Abstract: The invention provides ophthalmic formulations containing well-defined substituted gamma lactams. The formulations described herein are useful in treating a variety of ocular diseases related to ocular hypertension, such as for example, glaucoma.

Abstract: A method and apparatus are provided that allows for the representation of a larger number of classes of network traffic and logical queues than is physically available on a per port basis within a network device. A number of logical queues, whose number can match the number of classes of network traffic a network device handles, may be supported across an aggregated set of ports even though the network device has fewer physical queues per port than there are classes of network traffic. The method and apparatus improve the management of network traffic sensitive to time delay and jitter, and further facilitates the operation of these applications in a simultaneous or near simultaneous manner.

Abstract: A method for modeling financial variables describing a client over a time period. The method may comprise the step of generating a first simulation of the time period. Generating the first simulation may comprise the steps of assigning the client to a first health-related state and advancing the first simulation from a first interval of the time period to a second interval of the time period. A probability that the client will transition from the first health-related state to a second health-related state may be calculated, the client may be randomly assigned to either the first health-related state or the second health-related state considering the probability. According to various embodiments, the methods may also comprise the steps of calculating a client income for the second interval; and calculating a plurality of client expenses for the second interval. Also, the various health-related states may include one or more of a healthy state, a long term care (LTC) state, a disabled state and a dead state.

Abstract: A system and method for characterizing a point in a three-dimensional digital medical image includes determining third order derivatives of the three-dimensional digital medical image at one or more points in the three-dimensional digital medical image. At each of the one or more points, one or more invariant or semi-invariant features that characterize a local geometry at the point is determined using the third order derivatives of the three-dimensional digital medical image. The invariant or semi-invariant features are used for automatic detection of lesions, abnormalities, and other anatomical structures of interest in the three-dimensional digital medical image.

Abstract: A method of displaying results of a financial model for forecasting at least one financial variable relating to a client. The method comprises the steps of receiving asset and liability data regarding the client; generating forecasted values for the financial variables over a number of simulations using the asset and liability data; and displaying a topographical chart on a user interface. The topographical chart may be positioned on a plane shown in the user interface. The plane may be defined by a time axis and a value axis for the at least one financial variable, such that a coordinate set on the plane represents the value of the at least one financial variable at a time point. The height of a first point on the topographical chart corresponding to the coordinate set may indicate a portion of the simulations that result in the coordinate set.

Abstract: A method for testing the continuity of a coil that is subjected to a high frequency pulse modulated current that includes sensing a coil voltage, determining a ratio of the sensed coil voltage to the supply voltage and comparing the ratio to a threshold to determine whether the solenoid coil is functional.

Abstract: Filtering a dispersed phase (e.g. oil) from a continuous liquid (e.g. water) of a dispersion a filter, for filtering a dispersed phase from a continuous liquid of a dispersion, the filter including a substrate having a plurality of apertures each extending directly through the substrate between a first surface and a second surface and a layer of material applied over at least a portion of the first surface, wherein the material rejects the continuous liquid to a greater extent than the dispersed liquid.

Abstract: A system and method to respond to intrusions detected on a network system including attached functions and a network infrastructure. The system includes means for receiving from an intrusion detection function information about intrusions, a directory service function for gathering and reporting at least the physical and logical addresses of devices of the network infrastructure associated with the detected intrusions, and a plurality of distributed enforcement devices of the network infrastructure for enforcing policies responsive to the detected intrusions. A policy decision function evaluates the reported detected intrusions and makes a determination whether one or more policy changes are required on the enforcement devices in response to a detected intrusion. A policy manager function configures the distributed enforcement devices with the responsive changed policy or policies.

Abstract: A masking film having improved wetting of substrates has an adhesion layer, a second layer, and optionally a core layer interposed between the adhesion layer and the second layer, wherein the adhesion layer comprises a blend of a metallocene polyolefin and a low density polyethylene and wherein the second layer provides increased stiffness, strength or mechanical properties to the film. The film may also include antistatic agents in at least one film layer.

Abstract: A composition is described herein comprising cyclosporin A, polysorbate 80, a polyoxyethylene stearate, and an oil; wherein the composition is an emulsion which is ophthalmically acceptable. Methods of treating diseases or conditions using said compositions, and medicaments related thereto, are also disclosed herein.

Abstract: A method for testing the continuity of a coil that is subjected to a high frequency pulse modulated current that includes sensing a coil voltage and comparing a ratio of the sensed coil voltage to the supply voltage to a threshold to determine whether the solenoid coil is functional.

Abstract: A composition is described herein comprising cyclosporin A, polysorbate 80, a polyoxyethylene stearate, and an oil; wherein the composition is an emulsion which is ophthalmically acceptable. Methods of treating diseases or conditions using said compositions, and medicaments related thereto, are also disclosed herein.

Abstract: The invention relates to a compound of formula (I) or a salt thereof: wherein: R1 is C1-4alkyl, C1-3fluoroalkyl, —CH2CH2OH or —CH2CH2CO2C1-2alkyl; R2 is a hydrogen atom (H), methyl or C1fluoroalkyl; R3 is optionally substituted C3-8cycloalkyl or optionally substituted mono-unsaturated-C5-7cycloalkenyl or an optionally substituted heterocyclic group of sub-formula (aa), (bb) or (cc); in which n1 and n2 independently are 1 or 2; and in which Y is O, S, SO2, or NR10; or R3 is a bicyclic group (dd) or (ee): and wherein X is NR4R5 or OR5a. The compounds are phosphodiesterase (PDE) inhibitors, in particular PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.

Abstract: A lighting element (1) comprises at least one light (3), means (13) for delivering electricity to the or each light, a pair of spaced apart plates (2,2?), at least one magnet (4,4?) located between the said plates and biasing means (8) for biasing the said plates apart, wherein a magnet (4) is attached to one of the pair of plates. In use the lighting element forms part of a lighting system in which the element is located between spaced apart transparent sheets (10), e.g. panes of glass.

Abstract: Combination of one or more CB2 modulators and one or more PDE4 inhibitors, and method of treating conditions which are mediated by the activity of CB2 receptors or conditions which are mediated by PDE4.

Abstract: In some embodiments, an apparatus and a system, as well as a method and an article, may include a signal integrity monitor that senses the signal transmitted between a surface device and a downhole device. The signal integrity monitor is adapted to disconnect power from the communication system if a fault in the communication line is detected.

Abstract: Disclosed herein are compositions containing brimonidine and timolol. Therapeutic methods and medicaments related thereto are also disclosed.

Abstract: Compositions, methods, and pharmaceutical products related to prostaglandin-related compounds and trefoil factor family peptides are disclosed herein. Of particular interest are compositions and methods useful for the treatment of glaucoma with a reduced occurrence of hyperemia.

Abstract: Disclosed herein are therapeutic methods, compositions, and medicaments related to cyclosporine.

Abstract: An orthopedic device includes at least one torque band disposable around a users' body and having opposing ends extending outwardly from the users' body and generally transverse to a users' spine along with apparatus applying counteracting forces to the ends in order to torque the body to the corrective posture. In addition, a support table may be provided along with a cervical device disposed on the table drop leaf and a pelvis/leg/feet carrier slidably disposed on the table. A lumbar sacral unit is disposed on the table between the cervical device and the pelvis/leg/feet carrier and a movable thorax carrier may be disposed on the support table between the sacral unit and the cervical device.