Abstract: The invention relates to genes and proteins of the THAP (THanatos (death)-Associated Protein) family comprising a THAP domain, and their use in diagnostics, treatment of disease, and in the identification of molecules for the treatment of disease. The invention also relates to the Par4 protein and SLC chemokine pathways, including the interaction of Par4 and SLC with THAP family proteins, and the recruitment and localization of Par4 to PML nuclear bodies.

Abstract: Benzo[f]naphthyridine derivatives of formula (I): benzo[f]naphthyridine derivatives and benzo[f]naphthyridine esters of formula (IVa): aminoquinoline derivatives of formula (X): processes for preparing such compounds; and compositions comprising them.

Abstract: The invention concerns a method for making food products with open-cell internal texture by baking in an oven a paste conventionally kneaded such as, dough for bread, pizza or the like. The invention is characterized in that it consists at least in preparing said dough without kneading to obtain a viscous paste with low consistency; pressurising it followed by sudden depressurisation through a nozzle adapted to generate a foam which can then be baked in the oven. The invention also concerns a device for implementing said method comprising hoppers (1) and vats (2), a mixer (3), a swelling machine (4) which pressurises the paste before depressurising it through a nozzle (5) and a tunnel oven (8). The invention is useful for making gluten-free bread.

Abstract: The present invention is directed to the SUT-2 and SUT-3 sulfate/anion exchanger polypeptides expressed in high endothelial venules endothelial cells (HEVECs). The invention also relates to drug screening assays for identifying compounds capable of inhibiting sulfate/anion transport and L-selectin mediated lymphocyte adhesion to high endothelial venules. Such compounds may be useful in the treatment of inflammatory conditions.

Abstract: Novel 1,8-benzo-naphthyridine derivatives of general formula (I): which are useful as antimicrobial agents.

Abstract: Benzo[f]naphthyridine derivatives of formula (I): 1

Abstract: An off chip driver circuit is adapted to output differential output signals at high speed rate and capable to drive high external loads without degradation of the output signals. Specifically the driver comprises a first differential pair of transistors having first differential input terminals to respectively receive differential input signals and having first differential output terminals to output the differential output signals. A first current source circuit is connected to a first common terminal of each transistor of the first differential pair of transistors. The current source is sized to provide a first current flow upon receiving the differential input signals. The driver further comprises at least a second differential pair of transistors having second differential output terminals connected in parallel to the first differential output terminals.

Abstract: Novel 1,8-benzo-naphthyridine derivatives of general formula (I): 1

Abstract: This invention relates to a process for monitoring the flow rate of oil that is injected into a two-stroke internal combustion engine where the oil is injected independently of the gasoline. According to the invention, the oil flow rate is based on a temperature that represents the heat load of the engine. More specifically, this temperature can be that of an element that constitutes the engine, such as that of the spark plug gasket.

Abstract: Disclosed is a delay interpolator (DI) circuit (or mixer) that can be driven by digital signals. This DI circuit may be incorporated in the loop of a delay interpolator voltage controlled oscillator (DIVCO) circuit. In turn, the digital DIVCO circuit may be inserted in the loop of a phase-locked loop (PLL) circuit for total digitalization thereof. The novel digital delay interpolator circuit (23) has the base structure of the conventional analog delay interpolator circuit except in that, at the first (bottom) level, the two standard NFET input devices which are normally controlled by an analog signal (typically generated by a preceding DAC) are respectively replaced by two arrays (24A, 24B) of smaller NFET devices connected in parallel. The gate of each NFET device of the first array is driven by a bit (c0, c1, . . . ) of the true phase of the digital signal. The gate of each NFET device of the second array is driven by a bit (c0, c1, . . . ) of the complementary phase of the digital signal.

Abstract: A device for protecting a vehicle or structure against attack by a shaped-charge munition includes at least one deployable bag fastened on an external wall of the vehicle or structure. The bag is inflated by a generator in response to the detection of an attack. As a result, the invention provides an effective protection against attack by shaped-charge munitions whatever the angle of incidence of these charges.

Abstract: A cache memory architecture having a separate redundant read bus fully dedicated to redundancy and fed by a single spare sub-array common to all memory sub-arrays of the cache memory. Redundant sense amplifiers are dotted to the redundant read bus, and normal sense amplifiers are connected to a main read bus. Normal and redundant data are valid and available at the same time at the outputs of the normal and redundant sense amplifiers. When the late select address signals become valid, then the correct information can be selected via a multiplexer provided with an INHIBIT input. The multiplexer is normally controlled by decoded signals generated by a decoder, unless redundancy is required. If redundancy is required, the information generated by the bit address comparator forces the multiplexer, via the INHIBIT input, to select the redundant read bus, instead of one read bus of the main read bus, and to output the redundant byte as the selected one.

Abstract: This invention relates to a novel 1,8 benzo[b]naphythyridine derivative of general formula (I), ##STR1## wherein R is H or a hydroxy, amino or alkylamino radical optionally substituted by amino or hydroxy, or R is dialkylamino of which the alkyl portions may form, with the nitrogen atom, a 5- or 6-membered heterocyclic ring which optionally contains a further heteroatom chosen from nitrogen, oxygen or sulphur, or R is C.sub.3-6 cycloalkylamino or an alkanylamino, N-alkyl N-alkanylamino or aminoalkylphenylamino radical; R.sub.1 and R.sub.2, which are the same or different, are in positions 2 and 3 and represent H, alkyl, C.sub.2-4 alkenyl, phenyl, or substituted phenyl, or R.sub.1 and R.sub.2 are in position 2 and represent alkyl; R.sub.3 is H or alkyl, fluoroalkyl, carboxyalkyl, C.sub.3-6 cycloalkyl, fluorophenyl, difluorophenyl, alkyloxy or alkylamino; and R.sub.4 is H or F, wherein the C.sub.

Abstract: A low power TTL/CMOS receiver circuit consists of four stages, each of which is, respectively, comprised of at least two complementary FET devices connected to each other in series. The various stages control each other by a variety of feedback interconnections. The use of feedback loops permits to significantly decrease the DC current in the input stage of the receiver circuit. It also realizes a substantial decrease in AC current consumption, although less significantly. Finally, delay variations between input and output signals are obtained as well as substantial improvements in the symmetry between the true and complement output signals of the receiver circuit.

Abstract: Plastic sheets of good optical quality suitable for use in the glazings of automotive vehicles, eye glasses etc., are made by depositing a hardenable liquid mass upon a taut moving ribbon of plastic which has been pretreated by tensioning and heating to remove wrinkles and creases which otherwise would render optically unsatisfactory the sheet formed on the ribbon upon hardening of the liquid mass. The temperature range within which the pretreatment should be conducted is 60.degree.-100.degree. C., with 70.degree.-90.degree. C. being preferred; the tension applied in the pretreatment should be a dekanewton or more per square millimeter, preferably 1.5-7.5 dekanewtons per mm.sup.2 ; and the time of pretreatment is at least a minute and preferably 5 or more minutes.

Abstract: A plurality of local address transition detector (LATD) circuits, one per address bit signal (Ai), of the type used in SRAMs to generate an on-chip clock pulse (LATDSi) that insures a correct timing of internal circuits such as sense amplifiers and address decoders that are essential for a correct READ/WRITE operation of the SRAM. According to one aspect of the invention, each LATD circuit includes: a first bipolar transistor (T1) serially connected with a first FET device (N1) forming a first branch; a second bipolar transistor (T2) serially connected with a second FET device (N2) forming a second branch. The first and second branches are connected in parallel between a first supply voltage (Vcc) and a common output node (N) connected to a circuit output terminal (30-i) where the output signal (LATDSi) generated by the LATD circuit (22-i) is available.

Abstract: Input ECL level signals are received and converted into output CMOS level signals by input buffer (30). The input buffer (30) biased between first and second supply voltage (Vcc, Vee) and is comprised of three stages. The first stage (11A) consists of a conventional emitter-follower transistor (Q1) and a current-switch (13) connected in series. The input signal VIN at the ECL level is applied to the base of the emitter-follower transistor (Q1). The output signals (VA, VB) obtained therefrom drive a second stage which consists of an input buffer circuit (20), which supplies two pairs of output signals (V1) V2; V1', V2') for each phase. Each pair of output signals drives an output driver (31; 31') forming the third stage. The input buffer circuit (20) is composed of two NPN bipolar transistor (T1; T2) connected in an emitter-follower configuration forming two branches. In each branch, the emitter load consists of three FET devices: two PFETs (P1, P3; P2, P4 ) and one NFET (N1; N2) serially connected.

Abstract: New benzo[b][1,8]naphthyridine derivatives of general formula (I), in which R.sub.1 is a hydrogen atom or a hydroxyl or alkyl radical, R.sub.2 is a hydrogen atom or an alkyl, fluoroalkyl, cycloalkyl (3 to 6 C), alkyloxy or alkylamino radical, R.sub.3 is a phenyl or phenylalkyl radical substituted with one or more halogen atoms or alkyl, cycloalkyl (3 to 6 C), alkyloxy, cyano, amino, alkylamino, dialkylamino, alkyloxyalkyl, hydroxyalkyl, hydroxyalkyloxy, methylenedioxy, aminoalkyl, alkylaminoalkyl or dialkylaminoalkyl radicals, or R.sub.3 is a heterocyclic radical, and R.sub.4 is a hydrogen atom or a fluorine atom, the alkyl radicals (1 to 4 C) being linear or branched, their salts, their preparation and compositions containing them.These new products are useful as antimicrobials, or in the treatment of AIDS.

Abstract: New benzo[b][1,8]naphthyridine derivatives of general formula (I) in which R.sub.1 is a hydrogen atom or an alkyl or hydroxyalkyl radical, R.sub.2 is a hydrogen atom or an alkyl, fluoroalkyl, cycloalkyl (3 to 6 C), alkoxy or alkylamino radical and R.sub.3 is alkyl, R.sub.4 and R.sub.5 are different and are hydrogen or alkyl, or R.sub.3 is H, alkyl or cycloalkyl and R.sub.4 and R.sub.5 are hydrogen, R.sub.6 is hydrogen or fluorine and n is equal to 1 or 2, their salts, their preparation and the compositions which contain them.

Abstract: In the manufacture of a 2-ply sheet of the type which includes on one surface thereof a self-healing polymeric material and on the other surface an adhesive polymeric material capable of adhering at elevated temperatures to a glass or plastic surface, the improvement comprising forming said adhesive polymeric material from a blocked polyurethane or a water soluble or water dispersible polyurethane, and preferably from a polyurethane that has blocked NCO groups and is water soluble or water dispersible.