Abstract: The present invention relates to humanised antigen binding proteins, such as antibodies, which bind to myostatin, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present invention also concerns the use of such humanised antigen binding proteins in the treatment or prophylaxis of diseases associated with any one or a combination of decreased muscle mass, muscle strength and muscle function.

Abstract: The present invention relates to antibodies which multiple antigen specificities and their use in treating human diseases

Abstract: The present invention relates to antigen binding proteins, such as antibodies, which bind to serum amyloid P component (SAP), polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present invention also concerns the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with amyloid deposition including systemic amyloidosis, local amyloidosis, Alzheimer's disease, and type 2 diabetes.

Abstract: A mobile device including a source for emitting electromagnetic radiation, an enclosure having a side wall, and a detector for detecting electromagnetic radiation emitted by the source is described. At least a portion of the sidewall is adapted to transmit electromagnetic radiation from the source. The source and detector are positioned inside the enclosure. The detector is spaced from the source, and is arranged to detect electromagnetic radiation from the source that is reflected from an object outside the enclosure and passes through the portion of the side wall.

Abstract: The present invention relates to antigen binding proteins to human IL-23, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as Rheumatoid Arthritis (RA).

Abstract: The present invention relates to antigen binding proteins to human IL-13, including anti-IL-13 antibodies and anti-IL-3/anti-IL-4 mAbdAbs, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as asthma or IPF.

Abstract: The invention relates to linkers suitable for use in antigen-binding proteins, certain antigen binding proteins and methods of making such proteins and uses thereof.

Abstract: A portable hyperbaric chamber system includes a soft-sided, foldable hyperbaric chamber and a substantially rigid, removable, external support structure. The chamber generally includes a wall of a substantially non-breathable, soft-sided, and foldable material and an accessway sealable with a non-breathable closure so as to maintain a hyperbaric pressure within the chamber. The chamber also includes at least one fastener, such as a bolt or threaded stud, extending from the wall that permits the chamber to be removably attached to the support structure, thereby to maintain the chamber in an uncollapsed state when the chamber interior is not maintained at a hyperbaric pressure. The support structure includes structures complementary to the fasteners (e.g., apertures to pass bolts and locking knobs to secure bolts).

Abstract: The present invention relates to antigen binding proteins to human IL-23, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as Rheumatoid Arthritis (RA).

Abstract: The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorders.

Abstract: Antigen binding proteins that bind ?-amyloid peptide, in particular human ?-amyloid peptide; methods of treating diseases or disorders characterised by elevated ?-amyloid levels or ?-amyloid deposits, particularly Alzheimer's disease and diseases or disorders affecting the eye or optic nerve characterised by elevated ?-amyloid levels or ?-amyloid deposits, including age related macular degeneration and glaucoma type diseases and ?-amyloid dependent cataract formation, with said antigen binding proteins; pharmaceutical compositions comprising said antigen binding proteins; and methods of manufacture.

Abstract: An integrated probe card and socket adapter includes probe needles for probing a wafer including a plurality of CSP IC each having a plurality of bumps. A socket adapter includes a socket body having an elevated portion and a recessed base portion. The recessed base portion has a base portion thickness and includes a plurality of base portion through-holes that align with and receive the bumps on at least one of said plurality of CSP IC after singulation (singulated CSP IC) for securing the singulated CSP IC thereto. The elevated portion includes a plurality of elevated portion through-holes for fastening to the probe card when the probe card is underlying. The base portion thickness is sized so that the probe needles extend into the base portion through-holes a sufficient distance to contact the bumps of the singulated CSP IC for testing using the probe card.

Abstract: The present invention relates to antigen binding proteins to human IL-13, including anti-IL-13 antibodies and anti-IL-3/anti-IL-4 mAbdAbs, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as asthma or IPF.

Abstract: The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorders.

Abstract: The present invention is related to the field of heating, ventilation and air conditioning (HVAC). More particularly, the present invention is related to methods and systems for controlled heating and cooling in order to reduce costs and the carbon footprint of said heating and cooling by optimizing the use of fresh air ventilation. The present invention is directed to mathematical algorithms incorporated into a controller and a method of determining control signals that are dependent on said mathematical algorithms and user programming that integrates information from multiple sensors, thermostats as well as weather information. Used in any home or building, the controller controls heating, cooling and ventilation systems in order to reduce costs and the carbon footprint of said heating and cooling by optimizing the use of fresh air ventilation. The controller works with typical HVAC systems generally in buildings and homes.

Abstract: The present invention relates to antibodies or antigen binding fragments thereof which specifically binds to IGF-1R, specifically hIGF-1R. Also disclosed are antibody preparations comprising antibodies or antigen binding fragments of the invention. Methods of producing such antibodies or antigen binding fragments and uses thereof are also included within the scope of the present invention.

Abstract: A hyperbaric chamber includes a collapsible, pressurizable bladder and an inflatable support member supporting the bladder in a substantially uncollapsed configuration. The inflatable support member may be either internal or external to the bladder, and, in embodiments, is a rib with curvature corresponding generally to the uncollapsed shape of the bladder. A stiffening stave may provide additional support. The bladder further includes an accessway into the interior thereof and a substantially non-breathable closure on the accessway. The closure includes a substantially air-impermeable gasket sandwiched between first and second zippers. A reinforcing zipper may provide additional strength to the closure. Similarly, a reinforcing harness substantially surrounding the bladder may provide additional strength to the bladder. A source of compressed air is in fluid communication with the interior of the bladder, and a cooling source may also be provided.

Abstract: A method of determining the distance, from a reference point, of a tracer emitting radiation comprising a first component emitted at a first known energy level and a second component emitted at a second known energy level, the intensity of a penetrating portion of the first component that penetrates a substance between the tracer and the reference point and the intensity of a penetrating portion of the second component of the radiation that penetrates the substance being a function of the rate of gamma radiation emission of the tracer as well as of the distance of the tracer from the reference point, the method comprising: a) measuring the intensity of the first penetrating portion and the intensity of the second penetrating portion; b) determining the ratio of the intensity of the first penetrating portion to the intensity of the second penetrating portion; and c) determining the distance of the tracer from the reference point.

Abstract: A new cultivar of Campanula, ‘Pinkins’, characterized by its flowers that are deep lilac pink in color with lighter colored centers, its refined foliage that is rich green in color with reddish purple highlights under intense light conditions, its moderate and less invasive growth habit than is typical for this type of Campanula, and its cold hardiness in U.S.D.A. Zone 3.