Abstract: The present invention concerns antigen binding proteins and fragments thereof which specifically bind B Cell Maturation Antigen (BCMA), particularly human BCMA (hBCMA) and which inhibit the binding of BAFF and APRIL to the BCMA receptor. Further disclosed are pharmaceutical compositions, screening and medical treatment methods.

Abstract: Systems, devices, and methods are described for the assessment, screening, monitoring, or diagnosis of developmental or cognitive conditions, including autism spectrum disorders (ASD) by analysis of eye tracking data generated from feedback received as a result of display of specific predetermined visual stimuli to a subject or patient. Subsequent to a calibration phase, a testing procedure is performed by presenting predetermined stimuli (e.g., videos) to a subject via a display device. Eye tracking data (from the subject moving his or her eyes in response to predetermined movies or other visual stimuli) are collected. During the data collection period, the system periodically presents targets to reflexively elicit the subject's gaze. These data are used to later verify accuracy. Analysis of the subject's viewing patterns during these stimuli is used for the assessment, screening, monitoring, or diagnosis of developmental or cognitive conditions such as ASD.

Abstract: Antigen binding proteins that bind Lymphocyte Activation Gene 3 (LAG-3), and more particularly to antigen binding proteins that cause depletion of LAG-3+ activated T cells.

Abstract: The present invention generally pertains to a system, method and kit for the detection and measurement of spectroscopic properties of light from a sample, or the scalable detection and measurement of spectroscopic properties of light from each sample present among multiple samples, simultaneously, wherein the system comprises: an optical train comprising a dispersing element; and an image sensor. The light detected and measured may comprise light scattered from a sample, emitted as chemiluminescence by a chemical process within a sample, selectively absorbed by a sample, or emitted as fluorescence from a sample following excitation.

Abstract: Antigen binding proteins that bind ?-amyloid peptide, in particular human ?-amyloid peptide; methods of treating diseases or disorders characterized by elevated ?-amyloid levels or ?-amyloid deposits, particularly Alzheimer's disease and diseases or disorders affecting the eye or optic nerve characterized by elevated ?-amyloid levels or ?-amyloid deposits, including age related macular degeneration and glaucoma type diseases and ?-amyloid dependent cataract formation, with the antigen binding proteins; pharmaceutical compositions comprising the antigen binding proteins; and methods of manufacture.

Abstract: Systems, devices, and methods are described for the assessment, screening, monitoring, or diagnosis of developmental or cognitive conditions, including autism spectrum disorders (ASD) by analysis of eye tracking data generated from feedback received as a result of display of specific predetermined visual stimuli to a subject or patient. Subsequent to a calibration phase, a testing procedure is performed by presenting predetermined stimuli (e.g., videos) to a subject via a display device. Eye tracking data (from the subject moving his or her eyes in response to predetermined movies or other visual stimuli) are collected. During the data collection period, the system periodically presents targets to reflexively elicit the subject's gaze. These data are used to later verify accuracy. Analysis of the subject's viewing patterns during these stimuli is used for the assessment, screening, monitoring, or diagnosis of developmental or cognitive conditions such as ASD.

Abstract: A prosthetic component assembly, such as an acetabular cup, includes a shell, a bearing positioner and a bearing. The shell and bearing positioner are configured to facilitate orienting the bearing positioner in multiple orientations relative to the shell and for securing the bearing positioner in a selected orientation of the multiple orientations relative to the shell. The bearing is configured to be received in the bearing positioner at multiple rotational orientations for optimal joint biomechanics. The bearing positioner is selected from among a plurality of lateralized positioners to accommodate the joint anatomy.

Abstract: A testing apparatus includes a housing having a port for receiving a discharge end of an electrical discharge device. A discharge-receiving circuit is operatively connected to the port, and is configured to receive a discharge from the electrical discharge device. The discharge-receiving circuit includes a default resistor and at least one supplemental resistor. When in a first setting, the discharge-receiving circuit is configured so as to pass the discharge automatically through at least the default resistor. When in a second setting, the discharge-receiving circuit is configurable so as to selectively pass the discharge through at least one of the plurality of resistors.

Abstract: The present disclosure relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise C-terminal additions, extensions or tags and/or certain amino acid substitutions. Such modified molecules (e.g., fusions and conjugates) comprise proteins, peptides, antigen binding molecules, antibodies or antibody fragments such as single variable domains. The disclosure further relates to uses and formulations of compositions comprising such modified C-terminally extended and/or amino acid substituted molecules and also to methods of production and expression of these.

Abstract: The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an antibody, wherein each epitope binding domain in capable of binding to VEGF, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with VEGF signalling, such as diabetic macular edema (DME), wet age-related macular degeneration (Wet AMD). diabetic retinopathy, retinal vein occlusion (RVO), and corneal neovascularisation, and polynucleotide sequences encoding said antigen binding constructs.

Abstract: The present invention generally pertains to a system, method and kit for the detection and measurement of spectroscopic properties of light from a sample, or the scalable detection and measurement of spectroscopic properties of light from each sample present among multiple samples, simultaneously, wherein the system comprises: an optical train comprising a dispersing element; and an image sensor. The light detected and measured may comprise light scattered from a sample, emitted as chemiluminescence by a chemical process within a sample, selectively absorbed by a sample, or emitted as fluorescence from a sample following excitation.

Abstract: The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorders.

Abstract: The present invention relates to Polycomb Repressive Complex 2 (PRC2) peptide inhibitors and their use for the treatment of cancer and other conditions associated with aberrant PRC2 methyltransferase activity.

Abstract: The present invention concerns antigen binding proteins and fragments thereof which specifically bind B Cell Maturation Antigen (BCMA), particularly human BCMA (hBCMA) and which inhibit the binding of BAFF and APRIL to the BCMA receptor. Further disclosed are pharmaceutical compositions, screening and medical treatment methods.

Abstract: The present invention relates to antigen binding proteins to human IL-13, including anti-IL-13 antibodies and anti-IL-3/anti-IL-4 mAbdAbs, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as asthma or IPF.

Abstract: A mobile device including a source for emitting electromagnetic radiation, an enclosure having a side wall, and a detector for detecting electromagnetic radiation emitted by the source is described. At least a portion of the sidewall is adapted to transmit electromagnetic radiation from the source. The source and detector are positioned inside the enclosure. The detector is spaced from the source, and is arranged to detect electromagnetic radiation from the source that is reflected from an object outside the enclosure and passes through the portion of the side wall.

Abstract: The present invention provides novel antigen-binding proteins derived from human germline VH domains, having improved expression and improved biophysical characteristics.

Abstract: The combination of a power toothbrush and a charging system includes a charging base unit (12) having a charging coil (22) wound around the interior surface (20) of a portion of the charging base unit, and connectable to a source of electric power and a rinsing vessel (26) adapted to hold a toothbrush, the rinsing glass having a lower surface (27) configured to fit onto the upper surface (14) of the charging unit. The vessel is configured to hold a tooth-brush in such a manner to prevent the toothbrush from tipping over when placed in the vessel, and further configured relative to the base unit that charging of the power tooth-brush can occur between a pickup coil (46) in the handle of the toothbrush and the charging coil in the base charging unit.

Abstract: A single controller interface (Smart-Stat) integrates the control of heating or cooling in buildings by simultaneously controlling Heating, Ventilation and Air Conditioning (HVAC) systems in concert with separate fresh air ventilation (FAV) systems. The Smart-Stat reduces costs and the carbon footprint of typical HVAC systems by optimizing the use of FAV. User-programmable set-points are incorporated with time-of-day and day-of-week as well as data from multiple sensors, thermostats and weather information. Mathematical algorithms are used to determine control signals to the HVAC or FAV systems. The Smart-Stat integrates the two separate systems into a single system that is able to direct the call for cooling or heating to the HVAC or FAV systems, depending on appropriate outside weather conditions. Any building can replace its existing HVAC system controller with the Smart-Stat controller and incorporate a FAV system to create a single integrated HVAC and FAV system.

Abstract: The amplitude control assembly for an oral care appliance includes a capacitance-sensing touch array (26) responsive to the position of a user's touch thereon to change the value of capacitance from the array, as determined by a sensor (30). A control assembly (24), responsive to the change of capacitance, changes an operating characteristic of the drive signal for the appliance, to change the amplitude of motion of a workpiece portion of the oral care appliance.