Abstract: Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.

Abstract: Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.

Abstract: There is disclosed an automatic door installation 100 configured to determine the presence of an obstacle 150 in one or more detection zones remote from a door opening, comprising: at least a first door 104 slidable in a door opening along a horizontal door axis from an open configuration to a closed configuration during a door closing operation; a plurality of transmitter-receiver pairs, each transmitter-receiver pair comprising: a transmitter 116 for transmitting a beam 140 and a receiver 118 for receiving a reflection of the beam, wherein one of the transmitter 116 and the receiver 118 is coupled to the first door so that, in use, the transmitter and receiver move closer together during the door closing operation; wherein the transmitter 116 defines a transmitter axis 120 corresponding to the optical axis of the beam; wherein the receiver 118 has a field of view 142 for receiving the beam, which is oriented around a receiver axis; and wherein the transmitter axis 120 and the receiver axis 122 are configure

Abstract: Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.

Abstract: There is disclosed a method of testing an optical door sensor 100 having an emitter 102 for emitting a light signal 104 and a receiver 106 for detecting the light signal 104, the optical door sensor 100 having at least one sensor operating parameter and further having a baseline state in which the receiver 102 can detect a light signal from the emitter 106. The method comprises setting the optical door sensor in an offset state 204, 304, in which a sensor operating parameter is offset from a baseline setting by an offset amount, the baseline setting corresponding to the baseline state of the optical door sensor; conducting a signal test 206 with the optical door sensor in the offset state; and generating an alert 216 when the signal test result is negative for the offset state and the offset amount is less than or equal to a limit margin. The signal test comprises: emitting a light signal from the emitter 208 and determining whether the light signal is detected by the receiver 210.

Abstract: A method and sensing apparatus for elevators that detects an intrusion into a volume defined relative to a path across an opening. The sensing apparatus has a closure member for the opening that can be controllably displaced to define a gap in the opening. A first group of at least two emitters of electromagnetic signals located on either the closure member or a boundary member are directed into the volume and a second group of at least two receivers for electromagnetic signals located on the opposite side of the gap to the emitters. The method causes at least one of the emitters to emit a primary beam along a first axis into the volume, allows at least one of the receivers to receive a secondary beam of radiation, and enables one or more of the receivers to provide an output signal into the network.

Abstract: The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

Abstract: Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.

Abstract: There is disclosed an automatic door installation 10 comprising: a door opening 16; and an optical door sensor comprising: a plurality of transmitters 30 arranged in a transmitter array 22, each transmitter 30 being configured to transmit an optical beam across the door opening along a respective beam path; a plurality of receivers 32 arranged in a receiver array 24, each receiver 32 being configured to generate a receiver output signal based on an intensity of light received. The plurality of receivers 32 are arranged in at least one set of receivers, the receivers of the or each set being linked so that the respective sensor output signals are combined into a compound signal for the respective set.

Abstract: There is disclosed an automatic door installation 100 configured to determine the presence of an obstacle 150 in one or more detection zones remote from a door opening, comprising: at least a first door 104 slidable in a door opening along a horizontal door axis from an open configuration to a closed configuration during a door closing operation; a plurality of transmitter-receiver pairs, each transmitter-receiver pair comprising: a transmitter 116 for transmitting a beam 140 and a receiver 118 for receiving a reflection of the beam, wherein one of the transmitter 116 and the receiver 118 is coupled to the first door so that, in use, the transmitter and receiver move closer together during the door closing operation; wherein the transmitter 116 defines a transmitter axis 120 corresponding to the optical axis of the beam; wherein the receiver 118 has a field of view 142 for receiving the beam, which is oriented around a receiver axis; and wherein the transmitter axis 120 and the receiver axis 122 are configure

Abstract: A method is disclosed of operating an automatic door installation comprising door sensor equipment including a door sensor. The automatic door installation is operable in at least a standard mode, in which the door sensor equipment conducts an obstacle check to determine whether an obstacle is present according to a first obstacle check procedure, and a contingency mode, in which the door sensor equipment conducts the obstacle check according to a different second obstacle check procedure. The method includes the steps of evaluating an operating condition of the automatic door installation; determining whether the operating condition lies within a standard operating range; and operating the automatic door installation in the contingency mode when the operating condition lies outside a respective standard operating range.

Abstract: A method of hazard highlighting for drawing visual attention to the alignment of first and second members, the first member having a first plane working surface and a first working edge; the second member having a second plane working surface and a second working edge; the first and second working edges being separated by a working clearance; the first and second members being displaceable relative to one another wherein, in a first operating configuration, the first and second plane working surfaces lie in a common plane with the first and second working edges juxtaposed with the working clearances separated by a minimum distance; and, in a second configuration, the first and second plane working surfaces do not lie in the common plane and the first and second working edges are displaced from one another to a greater or lesser degree with the working edges being separated by a distance greater than minimum; the method including the step of projecting a light ray or pattern from a location associated with the

Abstract: An activation device for a patient alarm system. The activation device comprises a resiliently deformable bladder defining an internal volume and a pressure switch in fluid communication with the internal volume and connected to an alarm system. Squeezing the resiliently deformable bladder operates the pressure switch, which activates the alarm system.

Abstract: The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

Abstract: A system that combines covert taggants with a cloud based IUID tag tracking system to protect items form counterfeiting, piracy, and diversion.

Abstract: There is disclosed a method of testing an optical door sensor 100 having an emitter 102 for emitting a light signal 104 and a receiver 106 for detecting the light signal 104, the optical door sensor 100 having at least one sensor operating parameter and further having a baseline state in which the receiver 102 can detect a light signal from the emitter 106. The method comprises setting the optical door sensor in an offset state 204, 304, in which a sensor operating parameter is offset from a baseline setting by an offset amount, the baseline setting corresponding to the baseline state of the optical door sensor; conducting a signal test 206 with the optical door sensor in the offset state; and generating an alert 216 when the signal test result is negative for the offset state and the offset amount is less than or equal to a limit margin. The signal test comprises: emitting a light signal from the emitter 208 and determining whether the light signal is detected by the receiver 210.

Abstract: There is disclosed a method of operating an automatic door installation comprising door sensor equipment including a door sensor 100, the automatic door installation being operable in at least a standard mode, in which the door sensor equipment conducts an obstacle check to determine whether an obstacle is present according to a first obstacle check procedure, and a contingency mode, in which the door sensor equipment conducts the obstacle check according to a different second obstacle check procedure. The method comprises: evaluating an operating condition of the automatic door installation; determining whether the operating condition lies within a standard operating range; and operating the automatic door installation in the contingency mode when it is determined that the operating condition lies outside the respective standard operating range.

Abstract: A communication device comprising: a first radio capable of communicating according to a first protocol and having a set of operational modes; and a second radio capable of communicating according to a second protocol, the communication device being configured to, in dependence on one or more communications by the second radio in accordance with the second protocol, selecting one mode of operation for the first radio from the set of operational modes, wherein said one or more communications comprises: sending a first message; and a response or non-response to the first message.

Abstract: The present invention relates to a method for producing a perforated breakable multi well plate comprising providing a multi well plate, and generating one or more perforated section lines along the width and/or length of the multi well plate by puncturing the multi well plate with a slotted blade for each section line to be generated, wherein the slotted blade is rigid and sharpened along one edge and a series of slots extends from the sharpened edge into the blade, thereby forming a series of sharp and rigid teeth alternating with slots. The invention further relates to a press tool usable in the above method as well as a perforated breakable multi well plate.

Abstract: The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild-type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptide. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID NOs: 2 and 4 and chimeric antibodies thereof as exemplified by ch806.