Abstract: The subject matter described herein is directed to Ferroportin inhibitor compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis. The compounds of Formula I and pharmaceutical salts thereof have the following structure: wherein R1, R2, R3, X1, X2, X3, X4, Y1, Y2, and Y3 are as described herein.

Abstract: A peripheral display apparatus that is wearable by a user. The peripheral display apparatus includes at least two light sources and at least one processor coupled to at least two light sources. The at least two light sources include a first light source and a second light source arranged at a first peripheral portion and a second peripheral portion of a field of view of user, respectively, first peripheral portion and second peripheral portion being positioned at opposite horizontal ends of field of view. The at least one processor or at least one external processor communicably coupled to at least one processor is configured to generate at least two images including a first image and a second image, wherein at least one processor is configured to display first image and second image simultaneously at first light source and second light source, respectively.

Abstract: An acoustic resonator includes a piezoelectric stack including a piezoelectric layer having a top surface and a bottom surface, a top electrode layer disposed above the top surface, and a bottom electrode layer disposed below the bottom surface. A number of acoustic wave reflectors are disposed on a side of the bottom electrode layer opposite the piezoelectric layer. Each acoustic wave reflector includes a high acoustic impedance layer and may include a low acoustic impedance layer. The acoustic resonator may include a tether that extends laterally to a stacking direction of the layers of the piezoelectric stack. A supporting structure may be coupled to the tether opposite the acoustic resonator for anchoring the acoustic resonator. A mirror, one or more phononic crystals, or both may be positioned on proximate the tether opposite the acoustic resonator to avoid resonant waves from exiting the acoustic resonator in use.

Abstract: The present invention provides engineered polypeptides that are useful for the asymmetric synthesis of ?-hydroxy-?-amino acids under industrial-relevant conditions. The present disclosure also provides polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing ?-hydroxy-?-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides of the present invention for the preparation of ?-hydroxy-?-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption. So, it has good industrial application prospects.

Abstract: A high-power electro-optic modulator (EOM) is formed to use specialized electrodes of a material selected to have a CTE that matches the CTE of the modulator's crystal. Providing CTE matching reduces the presence of stress-induced birefringence, which is known to cause unwanted modulation of the propagating optical signal. The specialized electrodes are preferably formed of a CuW metal matrix composite having a W/Cu ratio selected to create the matching CTE value. Advantageously, the CuW-based electrodes also exhibit a thermal conductivity about an order of magnitude greater than conventional electrode material (brass, Kovar) and thus provide additional thermal stability to the EOM's performance.

Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

Abstract: A bulk acoustic resonator operable in a bulk acoustic mode includes a resonator body mounted to a separate carrier that is not part of the resonator body. The resonator body includes a piezoelectric layer, a device layer, and a top conductive layer on the piezoelectric layer opposite the device layer. A surface of the device layer opposite the piezoelectric layer is for mounting the resonator body to the carrier.

Abstract: There is disclosed a method and system for controlling network timing precision of a seismic collector, and a terminal device. The method includes: using an interrupt mode to transmit a data packet; calculating an optimal network delay; and correcting a transmission error in a network timing process according to the optimal network delay, after which the physical layer of a server receives the data packet and sends the data from the physical layer of the server to the application layer of the server using the interrupt mode thereby timing the data packet.

Abstract: An acoustic resonator includes a piezoelectric stack including a piezoelectric layer having a top surface and a bottom surface, a top electrode layer disposed above the top surface, and a bottom electrode layer disposed below the bottom surface. A number of acoustic wave reflectors are disposed on a side of the bottom electrode layer opposite the piezoelectric layer. Each acoustic wave reflector includes a high acoustic impedance layer and may include a low acoustic impedance layer. The acoustic resonator may include a tether that extends laterally to a stacking direction of the layers of the piezoelectric stack. A supporting structure may be coupled to the tether opposite the acoustic resonator for anchoring the acoustic resonator. A mirror, one or more phononic crystals, or both may be positioned on proximate the tether opposite the acoustic resonator to avoid resonant waves from exiting the acoustic resonator in use.

Abstract: A network system dynamically determines a route, including start and end points, for vehicles in a transportation network. The transportation network receives a service request from a user of the transportation network including an origin location for the trip and a destination location for the trip. The transportation network then generates a waypoint plan for one or more vehicles, which includes the requested origin and destination in addition to any previously requested origins and destinations included in the vehicles current route. The network system then determines a directionality for each of the waypoints in the waypoint plan and retrieves candidate start and end points that have an associated directionality within a threshold angle of the directionality of each waypoint and are proximate to the waypoint. The network system evaluates each combination of retrieved candidate points to select a route for the vehicle.

Abstract: An immobilized chalcogen system or body includes an element of chalcogen, an electrically conductive material, and a hydrophilic membrane gate. The hydrophilic membrane gate may be used to isolate hydrophobic regions, one related to polychalcogenide ion(s) and another related to a hydrophobic electrolyte system. The hydrophilic membrane gate may prevent polychalcogenide from forming, and may provide control of undesirable parasitic mass transport and undesirable electron transport inside a chalcogen-based battery, and thereby allow the battery to cycle at a high specific capacity with a long cycling life. If desired, the immobilized chalcogen system or body may be employed in a cathode of a rechargeable battery.

Abstract: An embedded file network server based on a seismic data stream includes a broadband power management module, a main control unit, a serial-port-to-RS232 module, a PHY bridge layer, an SD card, and a network interface. The main control unit includes serial port, an SDIO interface, an internal RAM, DMA units, and a MAC drive layer. The main control unit performs seismic data interaction with an external device through the serial port, and receives seismic data through an internal interruption, and the received seismic data stream is stored in the internal RAM. The internal RAM transfers the received seismic data stream to the SDIO interface and MAC driver layer through the DMA units. The SDIO interface stores the seismic data stream in the SD card for data backup. The MAC driver layer is coupled to the PHY bridge layer for inputting and outputting the seismic data stream.

Abstract: A network system dynamically determines a route, including start and end points, for vehicles in a transportation network. The transportation network receives a service request from a user of the transportation network including an origin location for the trip and a destination location for the trip. The transportation network then generates a waypoint plan for one or more vehicles, which includes the requested origin and destination in addition to any previously requested origins and destinations included in the vehicles current route. The network system then determines a directionality for each of the waypoints in the waypoint plan and retrieves candidate start and end points that have an associated directionality within a threshold angle of the directionality of each waypoint and are proximate to the waypoint. The network system evaluates each combination of retrieved candidate points to select a route for the vehicle.

Abstract: The invention discloses a method and a system for calibrating a driving risk identification model. The calibration method comprises: S1. establishing a vehicle platform by installing an information acquisition device on a test vehicle; S2. acquiring synchronized test data related to the test vehicle and driving scenarios; S3. extracting moments when the drivers start to press the accelerator pedal, start to release the accelerator pedal, start to press the brake pedal in the driving scenarios, and start to release the brake pedal, so as to define risk level values respectively corresponding to the moments; S4. obtaining a risk identification curve of the drivers in different driving scenarios, wherein the risk identification curve represents the drivers' judgment of the risk level over time; S5. using the risk identification curve to calibrate the driving risk identification model.

Abstract: A wafer has a layer containing silicon, a layer of polycrystalline diamond deposited on the silicon-containing layer, and a bow-compensation layer on the other side of the silicon-containing layer for reducing wafer-bow. A method of making a bonded structure includes an activation process for creating dangling bonds on the surface of one substrate, followed by contact-bonding the surface to a second substrate at low temperature. A bonded structure may include two substrates contact bonded to each other, one substrate including a layer containing silicon, a layer of polycrystalline diamond, a bow-compensation layer for reducing wafer-bow of the first substrate, and the other substrate including gallium nitride, silicon carbide, lithium niobate, lithium tantalate, gallium arsenide, indium phosphide, or another suitable material other than diamond.

Abstract: A bulk acoustic resonator operable in a bulk acoustic mode includes a resonator body mounted to a separate carrier that is not part of the resonator body. The resonator body includes a piezoelectric layer, a device layer, and a top conductive layer on the piezoelectric layer opposite the device layer. A surface of the device layer opposite the piezoelectric layer is for mounting the resonator body to the carrier.

Abstract: The present disclosure relates to data distribution methods. One example method includes receiving an access policy, where the access policy includes flow description information, quality information of at least two links, and a data distribution policy on the at least two links, receiving a service data flow, and in response to determining that the access policy includes flow description information of the service data flow, determining link quality information of a link used for transmitting the service data flow, and distributing the service data on the link according to the data distribution policy, where the data distribution policy is a data distribution policy that is determined based on the access policy and that is corresponding to the link quality information and the flow description information of the service data flow.

Abstract: A method of increasing gene expression by manipulating the circadian clock is described that includes transforming a photosynthetic organism to include an expression control sequence that modulates the expression of a clock gene to increase expression of a target gene. Photosynthetic organism having a modified circadian cycle reflecting this method are also described.

Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

Abstract: A method of trading data includes posting, in a data trading system, data information related to data that is located in a storage apparatus independent of the data trading system and available for purchase and receiving, from a purchaser device, a compensation for the data. The method also includes facilitating, at least partially through a smart contract on a blockchain, a transfer of the data directly from the storage apparatus to the purchaser device; and facilitating, at least partially through the smart contract on a blockchain, a transfer of the compensation from the data trading system to a provider account.