Abstract: In some examples, a medical aspiration system includes a vacuum source; a vacuum tube coupled to the vacuum source; a vent tube; and a device configured to convert a constant suction force from the vacuum source into a periodic suction force, the device including a housing configured to receive a portion of the vacuum tube and a portion of the vent tube; a first plunger; a second plunger; and a rotatable cam configured to cause the first plunger to periodically compress the vacuum tube and to cause the second plunger to periodically compress the vent tube.

Abstract: In some examples, a catheter includes an elongated body comprising proximal and distal portions. The distal portion of the elongated body comprises an inner liner that includes a proximal liner section and a distal liner section that include different materials, and an outer jacket positioned over the inner liner. The distal liner section has a first hardness and the proximal liner section has a second hardness, where the first hardness is less than the second hardness.

Abstract: In some examples, an aspiration catheter system includes an outer catheter and an inner catheter configured to be positioned within the outer catheter lumen, and an alignment element. The outer catheter defines an outer catheter lumen and an outer catheter distal opening. The inner catheter defines an inner catheter lumen, an inner catheter distal opening, and a plurality of sidewall openings proximal to the inner catheter distal opening. The alignment element is configured to indicate a predetermined position of the inner catheter relative to the outer catheter when the inner catheter is received within the outer catheter distal opening. When the inner catheter is at the predetermined position, at least one sidewall opening of the plurality of sidewall openings remains positioned within the outer catheter lumen and at least one other sidewall opening of the plurality of sidewall openings is positioned distal to the outer catheter distal opening.

Abstract: In some examples, a medical aspiration system includes a vacuum source; a vacuum tube coupled to the vacuum source; a vent tube; and a device configured to convert a constant suction force from the vacuum source into a periodic suction force, the device including a housing configured to receive a portion of the vacuum tube and a portion of the vent tube; a first plunger; a second plunger; and a rotatable cam configured to cause the first plunger to periodically compress the vacuum tube and to cause the second plunger to periodically compress the vent tube.

Abstract: In some examples, an aspiration system a catheter and a fluid flow sensor. The fluid flow sensor includes a fluid inlet, a fluid outlet, and a flow oscillator. The fluid inlet is configured to receive fluid from the catheter. The flow oscillator configured to oscillate flow of the fluid through the fluid flow sensor to generate flow-induced vibrations. The fluid outlet is configured to discharge the fluid.

Abstract: In some examples, a medical aspiration system is configured to control medical aspiration based on a cardiac cycle of a patient. For example, a medical aspiration system can comprise a suction source configured to apply a suction force to a catheter to remove fluid from the catheter, and control circuitry configured to control the suction force applied by the suction source to the catheter based on a cardiac cycle of a patient.

Abstract: In some examples, a catheter includes an elongated body comprising proximal and distal portions. The distal portion of the elongated body comprises an inner liner that includes a proximal liner section and a distal liner section that include different materials, and an outer jacket positioned over the inner liner. The distal liner section has a first hardness and the proximal liner section has a second hardness, where the first hardness is less than the second hardness.

Abstract: In some examples, a catheter includes an elongated body comprising proximal and distal portions. The distal portion of the elongated body comprises an inner liner that includes a proximal liner section and a distal liner section that include different materials, and an outer jacket positioned over the inner liner. The distal liner section has a first hardness and the proximal liner section has a second hardness, where the first hardness is less than the second hardness.

Abstract: In some examples, an aspiration catheter system includes an outer catheter and an inner catheter configured to be positioned within the outer catheter lumen, and an alignment element. The outer catheter defines an outer catheter lumen and an outer catheter distal opening. The inner catheter defines an inner catheter lumen, an inner catheter distal opening, and a plurality of sidewall openings proximal to the inner catheter distal opening. The alignment element is configured to indicate a predetermined position of the inner catheter relative to the outer catheter when the inner catheter is received within the outer catheter distal opening. When the inner catheter is at the predetermined position, at least one sidewall opening of the plurality of sidewall openings remains positioned within the outer catheter lumen and at least one other sidewall opening of the plurality of sidewall openings is positioned distal to the outer catheter distal opening.

Abstract: In some examples, an aspiration system a catheter and a fluid flow sensor. The fluid flow sensor includes a fluid inlet, a fluid outlet, and a flow oscillator. The fluid inlet is configured to receive fluid from the catheter. The flow oscillator configured to oscillate flow of the fluid through the fluid flow sensor to generate flow-induced vibrations. The fluid outlet is configured to discharge the fluid.

Abstract: A stent delivery system can include a core member, an introducer sheath, and a microcatheter. The core member can have a first section and a second section distal to the first section. The second section can have a bending stiffness per unit length that is less than a bending stiffness per unit length of the first section. The introducer sheath can have a lumen configured to receive the core member therethrough. The introducer sheath can have a length of at least about 80 cm. The microcatheter can have a lumen and a proximal end configured to interface with a distal end of the introducer sheath for delivering the core member into the microcatheter lumen.

Abstract: In some examples, an outer jacket of a catheter body comprises a first section that decreases in durometer along a length of the first section in a direction towards a distal end of the catheter body, and a second section more distal than the first section and including the distal end of the catheter body, the second section having a higher durometer than a distal portion of the first section. The second section of the outer jacket and the inner liner define a distal opening of the catheter body that is configured to resist geometric deformation when the distal end of the catheter body is engaged with a guidewire.

Abstract: In some examples, a catheter includes an elongated body comprising proximal and distal portions. The distal portion of the elongated body comprises an inner liner that includes a proximal liner section and a distal liner section that include different materials, and an outer jacket positioned over the inner liner. The distal liner section has a first hardness and the proximal liner section has a second hardness, where the first hardness is less than the second hardness.

Abstract: A stent delivery system can include a core member, an introducer sheath, and a microcatheter. The core member can have a first section and a second section distal to the first section. The second section can have a bending stiffness per unit length that is less than a bending stiffness per unit length of the first section. The introducer sheath can have a lumen configured to receive the core member therethrough. The introducer sheath can have a length of at least about 80 cm. The microcatheter can have a lumen and a proximal end configured to interface with a distal end of the introducer sheath for delivering the core member into the microcatheter lumen.

Abstract: A stent delivery system can include a core member and a stent. The stent can be carried by an intermediate portion of the core member. The core member can have an elongate, spiral-cut tube extending proximally of the intermediate portion. The core member can have one or more flex zones having different bending stiffnesses.

Abstract: An intravascular intervention system can include a manipulation member sized for insertion into a blood vessel and an intervention member coupled to the manipulation member. The manipulation member can include a longitudinally extending tube having a helical cut extending along the tube. The helical cut can have an axial length of at least 50 cm and be continuous along the axial length. The intervention member can be compressible to a collapsed configuration for delivery to an endovascular treatment site through a catheter and be self-expandable from the collapsed configuration to an expanded configuration.

Abstract: A stent delivery system can include an elongate core member sized for insertion into a blood vessel. The core member can be configured to advance a stent toward a treatment location in the blood vessel. The core member can include a longitudinally extending tube having a helical cut extending along the tube. The helical cut can have an axial length of at least 50 cm and be continuous along the axial length.

Abstract: In some examples, an outer jacket of a catheter body comprises a first section that decreases in durometer along a length of the first section in a direction towards a distal end of the catheter body, and a second section more distal than the first section and including the distal end of the catheter body, the second section having a higher durometer than a distal portion of the first section. The second section of the outer jacket and the inner liner define a distal opening of the catheter body that is configured to resist geometric deformation when the distal end of the catheter body is engaged with a guidewire.

Abstract: A stent delivery system can include an elongate core member sized for insertion into a blood vessel. The core member can be configured to advance a stent toward a treatment location in the blood vessel. The core member can include a longitudinally extending tube having a helical cut extending along the tube. The helical cut can have an axial length of at least 50 cm and be continuous along the axial length.

Abstract: An intravascular intervention system can include a manipulation member sized for insertion into a blood vessel and an intervention member coupled to the manipulation member. The manipulation member can include a longitudinally extending tube having a helical cut extending along the tube. The helical cut can have an axial length of at least 50 cm and be continuous along the axial length. The intervention member can be compressible to a collapsed configuration for delivery to an endovascular treatment site through a catheter and be self-expandable from the collapsed configuration to an expanded configuration.