Abstract: Use of a polymer as a secondary suspending agent in a suspension polymerisation reaction is provided. The polymer comprising (i) residues of at least one ester-containing monomer, the ester-containing monomer (s) comprising one polymerisable carbon-carbon double bond per monomer and an ester group, and (ii) residues of at least one monomer comprising a sulfonate, sulfonic acid, sulfonic ester, sulfonamide or sulfonyl halide group the monomer (s) comprising a sulfonate, sulfonic acid, sulfonic ester group, sulfonamide or sulfonyl halide group comprising one polymerisable carbon-carbon double bond per monomer and a sulfonate, sulfonic acid, sulfonic ester, sulfonamide or sulfonyl halide group, the polymer optionally being partially hydrolysed such that a proportion of said ester groups form alcohol groups, the degree of hydrolysis of the polymer being from 0 to 30 mol %.

Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual to treatment of cardiovascular disorders with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

Abstract: A tractor cart system for attaching to a vehicle with a three point hitch is disclosed. The tractor cart system has a body having a bed, a three point hitch positioned substantially on the front of the body for engaging a three point hitch of the vehicle, and a rear connector positioned substantially on the rear of the body configured to engage one of a plurality of tractor attachments.

Abstract: An insertion tool for a heart valve includes a solid body portion in a first configuration having a first size and shape. The solid body portion in a second configuration having a second size smaller than the first size; said solid body portion comprises two or more parts; in the first configuration, the solid body portion provides a support portion for supporting a valve to be inserted by the insertion tool, and an insertion surface which protrudes distally from the support portion; the insertion surface is tapered from a small cross-section distally of the support portion to a greater cross section proximally to the support portion; in use the insertion surface elastically expands the periphery of an annulus into which the valve is to be fitted.

Abstract: A prosthetic valve in the form of a flap valve which includes one or more flaps arranged to allow movement of liquid through the valve only in one direction, in which the or each flap is made of a flexible open work structure of a medically acceptable metal such as titanium or a titanium alloy.

Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual to treatment of cardiovascular disorders with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

Abstract: A method and system for covert communication is provided by using a hybrid approach of pseudo-random noise (PN) sequencing with chaotic signals to make a transmitted waveform both hard to detect and hard to intercept by an unintended receiver. The method and system makes a covert communication system with chaotic signals practical for in-field use, including operation in a high noise power environment and allowing for easily changing between different security keys to maintain covertness.

Abstract: Disclosed is a method of regulating fluid flow for a targeted lung region. The method comprises injecting a therapeutic agent into the targeted lung region. The therapeutic agent induces a reaction in lung tissue of the targeted lung region or in a collateral pathway to the lung region to reduce collateral fluid flow into the targeted lung region. In one aspect, the method additionally comprises deploying a bronchial isolation device in the direct pathway to regulate fluid flow to the targeted lung region through the direct pathway. The therapeutic agent can comprise, for example, a sclerosing agent that induces a reaction that causes sclerosis in the lung tissue.

Abstract: Biomarkers that are useful for identifying a mammal that will respond therapeutically or is responding therapeutically to a method of treating cancer that comprises administering a microtubule-stabilizing agent. In one aspect, the cancer is breast cancer, and the microtubule-stabilizing agent is an epothilone or analog or derivative thereof, or ixabepilone.

Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual to treatment of cardiovascular disorders with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

Abstract: Disclosed are various disease indications and treatment methods that benefit from selective lung region isolation. A lung region is bronchially isolated by regulating the flow of fluid to and from the lung region, such as by implanting one or more bronchial isolation devices into one or more bronchial passageways that feed air to the lung region. The bronchial isolation devices can comprise, for example, one-way valves, two-way valves, occluders or blockers, ligating clips, glues, sealants, and sclerosing agents.

Abstract: A device and method are provided for protecting the inside of a microwave oven from food splattering during cooking. The device is made of breathable food grade paper, is a truncated cone in shape with a pleated side wall for rigidity and at least one reinforcing structure on a top surface. Top surface reinforcement may be one or more folded paper reinforcement bars or folded paper reinforcement members, shaped as circles, squares, or any other convenient shape. Reinforcement bars may be radial across the top surface or nonradial, and may be linear or curvilinear. The food shield device is made by conventional paper die stamping methods.

Abstract: The present invention describes polynucleotides that have been discovered to correlate to the relative sensitivity or resistance of cells, e.g., breast cell lines, to treatment with compounds that interact with and modulate, e.g., inhibit, protein tyrosine kinases, such as, for example, members of the Src family of tyrosine kinases, e.g., Src, Fgr, Fyn, Yes, Blk, Hck, Lck and Lyn, as well as other protein tyrosine kinases, including, Bcr-abl, Jak, PDGFR, c-kit and Eph receptors. These polynucleotides have been shown to have utility in predicting the resistance and sensitivity of breast cell lines to the compounds. Such polynucleotides comprise polynucleotide predictor or marker sets useful in methods of predicting drug response, and as prognostic or diagnostic indicators in disease management, particularly in those disease areas, e.g., breast cancer, in which signaling through one or more of the aforementioned Src tyrosine and protein tyrosine kinases is involved with the disease process.

Abstract: The present invention describes polynucleotides that have been discovered to correlate to the relative sensitivity or resistance of cells, e.g., breast cell lines, to treatment with compounds that interact with and modulate, e.g., inhibit, protein tyrosine kinases, such as, for example, members of the Src family of tyrosine kinases, e.g., Src, Fgr, Fyn, Yes, Blk, Hck, Lck and Lyn, as well as other protein tyrosine kinases, including, Bcr-abl, Jak, PDGFR, c-kit and Eph receptors. These polynucleotides have been shown to have utility in predicting the resistance and sensitivity of breast cell lines to the compounds. Such polynucleotides comprise polynucleotide predictor or marker sets useful in methods of predicting drug response, and as prognostic or diagnostic indicators in disease management, particularly in those disease areas, e.g., breast cancer, in which signaling through one or more of the aforementioned Src tyrosine and protein tyrosine kinases is involved with the disease process.

Abstract: Biomarkers that are useful for identifying a mammal that will respond therapeutically or is responding therapeutically to a method of treating cancer that comprises administering a microtubule-stabilizing agent. In one aspect, the cancer is breast cancer, and the microtubule-stabilizing agent is an epothilone or analog or derivative thereof, or ixabepilone.

Abstract: A lift drive comprising: a spiral drive element having an axis of rotation, a rack having teeth sized and shaped to be engaged by the spiral drive element, the rack having a longitudinal axis parallel to the axis of rotation, and a motor to rotate the spiral drive element, wherein upon the spiral drive element-rotating, one of the spiral drive element and the rack moves relative to the other along the longitudinal axis.

Abstract: A method for routing vias in a multilayer substrate is disclosed. One embodiment of a method may comprise providing a multilayer substrate with an internal bond surface having a plurality of internal bond pads and an external bond surface with a plurality of external bond pads. A plurality of power vias and ground vias may be routed from a first redistribution layer between the internal bond surface and the external bond surface to a second redistribution layer between the first redistribution layer and the external bond surface based on a via pattern. The via pattern may comprise routing a power via and a ground via adjacent one another spaced apart at a distance that is substantially equal to a minimum routing pitch associated with the multilayer substrate.

Abstract: A multilayer substrate having a bonding surface is disclosed. One embodiment of the substrate may comprise a bypass capacitor connection pad disposed on the bonding surface. The bypass capacitor connection pad may have a bypass capacitor power pad and a bypass capacitor ground pad. The substrate may also comprise a plurality of power vias routed from the bypass capacitor power pad to a first redistribution layer spaced apart from the bonding surface and a plurality of ground vias routed from the bypass capacitor ground pad to the first redistribution layer. The substrate may further comprise a plurality of power and ground vias routed from the first redistribution layer to a second redistribution layer according to a power and ground via pattern array, wherein the plurality of ground vias are jogged at the first redistribution layer to the plurality of power vias to form the power and ground via pattern array.

Abstract: The present invention describes polynucleotides and polypeptides that have been discovered to correlate to the relative intrinsic sensitivity or resistance of cells, e.g., colon cell lines, to treatment with compounds that interact with and inhibit src tyrosine kinases. These polynucleotides and polypeptides have been shown, through a weighted voting cross validation program, to have utility in predicting the intrinsic resistance and sensitivity of colon cell lines to these compounds. Such polynucleotides and polypeptides whose expression levels correlate highly with drug sensitivity or resistance comprise predictor or marker sets of polynucleotides and polypeptides that are useful in methods of predicting drug response and as prognostic or diagnostic indicators in disease management, particularly in those disease areas in which signaling through src tyrosine kinase of the src tyrosine kinase pathway is involved with the disease process.

Abstract: A lift drive comprising: a spiral drive element having an axis of rotation, a rack having teeth sized and shaped to be engaged by the spiral drive element, the rack having a longitudinal axis parallel to the axis of rotation, and a motor to rotate the spiral drive element, wherein upon the spiral drive element-rotating, one of the spiral drive element and the rack moves relative to the other along the longitudinal axis.