Patents by Inventor Rajesh A. Khanna
Rajesh A. Khanna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240129264Abstract: Techniques for managing digital messages to and from a proxy message address are disclosed. A system receives a message directed to a particular destination address. The system replaces any source address included in the message with a proxy address. When the system receives a reply to the message, the reply is directed to the proxy address. The system analyzes message data to identify a target address for the reply message. The system identifies contextual data associated with the reply message. The system transmits the reply message, and the contextual data, to the target address.Type: ApplicationFiled: April 12, 2023Publication date: April 18, 2024Applicant: Oracle International CorporationInventors: Nagaraj Nadendla, Karthik Kothandaraman, Rajesh Choudary Gudiputi, Advitya Khanna
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Publication number: 20240129269Abstract: Techniques for managing digital messages to and from a shared mailbox are disclosed. A system receives a message directed to a shared mailbox. The system analyzes contextual data in the message to identify a set of users with access to the shared mailbox who are recipients of the message. The system performs notification operations to notify different users with access to the shared mailbox of different messages. Notification operations include sending a notification to a particular communications platform, such as email, instant message, or text, that a message in the shared mailbox is associated with the recipient, tagging the message in the shared mailbox with names of recipients associated with the message, and/or categorizing the messages in the shared mailbox according to users.Type: ApplicationFiled: May 5, 2023Publication date: April 18, 2024Applicant: Oracle International CorporationInventors: Nagaraj Nadendla, Karthik Kothandaraman, Rajesh Choudary Gudiputi, Advitya Khanna
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Patent number: 11883403Abstract: The present invention relates to a tablet comprising Afatinib or a pharmaceutically acceptable salt thereof, wherein the tablet is obtained by direct compression. The present invention further relates to a process for manufacturing a tablet of the invention as well as the use of the tablet of the invention.Type: GrantFiled: March 22, 2022Date of Patent: January 30, 2024Assignee: Fresenius Kabi Oncology Ltd.Inventors: Rajesh Khanna, Neeraj Kumar, Vijay Kumar Sharma, Ankit Gaur, Dhiraj Khattar
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Patent number: 11877356Abstract: Systems, methods and computer software are disclosed for providing a bubble network are described. In one embodiment, a method is disclosed including providing an isolated base station having a coverage area, providing a local HetNet Gateway (HNG) disposed within the coverage area and in communication with the isolated base station, providing a local Evolved Packet Core (EPC) in communication with the local HNG and disposed within the coverage area, and wherein the bubble network is disconnected from a mobile operator core network.Type: GrantFiled: July 26, 2022Date of Patent: January 16, 2024Assignee: Parallel Wireless, Inc.Inventors: Rajesh Khanna, Patrick McPhee, Gaurav Kumar
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Publication number: 20240002361Abstract: Disclosed are compositions and methods for treating, preventing, or reducing neuropathic pain or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a patient. The compositions contain, or the methods involve, compounds that inhibit neuropilin receptor 1 signaling. The compounds are present in amounts effective to treat, prevent, or reduce one or more symptoms associated with neuropathic pain or SARS-CoV-2 in a patient.Type: ApplicationFiled: November 17, 2021Publication date: January 4, 2024Inventors: Rajesh Khanna, Aubin Moutal, Samantha Perez-Miller
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Publication number: 20230365544Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a piperazine or piperidine structure which function as either inhibitors of pan-T-type calcium channel activity (e.g., CaV3.1 voltage gated calcium channel activity) (e.g., CaV3.2 voltage gated calcium channel activity) (e.g., CaV3.3 voltage gated calcium channel activity) (e.g., depolarization-induced calcium influx) or specific inhibitors of CaV3.2 voltage gated calcium channel activity, and their use as therapeutics for the treatment and/or prevention of pan-T-type calcium channel related pain (e.g., CaV3.1 related pain) (e.g., CaV3.2 related pain) (e.g., CaV3.3 related pain) (e.g., HIV-associated peripheral sensory neuropathy, chemotherapy-induced peripheral neuropathy (CIPN), spinal nerve ligation (SNL) induced neuropathy) (e.g., tonic, neuropathic, and/or inflammatory pain) and related conditions.Type: ApplicationFiled: December 20, 2022Publication date: November 16, 2023Inventors: Jun Wang, Rajesh Khanna
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Publication number: 20230363902Abstract: An implantable prosthetic valve includes a radially collapsible and expandable annular frame having three commissure attachment portions and at least three rows of angled struts. The rows include a first row, a second row downstream of the first row, and a third row downstream of the second row. Each row of struts includes angled struts arranged in a zig-zag pattern defining a plurality of crowns. A leaflet structure includes three leaflets forming three commissures, each commissure being connected to one of the commissure attachment portions via sutures extending through apertures in the commissure attachment portions, wherein all of the apertures are located along the length of the frame between a first plane defined by the crowns of the second row of struts and a second plane defined by the crowns of the third row of struts.Type: ApplicationFiled: July 18, 2023Publication date: November 16, 2023Inventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh A. Khanna, Son V. Nguyen, Tamir S. Levi, Itai Pelled
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Publication number: 20230277310Abstract: An implantable prosthetic valve includes a radially collapsible and expandable annular frame having three commissure attachment portions and at least three rows of angled struts. The rows include a first row, a second row downstream of the first row, and a third row downstream of the second row. Each row of struts includes angled struts arranged in a zig-zag pattern defining a plurality of crowns. A leaflet structure includes three leaflets forming three commissures, each commissure being connected to one of the commissure attachment portions via sutures extending through apertures in the commissure attachment portions, wherein all of the apertures are located along the length of the frame between a first plane defined by the crowns of the second row of struts and a second plane defined by the crowns of the third row of struts.Type: ApplicationFiled: May 11, 2023Publication date: September 7, 2023Inventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh A. Khanna, Son V. Nguyen, Tamir S. Levi, Itai Pelled
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Patent number: 11744701Abstract: A prosthetic heart valve comprises a radially collapsible and expandable annular frame and a leaflet structure comprising three leaflets. Each leaflet has an upper edge portion, a curved lower edge portion and two side flaps, wherein each side flap is connected to an adjacent side flap of another leaflet to form commissures of the leaflet structure, with each commissure being attached to the frame. An annular inner sleeve comprises three U-shaped portions positioned along the curved lower edge portions of the leaflets. An annular outer sleeve extends around are outer surface of the frame, wherein the outer sleeve is made of pericardium. The frame is made of Nitinol and the prosthetic valve can be radially crimped to a radially collapsed configuration inside a sheath for delivery into a patient's body and self-expand to a radially expanded configuration when released from the sheath inside the patient's body.Type: GrantFiled: September 11, 2020Date of Patent: September 5, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh A. Khanna, Son V. Nguyen, Tamir S. Levi, Itai Pelled
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Publication number: 20230233544Abstract: Dysregulation of TAF1 function by various mechanisms can lead to disease in the central nervous system, such as the TAF1 Intellectual Disability (ID) Syndrome which currently has no therapeutic treatments. The present invention indicates that a novel T-type calcium channel enhancer, such as SAK3, has disease-modifying effects in animal models of TAF1 editing. In addition, the present invention provides insights into the molecular mechanism by which SAK3 exerts in pharmacologic effects. Moreover, the present findings imply that the T-Type voltage-gated calcium channels are novel molecular targets to develop therapeutics to treat TAF1 ID syndrome and that SAK3 is an attractive drug candidate to treat TAF1 associated neurologic disorders.Type: ApplicationFiled: June 11, 2021Publication date: July 27, 2023Inventors: Mark A. Nelson, Rajesh Khanna, Janakiraman Udaiyappan, Dhanalakshmi Shankara Raman
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Patent number: 11696826Abstract: An implantable prosthetic valve includes a radially collapsible and expandable annular frame having three commissure attachment posts and four rows of circumferential struts. The rows include a first row, a second row downstream of the first row, a third row downstream of the second row, and a fourth row downstream of the third row and defining an outflow end of the frame. Each row of circumferential struts includes angled struts arranged in a zig-zag pattern. A leaflet structure includes three leaflets forming three commissures, each commissure being connected to one of the commissure attachment posts only at locations along the commissure attachment posts between a first plane that is perpendicular to a longitudinal axis of the frame and intersects crowns of the third row of struts and a second plane that is perpendicular to the longitudinal axis and intersects crowns of the fourth row of struts.Type: GrantFiled: March 25, 2022Date of Patent: July 11, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh A. Khanna, Son V. Nguyen, Tamir S. Levi, Itai Pelled
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Publication number: 20230192674Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a piperazine or piperidine structure which function as inhibitors of the CaV3.2 voltage gated calcium channel activity (e.g., depolarization-induced calcium influx), and their use as therapeutics for the treatment and/or prevention of CaV3.2 related pain e g., HIV-associated peripheral sensory neuropathy, chemotherapy-induced peripheral neuropathy (CIPN), spinal nerve ligation (SNL) induced neuropathy) and related conditions.Type: ApplicationFiled: May 12, 2021Publication date: June 22, 2023Inventors: Jun Wang, Rajesh Khanna
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Publication number: 20230165677Abstract: An implantable prosthetic valve includes a radially collapsible and expandable annular frame having three commissure attachment posts and four rows of circumferential struts. The rows include a first row, a second row downstream of the first row, a third row downstream of the second row, and a fourth row downstream of the third row and defining an outflow end of the frame. Each row of circumferential struts includes angled struts arranged in a zig-zag pattern. A leaflet structure includes three leaflets forming three commissures, each commissure being connected to one of the commissure attachment posts only at locations along the commissure attachment posts between a first plane that is perpendicular to a longitudinal axis of the frame and intersects crowns of the third row of struts and a second plane that is perpendicular to the longitudinal axis and intersects crowns of the fourth row of struts.Type: ApplicationFiled: August 19, 2022Publication date: June 1, 2023Inventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh A. Khanna, Son V. Nguyen, Tamir S. Levi, Itai Pelled
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Patent number: 11648111Abstract: An implantable prosthetic valve includes a radially collapsible and expandable annular frame having three commissure attachment posts and four rows of circumferential struts. The rows include a first row, a second row downstream of the first row, a third row downstream of the second row, and a fourth row downstream of the third row and defining an outflow end of the frame. Each row of circumferential struts includes angled struts arranged in a zig-zag pattern. A leaflet structure includes three leaflets forming three commissures, each commissure being connected to one of the commissure attachment posts only at locations along the commissure attachment posts between a first plane that is perpendicular to a longitudinal axis of the frame and intersects crowns of the third row of struts and a second plane that is perpendicular to the longitudinal axis and intersects crowns of the fourth row of struts.Type: GrantFiled: December 21, 2021Date of Patent: May 16, 2023Assignee: Edwards Lifesciences CorporationInventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh A. Khanna, Son V. Nguyen, Tamir S. Levi, Itai Pelled
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Patent number: 11607557Abstract: Devices and systems for treating based on light therapy are disclosed. One example device includes an eyewear configured for placement in front of an eye to allow light to reach the eye, and one or more filters having transmission spectra within a range that approximately spans 450 to 570 nm associated with blue or green light. The one or more filters is configured to block light spectra outside of said range and to allow the blue or green light to reach the eye for administering light therapy to a subject exhibiting pain.Type: GrantFiled: October 30, 2020Date of Patent: March 21, 2023Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONAInventors: Mohab M. Ibrahim, Rajesh Khanna
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Patent number: 11502394Abstract: A communications backpack is disclosed. In one embodiment, the communications backpack includes a backpack; a Radio Area Network (RAN) device in mechanical communication with the backpack; a mini-server in mechanical communication with the backpack and in electrical communication with the RAN device; at least one hot swappable battery in mechanical communication with the backpack and in electrical communication with the RAN device and the mini-server; at least two antennas, wherein the two antennas are stored in a first position alongside the backpack and are movable to a second position where the two antennas are coupled to the backpack and in electrical communication with the RAN device; and wherein the communications backpack provides a coverage area of up to 3 kilometers (km).Type: GrantFiled: December 17, 2019Date of Patent: November 15, 2022Assignee: Parallel Wireless, Inc.Inventors: Jason Tiner, Rajesh Khanna, Patrick McPhee
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Publication number: 20220361290Abstract: Systems, methods and computer software are disclosed for providing a bubble network are described. In one embodiment, a method is disclosed including providing an isolated base station having a coverage area, providing a local HetNet Gateway (HNG) disposed within the coverage area and in communication with the isolated base station, providing a local Evolved Packet Core (EPC) in communication with the local HNG and disposed within the coverage area, and wherein the bubble network is disconnected from a mobile operator core network.Type: ApplicationFiled: July 26, 2022Publication date: November 10, 2022Inventors: Rajesh Khanna, Patrick McPhee, Gaurav Kumar
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Patent number: 11399414Abstract: Systems, methods and computer software are disclosed for providing a bubble network are described. In one embodiment, a method is disclosed including providing an isolated base station having a coverage area, providing a local HetNet Gateway (HNG) disposed within the coverage area and in communication with the isolated base station, providing a local Evolved Packet Core (EPC) in communication with the local HNG and disposed within the coverage area, and wherein the bubble network is disconnected from a mobile operator core network.Type: GrantFiled: April 8, 2020Date of Patent: July 26, 2022Assignee: Parallel Wireless, Inc.Inventors: Rajesh Khanna, Patrick McPhee, Gaurav Kumar
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Publication number: 20220211705Abstract: The present invention relates to a tablet comprising Afatinib or a pharmaceutically acceptable salt thereof, wherein the tablet is obtained by direct compression. The present invention further relates to a process for manufacturing a tablet of the invention as well as the use of the tablet of the invention.Type: ApplicationFiled: March 22, 2022Publication date: July 7, 2022Applicant: FRESENIUS KABI ONCOLOGY LIMITEDInventors: Rajesh KHANNA, Neeraj KUMAR, Vijay Kumar SHARMA, Ankit GAUR, Dhiraj KHATTAR
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Publication number: 20220211495Abstract: An implantable prosthetic valve includes a radially collapsible and expandable annular frame having three commissure attachment posts and four rows of circumferential struts. The rows include a first row, a second row downstream of the first row, a third row downstream of the second row, and a fourth row downstream of the third row and defining an outflow end of the frame. Each row of circumferential struts includes angled struts arranged in a zig-zag pattern. A leaflet structure includes three leaflets forming three commissures, each commissure being connected to one of the commissure attachment posts only at locations along the commissure attachment posts between a first plane that is perpendicular to a longitudinal axis of the frame and intersects crowns of the third row of struts and a second plane that is perpendicular to the longitudinal axis and intersects crowns of the fourth row of struts.Type: ApplicationFiled: March 25, 2022Publication date: July 7, 2022Applicant: Edwards Lifesciences CorporationInventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh A. Khanna, Son V. Nguyen, Tamir S. Levi, Itai Pelled