Abstract: The present invention provides a mutated antibody of the fully humanized HER2 antibody GB235-019, wherein the amino acid sequence of the heavy chain variable region and the amino acid sequence of the light chain variable region of the mutated antibody are respectively SEQ ID NO: 10, SEQ ID NO: 2; SEQ ID NO: 11, SEQ ID NO: 2; or SEQ ID NO: 12, SEQ ID NO: 2. The mutated antibody has the ability to specifically bind to human HER2 antigen, similar to the GB235-019 antibody. They can also be used in combination with additional HER2 positive tumor therapeutic agents for treating HER2 positive tumor, weakly positive tumor or negative tumor.

Abstract: A device comprises a contact reaction chamber, a circulating water inlet, a clear water basin, a circulating pump, a circulating water outlet, a solid phase extractant collecting tank, a magnetic holder, an electromagnet, a solid-liquid separation area, a drain valve, a wall sprinkling water inlet, and a wall sprinkling pipe, wherein, the contact reaction chamber is in a conical shape, and utilizes hydraulic power to perform stir to ensure no dead corner exists during contact stir; the obconical solid-liquid separation area increases the action area between a magnetic solid phase extractant and the electromagnet; the solid phase extractant collecting tank is in a downwards protruding dish shape to prevent the solid phase extractant from losing.

Abstract: A method for preparing a sapphire lens includes the following steps: sequentially forming an ink layer and a coating film layer on one surface of a large polymeric membrane; laser-cutting the obtained large polymeric membrane to form two or more small polymeric membranes that are as thick as the large polymeric membrane; laminating the surface of the small polymeric membrane that does not contain the ink layer and the coating film layer to one surface of a sapphire sheet, such that an adhesive layer is formed between the small polymeric membranes and the sapphire sheet, wherein the sapphire sheet has a thickness of 0.3 to 1.5 mm, and the polymeric membrane has a thickness of 0.02 to 0.2 mm; and pressing the obtained sheet material to remove bubbles, thereby obtaining a sapphire lens.

Abstract: The present invention provides a miniature wideband antenna for 5G, which includes a dielectric substrate, a coplanar waveguide feed structure on a front of the dielectric substrate, a main radiator, a second and third radiators and a first radiator on a back of the dielectric substrate. The antenna is small in size with operation band of 3 GHz-30 GHz which covers the various 5G frequency band and covers the current wireless modes of Wi-MAX, W-LAN, UWB and so on. The antenna guarantees future compatibility for various complicated communication modes and has good perspectives for many applications. Based on the antenna, the double-unit and four-unit MIMO antenna adopts orthogonal polarization and metamaterial unit. Thus, high unit separation is achieved without increase on the size of the antenna unit. The present invention has wide applications in small mobile device such as cell phone and laptop.

Abstract: Antibodies directed to the antigen Ang-2 and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen Ang-2. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

Abstract: Ultrasonic surgical device is provided. The device includes a shell which holds an energy converter and an amplitude-change pole. The energy converter may include piezoceramic stack that converts electrical signals into mechanical ultrasonic movement in the longitudinal direction of the device. The amplitude-change pole is a mechanical amplifier that uses mass differentials to amplify the ultrasonic motion. A cutting instrument interfaces with the amplitude-change pole. The system also includes a rotary drive device comprising a drive motor also axially arranged with the cutting instrument. The motor rotates the amplitude-change pole, energy converter, and ultimately the cutting instrument. In some embodiments the rate of rotation is at 40-1000 rpm, at 50-650 rpm and at 60-350 rpm depending on configuration.

Abstract: The present invention provides an anthropogenic glucagon-like peptide-1 (GLP-1) recombinant protein molecule fused with an anthropogenic immunoglobulin subtype (IgG2) Fc section and a preparation method and purpose thereof. The fusion protein has the biological activity of GLP-1, and also has a significantly prolonged half-life in vivo. The fusion protein can be used to treat type II diabetes, obesity, and other diseases that are treated by decreasing serum glucose, suppressing gastrointestinal motility, and emptying or suppressing food intake.

Abstract: Ultrasonic surgical device is provided. The device includes a shell which holds an energy converter and an amplitude-change pole. The energy converter may include piezoceramic stack that converts electrical signals into mechanical ultrasonic movement in the longitudinal direction of the device. The amplitude-change pole is a mechanical amplifier that uses mass differentials to amplify the ultrasonic motion. A cutting instrument interfaces with the amplitude-change pole. A drive motor causes on oscillation mechanism, which may be a rocker, to oscillate in a direction tangentially to the longitudinal axis. The oscillating mechanism may then couple to the energy converter, causing the entire cutting structure to move in this oscillation. This causes the cutter to ultrasonically vibrate along the longitudinal axis, while oscillating tangentially to the longitudinal axis.

Abstract: Implementations herein relate to a method for extraction of phthalates using hydrophilic magnetic resins with high specific surface areas. The implementations relate to a technical field of preparation of resins for fast enrichment and separation of trace organics in water. By adding magnetic particles, precursor resins may be prepared using divinylbenzene, vinyl benzoate and glycidyl methacrylate copolymerization ester. After the cross-linking reaction, surface areas of the resins are increased and hydrolysis of the ester group in alkaline solution may be implemented to obtain high specific surface magnetic resins rich in hydroxyl groups. The resins have higher adsorptive capacity and selectivity to adsorb phthalates in water samples. Rapid extraction may be implemented using magnetic solid phase extraction rod to achieve enrichment and separation of phthalates in a large amount of water samples.

Abstract: The present invention provides a method for preparing hydrophilic polymer foam. The method comprises a step of providing an isocyanate functionalized prepolymer (A) and a step of foaming and curing the prepolymer (A). The prepolymer (A) is prepared by reacting diisocyanate (A1) and polyether polyol (A2), wherein the diisocyanate (A1) is selected from any one and a combination of 1,4-butyl diisocyanate (BDI), lysine diisocyanate (LDI) and 1,5-pentyl diisocyanate (PDI); the polyether polyol (A2) is a copolymer of ethylene oxide (EO) and propylene oxide (PO) and/or butylene oxide (BO); the ethylene oxide has a weight percentage of about 50%-100% in the polyether polyol, and has an OH functionality degree of 3-6, a hydroxyl value of about 21 mg KOH/g-168 mg KOH/g and a number-average molecular weight of about 1000 g/mol to about 8000 g/mol; and NCO content in the prepolymer (A) is 1%-10%.

Abstract: In one aspect, the invention relates to a method of performing upsampling, that includes the steps of: receiving an input image; generating an initial upsampled image using the input image; generating a low-passed image using the input image; and performing self-similarity upsampling using the upsampled image and the low-passed image.

Abstract: Embodiments herein relate to methods for sludge reduction for pretreatment of nitrotoluene wastewater using electro-catalytic redox. The embodiments may include (a) adjusting a pH of the nitrotoluene wastewater to 1.5 to 2.0, standing for precipitation, draining sludge of the nitrotoluene wastewater at the bottom, obtaining supernatant of nitrotoluene wastewater, placing the supernatant through a cathode inlet into a cathode chamber of an electrochemical reactor; (b) performing electrochemical treatment, wherein reduction reaction of the supernatant of the nitrotoluene wastewater takes place at the cathode chamber, the nitrotoluene wastewater is placed into the anode chamber for oxidation reaction through the cathode outlet, the catholyte tank, and the anode inlet in sequence; (c) adjusting the nitrotoluene wastewater treated in step (b) via the anolyte tank, and then discharging the nitrotoluene wastewater into a biochemical system.