature of a second region of the optical device. The second region may include a portion of the first region. The second region may be smaller than the first region. The tunable element may be positioned in the second region such that a temperature of the tunable element is controlled based on the second temperature control circuit controlling the temperature of the second region. The tunable element may be one of (i) a laser for transmitting an outgoing optical signal and (ii) an optical filter coupled to a photodetector for receiving an incoming optical signal.

Abstract: The present disclosure is directed to an optical device including at least one temperature-dependent tunable element for controlling a wavelength of an optical signal, a first temperature control circuit for controlling a temperature of a first region of the optical device; and a second temperature control circuit for controlling a temperature of a second region of the optical device. The second region may include a portion of the first region. The second region may be smaller than the first region. The tunable element may be positioned in the second region such that a temperature of the tunable element is controlled based on the second temperature control circuit controlling the temperature of the second region. The tunable element may be one of (i) a laser for transmitting an outgoing optical signal and (ii) an optical filter coupled to a photodetector for receiving an incoming optical signal.

Abstract: A connector assembly includes an adapter, a housing, a ferrule, and a sensor. The housing is received by the adapter and has a bore. The ferrule is translatable within the bore of the housing. The sensor is mounted on the housing or on the adapter. The sensor is configured for detecting translation of the ferrule. An electrical characteristic of the sensor changes to indicate translation of the ferrule to a predetermined position.

Abstract: The present disclosure is directed to an optical device including at least one temperature-dependent tunable element for controlling a wavelength of an optical signal, a first sensor configured to indirectly monitor the optical signal, a second sensor configured to directly monitor the optical signal, and a control circuit. The tunable element may be one of (i) a laser for transmitting an outgoing optical signal and (ii) an optical filter coupled to a photodetector for receiving an incoming optical signal. The control circuit may be configured to receive first and second inputs from the first and second sensors, respectively, adjust the tuned wavelength of the tunable element from a first preselected wavelength to a second preselected wavelength based on the first input received from the first sensor, and maintain the tunable element at the second preselected frequency based on the second input received from the second sensor.

Abstract: A connector assembly includes an adapter, a housing device, a ferrule assembly, and a sensor. The housing device is received by the adapter and has a bore, a front end, and a rear end opposite the front end. A ferrule of the ferrule assembly is within the bore of the housing device and has a mating end extending beyond the front end of the housing device. The sensor is mounted on the rear end of the housing, the rear end of the ferrule assembly, or on the adapter confronting and spaced apart from the housing device or the ferrule assembly. The sensor is configured for detecting a force applied by the housing device or the ferrule assembly, respectively. An electrical characteristic of the sensor changes to indicate a predetermined force has been applied by the housing device or the ferrule assembly, respectively.

Abstract: A connector assembly includes an adapter, a housing device, a ferrule assembly, and a sensor. The housing device is received by the adapter and has a bore, a front end, and a rear end opposite the front end. A ferrule of the ferrule assembly is within the bore of the housing device and has a mating end extending beyond the front end of the housing device. The sensor is mounted on the rear end of the housing, the rear end of the ferrule assembly, or on the adapter confronting and spaced apart from the housing device or the ferrule assembly. The sensor is configured for detecting a force applied by the housing device or the ferrule assembly, respectively. An electrical characteristic of the sensor changes to indicate a predetermined force has been applied by the housing device or the ferrule assembly, respectively.

Abstract: A device may generate a transaction network associated with a plurality of accounts. The plurality of accounts may include a set of client accounts associated with a set of clients of an account manager, and a set of non-client accounts associated with a set of non-clients of the account manager. The transaction network may identify transactions among the set of client accounts and the set of non-client accounts. The device may identify, based on the transaction network, a community of accounts including a subset of client accounts for which transactions satisfy a threshold, and a non-client account that has transacted with one of the subset of client accounts. The device may determine target information, associated with the non-client account, including information associated with targeting a non-client, associated with the non-client account, by the account manager. The device may provide the target information and information associated with the community of accounts.