Abstract: The present disclosure relates generally to eukaryotic initiation factor 2B modulators of formula A, or a pharmaceutically acceptable salt, stereoisomer, or mixture of stereoisomers thereof and methods of making and using thereof.

Abstract: A glass container for storing pharmaceutical formulations may include a glass body formed from a Type IA or Type IB glass composition according to ASTM Standard E438-92(2011). The glass body may include a wall portion with an inner surface and an outer surface, a heel portion and a floor portion, wherein the inner surface of the glass container is formed by the inner surface of the glass body. The glass body may include at least a class A2 base resistance or better according to ISO 695, at least a type HGB2 hydrolytic resistance or better according to ISO 719 and Type 1 chemical durability according to USP <660>. The glass container does not comprise a boron-rich layer on the inner surface of the glass body in as formed condition.

Abstract: The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or prodrug thereof, and methods of making and using thereof.

Abstract: The present invention relates to methods and means for producing nitrogenase polypeptides in the mitochondria of plant cells.

Abstract: A firearm synchronized discharge device for facilitating a synchronized discharge of two or more firearms are described together with associated systems, firearms and methods. The device includes an actuator for engaging with a movable trigger of a first firearm, a sensor configured to generate a signal indicative of a force applied to the trigger and a first controller operatively coupled to the sensor and to the actuator. The actuator is configurable between a first configuration that prevents movement of the trigger toward a firearm-discharge position of the trigger, and a second configuration that permits movement of the trigger toward the firearm-discharge position of the trigger. When the force meets a criterion and the one or more other firearms are ready for discharge, the actuator is caused to transition from the first configuration to the second configuration to permit actuation of the trigger and discharge of the firearm.

Abstract: A coated glass pharmaceutical package includes a glass body having a Type 1 chemical durability according to USP 660, at least a class A2 base resistance or better according to ISO 695, and at least a type HGB2 hydrolytic resistance or better according to ISO 719, the glass body having an interior surface and an exterior surface and a wall extending therebetween. A lubricous coating having a thickness of less than or equal to 90 nm may be positioned on at least a portion of the exterior surface of the glass body but not on any portion of the interior surface. The portion of the coated glass package with the lubricous coating comprises a coefficient of friction that is at least 20% less than an uncoated glass package and the coefficient of friction does not increase by more than 30% after undergoing a depyrogenation cycle including exposure to a temperature of 250° C. for a time period of 30 minutes.

Abstract: In an example, a system includes a firmware controller to initiate a SM execution mode of the system. The firmware controller scans memory for a process pool tag. The firmware controller compares the process pool tag to a set of operating system process pool tags and detects a coherency discrepancy between the process pool tag and the set of operating system process pool tags. The firmware controller exits the SM execution mode of the system.

Abstract: Aspect pre-selection techniques using machine learning are described. In one example, an artificial assistant system is configured to implement a chat bot. A user then engages in a first natural-language conversation. As part of this first natural-language conversation, a communication is generated by the chat bot to prompt the user to specify an aspect of a category that is a subject of a first natural-language conversation and user data is received in response. Data that describes this first natural-language conversation is used to train a model using machine learning. Data is then received by the chat bot as part of a second natural-language conversation. This data, from the second natural-language conversation, is processed using the model as part of machine learning to generate the second search query to include the aspect of the category automatically and without user intervention.

Abstract: A method of inverting workpieces in a mass production process includes: advancing an end effector in electronic synchronization with advancement of a carrier to synchronize arrival of the carrier at a stop position with arrival of the end effector at an unloading position, in which the end effector is in alignment with a workpiece held by the carrier for engaging the workpiece; while the end effector is in engagement with the workpiece, retracting the end effector away from the carrier to unload the workpiece from the carrier and advancing the end effector back toward the carrier to load the workpiece back into the carrier; and rotating the end effector relative to the carrier to invert the workpiece in electronic synchronization with the retracting and advancing of the end effector for loading the workpiece back into the carrier when inverted.

Abstract: A client application is specified by a target tenant and represented in an OAuth provider, along with a corresponding secret. A source tenant consents to permissions to be executed by the client application on a resource of the source tenant. A target service uses the secret to obtain an access token from an authorization server coupled to the source tenant and uses the access token to obtain access, specified by the permissions, to the resource served by a source service acting on behalf of the source tenant.

Abstract: A computer is provided that includes a search engine. The search engine is configured to receive a search request and conduct a search against a database. Each record within the database includes or is associated with a display criteria or profile that specifies when data from that record can be included into a response to a search.

Abstract: Methods and systems described in this disclosure allow customers to quickly be authenticated. In some embodiments, a device and a user verifier are associated with a user profile. When a call is received from the device, the user may be requested to input the user verifier. After verifying that the device is unique to the user and that the user verifier matches the user verifier associated with the user profile, the user may be authenticated to the call or activity.

Abstract: A firearm synchronized discharge device for facilitating a synchronized discharge of two or more firearms are described together with associated systems, firearms and methods. The device includes an actuator for engaging with a movable trigger of a first firearm, a sensor configured to generate a signal indicative of a force applied to the trigger and a first controller operatively coupled to the sensor and to the actuator. The actuator is configurable between a first configuration that prevents movement of the trigger toward a firearm-discharge position of the trigger, and a second configuration that permits movement of the trigger toward the firearm-discharge position of the trigger. When the force meets a criterion and the one or more other firearms are ready for discharge, the actuator is caused to transition from the first configuration to the second configuration to permit actuation of the trigger and discharge of the firearm.

Abstract: The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.

Abstract: The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers or prodrug thereof, and methods of making and using thereof.

Abstract: An immersion cooling system includes an immersion tank defining an immersion chamber therein, an immersion working fluid, an energy source, an optical sensor, and a microcontroller. The immersion working fluid is positioned at least partially in the immersion chamber and the immersion working fluid has a liquid phase and a vapor phase. The energy source is positioned and oriented to direct an infrared beam through a portion of the vapor phase with a beam path and path length. The optical sensor is positioned in the beam path. The microcontroller is configured to determine vapor concentration in the immersion chamber based at least partially on data from the path length, the optical sensor, and the energy source.

Abstract: An immersion cooling system includes an immersion tank defining an immersion chamber therein, an immersion working fluid, a first electrode, and a second electrode. The immersion working fluid is positioned at least partially in the immersion chamber. The first electrode is electrically coupled to an electrical power source, and the second electrode is positioned proximate to the first electrode and defines a sampling region therebetween. A sample portion of the immersion working fluid is positioned in the sampling region, and the second electrode is coupled to a microcontroller configured to measure at least a current across the sampling region between the first electrode and the second electrode.

Abstract: A spa tub includes a spa shell configured to contain a volume of water; a circulation system configured to create a flow of the water to and from the spa shell; and a testing system configured to acquire water samples from the volume of water and to perform water quality tests on the water samples. The testing system includes a housing; a circulation pump disposed within the housing configured to acquire the water samples from the volume of water; a replaceable reagent cartridge removably received within the housing; and a water test assembly disposed within the housing. The water test assembly is configured to receive the water samples acquired by the circulation pump and a reagent from the reagent cartridge. The water test assembly is configured to mix the water samples and the reagent and to perform the water quality tests on the mixed water samples and reagent.

Abstract: The present invention relates to the use of strobilurin type compounds of formula I and the N-oxides and the salts thereof for combating phytopathogenic fungi containing an amino acid substitution F129L in the mitochondrial cytochrome b protein (also referred to as F129L mutation in the mitochondrial cytochrome b gene) conferring resistance to Qo inhibitors, and to methods for combating such fungi. The invention also relates to novel compounds, processes for preparing these compounds, to compositions comprising at least one such compound, and to seeds coated with at least one such compound.

Abstract: The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.