Abstract: The present invention provides a cancer vaccine comprising DNA repair-deficient cancer cells, wherein the cancer cells are contacted with a PARP inhibitor to induce DNA breaks. In another aspect, a method of treating a subject afflicted with a cancer comprising administering to the subject a therapeutically effective amount of a cancer vaccine comprising DNA repair-deficient cancer cells, wherein the cancer cells are contacted with a PARP inhibitor to induce DNA breaks, is provided. The present invention also provides a kit comprising DNA repair-deficient cancer cells modified as described herein, PARP inhibitors, immune checkpoint inhibitors, and combinations thereof, packaged in a suitable container.

Abstract: The present invention provides an ultra-thin optical component, including a mirror projection device and a reflector, where the mirror projection device is configured to refract image light symmetrically, then form a real image, and project the real image to the reflector, where the real image is located between a human eye and the reflector; and the reflector is configured to reflect the image light to the human eye. The present invention further provides a display device using the ultra-thin optical component and a virtual imaging method. By means of the ultra-thin optical component, the display device, and the imaging method in the present invention, an optical component is made thinner and lighter, and an image source display device is easier to configure and package, to achieve the appearance of ordinary glasses.

Abstract: Treatment chemicals (for example, scale inhibition chemicals) can be applied to fluids in a pipeline by diverting a side stream of the produced water from a pipeline into a vessel containing a solid material to release of an active fluid treatment agent from the solid material into the diverted produced water; merging the diverted produced fluid containing the active fluid treatment agent into the pipeline; and adjusting a flow rate of the diverted side stream of the produced water to change a level of the active fluid treatment agent in the flow of produced water in the pipeline. Treatment systems can include a pipeline, a vessel containing a solid treatment material; a bypass line providing a fluid connection between the pipeline and an inlet of the vessel; and a return line providing a fluid connection between an outlet of the vessel and the pipeline.

Abstract: The present disclosure provides a semiconductor device and a manufacturing method therefor. The manufacturing method for a semiconductor device is provided for forming through-holes in a semiconductor device, comprising: forming a plurality of shallow trench isolations in portions of a substrate corresponding to memory cell regions; forming a plurality of gates on surfaces of the portions of the substrate; forming spacers on side walls at both sides of the gates extending in the first direction; depositing a sacrificial layer on the memory cell region; removing portions of the sacrificial layer corresponding to the shallow trench isolations at memory cell drain, and depositing an isolation dielectric on the shallow trench isolations at the memory cell drain to form isolation strips; and removing the remaining sacrificial layer to form bottom through-holes in spaces formed after removing the remaining sacrificial layer.

Abstract: A freeform prism-lens group includes: a primary prism; a first auxiliary lens; and a beamsplitter film between the primary prism and the first auxiliary lens and having a predetermined beamsplitting ratio; wherein: the first auxiliary lens has a first optical surface substantially conforming to a neighboring freeform surface of the primary prism; and the first auxiliary lens has a second opposing optical surface distal from the primary prism that is planar, aspheric, or spherical with a curvature radius greater than 100 mm.

Abstract: An optical imaging system having a free-form surface includes an image source for generating image light, a lens assembly for reflecting the image light incident thereon, a first reflective surface, a second reflective surface, and a beam splitter that are disposed opposite to each other. The present disclosure allows the image light to pass through the lens assembly twice, reduces the weight of the optical system, and makes the system structure more compact, thus providing an optical imaging system featuring low distortion, high image quality, and a compact structure. A reflective surface is disposed between the image source and the lens assembly, so that the distance between the image source and the lens assembly can be reduced. The second reflective surface is designed as a free-form surface and a first lens and a second lens are aspheric lenses.

Abstract: A light-weight and ultrathin waveguide optical element having a large field of view includes two or more layers of waveguide plates provided to be overlapped with each other. Within each layer of the waveguide plate are included multiple reflective surfaces with different reflectivity, such that light transmitted through the waveguide plate has a substantially uniform distribution of intensity in a predetermined area when exiting from the waveguide plate. The waveguide optical element is ultrathin such that it can be directly mounted into a spectacle frame. Use of the waveguide optical element with a projection optical assembly can improve user experience as well as display effect with good contrast.

Abstract: A wearable augmented reality (AR) or virtual reality (VR) display apparatus includes an optical waveguide; an optical free-form surface; and a microdisplay; wherein optical free-form surface is optically coupled to the waveguide through an inclined optical path. A near-eye display apparatus includes two or more layers of waveguide plates arranged to overlap with each other, wherein within each layer of the waveguide plate includes multiple reflective surfaces different in reflectivity, so as to ensure that light transmitted through the waveguide plate has a substantially uniform distribution of intensity in a predetermined area when exiting outward from the waveguide plate. The waveguide optical element is ultrathin so as to be directly mounted into a spectacle frame. User experience and contrast level are also improved.

Abstract: Dissolving iron sulfide on the carbon steel tubing to yield chelated iron is achieved by treating the carbon steel tubing with a composition including an iron chelant and an additive. The additive includes at least one of an oxidizing agent and a base. A weight ratio of the iron chelant to the additive is in a weight range of 50:1 to 5:1.

Abstract: Mitigating corrosion and surface scale formation in a sour gas well includes providing an oil-based liquid to a sour gas well having carbon steel tubing with iron sulfide on a surface of the carbon steel tubing, contacting the carbon steel tubing with the oil-based liquid, and adsorbing a first portion of the oil-based liquid onto the iron sulfide, thereby yielding a hydrophobic coating on the carbon steel tubing.

Abstract: Treating carbon steel tubing includes contacting the carbon steel tubing with a first treatment solution including a salt; corroding the carbon steel tubing with the salt to yield a corroded surface on the carbon steel tubing; contacting the corroded surface on the carbon steel tubing with a second treatment solution comprising sulfide ions; and forming an iron sulfide layer on the corroded surface of the carbon steel tubing by chemically bonding the sulfide ions in the second treatment solution with iron in the carbon steel tubing. In some cases, the first treatment solution also includes sulfide ions, and the iron sulfide layer is formed by contacting the carbon steel tubing with the first treatment solution.

Abstract: A light-weight and ultrathin waveguide optical element having a large field of view includes two or more layers of waveguide plates provided to be overlapped with each other. Within each layer of the waveguide plate are included multiple reflective surfaces with different reflectivity, such that light transmitted through the waveguide plate has a substantially uniform distribution of intensity in a predetermined area when exiting from the waveguide plate. The waveguide optical element is ultrathin such that it can be directly mounted into a spectacle frame. Use of the waveguide optical element with a projection optical assembly can improve user experience as well as display effect with good contrast.

Abstract: A wearable augmented reality (AR) or virtual reality (VR) display apparatus includes an optical waveguide; an optical free-form surface; and a microdisplay; wherein optical free-form surface is optically coupled to the waveguide through an inclined optical path. A near-eye display apparatus includes two or more layers of waveguide plates arranged to overlap with each other, wherein within each layer of the waveguide plate includes multiple reflective surfaces different in reflectivity, so as to ensure that light transmitted through the waveguide plate has a substantially uniform distribution of intensity in a predetermined area when exiting outward from the waveguide plate. The waveguide optical element is ultrathin so as to be directly mounted into a spectacle frame. User experience and contrast level are also improved.

Abstract: A transmissive photonic crystal fiber ring resonator employing single optical beam-splitter comprises: a first fiber-optic collimator, a second fiber-optic collimator, a first photonic crystal fiber collimator, a second photonic crystal fiber collimator, an optical beam-splitter, and a fixture. The first fiber-optic collimator, the second fiber-optic collimator, the first photonic crystal fiber collimator, the second photonic crystal fiber collimator, and the optical beam-splitter are fixed on the fixture; the fiber pigtails of the first fiber-optic collimator and the second fiber-optic collimator are the input/output ports; the fiber pigtails of the first photonic crystal fiber collimator and the second photonic crystal fiber collimator are connected.

Abstract: A transmissive photonic crystal fiber ring resonator employing single optical beam-splitter comprises: a first fiber-optic collimator, a second fiber-optic collimator, a first photonic crystal fiber collimator, a second photonic crystal fiber collimator, an optical beam-splitter, and a fixture. The first fiber-optic collimator, the second fiber-optic collimator, the first photonic crystal fiber collimator, the second photonic crystal fiber collimator, and the optical beam-splitter are fixed on the fixture; the fiber pigtails of the first fiber-optic collimator and the second fiber-optic collimator are the input/output ports; the fiber pigtails of the first photonic crystal fiber collimator and the second photonic crystal fiber collimator are connected.

Abstract: The present invention discloses an aluminum-based metallic glass cladding layer and a preparation method thereof. The aluminum-based metallic glass cladding layer takes aluminum-based amorphous alloy powder as a raw material and is prepared by a magnetic field stirring laser cladding molding technology; the aluminum-based amorphous alloy powder consists of the following elements: 5 wt %-8 wt % of Ni, 3 wt %-6 wt % of Y, 1 wt %-5 wt % of Co, 0.5 wt %-3 wt % of La and Al as balance; the particle size range of the aluminum-based amorphous alloy powder is 25-71 mum; and the oxygen content of the aluminum-based amorphous alloy powder is below 1,000 ppm.

Abstract: Disclosed are an optically pure compound having formula I, its pharmaceutically acceptable salt and its pharmaceutically acceptable solvate, and a use thereof in manufacturing medicaments and pharmaceutical compositions. A process for preparing the compound defined therein is also provided.

Abstract: Systems and methods to treat wastewater are described herein. A wastewater treatment system may include a primary treatment system, a secondary treatment system, a disinfection treatment system, a solids treatment system, one or more fluid treatment systems, or combinations thereof.

Abstract: Systems and methods to degas fluids are described herein. A fluid degassing treatment system may include a reservoir and/or one or more fluid treatment systems.

Abstract: Systems and methods to degas fluids are described herein. A fluid degassing treatment system may include a reservoir and/or one or more fluid treatment systems.