Abstract: A pigmented aqueous basecoat material is disclosed. The pigmented aqueous basecoat material includes a polyether-based reaction product which is preparable by a reaction of trimesic acid with at least one polyether of the general structural formula (I) R is a C3 to C6 alkylene radical and n is selected accordingly such that the at least one polyether possesses a number-average molecular weight of 500 to 5000 g/mol. The trimesic acid and the at least one polyether are used in the reaction in a molar ratio of 0.7/2.3 to 1.6/1.7 and the resulting reaction product possesses an acid number of 10 to 50 mg KOH/g.

Abstract: The present invention relates to a biomarker for early stage ovarian cancer. Specifically, expression of the biomarker Annexin A2 is higher in the plasma of subjects with early stage ovarian cancer. Accordingly, methods of detecting early stage ovarian cancer in a subject, of identifying a subject having early stage ovarian cancer, and of determining if a subject is susceptible to developing ovarian cancer, are provided. Also provided are methods of screening candidate therapeutic agents for use in treating early stage ovarian cancer, and compositions and kits for detecting early stage ovarian cancer in a subject, for identifying a subject having early stage ovarian cancer, and for determining if a subject is susceptible to developing ovarian cancer.

Abstract: The door check includes a retaining bar (20) which can be connected to one of the two door assembly parts, i.e. the door (8) or the door frame (6), and a retaining housing (13) which can be connected to the other door assembly part. In order to design a door check that allows a vehicle door to be reliably and safely blocked in an automated manner, a threaded bar (50) can be accommodated in an axially movable fashion in a cavity of the retaining bar (20).

Abstract: The present invention relates to a pigmented aqueous basecoat material including a polyether-based reaction product which is preparable by reaction of (a) at least one carboxy-functional component which is preparable by esterification reaction of at least one dihydroxycarboxylic acid (a1) with at least one dicarboxylic acid (a2) and/or the anhydride of a dicarboxylic acid (a2), the components (a1) and (a2) being used in a molar ratio of 0.5/3.0 to 1.7/1.8, with (b) at least one polyether of a general structural formula (I) in which R is a C3 to C6 alkylene radical and n is selected accordingly such that the polyether (b) possesses a number-average molecular weight of 500 to 5000 g/mol, the components (a) and (b) being used in the reaction in a molar ratio of 0.7/2.3 to 1.6/1.7, and the resulting reaction product possessing an acid number of 10 to 50 mg KOH/g.

Abstract: A coating material system including components (A) to (C) and also, optionally, further components, with, in a first option, all components (A) to (C) and also, where present, the further optional components being present separately from one another, in other words the individual components not being mixed with one another. In a second option of the coating material system, conversely, the aforementioned components may also be mixed wholly or at least partly with one another. Where the components are at least partly mixed with one another, for example, component (C) is mixed with component (A), while component (B) is present separately from this mixture of (A) and (C). Optionally, component (B) may also be mixed with a portion of component (C). Furthermore, the mixtures of (A) and (C) and of (B) and (C) may additionally include at least one optional component such as a solvent, for example.

Abstract: Described herein is a pigmented aqueous basecoat material including a polyether-based reaction product which is preparable by reaction of (a) at least one cyclic tetracarboxylic dianhydride having an aliphatic, aromatic, or araliphatic radical X bridging the two anhydride groups with (b) at least one polyether of the general structural formula (II) in which R is a C3 to C6 alkylene radical and n is selected accordingly such that the polyether (b) possesses a number-average molecular weight of 500 to 5000 g/mol, the components (a) and (b) being used in the reaction in a molar ratio of 0.7/2.3 to 1.6/1.7 and the resulting reaction product possessing an acid number of 5 to 80 mg KOH/g. Also described herein is a reaction product of specific dianhydrides and a polyether, and the use of the pigmented aqueous basecoat material or the reaction product.

Abstract: The present invention relates to a pigmented aqueous basecoat material comprising a polyether-based reaction product which is preparable by reaction of (a) at least one compound of the formula (I) X1—Y—X2??(I) in which X1 and X2, independently of one another, are each a functional group which is reactive toward hydroxyl groups, and Y is a divalent aliphatic or araliphatic, carboxy-functional organic radical having a number-average molecular weight of 100 to 1000 g/mol, with (b) at least one polyether of the general structural formula (II) in which R is a C3 to C6 alkylene radical and n is selected accordingly such that the polyether (b) possesses a number-average molecular weight of 200 to 4000 g/mol, where components (a) and (b) are used in the reaction in a molar ratio of 0.7/2.3 to 1.6/1.7 and the resulting reaction product possesses a number-average molecular weight of 500 to 15 000 g/mol and an acid number of 10 to 120 mg KOH/g.

Abstract: A dimer fatty acid-polyether-reaction product prepared by reacting a composition containing at least 80 wt % of one or more dimer fatty acids with at least one polyether of application formula (I) in a molar ratio of 0.7/2.3 to 1.6/1.7. The reaction product has a number-average molecular weight of 4800 to 40000 g/mol and an acid number of less than 10 mg KOH/g.

Abstract: The present invention relates to a pigmented aqueous basecoat material comprising a polyether-based reaction product which is preparable by reaction of (a) at least one diisocyanate of the formula (I) OCN—Y—NCO??(I) in which Y is a divalent aliphatic, aromatic or araliphatic hydrocarbon radical having from 6 to 30 carbon atoms, with (b) at least one polyether of the general structural formula (II) in which R is a C3 to C6 alkylene radical and n is selected accordingly such that the polyether (b) possesses a number-average molecular weight of 200 to 4000 g/mol, where components (a) and (b) are used in the reaction in a molar ratio of 0.7/2.3 to 1.6/1.7 and the resulting reaction product possesses a number-average molecular weight of 500 to 15 000 g/mol and an isocyanate content of less than 0.2%.

Abstract: The present invention relates to a pigmented aqueous basecoat material comprising a carboxy-functional dimer fatty acid-based reaction product which is preparable by reaction of (a) dimer fatty acids with (b) at least one compound of the general structural formula (I) where R is a C3 to C6 alkylene radical and n is selected accordingly such that the polyether (b) possesses a number-average molecular weight of 120 to 6000 g/mol, components (a) and (b) are used in a molar ratio of at least 1/1 and the resulting reaction product possesses a number-average molecular weight of 1000 to 20 000 g/mol and an acid number of 10 to 120 mg KOH/g.

Abstract: The present invention relates to a pigmented aqueous basecoat material comprising a reaction product which is preparable by reaction of (a) at least one aliphatic linear polyester having two functional end groups (a.1), with (b) at least one diene polymer having two functional end groups (b.1), where at least one type of group (a.1) is reacted in a linking manner with at least one type of group (b.1), said components (a) and (b) are used in the reaction in a molar ratio of 2.3/0.7 to 1.7/1.6 and the resulting reaction product possesses a number-average molecular weight of 1000 to 15 000 g/mol.

Abstract: A pigmented aqueous basecoat material that includes a reaction product obtained by reacting (a) a compound of formula (I) with (b) a compound of formula (II) at a molar ratio of 2.3/0.7 to 1.7/1.6, the reaction product having a number-average molecular weight of 500 to 15,000 g/mol, an acid number of less than 10 mg KOH/g, and a hydroxyl number of 25 to 250 mg KOH/g: X1—Y—X2??(I), wherein: X1 and X2 are each independently an epoxide-reactive functional group, or hydrogen, where at least one of X1 and X2 is the epoxide-reactive functional group; and Y is a divalent aliphatic, aromatic or araliphatic hydrocarbon radical having a number-average molecular weight of 100 to 2,500 g/mol, wherein R is a C3 to C6 alkylene radical and n is selected such that compound (b) possesses an epoxide equivalent weight of 100 to 2,000 g/mol.

Abstract: A pigmented aqueous basecoat material that includes a dimer fatty acid/polyesterdiol reaction product which is preparable by reacting (a) dimer fatty acids with (b) at least one polyesterdiol of the general structural formula (I) where: R is a divalent radical including 2-10 carbon atoms; R1 and R2 are independently straight-chain or branched alkylene radicals having 2-10 carbon atoms; X and Y are independently O, S or NR3, where R3 is hydrogen or an alkyl radical having 1-6 carbon atoms; and m and n are selected accordingly such that the polyesterdiol possesses a number-average molecular weight of 450-2200 g/mol, components (a) and (b) are used in a molar ratio of 0.7/2.3 to 1.3/1.7, and the resulting dimer fatty acid/polyesterdiol reaction product possesses a number-average molecular weight of 1200-5000 g/mol and an acid number <10 mg KOH/g.

Abstract: The present invention provides biological markers associated with gastric cancer. In particular, the present invention provides a method of diagnosing gastric cancer (GC) in a subject, the method including: measuring an expression level of one or more proteins in the subject, wherein the one or more proteins are selected from the group consisting of vitamin D binding protein (VDBP), clusterin, insulin like growth factor binding protein complex acid labile subunit (IGFALS), and afamin; comparing the expression level of the or each protein in the subject to a reference expression level for the or each protein; and diagnosing GC in the subject on the basis of the comparison.

Abstract: The present invention relates to a polymer, preparable by reacting at least one polymer, preparable by reacting (a) dimer fatty acids with at least (b) one polyether having a C3 to C6 alkylene radical and a number-average molecular weight of 450 to 2200 g/mol, components (a) and (b) are used in a molar ratio of 0.7/2.3 to 1.3/1.

Abstract: The present invention relates to the identification of biological markers of ovarian cancer. Specifically, cancer-associated autoantibodies to ANXA1, ARP3, SAHH, SERPH, ARAP1, OTUB1, ATP1A1, UBA1, and CFAH have been identified in subjects with early stage ovarian cancer. These autoantibodies can be utilised for a range of purposes including methods for detecting ovarian cancer, methods for screening for early stage ovarian cancer, and methods for assessing treatment response as well as disease progression and recurrence. The autoantibodies also represent prognostic markers of ovarian cancer development.

Abstract: The present invention provides biological markers associated with gastric cancer. In particular, the present invention provides a method of diagnosing gastric cancer (GC) in a subject, the method including: measuring an expression level of one or more proteins in the subject, wherein the one or more proteins are selected from the group consisting of vitamin D binding protein (VDBP), clusterin, insulin like growth factor binding protein complex acid labile subunit (IGFALS), and afamin; comparing the expression level of the or each protein in the subject to a reference expression level for the or each protein; and diagnosing GC in the subject on the basis of the comparison.

Abstract: The present invention relates to an aqueous coating composition comprising at least one aqueous dispersion comprising at least one copolymer (CP), said copolymer (CP) being preparable by (i) initially charging an aqueous dispersion of at least one polyurethane, and then (ii) polymerizing a mixture of olefinically unsaturated monomers in the presence of the polyurethane from (i), in which (a) a water-soluble initiator is used, (b) the olefinically unsaturated monomers are metered in such that a concentration of 6.0% by weight, based on the total amount of olefinically unsaturated monomers used for polymerization, in the reaction solution is not exceeded over the entire reaction time, and (c) the mixture of the olefinically unsaturated monomers comprises at least one polyolefinically unsaturated monomer and at least one linear hydroxy-functional reaction product (R) having an acid number less than 20 mg KOH/g, the preparation of which involves using at least one compound (v) containing two functional groups (v.

Abstract: Described herein is a method for producing a coating system on a substrate, including producing a cured basecoat film on the substrate by applying a pigmented aqueous basecoat material to the substrate and subsequently curing the basecoat material, wherein the basecoat material includes a polyether-based reaction product which is preparable by reaction of (a) at least one cyclic tetracarboxylic dianhydride having an aliphatic, aromatic or araliphatic radical X which bridges the two anhydride groups, with (b) at least one polyether of a general structural formula (II) in which R is a C3 to C6 alkylene radical and n is selected such that the polyether (b) possesses a number-average molecular weight of 500 to 5000 g/mol, and wherein components (a) and (b) are used in the reaction in a molar ratio of 0.7/2.3 to 1.6/1.7 and a resulting reaction product possesses an acid number of 5 to 80 mg KOH/g.

Abstract: The present invention relates to a door (10) for a domestic appliance, in particular an oven door (10) for a cooking oven. The door (10) comprises a front panel (12) and at least one door handle (14) made of metal and arranged at an outer side of said front panel (12). The door (10) comprises at least one electric and/or electronic device (18) arranged inside and/or at the door handle (14). The door (10) comprises at least one fastening element (24) for fastening the door handle (14) at the front panel (12). At least one conducting element (26) is attached at the inner side and/or outer side of the front panel (12).