Abstract: Described herein is a mixer system for producing aqueous coating materials from at least one aqueous pigment paste A, including at least one effect pigment, and at least one pigment-free component B, including an aqueous, acrylate-based microgel dispersion having a glass transition temperature Tg of 50 to 60° C., where both the aqueous pigment paste A and the component B each have a VOC value of less than or equal to 250 g/L. Further described herein is a method for producing aqueous coating materials having a VOC content of 0 to 250 g/L, in which the individual components A and B are stored separately and not mixed until shortly before application, to give the aqueous coating material. Further described herein is a method of using the mixer system of for producing aqueous coating materials for refinishing and/or for coating automobile bodies and/or plastics parts.

Abstract: The present invention relates to a bispecific antibody construct comprising a first human binding domain which binds to human CDH3 on the surface of a target cell and a second binding domain which binds to human CDS on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

Abstract: The present invention is directed to a biological marker of ovarian cancer, including early stage ovarian cancer. Specifically, the present invention provides methods for detecting ovarian cancer in a subject which include detecting an expression level of the biological marker junction plakoglobin in blood of the subject. An expression level of junction plakoglobin that is higher than a reference expression level for junction plakoglobin indicates that the subject has ovarian cancer. Methods of identifying a subject having ovarian cancer and methods of determining if a subject is susceptible to developing ovarian cancer are also provided based on detecting the expression level of junction plakoglobin in blood of the subject. The present invention also extends to methods of treatment of ovarian cancer together with methods of screening a candidate therapeutic agent for use in treating ovarian cancer.

Abstract: The present invention relates to a pigmented aqueous basecoat material comprising a polyether-based reaction product which is preparable by reaction of (a) at least one cyclic carboxylic anhydride comprising a free carboxylic acid group and/or the halide of a carboxylic acid group with (b) at least one polyether of the general structural formula (I) in which R is a C3 to C6 alkylene radical and n is selected accordingly such that the polyether (b) possesses a number-average molecular weight of 800 to 4000 g/mol, the components (a) and (b) being used in the reaction in a molar ratio of 0.7/2.3 to 1.6/1.7 and the resulting reaction product possessing an acid number of 10 to 50 mg KOH/g.

Abstract: A door arrester, in particular for a door of a motor vehicle, includes a door retainer rod (30) which can be mounted on either one of the door (2) or the body (3) so as to be pivotable and has a first side (35) with profiling (35a) formed on the first side (35); and a first braking element which can be arranged on the other of the door (2) or the body (3) and in sections bears against the first side (35) of the door retainer rod (30) under the effect of a preload, and which, with the profiling (35a) of the first side (35), defines at least one retaining position. The first braking element has a central boring, the door retainer rod (30) has an elongate through-hole (33), a guide pin (40) passes through the central boring and the through-hole (33), and the guide pin (40) permits an axial movement of the first braking element along the guide pin (40).

Abstract: A transmitter component includes an input terminal and a first semiconductor portion with doped regions of a control-side interface circuit. The control-side interface circuit converts a digital input signal received at the input terminal into a transmit radio frequency signal. A control-side metallization structure on at least one of two horizontal main surfaces of the first semiconductor portion includes at least a portion of a control-side antenna structure that emits the transmit radio frequency signal as radio wave. A transceiver circuit may include the transmitter component and a receiver component.

Abstract: A hydraulic control housing of modular construction consists of a first block, in which a compression chamber is formed, and a second block, which has a port to a reservoir. The compression chamber is connected to the reservoir via a duct extending through the control housing. A check valve is arranged in that duct section of the duct which extends through the first block.

Abstract: A cutting machine includes a cutting device and a co-operating conveyor device for conveying food products in a conveying direction. The conveyor device includes at least one conveyor unit having a conveyor belt which is guided by at least one deflection roll and which comes into contact with the food products in the contact area and having at least one guide means for guiding the conveyor belt. The at least one guide means has a first support portion for supporting the conveyor belt at a first height and a second support portion for supporting it at a second height, these heights being spaced apart in a direction extending perpendicularly to the conveying direction, and at least one recess arranged between the first height and the second height, in which the conveyor belt can give way at least partly due to contact with a food product.

Abstract: The present invention relates to the identification of biological markers of ovarian cancer. Specifically, cancer-associated autoantibodies to ANXA1, ARP3, SAHH, SERPH, ARAP1, OTUB1, ATP1A1, UBA1, and CFAH have been identified in subjects with early stage ovarian cancer. These autoantibodies can be utilised for a range of purposes including methods for detecting ovarian cancer, methods for screening for early stage ovarian cancer, and methods for assessing treatment response as well as disease progression and recurrence. The autoantibodies also represent prognostic markers of ovarian cancer development.

Abstract: A door holder, includes a retainer housing (230), which can be connected either to a door or a door frame, and a door retainer rod, which penetrates the retainer housing (230) and which can be articulated to the other of the door and the door frame The door retainer rod has at least one braking surface, and at least one braking element (50) that can be displaced toward the at least one braking surface is arranged on the retainer housing (230), which the braking element can be brought in contact with the at least one braking surface of the door retainer rod at least in some sections and thus produces a primary braking force component against the displacement of the door retainer rod, wherein the door retainer rod has at least one guiding surface, which is inclined with respect to the braking surface.

Abstract: Disclosed herein is a coating material system containing (A) at least one polyhydroxy group-containing compound, (B) at least one polyisocyanate-containing compound, and (C) at least one catalyst comprising lithium (Li) and bismuth (Bi) as metal components and where the molar ratio of lithium to bismuth is at least 7:1 [mol/mol], in which i) components (A), (B), and (C) are present separately from one another, or ii) are mixed wholly or at least partly with one another. Methods for producing and using the coating material system are also disclosed herein.

Abstract: Described herein is a coating material system which includes components (A) to (C) and (K) and also, optionally, further components, where all components (A) to (C) and (K) and also, where present, the further optional components are present separately from one another or are mixed wholly or at least partly with one another. Component (A) includes at least one polyhydroxy group-containing compound, where the polyhydroxy group-containing compound of component (A) has an acid number of between 0 and 30 mg KOH/g, and component (B) includes at least one polyisocyanate-containing compound. Component (C) is a catalyst including bismuth (Bi) as metal component and at least one further metal component such as lithium (Li). Component (K) is at least one mercapto group-containing compound. Further components which may be present in the coating material system include, for example, hydroxyl-containing compounds (D), coating additives (F), pigments (H) and/or solvents (J).

Abstract: Described herein is a curable coating composition including at least one Michael donor (A) having at least one acetoacetate group, at least one Michael acceptor (B) and at least one specific catalyst (C). Also described herein are a method of using the curable coating composition as a clear coating in a method to prepare a multilayer coating and a multilayer coating obtained from said process. Further described herein is a kit-of-parts including at least two separate containers C1 and C2, where the specific catalyst (C) and/or the at least one Michael acceptor (B) is contained in container C2. Additionally described herein is a method of using specific salts of carboxylic acids as catalyst in a reaction between a Michael donor (A) having at least one acetoacetate group and a Michael acceptor (B).

Abstract: Described herein are a curable coating composition including at least one Michael donor (A) having at least one thiol group, at least one Michael acceptor (B) and at least one specific catalyst (C), a method of using the curable coating composition as a clear coating in a process to prepare a multilayer coating and a multilayer coating obtained from said process. Also described herein is a kit-of-parts including at least two separate containers C1 and C2, where the specific catalyst (C) is contained in container C1 and/or C2. Finally, described herein is a method of using specific salts of carboxylic acids as catalyst in a reaction between a Michael donor (A) having at least one thiol group and a Michael acceptor (B).

Abstract: Described herein is a coating composition including one or more (meth)acrylic polymers including moieties of formula (I) *—C(?O)—O—CH2—Si(Ra)3?x(Rb)x??(I) where Ra=methoxy; Rb=an alkyl group containing 1 to 4 carbon atoms or an alkoxy group containing 1 to 4 carbon atoms; x is 0 or 1; and the asterisk * denotes the position at which the moiety of formula (I) is attached to the polymeric backbone of the (meth)acrylic polymer; further containing one or more catalysts of formula (II) H3C—C(Rc)(Rd)—C(?O)—O?M+??(II) where Rc and Rd=alkyl groups containing 1 to 6 carbon atoms, with the proviso that the sum of the number of carbon atoms in residues Rc and Rd ranges from 2 to 7, and M=for Li, K or Na, and further containing one or more aprotic organic solvents.

Abstract: Described herein is a mixer system for producing aqueous coating materials from at least one aqueous pigment paste A, including at least one color pigment, and at least one pigment-free component B, including an aqueous, acrylate-based microgel dispersion having a glass transition temperature Tg of 50 to 60° C., where both the aqueous pigment paste A and the component B each have a VOC value of less than or equal to 250 g/L. Further described herein is a method for producing aqueous coating materials having a VOC content of 0 to 250 g/L, in which the individual components A and B are stored separately and not mixed until shortly before application, to give the aqueous coating material. Further described herein is a method of using the mixer system for producing aqueous coating materials for refinishing and/or for coating automobile bodies and/or plastics parts.

Abstract: Described herein is a mixer system for producing aqueous coating materials from at least one aqueous pigment paste A, including at least one effect pigment, and at least one pigment-free component B, including an aqueous, acrylate-based microgel dispersion having a glass transition temperature Tg of 50 to 60° C., where both the aqueous pigment paste A and the component B each have a VOC value of less than or equal to 250 g/L. Further described herein is a method for producing aqueous coating materials having a VOC content of 0 to 250 g/L, in which the individual components A and B are stored separately and not mixed until shortly before application, to give the aqueous coating material. Further described herein is a method of using the mixer system of for producing aqueous coating materials for refinishing and/or for coating automobile bodies and/or plastics parts.

Abstract: Described herein is a coating composition including one or more resins of formula R—[NH—CO—NR1—R2—Si(Ra)3-x(Rb)x]y one or more catalysts of formula [H3C—C(Rc)(Rd)—C(?O)—O?]zMz+ and one or more aprotic organic solvents. Also described herein are a method of coating a substrate with the above coating composition, a thus coated substrate, and a multilayer coating and a substrate coated with such multilayer coating.

Abstract: The present invention relates to the identification of biological markers of ovarian cancer. Specifically, cancer-associated autoantibodies to ANXA1, ARP3, SAHH, SERPH, ARAP1, OTUB1, ATP1A1, UBA1, and CFAH have been identified in subjects with early stage ovarian cancer. These autoantibodies can be utilised for a range of purposes including methods for detecting ovarian cancer, methods for screening for early stage ovarian cancer, and methods for assessing treatment response as well as disease progression and recurrence. The autoantibodies also represent prognostic markers of ovarian cancer development.

Abstract: A retainer housing, in particular for a door check (30), includes a first housing part (2) with a cavity (3) for receiving a brake body (50) and a spring system (40) of a door check (30). The first housing part (2) has a first end (2b) and a second end (2c), and a closing piece (104) which is situated on one of the first end (2b) and second end (2c) of the housing part. The closing piece (104) has an upper face (104a) and a lower face (104b). Multiple elevations (6) are arranged on the lower face (4b; 104b) of the closing piece (4; 104), concentrically around a centre point of the lower face (4b; 104b). The elevations (6) have a stop face (7) for a spring system (40) of a door check (30).