Abstract: Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X=NRX then n is 1 or 2 and if X=CRXRY then n is 1; RX is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RY is selected from H, hydroxy, amino; or RX and RY may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are both hydrogen, or when X is CRXRY, RC1, RC2, RX and RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R1 is selected from H and halo.

Abstract: The invention relates to compounds in the treatment or prevention of disorders associated with Lamin A and/or Lamin C depletion or LMNA mutations, such as laminopathy, premature ageing disorders, normal ageing and cancer (such as a cancer characterised by low levels of LMNA expression).

Abstract: Embodiments of the present invention are directed to systems for performing non-contact based determination of the position of an implement. In one embodiment, a non-contact based measurement system is used to determine the relative position of an implement coupled with a mobile machine. The geographic position of the mobile machine is determined and the geographic position of said implement based upon the geographic position of the mobile machine and the position of the implement relative to the mobile machine.

Abstract: The present disclosure includes a method for altering one or more properties of a primary material. The method includes reducing the elasticity of a primary material and creating a delivery aperture through an outer layer of the primary material. Once the delivery aperture is created, or as the delivery aperture is created, introducing through the delivery aperture a secondary material into a sublayer of the primary material and applying a closure treatment to the primary material to close the delivery aperture. The secondary material includes one or more properties that are different from the primary material. By introducing the secondary material into the primary material, the secondary material locally changes the properties of the primary material. Examples of the variable properties include color, strength, flexibility, magnetism, and optical.

Abstract: Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X?NRX then n is 1 or 2 and if X?CRXRY then n is 1; RX is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RY is selected from H, hydroxy, amino; or RX and RY may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1and RC2 are both hydrogen, or when X is CRXRY, RC1, RC2, RX and RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R1 is selected from H and halo.

Abstract: A biomimetic skin for an animatronic figure and other applications is provided. The biomimetic skin may include an outer layer having a surface texture, and an inner layer attached to the outer layer. The inner layer may include a compressible cellular material. The outer layer may move correspondingly with the inner layer such that as the inner layer is moved the outer layer moves.

Abstract: An input device (10) comprises a panning mechanism (12). The panning mechanism comprises a sensor arrangement having first and second sensor components (46, 48), a movable carrier arrangement (40) for carrying the first sensor component and a fixed carrier arrangement (42) on which the second sensor component is mounted. The movable carrier arrangement is movable relative to the fixed carrier arrangement. The panning mechanism further includes constraining means (50) to constrain movement of the movable carrier arrangement relative to the fixed carrier arrangement in two directions. The movement of the movable carrier arrangement relative to the fixed carrier arrangement effects movement of the first sensor component relative to the second sensor component to create input signals such as input signals for a data processing apparatus.

Abstract: Embodiments of the present invention are directed to systems for performing non-contact based determination of the position of an implement. In one embodiment, a non-contact based measurement system is used to determine the relative position of an implement coupled with a mobile machine. The geographic position of the mobile machine is determined and the geographic position of said implement based upon the geographic position of the mobile machine and the position of the implement relative to the mobile machine.

Abstract: Embodiments of the present invention are directed to a method for performing non-contact based determination of the position of an implement. In one embodiment, the method includes using a non-contact based measurement system to determine a first measurement comprising the position of the implement relative to a mobile machine coupled with the implement, determining a second measurement comprising the geographic position of the mobile machine and determining the geographic position of the implement using the first measurement and the second measurement.

Abstract: A movable robotic structure including a frame or substrate, an outer skin connected to at least a portion of the frame and a vacuum source in fluid communication with the outer skin. The vacuum source, such as a vacuum pump, is activated to pull the outer skin into engagement with an outer surface of the frame. When pulled by the vacuum source, the skin may conform to the topography or texture of the frame, as well as become taut over at least a portion of the frame.

Abstract: Embodiments of the present invention are directed to systems for performing non-contact based determination of the position of an implement. In one embodiment, a non-contact based measurement system is used to determine the relative position of an implement coupled with a mobile machine. The geographic position of the mobile machine is determined and the geographic position of said implement based upon the geographic position of the mobile machine and the position of the implement relative to the mobile machine.

Abstract: Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X?NRX then n is 1 or 2 and if X?CRXRY then n is 1; RX is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RY is selected from H, hydroxy, amino; or RX and RY may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are both hydrogen, or when X is CRXRY, RC1, RC2, RX and RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R1 is selected from H and halo.

Abstract: Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X?NRX then n is 1 or 2 and if X?CRXRY then n is 1; RX is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RY is selected from H, hydroxy, amino; or RX and RY may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are both hydrogen, or when X is CRXRY, RC1, RC2, RX and RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R1 is selected from H and halo.

Abstract: A pressure cuff or garment for prophylactic treatment of deep vein thrombosis includes a series of three chambers arranged in series and coupled fluidically to one another by bleed tubes or chokes. The chambers are otherwise sealed to the environment, save for the first chamber which also provides an inlet/outlet for coupling to a fluid pump. The chambers are also of curved shape so as to overlap one another. The cuff or garment provides more effective pulsating pressure treatment than prior art structures.

Abstract: A method and system for auto recognition of at least one standoff target to determine position information for a mobile machine. One example automatically scans for at least one standoff target. A location for the at least one standoff target is determined. In addition, a distance and direction between the mobile machine and the at least one standoff target is generated. The location information for the at least one standoff target and the distance and direction between the mobile machine and the at least one standoff target is utilized to provide a position for the mobile machine.

Abstract: Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X?NRX then n is 1 or 2 and if X?CRXRY then n is 1; RX is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RY is selected from H, hydroxy, amino; or RX and RY may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are both hydrogen, or when X is CRXRY, RC1, RC2, RX and RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R1 is selected from H and halo.

Abstract: Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X?NRX then n is 1 or 2 and if X?CRXRY then n is 1; RX is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RY is selected from H, hydroxy, amino; or RX and RY may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are both hydrogen, or when X is CRXRY, RC1, RC2, RX and RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R1 is selected from H and halo.

Abstract: The invention relates to bicyclic heterocycles of formulae I and II with anti-cancer and/or anti-inflammatory activity and more specifically with MEK kinase inhibitory activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth, treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

Abstract: A movable robotic structure including a frame or substrate, an outer skin connected to at least a portion of the frame and a vacuum source in fluid communication with the outer skin. The vacuum source, such as a vacuum pump, is activated to pull the outer skin into engagement with an outer surface of the frame. When pulled by the vacuum source, the skin may conform to the topography or texture of the frame, as well as become taut over at least a portion of the frame.

Abstract: An input device for tracking three-dimensional movements. The input device includes a tracking structure and is in electronic communication with a computing device. The tracking structure is detectable by a tracking device. The tracking structure is configured so that as the input device is deformed, the tracking structure deforms correspondingly.