Abstract: Provided herein are processes for the preparation of 3,5-disubstituted-1,2,4-oxadiazoles and salts thereof comprising reacting a N-hydroxyamidine with an acyl chloride in a reaction mixture comprising a water-immiscible organic solvent and an aqueous base at relatively low reaction temperatures.

Abstract: Source data stored on a source device may be shared with other devices. Sharing the source data may include facilitating communication associated with the source data, based on a communication protocol, between a first device and another device. Receiving a first token associated with the source data may be facilitated. The first token may be encoded to generate a visual tag. An image of the visual tag may be provided to enable a second device to capture the image, retrieve the first token after decoding the visual tag, and use the first token to access the source data utilizing a communication protocol.

Abstract: A traction device comprises a frame, a first bladder portion, a second bladder portion, a spacer, and a pump. The first bladder expands in an outward direction a distance greater than in a transverse direction. The second bladder expands in an angular direction. The second bladder is positioned generally below and to the side of the first bladder. Upon expanding in the outward direction, the first bladder bears against the back of the user's neck. Upon expanding in the transverse direction, the first bladder applies an angular traction to the cervical spine. Upon expanding in the angular direction, the second bladder bears angularly against the back of the user's upper thoracic region.

Abstract: A method for network access of remote memory directly from a local instruction stream using conventional loads and stores. In cases where network IO access (a network phase) cannot overlap a compute phase, a direct network access from the instruction stream greatly decreases latency in CPU processing. The network is treated as yet another memory that can be directly read from, or written to, by the CPU. Network access can be done directly from the instruction stream using regular loads and stores. Example scenarios where synchronous network access can be beneficial are SHMEM (symmetric hierarchical memory access) usages (where the program directly reads/writes remote memory), and scenarios where part of system memory (for example DDR) can reside over a network and made accessible by demand to different CPUs.

Abstract: Source data stored on a source device may be shared with one or more devices. Sharing the source data may include facilitating obtaining an image of a visual tag from another device. A visual tag may be obtained via a communication method or optically captured via an optical device. The visual tag may comprise a visually encoded first token associated with the source data. The first token may be a non-public token based on the source data. The visual tag may be decoded to retrieve the first token. The device with the retrieved first token may provide for communication based on a communication protocol to a second device to download the source data using the retrieved first token. A device may be adapted to provide display of the visual tag or communicate or receive the visual tag.

Abstract: The present invention provides for compositions for administering a therapeutically effective amount of a therapeutic component. The compositions may include an ophthalmically acceptable carrier component; a therapeutically effective amount of a therapeutic component; and a retention component which may be effective to reduce wettability, induce viscosity, increase muco-adhesion, increase meniscus height on a cornea of an eye and/or increase physical apposition to a cornea of an eye of a composition.

Abstract: Provided herein are processes for the preparation of 3,5-disubstituted-1,2,4-oxadiazoles and salts thereof comprising reacting a N-hydroxyamidine with an acyl chloride in a reaction mixture comprising a water-immiscible organic solvent and an aqueous base at relatively low reaction temperatures.

Abstract: A traction device comprises a frame, a first bladder portion, a second bladder portion, a spacer, and a pump. The first bladder expands in an outward direction a distance greater than in a transverse direction. The second bladder expands in an angular direction. The second bladder is positioned generally below and to the side of the first bladder. Upon expanding in the outward direction, the first bladder bears against the back of the user's neck. Upon expanding in the transverse direction, the first bladder applies an angular traction to the cervical spine. Upon expanding in the angular direction, the second bladder bears angularly against the back of the user's upper thoracic region.

Abstract: A system and method for characterizing a point in a three-dimensional digital medical image includes determining third order derivatives of the three-dimensional digital medical image at one or more points in the three-dimensional digital medical image. At each of the one or more points, one or more invariant or semi-invariant features that characterize a local geometry at the point is determined using the third order derivatives of the three-dimensional digital medical image. The invariant or semi-invariant features are used for automatic detection of lesions, abnormalities, and other anatomical structures of interest in the three-dimensional digital medical image.

Abstract: The present invention provides for compositions for administering a therapeutically effective amount of a therapeutic component. The compositions may include an ophthalmically acceptable carrier component; a therapeutically effective amount of a therapeutic component; and a retention component which may be effective to reduce wettability, induce viscosity, increase muco-adhesion, increase meniscus height on a cornea of an eye and/or increase physical apposition to a cornea of an eye of a composition.

Abstract: Source data stored on a source device may be shared with other devices. Sharing the source data may include facilitating communication associated with the source data, based on a first communication protocol, between a first device and another device. Receiving a first token associated with the source data may be facilitated. The first token may be encoded to enable communication using a near proximity communication (NPC) protocol. Communication of the first token may be provided to a second device, located within five feet of the first device, using the NPC protocol, to enable the second device to access the source data utilizing a second communication protocol. The NPC protocol is a wireless communication protocol, and supports automatic connection between at least two devices located within five feet. The first and second devices are NPC-enabled devices.

Abstract: Source data stored on a source device may be shared with one or more devices. Sharing the source data may include facilitating receiving, at a first device, a first token associated with the source data, from a second device, using a near proximity communication (NPC) protocol. The NPC protocol may support generation of the first token based on detection of presence of the first device within five feet of the second device. The first token may be encoded for NPC communication and may be non-public. The first token may be based on the source data and the receipt of the first token may be based on the detection. The first token may be decoded and communicated, based on a first communication protocol, to a third device to download the source data using the decoded first token. The second device may be an NPC-enabled device.

Abstract: The invention provides ophthalmic formulations containing well-defined substituted gamma lactams. The formulations described herein are useful in treating a variety of ocular diseases related to ocular hypertension, such as for example, glaucoma.

Abstract: Compositions useful for improving effectiveness of alpha-2-adrenergic agonist components include carrier components, alpha-2-adrenergic agonist components, solubility enhancing components which aid in solubilizing the alpha-2-adrenergic agonist components. In one embodiment, the alpha-2-adrenergic agonist components include alpha-2-adrenergic agonists. In another embodiment, the solubility enhancing components include carboxymethylcellulose.

Abstract: A function is provided in a network system for policy-based dynamic mirroring for network traffic. The function monitors events, topology and status of the network and installs, enables, selects or changes traffic mirrors associated with the operation of one or more devices of the network. The mirror policies are established based on network polices and/or rules. The mirror policies and the enablement, installation, selection or changing of them are based on multiple criteria. The function provides for the selection of traffic to mirror, how much of it to mirror, where to mirror it and when to stop the mirroring. The function may be established in network entry devices as well as core switching devices of the network. The function can select portals for the mirroring activity and can secure the mirroring.

Abstract: A function is provided in a network system for the dynamic mirroring of network traffic for a variety of purposes including the identification of characteristics of the traffic. Multiple criteria are established for when, what and where to mirror the traffic. The criteria include what frames of traffic to mirror, what portions of the selected frames to mirror, one or more portals through which to mirror the selected frames, a destination for the mirroring and the establishment of a mirror in a device to carry out the mirroring. The criteria may also include when to stop the mirroring. The mirroring instructions can be changed based on the detection of a triggering event, such as authentication, device type or status, ownership of an attached function attached to the device, flow status, but not limited to that. The function may be established in one or more devices of the network.

Abstract: A network architecture system that expands the control network administrators have on existing networks. The system provides application identification and usage data by user, by device and network location. Dynamic traffic mirroring of the system allows for the efficient use of a tool to identify computer applications running on the network. The system includes the ability to embed the tool where needed rather than pervasively based on the use of the dynamic mirroring to bring the packets to the tool. The architecture implemented functions allow the ability to start small with a single application identification tool added to a network management server, examine flows from throughout the network (via mirroring) and upgrade policy control based on real application identification data and usage, then grow to pervasive deployment where virtually all new flows could be identified and controlled via policy. This architecture enables substantially complete application visibility and control.

Abstract: A function is provided for effectively identifying computer applications running on a network. The function receives information related to frames of packets moving through the network. The information is compared to known information about computer applications. The known information is obtained from a plurality of mechanisms, including the option of obtaining it through custom mechanisms. The comparison information is scored for each of the plurality of mechanisms and those scores are combined to establish a single score indicative of the likely computer application associated with the received frames. One or more mathematical operations can be used to combine the scores. The mechanisms may be weighted for likely accuracy and the score that is established may include with it an indication of the level of confidence in that score. One or more of the plurality of mechanisms may be used to weight others of the types of mechanisms.

Abstract: A function is provided for identifying computer applications running on a network. Information obtained from frames having content associated with computer applications is examined and compared to information stored on the network. The stored information is obtained from a plurality of mechanisms including computer application signatures. An application identification engine of the function compares examined content with the known application information and determines an indication of the likely computer application associated with the examined frames. The determination output may include a level of confidence in the accuracy of the determination. The function includes an application programming interface to allow the introduction into the engine of custom mechanisms for application identification. The different mechanisms may be weighted. The function may be provided in one or more devices of the network including a standalone appliance.

Abstract: A function is provided in a network system for adjusting network policies associated with the operation of network infrastructure devices of the network system. Network policies are established on network devices including packet forwarding devices. The network has a capability to identify computer applications associated with traffic running on the network. A network policy controller of the network is arranged to change one or more policies of one or more network devices based on computer application information acquired. The policies changed may be network policies as well as mirroring policies. An example policy to change is direct a network device to mirror traffic to an application identification appliance for the purpose of identifying applications running on the network through a plurality of mechanisms. The function may be provided in one or more devices of the network.