Abstract: A system, method, and machine-readable storage medium for restoring a data object for a specified active time period are provided. In some embodiments, the method includes receiving, by a storage device from a client, a request specifying an active time period for a data object to remain stored on an accessible tier. The method also includes determining, by the storage device, that the active time period has elapsed. The method further includes responsive to a determination that the active time period has elapsed, sending, by the storage device, a request to a server storing the data object to move the data object from the accessible tier to an archive tier. Data objects that are stored on the accessible tier are accessible by the client, and data objects that are stored on the archive tier are inaccessible by the client.

Abstract: The method includes providing a filler material that is water insoluble, the providing provides the filler material with more than 98% alpha-cellulose, 0.01% to less than 2% ash and a remainder hemicellulose, infusing at least one first consumable within the filler material and inserting a matrix within at least one first containing structure to form a capsule, the matrix including the filler material.

Abstract: A system, method, and machine-readable storage medium for analyzing a state of a data object are provided. In some embodiments, the method includes receiving, at a storage device, a metadata request for the data object from a client. The data object is composed of a plurality of segments. The method also includes selecting a subset of the plurality of segments and obtaining a segment state for each segment of the subset. Each segment state indicates whether the respective segment is accessible via a backing store. The method further includes determining a most restrictive state of the one or more segment states and sending state information to the client in response to the metadata request, the state information being derived from the most restrictive state.

Abstract: An end effector drive mechanism has first and second pulleys and first and second jaws configured as a torque-amplifying tool assemblies. Each pulley jaw pair is configured as kinematic assembly having a compact footprint that can amplify outputs to increase the grip force applied by the jaws. The end effector drive mechanism is within a pulley envelope defined by the first and second pulleys. In certain configurations, the tool assemblies are configured to produce a grip force independent from a push-pull force that is exerted on (or by) the jaws. In certain configurations, the tool assemblies are configured to prevent undesirable reverse rotations and limit the range of travel of the jaws (or pulleys).

Abstract: The present invention relates to cell-based assays involving HER2. The assays use assay cells that are transfected with cassettes containing the HER2 gene of interest and measure the effect of mutations on the activity of HER2, and on their response to inhibitors.

Abstract: A system, method, and machine-readable storage medium for restoring a data object for a specified active time period are provided. In some embodiments, the method includes receiving, by a storage device from a client, a request specifying an active time period for a data object to remain stored on an accessible tier. The method also includes determining, by the storage device, that the active time period has elapsed. The method further includes responsive to a determination that the active time period has elapsed, sending, by the storage device, a request to a server storing the data object to move the data object from the accessible tier to an archive tier. Data objects that are stored on the accessible tier are accessible by the client, and data objects that are stored on the archive tier are inaccessible by the client.

Abstract: A printed circuit board (PCB) device including one or more insulating layers and one or more conducting layers arranged to form a layer stack; and one or more blind holes disposed along a side edge of the layer stack and parallel to a plane of the layer stack. Each of the one or more blind holes along the side edge of the layer stack is configured to receive a pin. Each pin can make an electrical connection with a corresponding blind hole.

Abstract: A system, method, and machine-readable storage medium for restoring a data object for a specified active time period are provided. In some embodiments, the method includes receiving, by a storage device from a client, a request specifying an active time period for a data object to remain stored on an accessible tier. The method also includes determining, by the storage device, that the active time period has elapsed. The method further includes responsive to a determination that the active time period has elapsed, sending, by the storage device, a request to a server storing the data object to move the data object from the accessible tier to an archive tier. Data objects that are stored on the accessible tier are accessible by the client, and data objects that are stored on the archive tier are inaccessible by the client.

Abstract: A bath screen for mounting on a rim of a bathtub includes a fixed part and a movable panel attached to the fixed part by one or more hinges. The bath screen also includes a channel member disposed at or near a lower corner or edge of the fixed part or the movable panel and extending beneath the one or more hinges, the channel member being arranged to collect water falling from above and to divert the collected water inboard of the one or more hinges.

Abstract: The present invention relates to cell-based assays involving HER2. The assays use assay cells that are transfected with cassettes containing the HER2 gene of interest and measure the effect of mutations on the activity of HER2, and on their response to inhibitors.

Abstract: A system, method, and machine-readable storage medium for analyzing a state of a data object are provided. In some embodiments, the method includes receiving, at a storage device, a metadata request for the data object from a client. The data object is composed of a plurality of segments. The method also includes selecting a subset of the plurality of segments and obtaining a segment state for each segment of the subset. Each segment state indicates whether the respective segment is accessible via a backing store. The method further includes determining a most restrictive state of the one or more segment states and sending state information to the client in response to the metadata request, the state information being derived from the most restrictive state.

Abstract: A multifunctional knife holder is disclosed, which includes a falling prevention base, a knife holder body, a top cover and a locking bar. The knife holder body is of a cylinder structure with an opening at a top thereof and with a cavity inside. A plurality of partition plates are provided inside the knife holder body, are vertically arranged at intervals and divide the cavity into a plurality of sub-chambers. The top cover is connected with the top of the knife holder body and provided with a plurality of through slots communicated with the sub-chambers. A tension spring is provided on an inner wall of the knife holder body. The locking bar is connected with a plurality of magnetic pressing plates arranged at intervals along a length direction of the locking bar. The locking bar is disposed through the plurality of partition plates and abuts against the tension spring.

Abstract: A system, method, and machine-readable storage medium for analyzing a state of a data object are provided. In some embodiments, the method includes receiving, at a storage device, a metadata request for the data object from a client. The data object is composed of a plurality of segments. The method also includes selecting a subset of the plurality of segments and obtaining a segment state for each segment of the subset. Each segment state indicates whether the respective segment is accessible via a backing store. The method further includes determining a most restrictive state of the one or more segment states and sending state information to the client in response to the metadata request, the state information being derived from the most restrictive state.

Abstract: A dispenser for dispensing a flowable product from a container has a pump module mounted on the container at an opening thereof. The pump module includes a pump body, which defines a pump chamber and a pump chamber inlet for product to flow from the container interior into the pump chamber. A pump actuator is operable in a pumping stroke relative to the pump body to vary the volume of the pump chamber and dispense the product. The pump includes a movable body portion which is operable in a displacement stroke into the container. The movable portion has a displacement body with a product-engaging face directed onto an interior product space of the container upstream of the pump chamber inlet, to assist priming. Below this a disrupter member, a grid of narrow bars, projects to penetrate the product.

Abstract: A system, method, and machine-readable storage medium for restoring a data object for a specified active time period are provided. In some embodiments, the method includes receiving, by a storage device from a client, a request specifying an active time period for a data object to remain stored on an accessible tier. The method also includes determining, by the storage device, that the active time period has elapsed. The method further includes responsive to a determination that the active time period has elapsed, sending, by the storage device, a request to a server storing the data object to move the data object from the accessible tier to an archive tier. Data objects that are stored on the accessible tier are accessible by the client, and data objects that are stored on the archive tier are inaccessible by the client.

Abstract: A bath screen for mounting on a rim of a bathtub includes a fixed part and a movable panel attached to the fixed part by one or more hinges. The bath screen also includes a channel member disposed at or near a lower corner or edge of the fixed part or the movable panel and extending beneath the one or more hinges, the channel member being arranged to collect water falling from above and to divert the collected water inboard of the one or more hinges.

Abstract: A printed circuit board (PCB) device including one or more insulating layers and one or more conducting layers arranged to form a layer stack; and one or more blind holes disposed along a side edge of the layer stack and parallel to a plane of the layer stack. Each of the one or more blind holes along the side edge of the layer stack is configured to receive a pin. Each pin can make an electrical connection with a corresponding blind hole.

Abstract: A printed circuit board (PCB) device including one or more insulating layers and one or more conducting layers arranged to form a layer stack; and one or more blind holes disposed along a side edge of the layer stack and parallel to a plane of the layer stack. Each of the one or more blind holes along the side edge of the layer stack is configured to receive a pin. Each pin can make an electrical connection with a corresponding blind hole.

Abstract: A system, method, and machine-readable storage medium for analyzing a state of a data object are provided. In some embodiments, the method includes receiving, at a storage device, a metadata request for the data object from a client. The data object is composed of a plurality of segments. The method also includes selecting a subset of the plurality of segments and obtaining a segment state for each segment of the subset. Each segment state indicates whether the respective segment is accessible via a backing store. The method further includes determining a most restrictive state of the one or more segment states and sending state information to the client in response to the metadata request, the state information being derived from the most restrictive state.

Abstract: The present invention relates to novel linear and cyclic polypeptides that bind to IL-23 receptor and inhibit the binding of IL-23 to its corresponding receptor and cell signaling thereof. The novel polypeptides of the present invention has a core structure of WX1X2X3W, where W is tryptophan, and X1, X2 and X3 are amino acids, with the proviso that when one of X1, X2 or X3 is W, the remaining two of X1, X2 or X3 cannot be W. Preferred core structures include WVDYW or WQDYW. The present invention relates a composition containing the novel polypeptides (linear or cyclic), and use of same in inhibiting cell functions including production of IL-22 and IL-17F from immune cells as well as in treating IL-23 associated human diseases including, for example, inflammatory bowel diseases, psoriasis and Crohn's disease, ulcerative colitis and multiple sclerosis.