Abstract: A system for medication delivery comprises a package containing a medication and a dosing device for delivering a dose of the medication, formulated as a multiparticulate, microspheres, a powder or a liquid. The package comprises a bottle, a bottle insert that covers a bottle opening and includes a dispense nozzle. The dispense nozzle is sealed using a valve that opens when the dosing device is engaged with the bottle. A closure covers the bottle insert and closes the bottle. The dosing device, similar to an oral syringe, comprises a barrel with a valve at a distal end of the barrel, a plunger and a dose control clip for attachment to the plunger. After the dosing device is connected to, the valve of the dispense nozzle, withdrawal of the plunger causes the dosing device to receive the dose of the medication, a user pushes the plunger which pushes the medication through the valve of the barrel and into a patient's mouth.

Abstract: The subject invention provides a drug delivery device for injecting medicament which includes a tubular reservoir; a stopper slidably disposed in the reservoir; a spring for moving the stopper in the reservoir; at least one needle, the needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end, the lumen being in direct or indirect communication with the reservoir; a needle driver for displacing the needle; and an actuator. Activation of the actuator causes the spring to move the stopper and the needle driver to displace the needle. The needle moves relative to, and separately from, the reservoir with the needle being displaced. Advantageously, with the subject invention, a drug delivery device is provided wherein a needle is moved, relative to the reservoir, in being displaced for injection. This permits control of the needle displacement separate from the reservoir.

Abstract: A system includes an access cannula, a deployment cannula having a plurality of engagement arms, and a containment bag. The deployment cannula is slidable within the access cannula between an initial condition, wherein the engagement arms are retained in a contracted configuration, and a deployed condition, wherein the engagement arms are disposed in an expanded configuration. The containment bag includes an open end portion configured to receive the first elongated tubular member and the second elongated tubular member. In the initial condition, a portion of the containment bag towards the open end portion is positioned adjacent at least one of the first elongated tubular member or the second elongated tubular member. In the deployed condition, the portion of the containment bag is expanded such that the portion of the containment bag is spaced-apart from the at least one of the first elongated tubular member or the second elongated tubular member.

Abstract: An arterial blood module (16) that is removably connectable to an arterial blood collection element (14) is disclosed. The arterial blood module includes a housing (30), a needle (32), a cap (34) removably securable over the needle, a mixing chamber (36), and a safety shield (38) engaged with a portion of the housing and transitionable from a first shield position in which a portion of the needle is exposed to a second shield position in which the needle is shielded by a portion of the safety shield. In one embodiment, the present disclosure includes an arterial blood collection system (10) that includes an arterial blood collection element (14) defining a collection chamber (20) and an arterial blood module (16) removably connectable to a portion of the arterial blood collection element.

Abstract: The disclosure provides driver components, systems and drive methods that facilitate improved dose setting, correcting, and/or dispensing in a multiple use pen-type injection device. In particular, various novel braking systems are disclosed that can be implemented within pen-type injection devices to achieve such improvements.

Abstract: An actuating device having integrated plunger is configured to be removably mounted to an automatic mixing device for a syringe. The actuating device includes lower and upper housings, a trigger member, a lockout ring, a mixing biasing member, a delivery plunger, a plunger biasing member, and a mixing plunger. The mixing plunger is releasably engaged with the trigger member in an initially locked state and engageable with at least one seal of the mixing device. The trigger member is operable to initiate decompression of the mixing biasing member and engagement of the mixing plunger with the at least one seal of the mixing device. The delivery plunger may also be activated to expand from a first, collapsed configuration to a second, expanded configuration by actuation of the trigger member.

Abstract: A system includes an access cannula, a deployment cannula having a plurality of engagement arms, and a containment bag. The deployment cannula is slidable within the access cannula between an initial condition, wherein the engagement arms are retained in a contracted configuration, and a deployed condition, wherein the engagement arms are disposed in an expanded configuration. The containment bag includes an open end portion configured to receive the first elongated tubular member and the second elongated tubular member. In the initial condition, a portion of the containment bag towards the open end portion is positioned adjacent at least one of the first elongated tubular member or the second elongated tubular member. In the deployed condition, the portion of the containment bag is expanded such that the portion of the containment bag is spaced-apart from the at least one of the first elongated tubular member or the second elongated tubular member.

Abstract: The subject invention provides a drug delivery device for injecting medicament which includes a tubular reservoir; a stopper slidably disposed in the reservoir; a spring for moving the stopper in the reservoir; at least one needle, the needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end, the lumen being in direct or indirect communication with the reservoir; a needle driver for displacing the needle; and an actuator. Activation of the actuator causes the spring to move the stopper and the needle driver to displace the needle. The needle moves relative to, and separately from, the reservoir with the needle being displaced. Advantageously, with the subject invention, a drug delivery device is provided wherein a needle is moved, relative to the reservoir, in being displaced for injection. This permits control of the needle displacement separate from the reservoir.

Abstract: A system including an adapter for sequential engagement with a cartridge containing a first substance and a vial containing a second substance is disclosed. The adapter is configured to first engage with the vial and subsequently engage with the cartridge such that the cartridge is in fluid communication with the vial via the adapter. The system includes a latch member engageable with a portion of the cartridge. A plunger rod includes a protrusion and is adapted to communicate with the latch member, the plunger rod being transitionable from a disengaged position, in which the protrusion of the plunger rod is disengaged from the latch member and the latch member is locked to the cartridge, to an engaged position, in which the protrusion is engaged with the latch member and the latch member is unlocked from the cartridge and locked to the plunger rod.

Abstract: A medication injection pen comprises a dose set knob rotatable with respect to a housing to set a desired injection dose. The dose set knob comprises at least one internal thread. A leadscrew includes a thread element for advancing in a first direction via a corresponding thread engagement. A driver is rotationally fixed to the leadscrew and is rotatable in a first direction to rotate and advance the leadscrew in the first direction. The setback member is rotationally fixed to the driver. The dose stop member is rotationally coupled to the setback member and is axially movable relative to the dose set knob when the dose set knob is rotated relative to the setback member. Axial movement of the dose stop member limits the user from setting a dose that is greater than an injectable volume of medication remaining in a cartridge.

Abstract: A medication injection method where a dose set knob of a medication injection pen is rotated with respect to the housing of the medication injection pen during dose setting and dose correcting, a driver is selectively engages with the dose set knob, the driver being rotatably fixed with respect to the housing during dose setting and dose correcting, the driver is moved axially with the dose set knob during the dose setting and the dose correcting, and the driver is rotated with the dose set knob during an injection.

Abstract: A system including an adapter for sequential engagement with a cartridge containing a first substance and a vial containing a second substance is disclosed. The adapter is configured to first engage with the vial and subsequently engage with the cartridge such that the cartridge is in fluid communication with the vial via the adapter. The system includes a latch member engageable with a portion of the cartridge. A plunger rod includes a protrusion and is adapted to communicate with the latch member, the plunger rod being transitionable from a disengaged position, in which the protrusion of the plunger rod is disengaged from the latch member and the latch member is locked to the cartridge, to an engaged position, in which the protrusion is engaged with the latch member and the latch member is unlocked from the cartridge and locked to the plunger rod.

Abstract: A drive assembly for a drug delivery system includes a plunger member configured to engage and move a stopper within a container, with the plunger member having a first position and a second position axially spaced from the first position, a leadscrew configured to move the plunger member from the first position to the second position, and a biasing member configured to bias the leadscrew in a rotational direction, where rotational movement of the leadscrew is configured to move the plunger member from the first position to the second position.

Abstract: A removal device (121, 221) for removing and disposing of a pen needle (113, 213) connectable to a drug delivery device (111, 211) includes a body (123, 223) having a cavity (141, 241) for receiving the pen needle of the drug delivery device such that a patient end (116, 216) of a needle (115, 215) of the pen needle is covered by the body. An ejector (151, 251) is movably connected to the body (123, 223) for engaging the received pen needle (113, 213) and selectively ejecting the engaged pen needle from the body. The pen needle (113, 213) is securely retained within the removal device (121, 221) without exposing the needle (115, 215) of the pen needle until the pen needle (113, 213) can be properly disposed of, such as in a sharps container, thereby substantially preventing an accidental needle stick.

Abstract: Methods of securely dispensing a substance to an intended user are provided. In some instances, a method of securely dispensing a substance to an intended user includes moving a valve of a locking cap fixedly secured to a housing containing the substance to an open state that allows the substance to be dispensed from the housing to the intended user; determining that a unique biometric attribute of the intended user is detected; and dispensing the substance from the housing to the intended user in response to determining that the unique biometric attribute of the intended user is detected.

Abstract: A medication injection pen, comprising a housing, a dose set knob that rotates with respect to the housing during dose setting and dose correcting, and a driver selectively engaged with the dose set knob, the driver rotatably fixed with respect to the housing during dose setting and dose correcting, wherein the driver moves axially with the dose set knob during dose setting and dose correcting, and the driver rotates with the dose set knob during an injection.

Abstract: The subject invention provides a drug delivery device for injecting medicament which includes a tubular reservoir; a stopper slidably disposed in the reservoir; a spring for moving the stopper in the reservoir; at least one needle, the needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end, the lumen being in direct or indirect communication with the reservoir; a needle driver for displacing the needle; and an actuator. Activation of the actuator causes the spring to move the stopper and the needle driver to displace the needle. The needle moves relative to, and separately from, the reservoir with the needle being displaced. Advantageously, with the subject invention, a drug delivery device is provided wherein a needle is moved, relative to the reservoir, in being displaced for injection. This permits control of the needle displacement separate from the reservoir.

Abstract: A drive assembly for a drug delivery system includes a plunger member configured to engage and move a stopper within a container, with the plunger member having a first position and a second position axially spaced from the first position, a leadscrew configured to move the plunger member from the first position to the second position, and a biasing member configured to bias the leadscrew in a rotational direction, where rotational movement of the leadscrew is configured to move the plunger member from the first position to the second position.

Abstract: A medication injection pen, including a housing, a dose set knob (DSK) comprising an internal key, and a dose stop member engaging the dose set knob. Rotation of the dose set knob to set a medication dose causes rotation of the dose stop member with respect to the dose set knob, and when the dose set knob is rotated to a last dose setting position, the dose stop member rotationally abuts the internal key thereby preventing further rotational movement of the dose set knob in a dose setting direction.

Abstract: A self-injection device (100, 200), including a pen body (108, 208) connectable to a pen needle (10), and a cap (104, 204) selectively connectable to the pen body (108, 208) in a first orientation with respect to the pen body (108, 208) to minimize the length or volume of the self injection device (100, 200), and in a second orientation to provide sufficient length or volume in an interior of the cap (104, 204) to house a pen needle (10) connected to the pen body (108, 208).