Abstract: There is disclosed the cloning and identification of human IL-23R splice variants caused by alternative splicing of the IL-23R mRNA in human. Alternative mRNA forms occur through skipping one, multiple full exons or partial exons, within the IL-23R gene. A total of twenty-five (25) different IL-23R transcripts were identified. A novel exon deletion (exon 9) isoform in the interleukin 23 receptor is disclosed, denoted as ?9. The present application also describes a quantitative assay to measure different IL-23R isoform. Detection of ?9 isoform of IL-23R is predominantly present in colon and cervical tissues. A decrease in ?9 is observed in inflamed colon tissues in Crohn's patients. There is disclosed a method of predicting Crohn's disease by measuring ?9 isoform of IL-23R.

Abstract: There is disclosed the cloning and identification of human IL-23R splice variants caused by alternative splicing of the IL-23R mRNA in human. Alternative mRNA forms occur through skipping one, multiple full exons or partial exons, within the IL-23R gene. A total of twenty-five (25) different IL-23R transcripts were identified. A novel exon deletion (exon 9) isoform in the interleukin 23 receptor is disclosed, denoted as ?9. The present application also describes a quantitative assay to measure different IL-23R isoform. Detection of ?9 isoform of IL-23R is predominantly present in colon and cervical tissues. A decrease in ?9 is observed in inflamed colon tissues in Crohn's patients. There is disclosed a method of predicting Crohn's disease by measuring ?9 isoform of IL-23R.

Abstract: A naturally-occurring soluble truncated IL-23R? protein (i.e., ?9 IL-23R?) is shown to be present in a biological sample and can serve as a diagnostic tool for autoimmune diseases. There is provided an enzyme-linked immunosorbent assay (ELISA) and test kit for the serological detection of the soluble truncated form of IL-23R? protein. More particularly, antibody-sandwich ELISA method and kits for ?9 IL-23R? as an antigen were developed to detect ?9 IL-23R? levels in biological samples from a mammal and a human patient and are used as a diagnostic index. The present disclosed ELISA has utility as a diagnostic tool to detect Crohn's disease in patients using EDTA-plasma.

Abstract: There is disclosed the cloning and identification of human IL-23R splice variants caused by alternative splicing of the IL-23R mRNA in human. Alternative mRNA forms occur through skipping one, multiple full exons or partial exons, within the IL-23R gene. A total of twenty-five (25) different IL-23R transcripts were identified. A novel exon deletion (exon 9) isoform in the interleukin 23 receptor is disclosed, denoted as ?9. The present application also describes a quantitative assay to measure different IL-23R isoform. Detection of ?9 isoform of IL-23R is predominantly present in colon and cervical tissues. A decrease in ?9 is observed in inflamed colon tissues in Crohn's patients. There is disclosed a method of predicting Crohn's disease by measuring ?9 isoform of IL-23R.

Abstract: The present invention relates to an isolated naturally-occurring soluble truncated IL-23R? protein, which is a translated protein resulting from a mRNA splice variant of IL-23R?. The soluble IL-23R? proteins (e.g., ?9 and ?8,9) represents a novel soluble IL-23R? protein, which is lacking a transmembrane domain and has a unique eight (8) amino acids (GLKEGSYC) at its C-terminus end (due to frame-shift). ELISA reveals that ?9 is present in blood and can serve as a diagnostic tool for auto-immune diseases including Crohn's disease. There is also provided a method of recombinant production for this soluble truncated form of IL-23R? protein. More importantly, the present invention provides an utility application of the ?9 and ?8,9 protein in inhibit IL-23R-mediated cell signaling. More particularly, ?9 and ?8,9 blocks STAT3 formation as well as Th17 maturation. There is provided a therapeutic application of ?9 and ?8,9 in treating a human patient inflicted with Crohn's disease.

Abstract: There is disclosed the cloning and identification of human IL-23R splice variants caused by alternative splicing of the IL-23R mRNA in human. Alternative mRNA forms occur through skipping one, multiple full exons or partial exons, within the IL-23R gene. A total of twenty-five (25) different IL-23R transcripts were identified. A novel exon deletion (exon 9) isoform in the interleukin 23 receptor is disclosed, denoted as ?9. The present application also describes a quantitative assay to measure different IL-23R isoform. Detection of ?9 isoform of IL-23R is predominantly present in colon and cervical tissues. A decrease in ?9 is observed in inflamed colon tissues in Crohn's patients. There is disclosed a method of predicting Crohn's disease by measuring ?9 isoform of IL-23R.

Abstract: A novel lofted fiber or pile-type of fabric such as fleece, and an improved method of weaving the same. The improved lofted fiber or pile-type of fabric includes an underlying fabric substrate, a plurality of lofted fibers coupled into one portion of the underlying fabric substrate, and a different portion of the underlying fabric substrate adjacent to the portion having the plurality of lofted fibers that is substantially devoid of all lofted fibers.

Abstract: A device comprises a manipulandum moveable in at least two degrees of freedom including a first link rotatably moveable about a pivot axis and a second link rotatably moveable about a pivot axis. The first link and the second link are coupled to a ground member. A first actuator is configured to engage the first link and provide an output about a drive axis of the first actuator. A second actuator is configured to engage the second link and provide an output about a drive axis of the second actuator. The drive axis of the first actuator is substantially parallel to the drive axis of the second actuator. The first actuator and the second actuator are each configured to receive a signal associated with a force feedback. The force feedback being associated with the manipulandum.

Abstract: Systems and methods for providing a haptic manipulandum are described. In one described system, a lever arm is pivotably coupled to a housing, and configured to apply a processor-controlled force to a substantially-spherical manipulandum to provide a haptic effect. The described system may include a processor in communication with an actuator for providing the haptic effect.

Abstract: Systems and methods for providing a haptic manipulandum are described. In one described system, a lever arm is pivotably coupled to a housing, and configured to apply a processor-controlled force to a substantially-spherical manipulandum to provide a haptic effect. The described system may include a processor in communication with an actuator for providing the haptic effect.

Abstract: Systems and methods for providing a haptic manipulandum are described. In one described system, a lever arm is pivotably coupled to a housing, and configured to apply a processor-controlled force to a substantially-spherical manipulandum to provide a haptic effect. The described system may include a processor in communication with an actuator for providing the haptic effect.

Abstract: A device comprises a manipulandum moveable in at least two degrees of freedom including a first link rotatably moveable about a pivot axis and a second link rotatably moveable about a pivot axis. The first link and the second link are coupled to a ground member. A first actuator is configured to engage the first link and provide an output about a drive axis of the first actuator. A second actuator is configured to engage the second link and provide an output about a drive axis of the second actuator. The drive axis of the first actuator is substantially parallel to the drive axis of the second actuator. The first actuator and the second actuator are each configured to receive a signal associated with a force feedback. The force feedback being associated with the manipulandum.

Abstract: Systems and methods for providing resistive and vibrotactile feedback from a single actuator are described. One described system comprises a manipulandum, and a resistive haptic actuator configured to generate a resistive haptic force in order to generate a vibrotactile haptic effect.

Abstract: A device comprises a manipulandum moveable in at least two degrees of freedom including a first link rotatably moveable about a pivot axis and a second link rotatably moveable about a pivot axis. The first link and the second link are coupled to a ground member. A first actuator is configured to engage the first link and provide an output about a drive axis of the first actuator. A second actuator is configured to engage the second link and provide an output about a drive axis of the second actuator. The drive axis of the first actuator is substantially parallel to the drive axis of the second actuator. The first actuator and the second actuator are each configured to receive a signal associated with a force feedback. The force feedback being associated with the manipulandum.

Abstract: Systems and methods for providing resistive and vibrotactile feedback from a single actuator are described. One described system comprises a manipulandum, and a resistive haptic actuator configured to generate a resistive haptic force in order to generate a vibrotactile haptic effect.

Abstract: Systems and methods for providing a haptic manipulandum are described. In one described system, a lever arm is pivotably coupled to a housing, and configured to apply a processor-controlled force to a substantially-spherical manipulandum to provide a haptic effect. The described system may include a processor in communication with an actuator for providing the haptic effect.

Abstract: A sensor apparatus and electrode configuration within the sensor apparatus for measuring electrical characteristics of an aqueous fibrous composition. The electrode configuration includes an elongated ground electrode and at least one segmented electrode to form an array of measurement electrode cells. The electrode configuration further includes an array of reference electrode cells formed by a plurality of reference electrodes built into the array of measurement electrode cells. The measurement electrode cells and reference electrode cells have a different sensitivity to water weight of the aqueous fibrous composition and the same sensitivity to conductivity of the aqueous fibrous composition. The measurement apparatus obtains simultaneous resistive measurements from both measurement and reference cells and determines the ratio of the measurements such that the affects from conductivity is canceled out of the measurement ratio.

Abstract: A method and apparatus for performing multiple frame image compression and decompression of motion video data are provided. In one embodiment, a plurality of sequential frames in a motion video sequence are collected and digitally filtered as a single image. At least some of the results of the digital filtering are then encoded to generate compressed data. In another embodiment, a plurality of sequential frames are filtered as if the boundary of each frame is adjacent to a boundary in the same spatial location of another of the plurality of sequential frames.

Abstract: A sensor apparatus and electrode configuration within the sensor apparatus for measuring electrical characteristics of an aqueous fibrous composition. The electrode configuration includes an elongated ground electrode and at least one segmented electrode to form an array of measurement electrode cells. The electrode configuration further includes an array of reference electrode cells formed by a plurality of reference electrodes built into the array of measurement electrode cells. The measurement electrode cells and reference electrode cells have a different sensitivity to water weight of the aqueous fibrous composition and the same sensitivity to conductivity of the aqueous fibrous composition. The measurement apparatus obtains simultaneous resistive measurements from both measurement and reference cells and determines the ratio of the measurements such that the affects from conductivity is canceled out of the measurement ratio.

Abstract: Methods are provided for significantly reducing electron trapping in semiconductor devices having a floating gate and an overlying dielectric layer. The methods form a nitrogen-rich region within the floating gate near the interface to an overlying dielectric layer. The methods include selectively introducing nitrogen into the floating gate prior to forming the overlying dielectric layer. This forms an initial nitrogen concentration profile within the floating gate. An initial portion of the overlying dielectric layer is then formed of a high temperature oxide (HTO). The temperature within the floating gate is purposely raised to an adequately high temperature to cause the initial nitrogen concentration profile to change due to the migration of the majority of the nitrogen towards the interface with the overlying dielectric layer and an interface with an underlying layer.