Abstract: A method of increasing the efficiency of the Aviation Environmental Design Tool (AEDT) by using a computer algorithm to generate an input file with far fewer flight tracks than would normally be required to obtain the same AEDT results using the same data pool.

Abstract: The invention relates to combinations of urolithins with therapeutic agents, particularly combinations of urolithins with immunotherapy treatments, such as immune checkpoint blockage therapies, such as PD-1 antagonists. The invention also relates to pharmaceutical compositions comprising said combinations, processes of preparing said pharmaceutical compositions and methods of treating diseases with said compositions. In one embodiment, the immune checkpoint blockage therapy is selected from an anti-PD-1 antibody, an anti-PD-L1 antibody, an anti-CTLA4 antibody or a fusion protein.

Abstract: A method of increasing the efficiency of the Aviation Environmental Design Tool (AEDT) by using a computer algorithm to generate an input file with far fewer flight tracks than would normally be required to obtain the same AEDT results using the same data pool.

Abstract: A stacked luminescent solar concentrator includes two separate absorption/emission cells, each having a layer of luminophore-type material, wherein a top layer is a high band gap layer comprised of quantum dots in polymer, wherein the quantum dots are engineered so as to absorb a significant percentage of photons above bandgap. The bottom layer is a lower band gap layer comprised of quantum dots in polymer, wherein the quantum dots in the second layer are engineered so as to absorb photons not absorbed in the top layer, thus increasing total percentage of absorbed photons. Photovoltaic cells are located below the layers at the bottom of the cells or at the edges of the cells. The sides and lower surfaces of the cells may include reflective surfaces as discussed further herein. Reflection losses from the top surface thereof may be minimized using a broadband anti-reflective coating (AR) on the surface.

Abstract: A stacked luminescent solar concentrator includes two separate absorption/emission cells, each having a layer of luminophore-type material, wherein a top layer is a high band gap layer comprised of quantum dots in polymer, wherein the quantum dots are engineered so as to absorb a significant percentage of photons above bandgap. The bottom layer is a lower band gap layer comprised of quantum dots in polymer, wherein the quantum dots in the second layer are engineered so as to absorb photons not absorbed in the top layer, thus increasing total percentage of absorbed photons. Photovoltaic cells are located below the layers at the bottom of the cells or at the edges of the cells. The sides and lower surfaces of the cells may include reflective surfaces as discussed further herein. Reflection losses from the top surface thereof may be minimized using a broadband anti-reflective coating (AR) on the surface.

Abstract: A stacked luminescent solar concentrator includes two separate absorption/emission cells, each having a layer of luminophore-type material, wherein a top layer is a high band gap layer comprised of quantum dots in polymer, wherein the quantum dots are engineered so as to absorb a significant percentage of photons above bandgap. The bottom layer is a lower band gap layer comprised of quantum dots in polymer, wherein the quantum dots in the second layer are engineered so as to absorb photons not absorbed in the top layer, thus increasing total percentage of absorbed photons. Photovoltaic cells are located below the layers at the bottom of the cells or at the edges of the cells. The sides and lower surfaces of the cells may include reflective surfaces as discussed further herein. Reflection losses from the top surface thereof may be minimized using a broadband anti-reflective coating (AR) on the surface.

Abstract: A gas turbine engine includes a compressor, combustor, and turbine having a row of blades mounted inside a surrounding turbine shroud. A heat exchanger is used for cooling pressurized air bled from the compressor. A distribution network joins the heat exchanger to the turbine for selectively channeling air from the heat exchanger below the blades and above the shroud for controlling blade tip clearance.

Abstract: A row of turbine blades is surrounded by a turbine shroud. The shroud is supported by a turbine case having a pair of radially outwardly extending rails. The rails are perforate for channeling therethrough control air to control thermal radial movement of the case, and in turn radial position of the shroud supported therefrom.

Abstract: A combustor has a flow sleeve and a flow liner defining a generally axial flow direction of compressor discharge air toward combustor burners. A casing is secured to the forward end of the flow sleeve defining an annular plenum along the interior of the flow sleeve. Openings through the flow sleeve supply compressor discharge air into the plenum where the air changes direction for flow through apertures into and generally coaxially with the free air stream. The axial injection minimizes or eliminates energy losses due to cross flow injection within the axial air stream while continuing to cool the liner.

Abstract: A row of turbine blades is surrounded by a turbine shroud. The shroud is supported by a turbine case having a pair of radially outwardly extending rails. The rails are perforate for channeling therethrough control air to control thermal radial movement of the case, and in turn radial position of the shroud supported therefrom.

Abstract: A gas turbine engine includes a compressor, combustor, and turbine having a row of blades mounted inside a surrounding turbine shroud. A heat exchanger is used for cooling pressurized air bled from the compressor. A distribution network joins the heat exchanger to the turbine for selectively channeling air from the heat exchanger below the blades and above the shroud for controlling blade tip clearance.

Abstract: A pacing control is used in a multiple-chamber cardiac pacing system, which, upon detecting an atrial arrhythmia, automatically switches to a special therapy mode and administers a selected anti-tachycardia pacing (ATP) therapy in the atrium, and which switches to a standard pacing mode following delivery of the ATP therapy. The pacing control adjusts the timing of pacing pulses to be delivered to the atrium and/or the ventricle to minimize any potential ventricular pauses that may result from the switch from the therapy mode to the standard pacing mode.

Abstract: The invention is directed to techniques for applying overdrive pacing to one or both atria following termination of an AF episode, to prevent a recurrent AF episode. An implantable medical device such as a pacemaker applies overdrive pacing according to overdrive pacing parameters, and sets the parameters as a function of the response of the patient to overdrive pacing. The parameters may be adjusted upward or downward, so that overdrive pacing may be applied effectively but not over-applied.

Abstract: The efficacy of cardiac resynchronization therapy applied to a patient's heart by an implantable device are improved by obtaining acute hemodynamic feedback during implantation of a pacing device. A first and a second transducer are temporarily placed proximate to a portion of the patient's heart during device implant, and a distance between the transducers is monitored as the therapy is applied. A parameter (e.g. lead location, biventricular pacing, pacing rate, or the like) of the cardiac therapy is adjusted in response to the distance between the transducers until a desired result is obtained, after which the first and second transducers can be removed from the patient.

Abstract: An implantable medical device (IMD) senses physiological episodes and stores data associated with the physiological episodes in the IMD. The data is then processed based on a pattern of recurrence of the physiological episodes.

Abstract: A laminate is disclosed that comprises at least two layers of fibrous nonwoven mats in which the majority of the fibers in at least one of the mats are glass fibers, the layers being bonded together with an adhesive, needling, stitch bonding or a mixture of two or more of these bonding techniques, one of the mats having a basis weight of at least 3 lbs. per 100 sq. ft and at least 1.5 times the basis wt. of the other mat. The laminates are especially useful in making acoustical panels for office partitions.

Abstract: A floor box for providing access to multiple utilities in a floor structure. The floor box includes a housing having a bottom wall and one or more side walls extending from the bottom wall and defining an interior space therebetween. A partition wall attached to the bottom wall and the side walls partially divides the interior space. A flange is attached at the upper edges of the side walls and includes a surface extending outwardly therefrom. A cover assembly includes a frame mounted to the flange. The frame has a cross member overlying the partition wall and cooperating therewith to divide the interior space into first and second compartments. The cover assembly further includes first and second access doors movable relative to the frame between open and closed positions for providing access to the first and second compartments respectively. A gasket seals the first and second compartments.

Abstract: A method and device for controlling delivery of therapy in an implantable device that includes sensing a plurality of events, detecting whether there is an increase in the frequency of first events of the plurality of events corresponding to onset of a second event of the plurality of sensed events, adjusting parameters associated with delivery of the therapy in response to the detected increased frequency of first sensed events, and delivering the therapy using the adjusted parameters.

Abstract: A method and device for determining an optimal lower rate and adjusting the programmed lower pacing rate to the optimal rate that includes monitoring a parameter in response to therapy delivered at a first rate during a first time period to generate first parameter data, and determining whether the therapy was delivered for a predetermined portion of the first time period. The parameter is monitored in response to the therapy delivered at a next rate during a next time period to generate next parameter data, and a determination is made as to whether the therapy was delivered for a predetermined portion of the next time period. A metric corresponding to the first parameter data is determined to generate a first parameter metric, and corresponding to the next parameter data to generate a next parameter metric used for determining an optimal therapy delivery rate.

Abstract: Control of defibrillation therapy delivered by implantable medical devices (IMDS) using hemodynamic sensor feedback is disclosed. The hemodynamic sensor feedback allows for increased control over application of atrial defibrillation therapy. Specifically, the therapy is delivered when a fibrillation episode results in a discrete loss of hemodynamic function. Defibrillation therapy is thus withheld for hemodynamically benign arrhythmias.