Patents by Inventor Rajesh A. Khanna
Rajesh A. Khanna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140378407Abstract: The present invention relates to a process of preparing a stable pharmaceutical composition of compounds which are susceptible to hydrolysis comprising a. Addition of required quantity of pharmaceutically acceptable lyophilization excipients optionally in Water for Injection in a formulation vessel; b. Addition of organic solvent to form a appropriate proportion of aqueous and organic solvent; c. Maintaining the temperature of the formulation vessel from the range ?5±1° C. to ?5±3° C.; d. Addition of required quantity of compound susceptible to hydrolysis to form a solution and lyophilizing the solution.Type: ApplicationFiled: March 29, 2012Publication date: December 25, 2014Applicant: Fresenius Kabi Oncology LimitedInventors: Dhiraj Khattar, Rajesh Khanna, Sanjay Motwani, Minakshi Garg, Vikas Chandel, Mukti Yadav, Vijay Kumar Kyama, Vikas Bhandari
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Publication number: 20130325098Abstract: A minimally invasive catheter system and method for extraction of a shape memory device such as a nitinol stent, from inside a tubular organ, is provided. The catheter system comprises a multi-lumen tube with at least one expandable balloon and an extraction device. The multi-lumen tube has multiple ports, which are used for injecting fluid inside the tubular organ and the expandable balloon, and inserting the extraction device. The catheter system is inserted inside the lumen of the tubular organ percutaneously. A cold fluid is injected into the expandable balloon and the lumen of the tubular organ. This cold fluid converts the shape memory device from an expanded state to a collapsed state. The shape memory device in the collapsed state is then removed with the help of the extraction device.Type: ApplicationFiled: May 20, 2013Publication date: December 5, 2013Applicant: Edwards Lifesciences CorporationInventors: Pranav Desai, Rajesh Khanna
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Publication number: 20130210698Abstract: N-type voltage-gated calcium channels (CaV2.2) are critical mediators of neurotransmitter release and are thought to be involved with transmission of nociception. The use of conventional CaV2.2 blockers in pain therapeutics is limited by side effects. Reported herein is a means to suppress both inflammatory and neuropathic pain without directly blocking CaV2.2, but rather by inhibiting the binding of the axonal collapsin response mediator protein 2 (CRMP-2), a protein known to enhance CaV2.2 function. A 15 amino acid peptide of CRMP-2 fused to the protein transduction domain of the HIV tat protein (TAT CBD3) reduced meningeal blood flow induced by activation of the trigeminovascular system, prevented inflammation-induced tactile hypernociception induced by intraplantar formalin and nocifensive behavior following corneal capsaicin application, and reversed neuropathic hypernociception produced by the antiretroviral drug 2?,3?-dideoxycytidine. Preventing CRMP-2—mediated enhancement of CaV2.Type: ApplicationFiled: June 10, 2011Publication date: August 15, 2013Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATIONInventor: Rajesh Khanna
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Patent number: 8454685Abstract: An implantable prosthetic valve, according to one embodiment, comprises a frame, a leaflet structure, and a skirt member. The frame can have a plurality of axial struts interconnected by a plurality of circumferential struts. The leaflet structure comprises a plurality of leaflets (e.g., three leaflets arrange to form a tricuspid valve). The leaflet structure has a scalloped lower edge portion secured to the frame. The skirt member can be disposed between the leaflet structure and the frame.Type: GrantFiled: June 23, 2011Date of Patent: June 4, 2013Assignee: Edwards Lifesciences CorporationInventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh Khanna, Son Nguyen, Tamir Levi, Itai Pelled
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Publication number: 20120290078Abstract: A heart valve delivery system is provided wherein a prosthetic valve is carried on a valve catheter inside a tubular delivery sleeve. The valve catheter has a distal end coupled to a mop. The mop comprises a plurality of flexible extensions configured for releasable attachment to the prosthetic valve. A lead screw nut is coupled to a proximal end of the tubular delivery sleeve and a lead screw is coupled to the valve catheter. The lead screw engages the lead screw nut and rotation of the lead screw causes the delivery sleeve to retract relative to the valve catheter and the prosthetic valve for exposing the prosthetic valve. The flexible extensions of the mop allow expansion of the valve while maintaining the attachment during placement of the valve at a native valve site.Type: ApplicationFiled: April 17, 2012Publication date: November 15, 2012Applicant: EDWARDS LIFESCIENCES CORPORATIONInventors: Henry Bourang, Thanh Huy Le, David M. Taylor, Sam Sok, Mario Iobbi, Rajesh Khanna, Dave J. Evans
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Patent number: 8167932Abstract: A heart valve delivery system is provided wherein a prosthetic valve is carried on a valve catheter inside a delivery sleeve. A step balloon protrudes from the delivery sleeve and provides a tapered surface for facilitating advancement through a body vessel. The step balloon also aids in crossing the leaflets of a native valve. After the prosthetic valve is positioned within the native valve, the delivery sleeve is retracted to expose the prosthetic valve. In one embodiment, the delivery sleeve is retracted by the use of a lead screw, which effectuates relative movement between the valve catheter and delivery sleeve. The prosthetic valve is preferably self-expandable. If necessary, the step balloon may be expanded to securely seat the prosthetic valve at the site of the native valve.Type: GrantFiled: October 18, 2005Date of Patent: May 1, 2012Assignee: Edwards Lifesciences CorporationInventors: Henry Bourang, Thanh Huy Le, David M. Taylor, Sam Sok, Mario Iobbi, Rajesh Khanna, Dave J. Evans
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Publication number: 20110319991Abstract: An implantable prosthetic valve, according to one embodiment, comprises a frame, a leaflet structure, and a skirt member. The frame can have a plurality of axial struts interconnected by a plurality of circumferential struts. The leaflet structure comprises a plurality of leaflets (e.g., three leaflets arrange to form a tricuspid valve). The leaflet structure has a scalloped lower edge portion secured to the frame. The skirt member can be disposed between the leaflet structure and the frame.Type: ApplicationFiled: June 23, 2011Publication date: December 29, 2011Applicant: Edwards Lifesciences CorporationInventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh Khanna, Son Nguyen, Tamir Levi, Itai Pelled
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Publication number: 20110301189Abstract: A stable pharmaceutical compositions of Rapamycin Esters, in particular Rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid that is free of antioxidants and a process of preparing the same.Type: ApplicationFiled: June 2, 2011Publication date: December 8, 2011Applicant: FRESENIUS KABI ONCOLOGY LTD.Inventors: Dhiraj Khattar, Rajesh Khanna, Poonam Singla, Abhilasha Yadav, Vinay Gupta, Rajesh Kini, Sushil Kumar Dubey
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Patent number: 7993394Abstract: An implantable prosthetic valve, according to one embodiment, comprises a frame, a leaflet structure, and a skirt member. The frame can have a plurality of axial struts interconnected by a plurality of circumferential struts. The leaflet structure comprises a plurality of leaflets (e.g., three leaflets arrange to form a tricuspid valve). The leaflet structure has a scalloped lower edge portion secured to the frame. The skirt member can be disposed between the leaflet structure and the frame.Type: GrantFiled: June 8, 2009Date of Patent: August 9, 2011Inventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh Khanna, Son Nguyen, Tamir Levi, Itai Pelled
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Publication number: 20100036484Abstract: An implantable prosthetic valve, according to one embodiment, comprises a frame, a leaflet structure, and a skirt member. The frame can have a plurality of axial struts interconnected by a plurality of circumferential struts. The leaflet structure comprises a plurality of leaflets (e.g., three leaflets arrange to form a tricuspid valve). The leaflet structure has a scalloped lower edge portion secured to the frame. The skirt member can be disposed between the leaflet structure and the frame.Type: ApplicationFiled: June 8, 2009Publication date: February 11, 2010Inventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhoh, Rajesh Khanna, Son V. Nguyen, Tamir Levi, Itai Pelled
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Patent number: 7622979Abstract: A timing-constrained circuit (e.g., a self-timed circuit) of optimal performance is achieved by allowing the delay of the circuit to be changed dynamically as a function of operating conditions (e.g., operating voltages or temperatures). The delay of timing signals in the timing-constrained circuit for a given operating condition may be selected to have the minimum margin for that operating condition among the available delays to maximize performance over the entire dynamic range of operating conditions.Type: GrantFiled: October 31, 2007Date of Patent: November 24, 2009Assignee: Sun Microsytems, Inc.Inventors: Ajay Bhatia, Rajesh Khanna
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Publication number: 20090157161Abstract: A minimally invasive catheter system and method for extraction of a shape memory device such as a nitinol stent from inside a tubular organ, is provided. The catheter system comprises a multi-lumen tube with at least one expandable balloon and an extraction device. The multi-lumen tube has multiple ports, which are used for injecting fluid inside the tubular organ and the expandable balloon, and inserting the extraction device. The catheter system is inserted inside the lumen of the tubular organ percutaneously. A cold fluid is injected into the expandable balloon and the lumen of the tubular organ. This cold fluid converts the shape memory device from an expanded state to a collapsed state. The shape memory device in the collapsed state is then removed with the help of the extraction device.Type: ApplicationFiled: October 15, 2008Publication date: June 18, 2009Applicant: Edwards Lifesciences CorporationInventors: Pranav Desai, Rajesh Khanna
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Publication number: 20090108899Abstract: A timing-constrained circuit (e.g., a self-timed circuit) of optimal performance is achieved by allowing the delay of the circuit to be changed dynamically as a function of operating conditions (e.g., operating voltages or temperatures). The delay of timing signals in the timing-constrained circuit for a given operating condition may be selected to have the minimum margin for that operating condition among the available delays to maximize performance over the entire dynamic range of operating conditions.Type: ApplicationFiled: October 31, 2007Publication date: April 30, 2009Inventors: Ajay Bhatia, Rajesh Khanna
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Publication number: 20080021546Abstract: A system and method for deploying balloon-expandable (i.e., plastically-expandable) prosthetic heart valves so that they assumed their desired operational shape. The system includes a balloon that accommodates non-uniform expansion resistance in the heart valve to expanded to its desired tubular or other shape. The heart valve may have substantially more structural elements adjacent one end, typically the inflow end, and the balloon is tapered so as to expand the inflow end before the outflow so that the valve ends up in a tubular shape. Alternatively, a stepped balloon with a larger diameter proximal section adjacent the inflow end of the valve may be used. A method includes applying a non-linear expansion forced to the interior of a plastically-expandable prosthetic heart valve to overcome areas of greater resistance to expansion and result in uniform expansion.Type: ApplicationFiled: July 18, 2006Publication date: January 24, 2008Inventors: Tim Patz, Marlowe Patterson, Rajesh Khanna, Jackie Lau, Mike Zhu, Hsingching Crystal Hsu
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Publication number: 20070239254Abstract: A valve-retrieval device permits a non-deployed valve mounted on a balloon catheter to be retracted back into an introducer sheath for removal from a patient's body. In particular embodiments, the valve-retrieval device is adapted to be placed on a balloon catheter shaft and then advanced over the shaft into the blood vessel via the introducer sheath. The valve-retrieval device has an expandable distal end portion that assumes an expanded shape when advanced out of the introducer sheath. The valve is positioned within or adjacent the distal end portion of the retrieval device, and the retrieval device and the balloon catheter are retracted together back into the introducer sheath. The distal end portion of the retrieval device, rather than the outer surface portion of the valve covered thereby, contacts the distal end and inner surface of the introducer sheath to facilitate retraction of the valve into the introducer sheath.Type: ApplicationFiled: April 7, 2006Publication date: October 11, 2007Inventors: Chris Chia, Rajesh Khanna, Philippe Marchand, David Taylor
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Publication number: 20070088431Abstract: A heart valve delivery system is provided wherein a prosthetic valve is carried on a valve catheter inside a delivery sleeve. A step balloon protrudes from the delivery sleeve and provides a tapered surface for facilitating advancement through a body vessel. The step balloon also aids in crossing the leaflets of a native valve. After the prosthetic valve is positioned within the native valve, the delivery sleeve is retracted to expose the prosthetic valve. In one embodiment, the delivery sleeve is retracted by the use of a lead screw, which effectuates relative movement between the valve catheter and delivery sleeve. The prosthetic valve is preferably self-expandable. If necessary, the step balloon may be expanded to securely seat the prosthetic valve at the site of the native valve.Type: ApplicationFiled: October 18, 2005Publication date: April 19, 2007Inventors: Henry Bourang, Thanh Le, David Taylor, Sam Sok, Mario Iobbi, Rajesh Khanna, Dave Evans
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Patent number: 7141064Abstract: A process and system for compressing bioprosthetic tissue for use in medical implants. The process involves placing the tissue between two compressive surfaces and applying a force to reduce any nonuniformity of thickness in the tissue, while at the same time reduce the overall thickness. One particularly useful application is the compression of bioprosthetic sheet during the preparation of heart valve leaflets. Bovine pericardium may be compressed to reduce its thickness by about 50%, and then formed into heart valve leaflets. The thinned leaflets have substantially the same absolute strength as those made from uncompressed tissue, and are particular desirable for use in minimally invasive valves which must be compressed into a small profile. The thin tissue enables a reduction in the overall size of the minimally invasive heart valve for delivery. For instance, rolled MIS valves may be reduced in size to as small as 20 mm in diameter.Type: GrantFiled: May 8, 2002Date of Patent: November 28, 2006Assignee: Edwards Lifesciences CorporationInventors: Michael J. Scott, Rajesh A. Khanna
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Publication number: 20030212454Abstract: A process and system for compressing bioprosthetic tissue for use in medical implants. The process involves placing the tissue between two compressive surfaces and applying a force to reduce any nonuniformity of thickness in the tissue, while at the same time reduce the overall thickness. One particularly useful application is the compression of bioprosthetic sheet during the preparation of heart valve leaflets. Bovine pericardium may be compressed to reduce its thickness by about 50%, and then formed into heart valve leaflets. The thinned leaflets have substantially the same absolute strength as those made from uncompressed tissue, and are particular desirable for use in minimally invasive valves which must be compressed into a small profile. The thin tissue enables a reduction in the overall size of the minimally invasive heart valve for delivery. For instance, rolled MIS valves may be reduced in size to as small as 20 mm in diameter.Type: ApplicationFiled: May 8, 2002Publication date: November 13, 2003Inventors: Michael J. Scott, Rajesh A. Khanna
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Patent number: 6427226Abstract: Tools and techniques used in conjunction with integrated circuit path timing information can selectively reduce the channel length of transistors in cells associated with the most critical paths in an integrated circuit, while keeping the overall integrated circuit design within a specified power budget. Moreover, by targeting pins of cells (and thus their associated transistors) that are used by multiple paths, and/or that offer the greatest potential speed improvement, timing violations along critical paths can be reduced or eliminated with a relatively few number of replacements. Paths within a certain timing violation range are selected for analysis. The pins within those paths are ranked by pin criticality, which can depend on, for example, the number of times a particular pin occurs in any path, the timing enhancement associated with replacing a cell having that pin, and the impact of replacing a cell having that pin would have on the power budget.Type: GrantFiled: May 25, 1999Date of Patent: July 30, 2002Assignee: Advanced Micro Devices, Inc.Inventors: Dhiraj Mallick, Jacob Thomas, Rajesh Khanna, Anil L. Pandya, Satish Kumar Raj
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Patent number: 6081136Abstract: A NOR gate pair includes a first and second NOR gate, each with a plurality of inputs and an output. A first NAND gate has a first input coupled to the output of the first NOR gate, a second input coupled to the output of the second NOR gate through a first input inverter, and an output. A second NAND gate has a first input coupled to the output of the second NOR gate, a second input coupled to the output of the first NOR gate through a second input inverter, and an output. A first output inverter is coupled to the output of the first NAND gate and a second output inverter is coupled to the output of the second NAND gate. This configuration assures that NOR gates used in a one-hot-decode decoder will all have logic-low outputs during a precharge phase.Type: GrantFiled: December 19, 1997Date of Patent: June 27, 2000Assignee: Advanced Micro Devices, Inc.Inventors: Rajesh Khanna, Hamid Partovi