Abstract: Provided are crystalline forms of a KRAS G12C inhibitor compound and to processes for their preparation. Furthermore, provided is pharmaceutical composition comprising said crystalline forms, and at least one pharmaceutically acceptable excipient. The pharmaceutical composition can be used as a medicament, in particular for the treatment of cancer, and KRAS G12C-mutant cancer.

Abstract: It relates to a pharmaceutical combination comprising a KRAS G12C inhibitor, in particular 1-{6-[(4M)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro [3.3] heptan-2-yl} prop-2-en-1-one (Compound A) and one or more therapeutically active agents selected from a SHP2 inhibitor (e.g. TNO155) and a PD-1 inhibitor, pharmaceutical compositions comprising the same; and methods of using such combinations and compositions in the treatment or prevention of a cancer or a tumor, in particular wherein the cancer or tumor is KRAS G12C mutated.

Abstract: Techniques are provided for operating a magnetic resonance tomography unit. The operation includes determining a B0 field map, determining an excitation of the nuclear spins that is to be achieved, and determining a spectrally selective, generic excitation pulse for transmission by the transmitter via the antenna in dependence upon the B0 field map. The generic excitation pulse is designed to generate the excitation of the nuclear spins that is to be achieved in the patient except for local differences. The operation also comprises determining a spectrally selective, dynamic excitation pulse for transmission by the transmitter via the antenna in dependence upon the B0 field map. The excitation pulse is designed so as to compensate the local differences and thus to generate the excitation of the nuclear spins that is to be achieved in the patient, and outputting the excitation pulse via the antenna.

Abstract: A magnetic resonance tomography (MRT) unit includes a field magnet, a transmitter, and a transmitting antenna. The MRT unit also has a transmission interference suppression facility with a transmission interference suppression controller, a plurality of sensors, and a transmission interference suppression antenna. The transmission interference suppression facility is configured to pick up, with the sensors, an excitation signal of the transmitter, determine, with the transmission interference suppression controller, a transmission interference suppression signal as a function of the excitation signal of the transmitter, and emit the signal via the transmission interference suppression antenna, so that at a predetermined location outside of the MRT unit, an electromagnetic alternating field of an excitation signal emitted by the transmitter via the transmitting antenna is attenuated.

Abstract: In accordance with a method for operating an MRT system a first MR recording is performed so as to map an object to generate first MR data that represents the object. The first MR recording is performed in accordance with a first k-space scanning scheme and during the first MR recording at least one first excitation pulse is transmitted. A second MR recording that is different from the first MR recording is performed to generate second MR data and a noise component is determined in dependence upon the second MR data by a computing unit and the noise component represents an influence of at least one external noise source. An MR image is generated by the computing unit in dependence upon the first MR data and in dependence upon the noise component.

Abstract: An imaging apparatus has an MRT system with an MR receiving antenna configured to receive a first receive signal containing an MR signal from an object to be examined during an examination period. The imaging apparatus includes a modality for examining the object and/or for acting on the object via mechanical or electromagnetic waves, wherein the modality has an electronic circuit. The imaging apparatus includes an auxiliary antenna arranged and configured to receive a second receive signal containing an interference signal generated by the electronic circuit during the examination period. The imaging apparatus has a processing system configured to suppress interference in the first receive signal based on the first and the second receive signal.

Abstract: Systems and Methods for determining a position of an object introduced into a body. An RF pilot tone is generated and is radiated into the body. Response signals modulated by the radiating into the body are received by a plurality of MRI receiver coils arranged spatially distributed outside the body and are converted into respective measurement signals. From the measurement signals, the position of the object is determined.

Abstract: A method for creating a roadmap for a medical workflow includes providing a multidimensional image-dataset including a plurality of images of a predefined organ combined with a number of state-dimensions characterizing a movement state of a moving organ. Measured pilot tone data is provided from a continuous pilot tone signal acquisition. A coordinate is determined for each state-dimension based on the measured pilot tone data, and an image of the multidimensional image-dataset is selected based on the number of determined coordinates of each state dimension.

Abstract: A magnetic resonance tomography system with a sensor for detecting spikes and with a gradient coil. Nuclear spins of an object under observation are excited by a magnetic alternating field of the magnetic resonance tomography system. A gradient field is generated by the magnetic resonance tomography system using the gradient coil. A magnetic resonance signal is acquired using a receiving antenna of the magnetic resonance tomography system and an interference signal using the sensor. From the magnetic resonance signal an image is reconstructed as a function of the acquired interference signal of the sensor.

Abstract: An MR sequence for an object is simulated by a computing unit in order to determine a simulation signal relating to a course of a transverse magnetization of nuclear spins. Depending on the simulation signal, a resting period of the MR sequence is determined during which an expected MR signal amplitude is always less than or equal to a predetermined limit value. An MR recording is carried out in accordance with the MR sequence, wherein an analysis signal is received in each case by a main receiving antenna and at least one auxiliary receiving antenna during an analysis period corresponding to the resting period and at least one interference suppression parameter is determined in dependence on the analysis signals. An MR signal is received by the main receiving antenna and an interference signal is received in each case by the at least one auxiliary receiving antenna.

Abstract: A magnetic resonance tomography scanner with a noise suppressor for suppressing interferences of reception and a method for operation of the magnetic resonance tomography scanner are provided. The noise suppressor receives an interference signal with a sensor, determines a noise suppression signal with a noise suppression controller, and sends the noise suppression signal using a controllable radio frequency amplifier via a transmit antenna, so that the interference signal on a receive antenna of the magnetic resonance tomography scanner is reduced.

Abstract: An instrument, a magnetic resonance tomography system and a method for detecting a relative position of the instrument in relation to the magnetic resonance tomography system. An encoded locator signal in a frequency range of the magnetic resonance tomography system is emitted by a transponder on the instrument, received by a plurality of sensors disposed on the magnetic resonance tomography system and a relative position of the transponder in relation to the sensors is determined by the locator signal detected by the sensors.

Abstract: Systema and methods to improve the suppression of interference fields outside a magnetic resonance tomography unit. A radiofrequency alternating electromagnetic field of the magnetic resonance tomography unit is generated and measured. A step series is repeated multiple times. The step series includes generating an electromagnetic interference-reduction field for reducing the magnetic field strength at at least one defined location on the basis of a product of a weighting factor and a defined interference-reduction field strength; measuring a magnetic field strength of the generated interference-reduction field; determining an adjustment factor for the weighting factor in such a way as to minimize a sum of the measured field strength of the alternating electromagnetic field and the product of the adjustment factor and the measured interference-reduction field strength; and updating the weighting factor by multiplying by the adjustment factor.

Abstract: According to one or more example embodiments, a computer-implemented method for at least partially suppressing a field emitted by a magnetic resonance device during an examination, the emitted field being at least one of an electric field or a magnetic field, the method comprises measuring a signature of the emitted field with a sensor facility; providing a trained function which is configured, based on a signature to generate a field information item relating to the emitted field upon which the respective signature is based; creating a field information item for the emitted field by inputting the signature into the trained function; and suppressing the emitted field by generating a counterfield with a transmitting facility based on the created field information item, the counterfield being at least one of an electric counterfield or a magnetic counterfield, wherein the counterfield is generated such that the counterfield least partially suppresses the emitted field.

Abstract: In order to improve fat saturation in magnetic resonance technology (MRT) methods, a method for spectral saturation that includes specifying or ascertaining a first resonance frequency of a first substance and a first saturation frequency for a second substance is provided. A saturation pulse that causes no saturation of the first substance at the first resonance frequency is generated. The saturation pulse has a first spectral peak for saturation of the second substance at the first saturation frequency and a second spectral peak at a second saturation frequency. This allows a widening of a spectral saturation bandwidth of a dynamic saturation.

Abstract: To operate a magnetic resonance tomography system, first analysis signals are received by a main receive antenna and an auxiliary receive antenna. Based thereon, a first interference source and first weighting factors are determined. Second analysis signals are received by the main receive antenna and the auxiliary receive antenna and in accordance with the first weighting factors, a combination of the second analysis signals is created. Based thereon, a second interference source is determined. Second weighting factors are determined in order to suppress the influence of the first interference source and an influence of the second interference source. A magnetic resonance signal is received during an examination phase by the main receive antenna and an interference signal by the auxiliary receive antenna. An interference-suppressed magnetic resonance signal is created as a combination of the magnetic resonance signal and the interference signals depending on the second weighting factors.

Abstract: A computer-implemented method is provided for at least partially suppressing an electromagnetic field emitted by a magnetic resonance device during an examination. The method includes measuring a signature of the emitted electromagnetic field using a sensor facility; providing a reference field profile, the reference field profile characterizing an electromagnetic reference field produced by the magnetic resonance device; adapting the reference field profile to the measured signature; and suppressing the emitted electromagnetic field based upon the adapted reference field profile.

Abstract: The invention refers to a single-chain circular permuted caspase-2 comprising the following structure from N- to C-terminus: i) a small subunit of a caspase-2, or a functionally active variant thereof; and ii) a large subunit of a caspase-2, or a functionally active variant thereof, wherein said cp caspase-2 comprises one or more amino acid substitutions increasing P1? tolerance of said cp caspase-2 compared to a cp caspase-2 without said amino acid substitutions.

Abstract: An imaging apparatus has an MRT system with an MR receiving antenna configured to receive a first receive signal containing an MR signal from an object to be examined during an examination period. The imaging apparatus includes a modality for examining the object and/or for acting on the object via mechanical or electromagnetic waves, wherein the modality has an electronic circuit. The imaging apparatus includes an auxiliary antenna arranged and configured to receive a second receive signal containing an interference signal generated by the electronic circuit during the examination period. The imaging apparatus has a processing system configured to suppress interference in the first receive signal based on the first and the second receive signal.

Abstract: A magnetic resonance tomography system has an interference suppression transmitter and an interference suppression antenna. The interference suppression transmitter is configured to output an interference suppression signal via the interference suppression antenna as a function of a transmission interference suppression parameter determined from a patient property. In a predetermined region of an environment of the magnetic resonance tomography system, a field strength of the excitation pulse is reduced by destructive interference.