Patents by Inventor Richard R. Bott

Richard R. Bott has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered glucosyltransferases
    Patent number: 11952598
    Abstract: Disclosed herein are glucosyltransferases with modified amino acid sequences. Such engineered enzymes exhibit improved alpha-glucan product yields and/or lower leucrose yields, for example. Further disclosed are reactions and methods in which engineered glucosyltransferases are used to produce alpha-glucan.
    Type: Grant
    Filed: June 4, 2021
    Date of Patent: April 9, 2024
    Assignee: NUTRITION & BIOSCIENCES USA 4, INC.
    Inventors: Yougen Li, Mark S. Payne, Jared B. Parker, Slavko Kralj, Veli Alkan, Richard R. Bott, Robert Dicosimo, Qiong Cheng, Ellen D. Semke, Susan Marie Hennessey
  • Protease variants and uses thereof
    Patent number: 11946080
    Abstract: Disclosed herein is one or more subtilisin variants, nucleic acids encoding same, and compositions and methods related to the production and uses thereof, including one or more subtilisin variants that has improved stability and/or soil removal compared to one or more reference subtilisin.
    Type: Grant
    Filed: June 18, 2017
    Date of Patent: April 2, 2024
    Assignee: DANISCO US INC.
    Inventors: Richard R. Bott, David A. Estell, Frits Goedegebuur, Harm Mulder, Sina Pricelius
  • PROTEASE VARIANTS AND USES THEREOF
    Publication number: 20240093124
    Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
    Type: Application
    Filed: April 17, 2023
    Publication date: March 21, 2024
    Inventors: Joshua Roy Basler, Michael Stoner, James T. Kellis, Jr., Adam Garske, David Marquez, Katherine Augustyn, Priyanka Chandrasekaran, Miles Christopher Scotcher, Lilia Maria Babe, Richard R. Bott, David A. Estell, Gudrun Vogtentanz, Sina Pricelius, Jian Yao
  • ALPHA-AMYLASE COMBINATORIAL VARIANTS
    Publication number: 20230348879
    Abstract: Disclosed are compositions and methods relating to variant alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.
    Type: Application
    Filed: September 1, 2022
    Publication date: November 2, 2023
    Inventors: LUIS G CASCAO-PEREIRA, DINA FINAN, DAVID EDWARD WILDES, PIETER AUGUSTINUS, ROEL HERMANT, MONICA OCHA RUIZ, DEWY VAN TOL, RICHARD R. BOTT, MARC KOLKMAN
  • Protease variants and uses thereof
    Patent number: 11661567
    Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: May 30, 2023
    Assignee: Danisco US Inc.
    Inventors: David Marquez, Michael Stoner, James T. Kellis, Jr., Adam Garske, Joshua Roy Basler, Katherine Augustyn, Priyanka Chandrasekaran, Miles Christopher Scotcher, Lilia Maria Babe, Richard R. Bott, David A. Estell, Gudrun Vogtentanz, Sina Pricelius, Jian Yao
  • -clade serine proteases
    Patent number: 11499146
    Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more Bacillus gibsonii-clade subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: November 15, 2022
    Assignee: DANISCO US INC.
    Inventors: Lilia Maria Babe, Richard R. Bott, David A. Estell, Harm Mulder, Frits Goedegebuur, Jian Yao, Sina Pricelius, Miles Scotcher
  • AprL-clade subtilisin protease variants and uses thereof
    Patent number: 11473075
    Abstract: The present disclosure provides AprL-clade protease enzymes, including variant AprL-clade protease enzymes, nucleic acids encoding same, and compositions and methods related to the production and use thereof, including an AprL-clade variant subtilisin enzyme that has improved stability and/or soil removal compared to a parent AprL-clade subtilisin enzyme.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: October 18, 2022
    Assignee: DANISCO US INC.
    Inventors: David A. Estell, Frits Goedegebuur, Marc Anton Bernhard Kolkman, Rie Mejldal, Katherine Augustyn, Lilia Maria Babe, Richard R Bott, Jian Yao, Roopa Santosh Ghirnikar
  • Serine proteases of the -clade
    Patent number: 11384348
    Abstract: The present disclosure relates to serine proteases cloned from Bacillus gibsonii, and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
    Type: Grant
    Filed: December 4, 2019
    Date of Patent: July 12, 2022
    Assignee: DANISCO US INC
    Inventors: Marc Kolkman, Frits Goedegebuur, Lilia Maria Babe, Rie Mejldal, Harm Mulder, Anja Hemmingsen Kellett-Smith, Richard R Bott, Miles Christopher Scotcher
  • ENGINEERED GLUCOSYLTRANSFERASES
    Publication number: 20210395705
    Abstract: Disclosed herein are glucosyltransferases with modified amino acid sequences. Such engineered enzymes exhibit improved alpha-glucan product yields and/or lower leucrose yields, for example. Further disclosed are reactions and methods in which engineered glucosyltransferases are used to produce alpha-glucan.
    Type: Application
    Filed: June 4, 2021
    Publication date: December 23, 2021
    Inventors: Yougen Li, MARK S. PAYNE, JARED B. PARKER, SLAVKO KRALJ, VELI ALKAN, RICHARD R. BOTT, ROBERT DICOSIMO, QIONG CHENG, ELLEN D. SEMKE, SUSAN MARIE HENNESSEY
  • Glucoamylase variants with altered properties
    Patent number: 11130946
    Abstract: The present invention relates to variants of a parent glucoamylase having altered properties (e.g., improved thermostability and/or specific activity). In particular, the present invention provides compositions comprising the variant glucoamylases, including starch hydrolyzing compositions, animal feed compositions and cleaning compositions. The invention also relates to DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: September 28, 2021
    Assignee: Danisco US Inc.
    Inventors: Pieter Van Solingen, Richard R. Bott, Wolfgang Aehle, Martijn Scheffers
  • Engineered glucosyltransferases
    Patent number: 11028373
    Abstract: Disclosed herein are glucosyltransferases with modified amino acid sequences. Such engineered enzymes exhibit improved alpha-glucan product yields and/or lower leucrose yields, for example. Further disclosed are reactions and methods in which engineered glucosyltransferases are used to produce alpha-glucan.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: June 8, 2021
    Assignee: NUTRITION & BIOSCIENCES USA 4, INC.
    Inventors: Yougen Li, Mark S. Payne, Jared B. Parker, Slavko Kralj, Veli Alkan, Richard R. Bott, Robert Dicosimo, Qiong Cheng, Ellen D. Semke, Susan Marie Hennessey
  • Methods of making serine proteases
    Patent number: 11008559
    Abstract: The present disclosure relates to serine proteases cloned from Bacillus Akibai and Bacillus Clarkii, and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: May 18, 2021
    Assignee: DANISCO US INC
    Inventors: Marc Kolkman, Rie Mejldal, Anja Hemmingsen Kellett Smith, Lilia Maria Babe, Richard R. Bott
  • SERINE PROTEASES OF BACILLUS SPECIES
    Publication number: 20200407703
    Abstract: The present disclosure relates to serine proteases cloned from Bacillus spp., and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
    Type: Application
    Filed: September 17, 2020
    Publication date: December 31, 2020
    Inventors: MARC KOLKMAN, Anja Hemmingsen Kellett-Smith, Rie Mejldal, Richard R. Bott, Lilia Marie Babe
  • PROTEASE VARIANTS AND USES THEREOF
    Publication number: 20200332229
    Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
    Type: Application
    Filed: May 31, 2017
    Publication date: October 22, 2020
    Applicant: Danisco US Inc.
    Inventors: David MARQUEZ, Michael STONER, James T. KELLIS, JR., Adam GARSKE, Joshua Roy BASLER, Katherine AUGUSTYN, Priyanka CHANDRASEKARAN, Miles Christopher SCOTCHER, Lilia Maria BABE, Richard R. BOTT, David A. ESTELL, Gudrun VOGTENTANZ, Sina PRICELIUS, Jian YAO
  • GLUCOAMYLASE VARIANTS WITH ALTERED PROPERTIES
    Publication number: 20200270595
    Abstract: The present invention relates to variants of a parent glucoamylase having altered properties (e.g., improved thermostability and/or specific activity). In particular, the present invention provides compositions comprising the variant glucoamylases, including starch hydrolyzing compositions, animal feed compositions and cleaning compositions. The invention also relates to DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells.
    Type: Application
    Filed: January 14, 2020
    Publication date: August 27, 2020
    Inventors: PIETER VAN SOLINGEN, RICHARD R. BOTT, WOLFGANG AEHLE, MARTIJN SCHEFFERS
  • SERINE PROTEASES OF THE BACILLUS GIBSONII-CLADE
    Publication number: 20200248160
    Abstract: The present disclosure relates to serine proteases cloned from Bacillus gibsonii, and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
    Type: Application
    Filed: December 4, 2019
    Publication date: August 6, 2020
    Inventors: MARC KOLKMAN, FRITS GOEDEGEBUUR, LILIA MARIA BABE, RIE MEJLDAL, HARM MULDER, ANJA HEMMINGSEN KELLETT-SMITH, RICHARD R BOTT, MILES CHRISTOPHER SCOTCHER
  • Glucosyltransferase amino acid motifs for enzymatic production of linear poly alpha-1,3-glucan
    Patent number: 10633638
    Abstract: Reactions comprising water, sucrose, and one or more glucosyltransferase enzymes are disclosed herein. Glucosyltransferase enzymes used in these reactions comprise certain motifs allowing production of insoluble poly alpha-1,3-glucan having at least 95% alpha-1,3 glycosidic linkages.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: April 28, 2020
    Assignee: DUPONT INDUSTRIAL BIOSCIENCES USA, LLC
    Inventors: Mark S. Payne, Yefim Brun, Richard R. Bott
  • AprL-CLADE PROTEASE VARIANTS AND USES THEREOF
    Publication number: 20200123522
    Abstract: The present disclosure provides AprL-clade protease enzymes, including variant AprL-clade protease enzymes, nucleic acids encoding same, and compositions and methods related to the production and use thereof, including an AprL-clade variant subtilisin enzyme that has improved stability and/or soil removal compared to a parent AprL-clade subtilisin enzyme.
    Type: Application
    Filed: December 19, 2019
    Publication date: April 23, 2020
    Inventors: David A Estell, Frits Goedegebuur, Marc Anton Bernhard Kolkman, Rie Mejldal, Katherine Augustyn, Lilia Maria Babe, Richard R Bott, Jian Yao, Roopa Santosh Ghirnikar
  • NOVEL METALLOPROTEASES
    Publication number: 20200115693
    Abstract: Aspects of the present compositions and methods relate to novel metalloproteases polynucleotides encoding the novel metalloprotease, compositions and methods for use thereof.
    Type: Application
    Filed: December 17, 2019
    Publication date: April 16, 2020
    Inventors: Lilia Maria Babe, RICHARD R BOTT, ROOPA SANTOSH GHIRNIKAR, FRITS GOEDEGEBUUR, XIAOGANG GU, MARC ANTON BERNHAR KOLKMAN, JIAN YAO, SHUKUN YU
  • ALPHA-AMYLASE COMBINATORIAL VARIANTS
    Publication number: 20200087644
    Abstract: Disclosed are compositions and methods relating to variant alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.
    Type: Application
    Filed: March 4, 2019
    Publication date: March 19, 2020
    Inventors: Luis G. Cascao-Pereira, Dina Finan, David Edward Wildes, Pieter Augustinus, Roel Hermant, Monica Ocha Ruiz, Dewy Van Tol, Richard R Bott, Marc Kolkman