Abstract: In a method for correction of a B0 field map measured with a magnetic resonance device, that describes deviations from a nominal field strength in the homogeneity area of the magnetic resonance device by deviations from a nominal frequency for protons bonded to water, the deviations being represented as Larmor frequency values for different picture elements shifted by chemical shifts, the B0 field map is recorded with spins of the fat and water protons not in phase. The B0 field map is segmented by evaluating the differences of the Larmor frequency values of adjacent picture elements of the B0 field map in at least two contiguous clusters. For each cluster, a decision is made on the basis of a smoothness criterion and a compactness criterion as to whether a cluster containing a majority of protons bonded into fat is involved.

Abstract: In a method and a control sequence determination device for determining a magnetic resonance system control sequence includes at least one radio-frequency pulse train to be emitted by a magnetic resonance system, a target magnetization is acquired and a k-space trajectory is determined. A radio-frequency pulse train for the k-space trajectory is then determined in an RF pulse optimization method using a target function, wherein the target function includes a combination of different trajectory curve functions, of which at least one trajectory curve function is based on a trajectory error model. A method for operating a magnetic resonance system uses such a control sequence and a magnetic resonance system has such a control sequence determination device.

Abstract: In a method to generate a spatially selective excitation in an imaging region of a magnetic resonance apparatus that precedes an acquisition of magnetic resonance data, in the course of the excitation an excitation trajectory in k-space is traversed, the excitation trajectory having a symmetry relative to the k-space center in at least one direction of k-space in the sense that a first traversed extreme value in this direction corresponds to the negative of the other extreme value traversed in this direction, so the excitation trajectory is shortened in the at least one directions on one side of the zero point between the extreme values, and the shortened excitation trajectory is used for excitation.

Abstract: A method for establishing a magnetic resonance system actuation sequence is described. A first number of field distribution maps are acquired for slices of the measurement region, and a radiofrequency pulse train is established on the basis thereof for the magnetic resonance system actuation sequence. This acquisition of the first number of field distribution maps may be brought about on the basis of an acquisition scheme. A reduced number of field distribution representation maps are established on the basis of the acquired field distribution maps, which field distribution representation maps represent the first number of acquired field distribution maps in accordance with a predetermined optimization criterion, and the radiofrequency pulse train is established on the basis of the field distribution representation maps.

Abstract: Disclosed is a method for producing a recombinant protein of interest which is characterised by the following steps: (a) providing a first part of an Npro autoprotease and providing a second part of an Npro autoprotease, wherein said second part is fused by a peptidic bond to a protein of interest but said second part alone does not exhibit a proteolytic activity, and wherein complementation of said first part with the second part forms an autoproteolytically active Npro autoprotease, (b) contacting the first part of the Npro autoprotease with the second part of the Npro autoprotease so that an autoproteolytically active Npro autoprotease is formed and the protein of interest fused by the peptidic bond to the second part of the Npro autoprotease is proteolytically cleaved off the second part of the Npro autoprotease at the peptidic bond, and (c) recovering the protein of interest.

Abstract: Disclosed is a method for producing a recombinant protein of interest, the method being characterised in by the following steps: (a) providing a fusion protein comprising an Npro autoprotease moiety and a protein of interest moiety in inclusion bodies, (b) solubilising the inclusion bodies, (c) allowing the fusion protein to be cleaved by the Npro autoprotease moiety under chaotropic conditions, wherein the recombinant protein of interest is cleaved from the fusion protein and wherein the recombinant protein of interest is not yet renatured or simultaneously renatured, and (d) recovering the protein of interest, optionally including a renaturing step for the protein of interest.

Abstract: A balanced web analytics scorecard comprises perspectives, objectives and measures based on web analytics. The balanced web analytics scorecard comprises at least one perspective relating to web-based activities of an organization, such as a traffic generation perspective, a visitor engagement perspective, a growth and innovation perspective or an e-commerce perspective. The web analytics are based on user interactions with a website. Scores for web analytic-based measures are calculated based on the web analytics, and scores for objectives associated with web analytic-based measures are based on measure scores. Updated balanced web analytics scorecards can be stored on computer-readable media or presented at a display of a computing device.

Abstract: A method and a control sequence determination device for the determination of a magnetic resonance system activation sequence including at least one high-frequency pulse sequence to be transmitted by a magnetic resonance system are provided. A current B0 map and optionally a target magnetization are acquired. In addition, a k-space trajectory type is determined. An error density is calculated in a k-space based on the current B0 map and optionally based on the target magnetization using an analytic function. This analytic function defines an error density in the k-space as a function of the current B0 map and optionally the target magnetization. Taking account of the error density in the k-space, a k-space trajectory of the specified k-space trajectory type is determined. The high-frequency pulse sequence is determined for the k-space trajectory in an HF pulse optimization process.

Abstract: In method and a control sequence determination device to determine a magnetic resonance system control sequence that includes at least one radio-frequency pulse train to be emitted by a magnetic resonance system, a target magnetization (m) is initially detected, and an energy distribution function in k-space is determined on the basis of the target magnetization. A k-space trajectory is then determined under consideration of the energy distribution function in k-space, for which the radio-frequency pulse train is then determined in an RF pulse optimization method. The method is suitable for operation of a magnetic resonance system, and a magnetic resonance system includes such a control sequence determination device.

Abstract: An electromagnetic linear actuator has a frame (stator) and an armature each at least partially formed of soft magnetic material. The armature can be moved relative to the frame along a longitudinal axis, they form a gap therebetween in an open position and lie against each other in a closed position with the gap closed. A first armature coil is connected to the armature so that a force acting on the first armature coil is transferred to the armature. An excitation magnetic field is generated and guided at least partially by the frame and the armature and acts with a force on the first armature coil when current flows through the first armature coil, to close the gap. The frame, the armature, and the excitation magnetic field are configured so that a retaining force takes effect when the gap between the frame and the armature is closed.

Abstract: An embodiment relates to the increased expression of polypeptides in eukaryotic cells. A method for increased production is described using an expression vector comprising a polynucleotide encoding a desired polypeptide and a G quartet like motif sequence.

Abstract: Method for the production of indexable inserts, which exhibits the following: Deposition of a layer of cutting tip material forming the indexable inserts (40) by means of a PVD method on a dissolvable profiled substrate (10), and—dissolving of the substrate to produce the form of free-standing parts as indexable inserts.

Abstract: The present invention relates to a method of treating and/or preventing Alzheimer's disease and/or other tauopathies.

Abstract: The present invention relates to a method of preventing or treating a disease correlated with or caused by non-physiologically increased intracellular levels of the catalytic subunit of microtubule-associated protein phosphatase 2A (PP2Ac) comprising administering to a subject affected by said disease or in danger of developing said disease a pharmaceutically effective amount of a protein selected from the group of MID1 or MID2 or a nucleic acid encoding said protein.

Abstract: An adapter for a handpiece system , especially for use in conjunction with medical and dental light emitting apparatus for the transmission of light to cure photo-polymerisable materials. A device, preferably in the form of an adapter, enables the user to correctly match the polarity of the contacts in the supply hose or conduit with those of the light emitting apparatus.

Abstract: A medical handle comprises a drive unit and a control device or circuit for driving a medical tool. The control device or circuit comprises a control and/or regulating circuit for controlling and/or regulating the drive unit, the drive unit comprises at least one magnetic element and a sensor system for determining the alignment of the at least one magnetic element. To achieve simpler assembly and a greater resistance to the ambient conditions that prevail during sterilization in comparison with known handles, the sensor system and the control and/or regulating circuit are combined in a joint control module, and the at least one magnetic element is arranged in the medical handle in such a way that at least a part of the control module can be positioned in the immediate vicinity of the at least one magnetic element and that the sensor system is arranged in the control module in such a way that it can be positioned in the immediate vicinity of the at least one magnetic element.

Abstract: The present invention relates to a method of preventing or treating a disease correlated with or caused by non-physiologically increased intracellular levels of the catalytic subunit of microtubule-associated protein phosphatase 2A (PP2Ac) comprising administering to a subject affected by said disease or in danger of developing said disease a pharmaceutically effective amount of a protein selected from the group of MID1 or MID2 or a nucleic acid encoding said protein.

Abstract: A printing and/or varnishing machine having a plurality of sheet-guiding cylinders in which at least one of the cylinders has an outer detachable packing which has enhanced ink repellent characteristics and which significantly reduces wear. The packing has a layered structure which includes a flexible backing material 12, the underside of which is assigned to the base body of the sheet-guiding cylinder 3, a coating 13 of molybdenum or tungsten carbide/cobalt which is adhesively applied to the upper side of the backing material 12, and a sealing layer 14 of a material made from the group of polysiloxanes which is adhesively applied to the upper side of the coating 13. The side of the packings 5, 6 which faces the material to be printed has a surface profile consisting of cones 18 with rounded tips 16 for reduced sheet contact.

Abstract: A printing and/or varnishing machine having a plurality of sheet-guiding cylinders in which at least one of the cylinders has an outer detachable packing which has enhanced ink repellent characteristics and which significantly reduces wear. The packing has a layered structure which includes a flexible backing material 12, the underside of which is assigned to the base body of the sheet-guiding cylinder 3, a coating 13 of molybdenum or tungsten carbide/cobalt which is adhesively applied to the upper side of the backing material 12, and a sealing layer 14 of a material made from the group of polysiloxanes which is adhesively applied to the upper side of the coating 13. The side of the packings 5, 6 which faces the material to be printed has a surface profile consisting of cones 18 with rounded tips 16 for reduced sheet contact.

Abstract: An adapter for a handpiece system , especially for use in conjunction with medical and dental light emitting apparatus for the transmission of light to cure photo-polymerisable materials. A device, preferably in the form of an adapter, enables the user to correctly match the polarity of the contacts in the supply hose or conduit with those of the light emitting apparatus.