Abstract: A damage identification method based on cable force tests of a cable system and test error self-adaptive analysis is proposed to measure cable forces in prestressed steel structures and find out possible damage positions of the cable system. The method includes placing a laser velocimeter; measuring the vibration speed history data of the measuring point P on the cable by the laser velocimeter; calculating the cable force; calculating all the cable forces of the cable system through the same procedure; analyzing error between cables and finding out the possible damage of the cable or of the tie rod connected to the cable. The dynamic response characteristics of both in-plane and out-of-plane of a cable can be obtained through the method of the present invention. The self-verified more accurate results can be obtained, and the damage in a cable system can be determined according to error self-adaptive analysis.

Abstract: The present disclosure provides certain tricyclic compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Abstract: A record of authorization including user information is received and appended to a blockchain. The record of authorization authorizes access by a third-party application to the user information for an access duration. The user information is encrypted by a group key and access duration is based on a change to the group key. The group key comprises a public/private key pair, and the access duration is implemented by an authorization group of nodes having the group key. The group key corresponds to either a valid group key at or near the start of the access duration, that enables decryption of a message in the record of authorization that includes the user information, or an incompatible group key at or after the end of the access duration, that does not enable decryption of the message in the record of authorization that includes the user information.

Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

Abstract: An immobilized selenium body, made from carbon and selenium and optionally sulfur, makes selenium more stable, requiring a higher temperature or an increase in kinetic energy for selenium to escape from the immobilized selenium body and enter a gas system, as compared to selenium alone Immobilized selenium localized in a carbon skeleton can be utilized in a rechargeable battery Immobilization of the selenium can impart compression stress on both the carbon skeleton and the selenium. Such compression stress enhances the electrical conductivity in the carbon skeleton and among the selenium particles and creates an interface for electrons to be delivered and or harvested in use of the battery. A rechargeable battery made from immobilized selenium can be charged or discharged at a faster rate over conventional batteries and can demonstrate excellent cycling stability.

Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

Abstract: The subject matter described herein is directed to ferroportin inhibitor compounds of Formula I or I? and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis, and also kidney injuries.

Abstract: The present invention discloses a UWB base station and a positioning method therefor. The UWB base station includes four antennae, obverse sides of the four antennae respectively face four azimuth directions, by which 360° may be uniformly divided, on a horizontal section. Azimuth directions faced by the first and the third antenna differ by 180°, and azimuth directions faced by the second and the fourth antenna differ by 180°. The station further includes a single-pole and a double-pole double-throw switch and a UWB module, the UWB module includes a transmitting end, a first and a second receiving end; first receiving end is respectively connected to the second and fourth antenna through single-pole double-throw switch; and transmitting end and second receiving end are respectively connected to the first and third antenna through double-pole double-throw switch. According to the invention, 360° omnidirectional positioning can be achieved, and the positioning precision is high.

Abstract: A seat cushion structure capable of adjusting softness and hardness, comprising a cushion sponge (1), a wheel-spoke seat inner housing (2), a seat sponge (3) and a seat outer housing (4), which are sequentially disposed from top to bottom; a coil spring (11) is fixedly provided on the wheel-spoke seat inner housing (2); an adjustment handle (5) is provided outside the seat outer housing (4), an adjustment mechanism is connected to the adjustment handle (5) and provided inside the seat outer housing (4); the adjustment mechanism is also connected to the coil spring (11), configured for adjusting contraction radius of the coil spring (11); the adjustment mechanism is capable of adjusting contraction radius of the coil spring (11) since being controlled by the adjustment handle (5), thereby the softness and hardness of the seat cushion structure is adjusted.

Abstract: The present invention provides engineered polypeptides that are useful for the asymmetric synthesis of ?-hydroxy-?-amino acids under industrial-relevant conditions. The engineered polypeptides disclosed in this invention were developed through directed evolution based on the ability of catalytic synthesis of (2S, 3R)-2-amino-3-hydroxy-3-(4-nitrophenyl) propanoic acid. The present disclosure also provides polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing ?-hydroxy-?-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides of the present invention for the preparation of ?-hydroxy-?-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption. So, it has good industrial application prospects.

Abstract: Provided herein are engineered decarboxylase polypeptides that are useful for catalyzing the decarboxylation of amino acids such as L-tyrosine to produce tyramine or catalyzing the decarboxylation of L-DOPA to produce dopamine. Also provided are the preparation process of engineered decarboxylase polypeptides as well as reaction process under industrial-relevant conditions. The disclosure also provides polynucleotide sequences encoding engineered decarboxylase polypeptides, recombinant host cells capable of expressing engineered decarboxylase polypeptides, and methods of producing tyramine or dopamine using the engineered decarboxylase polypeptides. Compared to the wild type decarboxylase, the engineered polypeptide provided by this disclosure has better activity and/or stability. The use of the engineered polypeptides for the preparation of tyramine or dopamine reduces the production cost and has a good industrial application prospect.

Abstract: An immobilized selenium body, made from carbon and selenium and optionally sulfur, makes selenium more stable, requiring a higher temperature or an increase in kinetic energy for selenium to escape from the immobilized selenium body and enter a gas system, as compared to selenium alone. Immobilized selenium localized in a carbon skeleton can be utilized in a rechargeable battery. Immobilization of the selenium can impart compression stress on both the carbon skeleton and the selenium. Such compression stress enhances the electrical conductivity in the carbon skeleton and among the selenium particles and creates an interface for electrons to be delivered and or harvested in use of the battery. A rechargeable battery made from immobilized selenium can be charged or discharged at a faster rate over conventional batteries and can demonstrate excellent cycling stability.

Abstract: The present disclosure provides, in part, a priming and boosting vector-based platform to develop vaccines against pathogens that is tailored to elicit a broad T cell response targeting conserved viral epitopes. The universal vaccines are prepared against an immunogen of an infectious pathogenic organism selected from a virus, a bacteria, a fungus or a protozoan comprising at least one ribonucleic acid (RNA) polynucleotide comprising an open reading frame encoding at least one polypeptide antigen or an immunogenic fragment thereof, wherein the polypeptide antigen, or the immunogenic fragment thereof, comprises a conserved internal protein that is enriched in CD8+ T cell recognition antigens. The effectiveness of the priming and boosting platform is tested in a humanized mouse model comprising a fully functional human immune system.

Abstract: A vehicle door lock is disposed in a vehicle door and includes a ratchet wheel rotatable between a locked position where it captures a lock catch disposed on a vehicle body and an unlocking position where it releases the lock catch to allow the vehicle door to be opened. The vehicle door lock further includes an ice-breaking mechanism disposed in the vehicle door, and the ice-breaking mechanism applies a torque to the ratchet wheel to cause the ratchet wheel to rotate in a direction to push the lock catch so as to open the vehicle door. The vehicle door lock can be opened by pushing the ratchet wheel with e ice-breaker mechanism when the vehicle door is frozen or deformed due to collision, the operation noise is low, the cost is low, and the paint surface of the vehicle door is protected.

Abstract: An immobilized selenium body, made from carbon and selenium and optionally sulfur, makes selenium more stable, requiring a higher temperature or an increase in kinetic energy for selenium to escape from the immobilized selenium body and enter a gas system, as compared to selenium alone. Immobilized selenium localized in a carbon skeleton can be utilized in a rechargeable battery. Immobilization of the selenium can impart compression stress on both the carbon skeleton and the selenium. Such compression stress enhances the electrical conductivity in the carbon skeleton and among the selenium particles and creates an interface for electrons to be delivered and or harvested in use of the battery. A rechargeable battery made from immobilized selenium can be charged or discharged at a faster rate over conventional batteries and can demonstrate excellent cycling stability.

Abstract: The application relates to a compound of Formula (I?) or (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of SSAO, a pharmaceutical composition comprising a compound of Formula (I?) or (I), and a method of treating or preventing a disease in which SSAO plays a role.

Abstract: The present disclosure provides, in part, a priming and boosting vector-based platform to develop vaccines against pathogens that is tailored to elicit a broad T cell response targeting conserved viral epitopes. The universal vaccines are prepared against an immunogen of an infectious pathogenic organism selected from a virus, a bacteria, a fungus or a protozoan comprising at least one ribonucleic acid (RNA) polynucleotide comprising an open reading frame encoding at least one polypeptide antigen or an immunogenic fragment thereof, wherein the polypeptide antigen, or the immunogenic fragment thereof, comprises a conserved internal protein that is enriched in CD8+ T cell recognition antigens. The effectiveness of the priming and boosting platform is tested in a humanized mouse model comprising a fully functional human immune system.

Abstract: A system, method and apparatus to record data relevant to hardware errors identified by microprocessors. For example, in response to a hardware error, a microprocessor can store first data about the error in registers in the microprocessor and start to execute instructions configured in firmware and/or in an operating system. Execution of the instructions in response to the hardware error causes the microprocessor to: generating second data about the error based at least in part on the first data in the registers; and store the second data at a location not affected by restarting execution of an operating system in the processor. For example, the execution of the instructions can cause the microprocessor to decode the first data to obtain a temperature the computing device as part of the second data.

Abstract: A quasi-real-time data collection system for a competitive power market includes a distributed data collection unit, a centralized data collection unit, and a main collection station, where the distributed data collection unit is connected to an intelligent watt-hour meter by using an internal downlink communication module of the distributed data collection unit, and configures data item collection parameters and task execution parameters by using an internal collection task and scheme configuration module of the distributed data collection unit; the centralized data collection unit is connected to the main collection station by using an internal file conversion and uplink communication module of the centralized data collection unit; and the centralized data collection unit is connected to multiple distributed data collection units by using a local high speed power line carrier communication (HPLC) network.

Abstract: A method for patterning a stack having a mask with a plurality of mask features is provided. A targeted deposition is provided, wherein the targeted deposition comprises a plurality of cycles, wherein each cycle comprises flowing a precursor to deposit a layer of precursor and targeted curing the layer of precursor, comprising flowing a curing gas, flowing a modification gas, forming a plasma from the curing gas and modification gas, and exposing the layer of precursor to the plasma providing a targeted curing, wherein plasma from the curing gas cures first portions of the layer of precursor and plasma from the modification gas modifies second portions of the layer of precursor, wherein the modification of the second portion reduces curing of the layer of precursor of the second portions of the layer of precursor. The stack is etched through the targeted deposition.