Abstract: There is provided a plasmid system for transfection into a cell to create a producer cell, the system comprising: a. a helper plasmid comprising a first nucleotide sequence encoding Murine leukemia virus (MLV)-derived Gag and Pol poly-proteins; b. an envelope plasmid comprising a second nucleotide sequence encoding an Env protein; c. a genome plasmid comprising a third nucleotide sequence encoding a retroviral genome, wherein the first nucleotide sequence is codon-shuffled to remove any significant regions of homology with the third nucleotide sequence; and wherein the second nucleotide sequence is codon-optimised for expression in the producer cell.

Abstract: The current application discloses a composition that comprises at least one peptide with a sequence length of 6-12 amino acids, where 2-5 of those amino acids are cysteines for the treatment and cosmetics of animal hair, in preference human hair. There are several hair styling methods that involve breakage and reestablishment of disulfide bonds, allowing relaxation and straightening of the hair. However, the most effective methods currently used to modulate hair contain harmful chemicals. Thus, there is a constant demand for formulations that efficiently model the hair fiber without damage. Thus, the present invention aims to provide a composition for treatment of the hair, including animal and human hair, without the use of chemicals harmful to the hair fiber and consumer health and uses of said compositions in shampoo, lotion, serum, cream, conditioner, foam, elixir, oil, aerosol or mask.

Abstract: There is provided a plasmid system for transfection into a cell to create a producer cell, the system comprising: a. a helper plasmid comprising a first nucleotide sequence encoding Murine leukemia virus (MLV)-derived Gag and Pol poly-proteins; b. an envelope plasmid comprising a second nucleotide sequence encoding an Env protein; c. a genome plasmid comprising a third nucleotide sequence encoding a retroviral genome, wherein the first nucleotide sequence is codon-shuffled to remove any significant regions of homology with the third nucleotide sequence; and wherein the second nucleotide sequence is codon-optimised for expression in the producer cell.

Abstract: OPERATION AND FUNCTIONING METHOD OF AN ASSEMBLY AND CONTROL SYSTEM FOR ACCUMULATORS IN WORKSTATIONS, using a radio-base station rack, comprising processing center provided, at least with a battery presence sensor, at least a radio-base station rack door opening and closing sensor and an audible alarm device, allowed for use in equipment containing locks, both electromechanical and electromagnetic, and comprising the startup, verification, work and maintenance steps of an assembly and control system operation and functioning of accumulators in workstations.

Abstract: ASSEMBLY AND CONTROL SYSTEM FOR ACCUMULATORS IN WORKSTATIONS, presenting a system intended for battery control in radio-base stations rack comprising a processing center which controls a switching system, batteries, electromagnetic locks and sensors, in order to prevent non-authorized actions of such batteries inside the racks from occurring.

Abstract: “ELECTROMECHANICAL LOCKING SYSTEM FOR BATTERIES IN A CABINET” for application in a battery pack used in uninterrupted power supply (UPS) systems comprising a locking set with at least one electromechanical lock and a coupling system attached to a bracket, where the referred bracket is attached to an UPS system cabinet structure; a battery with at least a lock housing and an alignment element.

Abstract: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.

Abstract: Systems and methods for coordinating data exchanges are disclosed. One exemplary method generally includes receiving a work order for expected services by a terminal operator for handling cargo of a shipping line, converting the work order to a standard format, and requesting a pre-authorization for a transaction for the work order along with a virtual card number (VCN) for the shipping line. The method then includes receiving a final invoice for handling the cargo and extracting data from the final invoice for the expected services for handling the cargo and for unexpected services, and for a final invoice amount. The method further includes generating a standard form final invoice including the data for the expected services and the unexpected services, transmitting the standard form final invoice to the terminal operator and the shipping line, and initiating a transaction for the final invoice amount based on the VCN.

Abstract: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.

Abstract: The invention provides a composition comprising a reduced toxicity NetB epitope polypeptide and a reduced toxicity Clostridium perfringens alpha-toxin epitope polypeptide. The composition is useful as a vaccine providing complete protection against infection by C. perfringens.

Abstract: Communication network architectures, systems and methods for supporting a network of mobile nodes. As a non-limiting example, various aspects of this disclosure provide communication network architectures, systems, and methods for supporting a dynamically configurable communication network comprising a complex array of both static and moving communication nodes (e.g., the Internet of moving things).

Abstract: Communication network architectures, systems and methods for supporting a network of mobile nodes. As a non-limiting example, various aspects of this disclosure provide communication network architectures, systems, and methods for supporting a dynamically configurable communication network comprising a complex array of both static and moving communication nodes (e.g., the Internet of moving things).

Abstract: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.

Abstract: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.

Abstract: There is provided a NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position between amino acids 130 and 297 as compared with the equivalent position in SEQ ID NO:3, the mutation preferably being located within a rim domain, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:1 and having reduced toxicity compared with the toxicity of SEQ ID NO:1. The polypeptide is useful to vaccinate a subject against infection by Clostridium perfringens.

Abstract: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.

Abstract: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.

Abstract: There is provided a NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position between amino acids 130 and 297 as compared with the equivalent position in SEQ ID NO:3, the mutation preferably being located within a rim domain, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:1 and having reduced toxicity compared with the toxicity of SEQ ID NO:1. The polypeptide is useful to vaccinate a subject against infection by Clostridium perfringens.

Abstract: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.

Abstract: The invention relates to a method for at least partially deconstructing a flat display screen (10), the screen (10) comprising: —a substantially flat faceplate (11) comprising four side edges and a visible part (12) on a front face of the screen (10), said visible part (12) being intended to display images, —a frame (13) that mounts the faceplate (11) by partially covering at least the front face and two side edges, the method comprising steps of: —disposing (100) a single screen (10) on a holding device (20), and —clamping (110) the single screen (10) to the holding device (20). The method is essentially characterized in that it also comprises a step of: —effecting plastic deformation (120) of the frame (13) while maintaining the integrity of the faceplate (11).