Abstract: A method of transferring information stored in a mobile instrument, the information including a first information file (140) containing metadata and a pointer indicative of a first auxiliary file address; and a first auxiliary file (141) containing image information, the first auxiliary file being located at the first auxiliary file address. The method includes the steps of: storing the metadata in a second information file (140?); storing the image information in a second auxiliary file (142?) at a second auxiliary file address; generating a second pointer indicative of the second auxiliary file address; and storing the second pointer in the second information file. The instrument includes a camera (70); one or more spatial sensors; and an external sensor port (56). Power to the sensors can be controlled asynchronously. Various parsing methods are also described. The instrument includes a marker module configured to superimpose a marker on the image.

Abstract: The use of ?-adrenergic inverse agonists provides a new and highly efficient way of treating a number of pulmonary airway diseases, including asthma, emphysema, and chronic obstructive pulmonary diseases. In general, such a method comprises administering a therapeutically effective amount of a ?-adrenergic inverse agonist to the subject to treat the pulmonary airway disease. Particularly preferred inverse agonists include nadolol and carvedilol. In addition, methods are described for long-term administration of such inverse agonists and for determining the suitability of patients for long-term inverse agonist therapy.

Abstract: A method of transferring information stored in a mobile instrument, the information including a first information file containing metadata and a pointer indicative of a first auxiliary file address; and first auxiliary file containing image information, the first auxiliary file being located at the first auxiliary file address. The method includes the steps of: storing the metadata in a second information file; storing the image information in a second auxiliary file at a second auxiliary file address; generating a second pointer indicative of the second auxiliary file address; and storing the second pointer in the second information file. The instrument includes a camera; one or more spatial sensors; and an external sensor port. Power to the sensors can be controlled asynchronously. Various parsing methods are also described. The instrument includes a marker module configured to superimpose a marker on the image.

Abstract: Methods for administering beta-adrenergic inverse agonists with improved pharmacokinetic profiles for the treatment of pulmonary airway diseases are disclosed. The beta adrenergic inverse agonists are formulated in a controlled-release formulation comprising: (1) a beta-adrenergic inverse agonist in a therapeutically effective quantity; and (2) at least one agent that controls release of the beta-adrenergic inverse agonist resulting in a pharmacokinetic profile that minimizes acute detrimental reduction in airway function with the first dose and with each successive dose. This pharmacokinetic profile typically results in slow release of the drug into the bloodstream resulting in a large average Tmax>4 hours. The controlled-release formulation may consist of multilayered matrix or erosional tablets, gastric-retention tablets, osmotic pump oral formulations, multiparticulate capsules or tablets or dermal patch.

Abstract: The use of ?-adrenergic inverse agonists provides a new and highly efficient way of treating a number of pulmonary airway diseases, including asthma, emphysema, and chronic obstructive pulmonary diseases. In general, such a method involves administering a therapeutically effective amount of a ?-adrenergic inverse agonist to the subject to treat the pulmonary airway disease. Particularly preferred inverse agonists include nadolol and carvedilol. In addition, methods are described for long-tern administration of such inverse agonists and for determining the suitability of patients for long-term inverse agonist therapy.

Abstract: A method of transferring information stored in a mobile instrument, the information including a first information file (140) containing metadata and a pointer indicative of a first auxiliary file address; and a first auxiliary file (141) containing image information, the first auxiliary file being located at the first auxiliary file address. The method includes the steps of: storing the metadata in a second information file (140?); storing the image information in a second auxiliary file (142?) at a second auxiliary file address; generating a second pointer indicative of the second auxiliary file address; and storing the second pointer in the second information file. The instrument includes a camera (70); one or more spatial sensors; and an external sensor port (56). Power to the sensors can be controlled asynchronously. Various parsing methods are also described. The instrument includes a marker module configured to superimpose a marker on the image.

Abstract: The use of ?-adrenergic inverse agonists provides a new and highly efficient way of treating a number of pulmonary airway diseases, including asthma, emphysema, and chronic obstructive pulmonary diseases. In general, such a method comprises administering a therapeutically effective amount of a ?-adrenergic inverse agonist to the subject to treat the pulmonary airway disease. Particularly preferred inverse agonists include nadolol and carvedilol.

Abstract: The present invention describes a method for treating a disease or condition associated with the activity of a G protein coupled receptor (GPCR) comprising administering an inverse agonist for the GPCR, alone or in combination with an agonist for the GPCR, to an organism with a disease or condition associated with the activity of the GPCR in a quantity and for a period that causes an increase in the population of spontaneously active GPCRs associated with that physiological function, thereby producing a therapeutic effect to ameliorate the disease or condition. This provides a basis for so-called “paradoxical pharmacology.” These methods can be used to treat pulmonary airway diseases, including asthma and chronic allergic rhinitis, among other diseases and conditions, including obesity. The present invention further describes a screening method for screening a compound for inverse agonist activity to a GPCR.

Abstract: The present invention is an elastic seal for use with a sanitary probe. The elastic seal forms a layer between the probing member and the coating member to eliminate the formation of voids between the two. The elastic seal may include an elastic substance, such as silicon or rubber, to enable it to remain in contact with both the probing member and the coating member in the case that a change in temperature causes either or both to expand or contract. The elastic seal may have a coefficient of thermal expansion that is intermediate to a coefficient of thermal expansion of the probing member and a coefficient of thermal expansion of the coating member. The elastic seal prevents voids from forming in the probe assembly into which outside materials may enter.

Abstract: There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

Abstract: The use of ?-adrenergic inverse agonists provides a new and highly efficient way of treating a number of pulmonary airway diseases, including asthma, emphysema, and chronic obstructive pulmonary diseases. In general, such a method comprises administering a therapeutically effective amount of a ?-adrenergic inverse agonist to the subject to treat the pulmonary airway disease. Particularly preferred inverse agonists include nadolol and carvedilol. In addition, methods are described for long-term administration of such inverse agonists and for determining the suitability of patients for long-term inverse agonist therapy.

Abstract: The present invention is an elastic seal for use with a sanitary probe. The elastic seal forms a layer between the probing member and the coating member to eliminate the formation of voids between the two. The elastic seal may include an elastic substance, such as silicon or rubber, to enable it to remain in contact with both the probing member and the coating member in the case that a change in temperature causes either or both to expand or contract. The elastic seal may have a coefficient of thermal expansion that is intermediate to a coefficient of thermal expansion of the probing member and a coefficient of thermal expansion of the coating member. The elastic seal prevents voids from forming in the probe assembly into which outside materials may enter.

Abstract: A system and method of creating and employing an operating system (OS) image having selected functionality. A user, such as an original equipment manufacturer (OEM) of personal computers (PCs) or an information technology professional, selects a set of OS components from a plurality of OS components available in an installation OS image. The selected set of OS components is installed as the OS image on a computer readable medium such as a CD-ROM. The OS image includes a script for interacting with the OS image to perform functions desired by a user, such as booting a destination computer and installing a reference OS image or recovering the destination computer from a failed installation of the reference OS image.

Abstract: A cooler comprising coils and passageways defined by and between the coils through which ambient air moves, from the inlet of the cooler to the outlet of the cooler, is positioned with its outlet in register with an ambient air inlet for an enclosed space. A device that in use generates heat is positioned within the enclosed space. The enclosed space includes an ambient air inlet and an outlet through which ambient air from the ambient air inlet to the outlet. The cooler is used to cool the ambient air that is immediately forwardly of the ambient air inlet for the enclosed space. An air mover in the enclosed space, or thermal flow, is used for moving the cooled ambient air into the ambient air inlet, through the enclosed space, and out from the outlet of the enclosed space.

Abstract: A system and method of creating and employing an operating system (OS) image having selected functionality. A user, such as an original equipment manufacturer (OEM) of personal computers (PCs) or an information technology professional, selects a set of OS components from a plurality of OS components available in an installation OS image. The selected set of OS components is installed as the OS image on a computer readable medium such as a CD-ROM. The OS image includes a script for interacting with the OS image to perform functions desired by a user, such as booting a destination computer and installing a reference OS image or recovering the destination computer from a failed installation of the reference OS image.

Abstract: The present invention relates to a method of treatment of a disease comprising the step of administering to an animal a paradoxical pharmacologic agent, wherein the agent restores compensatory mechanisms or activates redundant mechanisms. More particularly, the invention relates to methods of treatment for hypertension.