Abstract: Refillable compression-activated pump devices having a first reservoir, a second reservoir connected by a one-way valve and methods of using the pump devices are provided. The compression-activated pumps can be filled with fluid containing a drug, pressurized by compressing the first or second reservoir to deliver the drug to another device, and refilled when drug is depleted.

Abstract: In an example, there is disclosed a security management console, comprising: a hardware platform, comprising a processor, a memory, and a data exchange layer (DXL) interface, the DXL interface comprising a hardware network connection and a software layer, the software layer to provide a two-layer messaging bus, wherein a lower layer is an internet protocol (IP) network, and an upper layer is a publish-subscribe enterprise service bus (ESB); an interface to a reputation database, the reputation database including cached reputations for a plurality of network objects, the reputations representing the network objects' safety within an enterprise serviced by the DXL; and instructions encoded within the memory to instruct the processor to: provide a DXL security console graphical user interface (GUI), the GUI including instructions to provide a graphical representation of an object, including the object's default reputation retrieved from the reputation database; receive a user input to override the object's defau

Abstract: In an example, there is disclosed a monolithic reputation update on a data exchange layer (DXL). According to one embodiment, designating a set of objects as good or bad can be achieved via a single administrative action by leveraging persistent client initiated connections to the DXL framework. This may enable communication of the reputation updates across a heterogeneous infrastructure, including systems potentially unreachable by the server, such as those behind a firewall or NAT.

Abstract: A body engaging manipulation instrument for use by a practitioner on body parts of an individual being treated formed of body engaging sections connected to a central gripping panel. A centrally located, raised gripping member extends outwardly from an upper surface of the gripping panel and a recessed gripping member having a shape complementary to the raised gripping member is located on a lower surface of the gripping panel. The body engaging sections are connected to the gripping panel at an angle greater than 90 degrees and are formed with a shaped tissue engaging edge corresponding to the tissue structure of a person being treated.

Abstract: A system for receiving and ejecting a fluid testing device test strip includes a strip connector having first and second guide rails, and divider walls each having a channel. A sled has first and second legs connected to a cross member. Each leg has a contact leg extending inwardly from a chamfered end. The first and second legs when positioned parallel to the guide rails have the contact leg captured in the divider wall channels retaining the sled in sliding contact with the guide rails for motions in loading and ejection directions. A mechanism assembly is movably connected to the fluid testing device. The cross member is coupled so operation in a first direction displaces the sled in the loading direction positioning the sled in a test strip test position, and opposite operation positions the contact legs in direct contact with and ejects the test strip.

Abstract: A unitary manipulation instrument for use by a practitioner on soft tissue of a person formed of a pair of planar sections, each section including an outer tissue engaging surface. The sections are interconnected and each section is located in a different spatial plane such that the sections are oriented at 90 degrees one with respect to the other.

Abstract: There is disclosed in one example, a computing apparatus, including: a hardware platform including a processor and a memory; a network interface; a data exchange layer (DXL) application programming interface (API), the DXL API including instructions to communicatively couple the apparatus to a DXL bus and provide a DXL abstraction layer on top of a TCP/IP-based communication network; and a reputation engine including instructions encoded within memory to instruct the processor to: receive a plurality of DXL messages from a first DXL endpoint; compute a composite reputation for the first DXL endpoint; receive from a second DXL endpoint a DXL message requesting a reputation for the first DXL endpoint; establish a private topic on the DXL bus between the computing apparatus and the second DXL endpoint; and publish the composite reputation to the private topic.

Abstract: In an example, a threat intelligence controller is configured to operate on a data exchange layer (DXL). The threat intelligence controller acts as a DXL consumer of reputation data for a network object, which may be reported in various different types and from various different sources. Of the devices authorized to act as reputation data producers, each may have its own trust level. As the threat intelligence controller aggregates data from various providers, it may weight the reputation reports according to trust level. The threat intelligence engine thus builds a composite reputation for the object. When it receives a DXL message requesting a reputation for the object, it publishes the composite reputation on the DXL bus.

Abstract: An extruder assembly has a frame with upstream and downstream ends. A barrel assembly on the frame has a passage. At least one material advancing component resides at least partially within the passage and is configured to be turned around an operating axis to thereby cause material to be conveyed from a passage inlet to a passage outlet. A drive assembly turns the at least one material advancing component around its operating axis and has a motor on the frame situated so that at least a part of the motor is in lengthwise overlapping relationship with the barrel assembly. The drive assembly is configured to turn the one material advancing component around its operating axis at a speed of at least 300 rpm.

Abstract: Dual-lumen devices for delivery of drugs to a drug reservoir, blood vessel or vascular graft and methods of using the same are provided. In one aspect, devices comprising a dual-lumen needle and dual-lumen catheter are provided for filling and removing drug formulations from a drug reservoir are provided. The drug reservoir can optionally be connected to or associated with a vascular graft or blood vessel for controlled delivery of the drug.

Abstract: A die assembly through which flowable material from a supply is controllably delivered to a processing assembly at which a sheet layer is formed. The die assembly has a main frame and a support assembly for the main frame. The support assembly includes components cooperating between the main frame and a base upon which the main frame is supported to allow controlled relative vertical movement between the main frame and base to thereby permit controlled alignment between the main frame and an upstream component that delivers flowable material from the supply to the die assembly.

Abstract: An apparatus (9) for plasma treating multiple containers. The apparatus includes a manifold (2) comprising at least a first chamber with multiple outlet openings and multiple hollow, electrically-conductive nozzles (10) for at least one of delivering or exhausting plasma-generating gas. The multiple hollow, electrically-conductive nozzles are connected to the multiple outlet openings and protrude from the manifold. A method of plasma treating multiple containers is also disclosed. The method includes providing a reactor system comprising an apparatus disclosed herein, inserting the multiple hollow, electrically-conductive nozzles into the multiple containers (30), evacuating the multiple containers, grounding the multiple hollow, electrically-conductive nozzles while applying radio frequency power to the multiple containers, providing a gas inside the containers, and generating a plasma. At least one of evacuating or providing the gas is carried out through the hollow, electrically-conductive nozzles.

Abstract: The present disclosure relates to a method for metabolic oligosaccharide engineering that incorporates derivatized alkyne-bearing sugar analogs as “tags” into cellular glycoconjugates. The disclosed method incorporates alkynyl derivatized Fuc and alkynyl derivatized ManNAc sugars into a cellular glycoconjugate. A chemical probe comprising an azide group and a visual probe or a fluorogenic probe is used to label the alkyne-derivatized sugar-tagged glycoconjugate. In one aspect, the chemical probe binds covalently to the alkynyl group by Cu(I)-catalyzed [3+2] azide-alkyne cycloaddition and is visualized at the cell surface, intracellularly, or in a cellular extract. The labeled glycoconjugate is capable of detection by flow cytometry, SDS-PAGE, Western blot, ELISA or confocal microscopy, and mass spectrometry.

Abstract: A barrel assembly through which flowable material is delivered to a die assembly through which the flowable material is delivered to form a sheet layer. The barrel assembly has: a conduit having a body with a length defining a lengthwise flow passage between upstream and downstream ends; and a support assembly for the conduit. The support assembly has: a) a conduit engaging assembly; and b) a guide assembly through which the conduit body and conduit engaging assembly are moved guidingly relative to a base, to which the guide assembly is mounted, in a path that is substantially parallel to the length of the conduit body.

Abstract: A system and method for testing and ejecting a test strip of a fluid testing medical device. The system includes parallel first and second guide rails defining a rail cavity between the guide rails. A sled includes a sled post and opposed first and second side leg sets each having at least one deflectable leg. Each of the deflectable legs is externally slidably engaged to one of the guide rails limiting the sled to only sliding motion in either a loading direction or an opposite ejection direction. An actuator arm is rotatably connected to a mechanism assembly. The sled post is received in an actuator arm slot. Actuator arm rotation in a loading rotational direction displaces the sled in the loading direction in a sliding motion. Subsequent opposite rotation of the actuator arm in an ejection rotational direction displaces the sled in the ejection direction and ejects the test strip.

Abstract: Rotating wellhead hanger assemblies are provided. In one embodiment, a wellhead hanger assembly includes a casing hanger and a casing hanger running tool coupled to the casing hanger. An exterior surface of the casing hanger includes a recess and the casing hanger running tool includes a dog that extends inward from the casing hanger running tool into the recess of the exterior surface of the casing hanger. Engagement of the dog with the recess of the casing hanger facilitates synchronous rotation of the casing hanger and its running tool. Additional systems, devices, and methods are also disclosed.

Abstract: Methods for metabolic oligosaccharide engineering that incorporates derivatized alkyne-bearing sugar analogs as “tags” into cellular glycoconjugates are disclosed. Alkynyl derivatized Fuc and alkynyl derivatized ManNAc sugars are incorporated into cellular glycoconjugates. Chemical probes comprising an azide group and a visual or fluorogenic probe and used to label alkyne-derivatized sugar-tagged glycoconjugates are disclosed. Chemical probes bind covalently to the alkynyl group by Cu(I)-catalyzed [3+2] azide-alkyne cycloaddition and are visualized at the cell surface, intracellularly, or in a cellular extract. The labeled glycoconjugate is capable of detection by flow cytometry, SDS-PAGE, Western blot, ELISA, confocal microscopy, and mass spectrometry.

Abstract: A modular self-massaging apparatus includes a framework and a ball assembly mounted to the framework. The ball assembly is modular and can be disassembled and reassembled in a variety of configurations. The apparatus is modular because the ball assembly and other ball assemblies can be applied to and carried in the apparatus at a variety of locations across the apparatus.

Abstract: A diverter valve for extruded materials, including a split cylinder in the cylindrical opening of a base, each cylinder half being independently pivotable. The base includes first and second inlets for first and second extruded material, and first and second outlets for the material. Base first and second flow paths carry the first and second extruded materials from the inlets to the output openings, and third and fourth flow paths carry extruded material from the first and second first inlet openings to the first and second outlets. The first and second inlet openings and the first and second output openings are axially open to the central opening, and the cylinder halves are adjacent along a plane substantially radial to the central opening axis with each of the cylinder halves including a recess open along the radial plane.

Abstract: In an example, there is disclosed a method or system for merging multiple system trees of different resources based in multiple locations over a data exchange layer. In one embodiment, there is disclosed a system for merging assets of different types within one or more tree-based locations. For example, an end node may be represented in a single location, a single message broker may provide services for and be represented in multiple locations. The asset to asset relationships within merged trees may be used to ensure availability of services and visualization of the system for management purposes.