Abstract: A method (400) for producing a titanium product is disclosed. The method (400) can include obtaining TiO2-slag (401), and producing a titanium product from the TiO2-slag using a metallic reducing agent (402) at a moderate temperature and a pressure to directly produce a titanium product chemically separated from metal impurities in the TiO2 slag (403). The titanium product can comprise TiH2 and optionally elemental titanium. Impurities in the titanium product can then removed (404) by leaching, purifying and separation to form a purified titanium product.

Abstract: Provided are an imaging system and method based on multiple-gamma photon coincidence events. The imaging system includes: a plurality of detector assemblies arranged in a non-parallel manner, a time coincidence module and a computer platform. Each detector assembly includes a collimator and a detector configured to measure time and to detect a multiple-gamma photon coincidence event constituted by a plurality of single-gamma photon events cascade-emitted by a radionuclide within a short time. The method is configured to determine validity of the multiple-gamma photon coincidence event, calculate a plurality of non-parallel projection lines where the decay of the radionuclide takes place, determine a location where the decay of the radionuclide takes place according to the non-parallel projection lines, and obtain a distribution of the radionuclide in the subject according to the location where the decay of the radionuclide takes places.

Abstract: Work described herein reveals 3D regulatory landscapes of hESCs representative of early human development. This work also demonstrates that cohesin-associated CTCF loops, and the cohesin-associate enhancer-promoter loops within them, dominate the organization of TADs. The CTCF-CTCF loops form a chromosomal scaffold of insulated neighborhoods that are largely preserved in vertebrates, and enhancer-promoter interactions occur within these neighborhoods. Genes are regulated in the context of conserved insulated neighborhood structures. Loss of neighborhood structures occurs frequently in cancer cells, and proto-oncogenes can be activated by genetic alterations that disrupt specific 3D chromosome structures.

Abstract: Managing rogue devices in a network through a network backhaul. A rogue device is detected in a network and a rogue device message that includes the rogue device is sent to a plurality of switches in a backhaul of the network. The rogue device is added into a rogue monitor table. Whether the rogue device is In-Net or Out-Of-Net is determined using forwarding tables of the plurality of switches in the backhaul of the network and the rogue monitor table. Mitigation is performed using a nearest switch to the rogue device of the plurality of switches in the backhaul of the network if it is determined that the rogue device is In-Net.

Abstract: Managing rogue devices in a network through a network backhaul. A rogue device is detected in a network and a rogue device message that includes the rogue device is sent to a plurality of switches in a backhaul of the network. The rogue device is added into a rogue monitor table. Whether the rogue device is In-Net or Out-Of-Net is determined using forwarding tables of the plurality of switches in the backhaul of the network and the rogue monitor table. Mitigation is performed using a nearest switch to the rogue device of the plurality of switches in the backhaul of the network if it is determined that the rogue device is In-Net.

Abstract: A climate control system is described that can include a thermal battery (100) with a heating bed (110) and cooling bed (120) and a conditioned air manifold adapted to direct heat transfer fluid across at least one of the heating bed (110) and the cooling bed (120) to condition inlet air. A method of controlling climate in an enclosure can be provided by contemporaneously generating a heating effect and a cooling effect from a reversible thermo chemical reaction and selectively directing thermal flows from a reversible thermo chemical reaction to the enclosure.

Abstract: Disclosed are methods for identifying the core regulatory circuitry or cell identity program of a cell or tissue, and related methods of diagnoses, screening, and treatment involving the core regulatory circuitry and/or cell identity programs identified using the methods.

Abstract: A novel electrical connector and method of manufacture is disclosed which provides an integral attachment and retention means for the purpose of electrically and mechanically interconnecting circuit elements in electronic devices, said circuit elements including but not limited to printed circuit boards, flexible printed circuits, rigid flex circuits, semiconductor package substrates, modules, and batteries. The electrical connector of the present invention utilizes a bonding material, disposed at least between the electrical spring contact elements on a surface of the connector, to bond and retain first and second portions of the electrical connector in an actuated state on a mating circuit element whereby stable and low resistance electrical interconnections are formed and maintained between the electrical connector and interconnection terminals on the mating circuit element. This design permits the electrical connector to be low-profile and use a reduced amount of space on a circuit member such as a PCB.

Abstract: Authenticating a client device coupled to an authenticator network device for a network. A service request is received from the client device at the authenticator network device. User credentials, including a user ID, a user key, and a nonce for a user are received at the authenticator network device. A token is generated using the received user credentials. The service request is modified to include the token and a user ID parameter that is the user ID to generate a modified service request. The modified service request is used to provide single sign-on access to a service that is the subject of the service request.

Abstract: Provided herein are improved compositions and methods for the directed control of gene expression.

Abstract: Authenticating a client device coupled to an authenticator network device for a network. A service request is received from the client device at the authenticator network device. User credentials, including a user ID, a user key, and a nonce for a user are received at the authenticator network device. A token is generated using the received user credentials. The service request is modified to include the token and a user ID parameter that is the user ID to generate a modified service request. The modified service request is used to provide single sign-on access to a service that is the subject of the service request.

Abstract: Provided herein are methods for identifying master transcription factors (TFs) in a cell type of interest and for transdifferentiation of a somatic cell, e.g., a fibroblast to the cell type of interest. Also provided herein are induced retinal pigment epithelium (iRPE) cell, master TFs therefor, methods for making iRPE cell, and methods and compositions for treating an ocular disease such as age-related macular degeneration.

Abstract: A novel interconnection structure and method of manufacture is provided which provides an improved means of interconnecting external connector interfaces, such as Universal Serial Bus (USB) connectors, to the internal system boards of electronic devices, such as laptop computers, tablets, and mobile phones. An external connector interface used for interconnecting separate electronic devices is connected to the internal system board of the device in which it resides by being interconnected mechanically and electrically, or alternatively being integral to and of a unitary structure with, a printed circuit substrate, said printed circuit substrate having a plurality of conductive, elastic spring contacts mounted on one surface, with at least one of said electrical spring contacts electrically interconnected to the external electrical connections of the USB connector, and said electrical spring contacts providing an electrical interconnection means to a system board inside the electronic device.

Abstract: An online system receives information describing a target group of online system users from a third party system that includes one or more user properties, which may identify an action performed by a an online user within a time interval to include the user in the target group. When an opportunity to present advertisement requests to a user is identified, the online system retrieves actions associated with the user and times associated with the actions. If an action associated with the user matches the action identified by the user properties and occurred within the time interval identified by the user properties, and other characteristics of the user satisfy at least a threshold number of the user properties, the online system includes the user in the target group. Advertisement requests having targeting criteria, including the target group, satisfied by characteristics of the user are evaluated for presentation to the user.

Abstract: Apparatuses and methods for pipelining memory operations with error correction coding are disclosed. A method for pipelining consecutive write mask operations is disclosed wherein a second read operation of a second write mask operation occurs during error correction code calculation of a first write mask operation. The method may further including writing data from the first write mask operation during the error correction code calculation of the second write mask operation. A method for pipelining consecutive operations is disclosed where a first read operation may be cancelled if the first operation is not a write mask operation. An apparatus including a memory having separate global read and write input-output lines is disclosed.

Abstract: An online system receives information describing a target group of online system users from a third party system that includes one or more user properties, which may identify actions to be performed by an online system user for inclusion in the target group. Additionally, information describing the target group includes metadata associated with the user properties identifying access to the user properties by additional third party systems. If an additional third party system requests access to the target group or to the user properties describing the target group, the online system determines whether the additional third party system is authorized to access the target group or the user properties based on the metadata. Further, the online system determines an amount of compensation the third party system is to receive if the additional third party system is authorized to access the target group or the user properties based on the metadata.

Abstract: Managing rogue devices in a network through a network backhaul. A rogue device is detected in a network and a rogue device message that includes the rogue device is sent to a plurality of switches in a backhaul of the network. The rogue device is added into a rogue monitor table. Whether the rogue device is In-Net or Out-Of-Net is determined using forwarding tables of the plurality of switches in the backhaul of the network and the rogue monitor table. Mitigation is performed using a nearest switch to the rogue device of the plurality of switches in the backhaul of the network if it is determined that the rogue device is In-Net.

Abstract: The instant disclosure relates to a connector including a wiring layer, a dielectric layer, a conductive structure, a first protective layer and at least one cantilever structure. The dielectric layer is disposed on the wiring layer, wherein the dielectric layer has at least one via hole to partially expose the wiring layer. The conductive structure is disposed on the inner wall of the at least one via hole of the dielectric layer and electrically connected to the wiring layer. The first protective layer is disposed on the dielectric layer. The cantilever structure is disposed between the first protective layer and the dielectric layer, wherein the at least one cantilever structure is electrically connected to the wiring layer via the conductive structure.

Abstract: Managing rogue devices in a network through a network backhaul. A rogue device is detected in a network and a rogue device message that includes the rogue device is sent to a plurality of switches in a backhaul of the network. The rogue device is added into a rogue monitor table. Whether the rogue device is In-Net or Out-Of-Net is determined using forwarding tables of the plurality of switches in the backhaul of the network and the rogue monitor table. Mitigation is performed using a nearest switch to the rogue device of the plurality of switches in the backhaul of the network if it is determined that the rogue device is In-Net.

Abstract: A functionally graded cemented tungsten carbide material produced via heat treating a sintered cemented tungsten carbide is disclosed and described. The heat treating process comprises at least a step that heats the sintered material to the multi-phase temperature range in which multiple phases including solid tungsten carbide, liquid metal binder, and solid metal binder coexist. Additionally, the material, after the heat treating process comprises a surface layer with lower metal binder content than the nominal value of metal binder content of the bulk of the material. The material is used to make tools for rock drilling, machining of metal alloys, and machining of non-metallic materials. The material can also be used to make engineered wear parts that are used in mechanical systems and applications where wear resistance is required or desired.