Abstract: The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild-type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptide. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID NOs: 2 and 4 and chimeric antibodies thereof as exemplified by ch806.

Abstract: The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild-type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptide. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID NOs: 2 and 4 and chimeric antibodies thereof as exemplified by ch806.

Abstract: The pharmaceutical use of amylases related to Bacillus alpha-amylases of SEQ ID NOs: 1-3, optionally in combination with a lipase and/or a protease. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II. The amylases of SEQ ID NOs: 1-3 are variants of amylases from Bacillus stearothermophilus, Bacillus licheniformis and Bacillus sp. The amylases of the invention have an improved efficacy in vivo, an improved pH-profile, a high specific activity, and/or an improved starch degradation profile.

Abstract: An air displacing device for transferring air from a first location to a second location comprising a housing including a fan, a prime mover for the fan, means defining an air inlet to receive air from the first location, and an air outlet to deliver air to the second location and a duct for air through the housing from the inlet to the outlet, the fan being operable by way of the prime mover to cause air to be displaced along the duct from the inlet to the outlet, the housing serving to define a datum plane characterised in that the housing has external members adapted for displacement between a first, standby, configuration where the projection of the housing from the datum plane is a minimum and so the volume of the housing is a minimum and a second, working, configuration where the projection of the housing from the datum plane is a maximum and so the volume of the housing is a maximum.

Abstract: A drier unit comprising a housing with an air inlet and an air outlet, a flow duct through the housing linking the air inlet to the air outlet; a fan disposed in the flow duct so as to displace air along the duct from the inlet to the outlet characterised in that the air outlet includes more than one outlet aperture, each aperture being directed to provide for the passage of air into a drying region adjacent the housing, air flow from one aperture being caused to interact with air flow from another aperture to generate swirling of air in the drying region. The invention further envisages means providing for air flow through the apertures to be coupled so that in the event of one or some of the apertures being blocked flow through the remaining unblocked aperture or apertures is increased.

Abstract: A drier information system is provided including display means relating to a given region of the system which means serves, at least while a drying cycle is in operation, to provide a visual display indicating at least one of the following parameters: the extent of the region; a boundary of the region; direction or example of manipulation of a pair of hands or other article while in the region to provide for a preferred drying sequence. The visual display can represent the parameters as a two dimensional array within or adjacent the region. Alternatively the visual display can represent the parameters as a virtual or actual three dimensional array within or adjacent the region.

Abstract: A method of operating a data processing system comprises executing a batch application, the executing comprising reading one or more inputs from one or more data files, performing updates on one or more records according to the or each input read from a data file, and issuing a syncpoint when said updates are completed. During the execution of the batch application, syncpoints are periodically issued and checkpoints are less frequently issued. Following detection of a failure of the batch application, the batch application is restarted with the last issued checkpoint, and the batch application is executed by reading one or more inputs from one or more data files, but not performing updates on said records, until the last issued syncpoint is reached.

Abstract: The present invention discloses a solution that automatically decomposes a batch process into multiple units of work without changing code of a preexisting batch application. In the solution, the batch application is first analyzed to identify a set of processing segments or units of work, where each unit of work is of a size that minimizes interference with other data accesses. Once each unit of work is defined, these units can execute one at a time. A syncpoint can be established for each unit before it is executed, which locks the records included in the unit. After the unit of work executes, the record lock can be released and a new syncpoint can be established for the next unit. If an execution problem occurs, execution for the unit of work can be terminated and chances can be restored to the syncpoint.

Abstract: A method of presenting content on the user interface display screen of a portable electronic device includes the presentation of a plurality of icons. The icons scale in size in accordance with a position of the respective icons along a curved path.

Abstract: The invention provides isolated nucleic acids encoding recombinant genomes or antigenomes of Human Parainfluenza Viruses that are useful as vaccines. The recombinant genomes or antigenomes can be incorporated into expression vectors for production of recombinant viruses in vitro. The invention also provides recombinant Human Parainfluenza viruses having one or more mutations that attenuate replication of the virus in a host.

Abstract: Systems, apparatus, and methods for the catalytic removal of at least one pollutant from an air stream via a catalytic precooler arranged in series with at least one augmentative catalytic device. The augmentative catalytic device may be located upstream or downstream from the catalytic precooler. The augmentative catalytic device may be integrated with the catalytic precooler, thereby eliminating the need for a separate housing and minimizing weight. Alternatively, the augmentative catalytic device may be disposed within a separate housing, thereby facilitating access for maintenance and decreasing direct maintenance costs.

Abstract: A Connector comprising a rigid base member covered by a resilient layer base member further comprising a contact member formed of a head portion and a stem portion, whereby the head portion is arranged to project from the outer surface of the resilient layer and the stem portion is located within the base member and the resilient layer, the stem portion being held in position by a retaining member. Preferably, the resilient layer is formed of an elsatomer material which extends around the periphery of the connector.

Abstract: Chimeric human-bovine respiratory syncytial virus (RSV) are infectious and attenuated in humans and other mammals and useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric RSV genome or antigenome which includes a partial or complete human or bovine RSV “background” genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) of a different RSV strain. Chimeric human-bovine RSV of the invention include a partial or complete “background” RSV genome or antigenome derived from or patterned after a human or bovine RSV strain or subgroup virus combined with one or more heterologous gene(s) or genome segment(s) of a different RSV strain or subgroup virus to form the human-bovine chimeric RSV genome or antigenome.

Abstract: A system and method for validating adherence of an UII identifier code to one of several prescribed DOD codes by means of a programmed series of tests. First the code is tested for a prescribed header and a last character message. If one or the other is not found, the process stops and an error message is displayed. Field separator characters are identified that divide the message into fields. If the header, end of message character, and field separator are found and tested successfully, the program proceeds, and searches for an identifier of one of the DOD prescribed semantic formats. The semantic format identifier is extracted and tested. If valid, the process proceeds. If not, an error message is displayed. In proceeding, each field is stored, and the data from each field is extracted in accordance with the format identifier that had been extracted.

Abstract: Chimeric human-bovine parainfluenza viruses (PIVs) are infectious and attenuated in humans and other mammals and useful individually or in combination in vaccine formulations for eliciting an anti-PIV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric PIV genome or antigenome which includes a partial or complete human or bovine PIV “background” genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) of a different PIV. Chimeric human-bovine PIV of the invention include a partial or complete “background” PIV genome or antigenome derived from or patterned after a human or bovine PIV virus combined with one or more heterologous gene(s) or genome segment(s) of a different PIV virus to form the human-bovine chimeric PIV genome or antigenome.

Abstract: The present invention relates to non-cytopathic negative-strand RNA virus replicons, and methods of making and using the replicons and replicon systems.

Abstract: A sealing element is formed from a desirably shaped body of a sealant material formulated from a first polymer in a concentration of about 25 percent to about 40 percent, an inert filler material in a concentration of about 20 percent to about 45 percent and a hydrocarbon resin in a concentration of about 1 percent to about 15 percent. The sealant material, when positioned about a first component is overmolded with a material forming a second component. The sealant material, which is heat activated, forms a seal between the first and second components.

Abstract: Attenuated respiratory syncytial virus (RSV) and vaccine compositions thereof are produced by introducing specific mutations associated with attenuating phenotypes into wild-type or RSV which is incompletely attenuated by cold-passage or introduction of mutations which produce virus having a temperature sensitive (ts) or cold adapted (ca) phenotype. Alternatively, recombinant RSV and vaccine compositions thereof incorporate attenuating and other mutations specifying desired structural and or phenotypic characteristics in an infectious RSV. Recombinant RSV incorporate desired mutations specified by insertion, deletion, substitution or rearrangement of a selected nucleotide sequence, gene, or gene segment in an infectious RSV clone. The immune system of an individual is stimulated to induce protection against natural RSV infection, or multivalently against infection by RSV and another pathogen, such as PIV, by administration of attenuated, biologically derived or recombinant RSV.

Abstract: Chimeric human-bovine parainfluenza viruses (PIVs) are infectious and attenuated in humans and other mammals and useful individually or in combination in vaccine formulations for eliciting an immune response to PIV or other pathogens. Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric PIV genome or antigenome which includes a partial or complete human or bovine PIV “background” genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) of a different PIV. Chimeric human-bovine PIV of the invention include a partial or complete “background” PIV genome or antigenome derived from or patterned after a human or bovine PIV virus combined with one or more heterologous gene(s) or genome segment(s) of a different pathogen, including different PIV virus to form the human-bovine chimeric PIV genome or antigenome.

Abstract: Chimeric human-bovine respiratory syncytial virus (RSV) are infectious and attenuated in humans and other mammals and useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric RSV genome or antigenome which includes a partial or complete human or bovine RSV “background” genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) of a different RSV strain. Chimeric human-bovine RSV of the invention include a partial or complete “background” RSV genome or antigenome derived from or patterned after a human or bovine RSV strain or subgroup virus combined with one or more heterologous gene(s) or genome segment(s) of a different RSV strain or subgroup virus to form the human-bovine chimeric RSV genome or antigenome.