Abstract: Described embodiments relate to a chemical processing instrument configured to receive one or more sample cartridges, to process one or more corresponding fluid samples. The chemical processing instrument comprises: a reagent dispenser configured to dispense one or more fluid reagents into a reagent vessel via an open top of the reagent vessel; and a pneumatic module configured to connect to a primary pneumatic port of a primary reaction vessel and selectively adjust a pressure within the primary reaction vessel when the lid is closed to draw fluid from the reagent vessel through a primary reagent channel into the primary reaction vessel.

Abstract: A method of assembling an adjustable fluid-filled lens assembly comprising biaxially tensioning an elastomeric membrane to a surface tension of greater than 180 N/m, typically greater than 1000 N/m; thermally conditioning the tensioned membrane, e.g., for one hour at a temperature of about 80° C., to accelerate relaxation of the membrane; mounting the membrane to a peripheral support structure whilst maintaining the tension in the membrane; assembling the mounted membrane with one or more other components to form an enclosure with the membrane forming one wall of the enclosure; and thereafter filling the enclosure with a fluid. The membrane may be formed from an aromatic polyurethane, and the fluid may be a phenylated siloxane. In some embodiments, the membrane is able to hold a substantially constant surface tension of at least 180 N/m for a period of at least 12 months.

Abstract: Described herein are devices, systems, and methods to aid in the manipulation of cells. The devices, methods, and systems disclosed herein can be applied towards, for example, automation of the in vitro fertilization process.

Abstract: Described herein are devices, systems, and methods to facilitate cryopreservation of a cell or a mass of a plurality of cells such as oocytes or embryos. A device of the disclosure can, for example, store oocytes or embryos during the vitrification and/or warming processes of in vitro fertilization.

Abstract: Described herein are devices, systems, and methods to facilitate cryopreservation of a cell or a mass of a plurality of cells such as oocytes or embryos. A device of the disclosure can, for example, store oocytes or embryos during the vitrification and/or warming processes of in vitro fertilization.

Abstract: A method of assembling an adjustable fluid-filled lens assembly comprising biaxially tensioning an elastomeric membrane to a surface tension of greater than 180 N/m, typically greater than 1000 N/m; thermally conditioning the tensioned membrane, e.g., for one hour at a temperature of about 80° C., to accelerate relaxation of the membrane; mounting the membrane to a peripheral support structure whilst maintaining the tension in the membrane; assembling the mounted membrane with one or more other components to form an enclosure with the membrane forming one wall of the enclosure; and thereafter filling the enclosure with a fluid. The membrane may be formed from an aromatic polyurethane, and the fluid may be a phenylated siloxane. In some embodiments, the membrane is able to hold a substantially constant surface tension of at least 180 N/m for a period of at least 12 months.

Abstract: A method of assembling an adjustable fluid-filled lens assembly comprising biaxially tensioning an elastomeric membrane to a surface tension of greater than 180 N/m, typically greater than 1000 N/m; thermally conditioning the tensioned membrane, e.g., for one hour at a temperature of about 80° C., to accelerate relaxation of the membrane; mounting the membrane to a peripheral support structure whilst maintaining the tension in the membrane; assembling the mounted membrane with one or more other components to form an enclosure with the membrane forming one wall of the enclosure; and thereafter filling the enclosure with a fluid. The membrane may be formed from an aromatic polyurethane, and the fluid may be a phenylated siloxane. In some embodiments, the membrane is able to hold a substantially constant surface tension of at least 180 N/m for a period of at least 12 months.

Abstract: A deformable membrane assembly comprises an at least partially flexible fluid-filled envelope, one wall of which is formed by an elastic membrane that is held around its edge by a resiliently bendable supporting ring, a fixed support for the envelope and selectively operable means for causing relative movement between the supporting ring and the support for adjusting the pressure of the fluid in the envelope, thereby to cause the membrane to deform. The bending stiffness of the ring varies round the ring such that upon deformation of the membrane the ring bends variably to control the shape of the membrane to a predefined form. The moving means comprise a plurality of ring-engaging members that are arranged to apply a force to the ring at spaced control points.

Abstract: Described herein are devices, systems, and methods to facilitate cryopreservation of a cell or a mass of a plurality of cells such as oocytes or embryos. A device of the disclosure can, for example, store oocytes or embryos during the vitrification and/or warming processes of in vitro fertilization.

Abstract: Described herein are devices, systems, and methods to aid in the manipulation of cells. The devices, methods, and systems disclosed herein can be applied towards, for example, automation of the in vitro fertilization process.

Abstract: A deformable membrane assembly comprises an at least partially flexible fluid-filled envelope, one wall of which is formed by an elastic membrane that is held around its edge by a resiliently bendable supporting ring, a fixed support for the envelope and selectively operable means for causing relative movement between the supporting ring and the support for adjusting the pressure of the fluid in the envelope, thereby to cause the membrane to deform. The bending stiffness of the ring varies round the ring such that upon deformation of the membrane the ring bends variably to control the shape of the membrane to a predefined form. The moving means comprise a plurality of ring-engaging members that are arranged to apply a force to the ring at spaced control points.

Abstract: An compression therapy device which improves on available products by combining the efficacy of bulky, active pneumatic devices with a convenience approaching that of a passive non-pneumatic device. This is achieved by using an air cell (6) with a flexible inner and a rigid outer wall (10) which enables therapeutic pressures to be achieved at lower overall inflation volume. This in turn allows miniature low power, silent pump (3) to be used enabling the device to be worn unobtrusively under clothing. Such a device is targeted at users with long term chronic venous conditions, variants of oedema, recovering from surgery, requiring travel comfort, improved leg circulation or accelerated recovery from exercise or injury.

Abstract: A method of assembling an adjustable fluid-filled lens assembly comprising biaxially tensioning an elastomeric membrane to a surface tension of greater than 180 N/m, typically greater than 1000 N/m; thermally conditioning the tensioned membrane, e.g., for one hour at a temperature of about 80° C., to accelerate relaxation of the membrane; mounting the membrane to a peripheral support structure whilst maintaining the tension in the membrane; assembling the mounted membrane with one or more other components to form an enclosure with the membrane forming one wall of the enclosure; and thereafter filling the enclosure with a fluid. The membrane may be formed from an aromatic polyurethane, and the fluid may be a phenylated siloxane. In some embodiments, the membrane is able to hold a substantially constant surface tension of at least 180 N/m for a period of at least 12 months.

Abstract: A deformable membrane assembly comprises an at least partially flexible fluid-filled envelope, one wall of which is formed by an elastic membrane that is held around its edge by a resiliently bendable supporting ring, a fixed support for the envelope and selectively operable means for causing relative movement between the supporting ring and the support for adjusting the pressure of the fluid in the envelope, thereby to cause the membrane to deform. The bending stiffness of the ring varies round the ring such that upon deformation of the membrane the ring bends variably to control the shape of the membrane to a predefined form. The moving means comprise a plurality of ring-engaging members that we arranged to apply a force to the ring at spaced control points.

Abstract: The present invention provides a deformable membrane assembly 1 comprising an elastic membrane 8 that is held under tension around its edge by a bendable membrane supporting member 2,10, a body of fluid in contact with one face of the membrane, the pressure of the fluid being controllable for adjusting the shape of the membrane, and one or more bending controllers 24 acting on the supporting member 2, 10 to control the bending of the supporting member in response to loading through tension in the membrane. The bending stiffness of the membrane-supporting member 2, 10 varies round its extent to control the profile of the edge of the membrane 8; etc. upon actuation. A variety of different types of bending controllers are disclosed which permit out-of-plane bending of the supporting member 2, 10 but prevent or control in-plane bending or deformation of the supporting member.

Abstract: A deformable membrane assembly comprises an at least partially flexible fluid-filled envelope, one wall of which is formed by an elastic membrane that is held around its edge by a resiliently bendable supporting ring, a fixed support for the envelope and selectively operable means for causing relative movement between the supporting ring and the support for adjusting the pressure of the fluid in the envelope, thereby to cause the membrane to deform. The bending stiffness of the ring varies round the ring such that upon deformation of the membrane the ring bends variably to control the shape of the membrane to a predefined form. The moving means comprise a plurality of ring-engaging members that are arranged to apply a force to the ring at spaced control points.

Abstract: A deformable membrane assembly comprises an at least partially flexible fluid-filled envelope, one wall of which is formed by an elastic membrane that is held around its edge by a resiliently bendable supporting ring, a fixed support for the envelope and selectively operable means for causing relative movement between the supporting ring and the support for adjusting the pressure of the fluid in the envelope, thereby to cause the membrane to deform. The bending stiffness of the ring varies round the ring such that upon deformation of the membrane the ring bends variably to control the shape of the membrane to a predefined form. The moving means comprise a plurality of ring-engaging members that are arranged to apply a force to the ring at spaced control points.

Abstract: A deformable membrane assembly comprising a fluid-filled envelope, one wall of which is formed by an elastic membrane that is held around its edge by a bendable supporting ring, a support for the envelope and at least three ring-engaging members that are arranged to apply a force to the ring at spaced control points for adjusting the shape of the membrane, with the ring bending to control the shape of the membrane to a predefined form. A control point is provided at or proximate each point on the ring where the profile of the ring that is needed to produce the predefined form of the membrane exhibits a turning point in the direction of the force applied at the control point between two adjacent points where the profile of the ring exhibits an inflection point or a turning point in the opposite direction.

Abstract: A centrifugal compressor that includes an impeller, a diffuser and a shroud. One of the diffuser and shroud includes a plurality of recesses and the other of the diffuser and shroud includes a plurality of radial vanes. The shroud covers the impeller and diffuser such that each radial vane projects into a respective recess.

Abstract: A deformable membrane assembly comprises an at least partially flexible fluid-filled envelope, one wall of which is formed by an elastic membrane that is held around its edge by a resiliently bendable supporting ring, a fixed support for the envelope and selectively operable means for causing relative movement between the supporting ring and the support for adjusting the pressure of the fluid in the envelope, thereby to cause the membrane to deform. The bending stiffness of the ring varies round the ring such that upon deformation of the membrane the ring bends variably to control the shape of the membrane to a predefined form. The moving means comprise a plurality of ring-engaging members that are arranged to apply a force to the ring at spaced control points.