Abstract: Deployment of arrangements of computing components coupled over a communication fabric are presented herein. In one example, a method includes detecting first computing components communicatively coupled to a first communication fabric having a first communication fabric type, and detecting second computing components communicatively coupled to a second communication fabric having a second communication fabric type. The method also includes receiving user commands to form compute units among a pool of computing components comprising the first computing components and the second computing components. Based at least on the user commands, the method includes forming the compute units for use by one or more users.

Abstract: Deployment of arrangements of physical computing components coupled over a communication fabric are presented herein. In one example, a method includes detecting disaggregated computing components communicatively coupled to at least a first communication fabric, and detecting converged computing components communicatively coupled to a second communication fabric. The method includes forming a free pool of computing components comprising the disaggregated computing components and the converged computing components, and receiving user commands to form compute units from among computing components included in the free pool of computing components. Based at least on the user commands, the method includes forming the compute units for use by one or more users.

Abstract: Machine templates are described herein that provide for enhanced configuration and deployment of arrangements of physical computing components coupled over a communication fabric. In one example, a method includes presenting a user interface indicating a plurality of templates each specifying at least a predefined arrangement of physical computing components for inclusion in compute units, and receiving a user selection indicating a selected template among the plurality of templates to form a target compute unit. The method includes allocating to the target compute unit a set of physical computing components according to the selected template, and instructing a management entity to establish the target compute unit based at least on logical partitioning within a communication fabric communicatively coupling the set of physical computing components of the target compute unit.

Abstract: Filtration apparatus for the assay of biological and biochemical reactants, for example, is provided and includes a substrate such as a plate having one or more wells open at each end, and a porous membrane positioned in each well forming a discrete filtering area. The filtration apparatus includes a seal that is in a compressible relationship with the face of the porous membrane, the surface of the compression element, and the well wall. Each well includes a compression element, such as an internal well insert or sleeve, which compresses the seal so that the seal contacts the membrane face, the surface of the compression element, and the well wall in a liquid-tight manner. The compression element may be configured so that it is fixed in the well such as by an interference fit with the well wall or by bonding to a surface of the substrate.

Abstract: Systems, methods, apparatuses, and software for data storage systems are provided herein. In one example, a data storage apparatus includes a processor configured to assign service levels in a queue for handling storage operations directed to one or more data storage drives. The processor can pre-allocate resources in the queue for selected ones of the service levels before ones of the storage operations associated with the selected ones of the service levels are received by the processor. The processor receives the storage operations, and based at least on the service levels, services the storage operations from the queue with the one or more data storage drives.

Abstract: Disaggregated computing architectures, platforms, and systems are provided herein. In one example, a method of operating a data processing system is provided. The method includes instructing a PCIe fabric communicatively coupling a plurality of physical computing components including PCIe devices and one or more PCIe switches to establish a first PCIe communication path between the management processor and a target PCIe device. The method also includes directing at least configuration data to the target PCIe device using the first PCIe communication path and instructing the PCIe fabric to remove the first PCIe communication path between the management processor and the target PCIe device. The method also includes instructing the PCIe fabric to establish a second PCIe communication path between a selected PCIe device and the target PCIe device configured according to the configuration data.

Abstract: Fluid containment pressure vessel that eliminates the outer support housing present in certain conventional vessels, and provides an improved cap-to-body interface. In certain embodiments, the cap is threaded and configured to threadingly engage with the body of the pressure vessel, and has sufficient structural integrity to withstand the pressures in the device without the need for a support housing. In certain embodiments, an interlock mechanism is provided that prevents the cap from being opened (e.g., removed from the body) while the device is under pressure. In certain embodiments, a pressure relief valve is provided with a pre-loaded biasing mechanism to achieve the required pressure release rate. The vessel can be used for sample preparation, including purification or concentration of samples, particularly protein samples.

Abstract: Systems, methods, apparatuses, and architectures for storage interposers are provided herein. In one example, an apparatus includes a host connector configured to couple to one or more host systems over associated host Peripheral Component Interconnect Express (PCIe) interfaces, and PCIe switch circuitry configured to receive storage operations over the host connector that are issued by the one or more host systems. The PCIe switch circuitry is configured to monitor when ones of the storage operations correspond to an address range and responsively indicate the ones of the storage operations to a control module. The control module is configured to selectively direct delivery of the ones of the storage operations to corresponding storage areas among one or more storage devices based at least on addressing information monitored for the ones of the storage operations in the PCIe switch circuitry.

Abstract: Systems, methods, apparatuses, and architectures for storage interposers are provided herein. In one example, a storage interposer module includes Peripheral Component Interconnect Express (PCIe) switch circuitry receives storage operations over a host connector that are issued by one or more host systems and transfers the storage operations for storage by one or more storage devices over drive PCIe interfaces. The storage interposer module also includes a control module configured to monitor the storage operations in the PCIe switch circuitry via a control interface coupled between the PCIe switch circuitry and the interposer control module, and selectively direct delivery of each of the storage operations to corresponding storage areas among the one or more storage devices based at least on information monitored about the storage operations in the PCIe switch circuitry.

Abstract: Systems, methods, apparatuses, and software for data storage systems are provided herein. In one example, a data storage system is provided that includes processing systems configured to receive storage operations for storage drives coupled over a communication fabric. The data storage system includes a control processor configured to establish a timer synchronization signal and distribute the timer synchronization signal to the processing systems. Each of the processing systems is configured to assign timestamps to received storage operations based on a timestamp counter synchronized among the processing systems using the timer synchronization signal. The processing systems are configured to order committing of the storage operations to the storage drives based at least on the timestamps associated with the storage operations.

Abstract: Systems, methods, apparatuses, and software for data storage systems are provided herein. In one example, a data storage apparatus includes a processor configured to assign service levels in a queue for handling storage operations directed to one or more data storage drives. The processor can pre-allocate resources in the queue for selected ones of the service levels before ones of the storage operations associated with the selected ones of the service levels are received by the processor. The processor receives the storage operations, and based at least on the service levels, services the storage operations from the queue with the one or more data storage drives.

Abstract: Systems, methods, apparatuses, and software for data storage systems are provided herein. In one example, a data storage platform includes one or more data storage modules each comprising storage drives coupled over a Peripheral Component Interconnect Express (PCIe) fabric with at least one processing module that receives storage operations directed to the one or more data storage modules over one or more network interfaces. The processing module is configured to assign service levels in a queue to the storage operations that are received over the one or more network interfaces. Based at least on the service levels, the processing module is configured to service the storage operations from the queue with the one or more data storage modules over the PCIe fabric.

Abstract: Fluid containment pressure vessel that eliminates the outer support housing present in certain conventional vessels, and provides an improved cap-to-body interface. In certain embodiments, the cap is threaded and configured to threadingly engage with the body of the pressure vessel, and has sufficient structural integrity to withstand the pressures in the device without the need for a support housing. In certain embodiments, an interlock mechanism is provided that prevents the cap from being opened (e.g., removed from the body) while the device is under pressure. In certain embodiments, a pressure relief valve is provided with a pre-loaded biasing mechanism to achieve the required pressure release rate. The vessel can be used for sample preparation, including purification or concentration of samples, particularly protein samples.

Abstract: Fluid containment pressure vessel that eliminates the outer support housing present in certain conventional vessels, and provides an improved cap-to-body interface. In certain embodiments, the cap is threaded and configured to threadingly engage with the body of the pressure vessel, and has sufficient structural integrity to withstand the pressures in the device without the need for a support housing. In certain embodiments, an interlock mechanism is provided that prevents the cap from being opened (e.g., removed from the body) while the device is under pressure. In certain embodiments, a pressure relief valve is provided with a pre-loaded biasing mechanism to achieve the required pressure release rate. The vessel can be used for sample preparation, including purification or concentration of samples, particularly protein samples.

Abstract: Sample preparation device that allows for a complete bind, wash, elute, buffer-exchange and concentration process to be carried out without sample transfer between multiple devices. The device includes a reservoir, a column for holding chromatography media, a holder region for holding a filtration device, and an outlet. The filtration device plugs into the holder region of the centrifugal device, and the assembly can be placed in an optional holder. The assembly, with or without the optional holder, can be placed in a conventional centrifuge tube for centrifugation. The entire bind, wash, elute, buffer exchange and concentration steps can be carried out with the apparatus without any pipette transfers (and the associated sample losses. The sample preparation device also can be used for binding and washing steps, in which case the filtration device is not needed, and for buffer exchange and concentration steps, in which case the media is not needed.

Abstract: The embodiments disclosed herein are directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips and other such devices is preferred in doing so.

Abstract: Systems, methods, apparatuses, and architectures for storage interposers are provided herein. In one example, a storage interposer module includes Peripheral Component Interconnect Express (PCIe) switch circuitry receives storage operations over a host connector that are issued by one or more host systems and transfers the storage operations for storage by one or more storage devices over drive PCIe interfaces. The storage interposer module also includes a control module configured to monitor the storage operations in the PCIe switch circuitry via a control interface coupled between the PCIe switch circuitry and the interposer control module, and selectively direct delivery of each of the storage operations to corresponding storage areas among the one or more storage devices based at least on information monitored about the storage operations in the PCIe switch circuitry.

Abstract: The present invention is a cell cultivating vessel or device, such as a single or multitier flask, including a cover having a top plate, a side wall and a resealable port; an intermediate tray for receiving cells and cell culture media, having a bottom plate, a side wall, and a gap region formed between an interior upwardly angled lip located on an interior portion of the intermediate tray bottom plate and an adjacent outwardly angled side wall portion of the intermediate tray bottom plate, wherein the lip has a outwardly swooping curvilinear edge feature; and a base tray for receiving the cells and cell culture media, including a bottom plate and a side wall.

Abstract: The invention relates to a single use cell culture assembly for use in carrying out bioreactions and growing microorganisms, and tissue and cell cultures. The cell culture assembly is designed to receive an insert having a microscope slide upper surface, and includes a well frame having a plurality of partitioned well compartments, adapted to be positioned on the upper surface of the insert, and includes a liquid-impermeable releasable seal positioned on or within the lower edge of the well frame for maintaining a liquid-impermeable barrier between well compartments.