Patents by Inventor Robert D. Ivarie

Robert D. Ivarie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Avian Transgenesis and Exogenous Proteins
    Publication number: 20140065690
    Abstract: This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of a bird and for expressing said exogenous sequences to alter the phenotype of the bird or to produce desired proteins. In particular, transgenic chickens are produced which express exogenous sequences in their oviducts. Eggs which contain exogenous proteins are also produced.
    Type: Application
    Filed: July 9, 2013
    Publication date: March 6, 2014
    Applicants: The University of Georgia Research Foundation, Inc., Synageva BioPharma Corp.
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
  • Method of making protein in an egg of a transgenic chicken
    Patent number: 8563803
    Abstract: The invention includes isolating pharmaceutical proteins from avian hard shell eggs containing pharmaceutical proteins wherein the pharmaceutical proteins are exogenous to the egg.
    Type: Grant
    Filed: June 24, 2005
    Date of Patent: October 22, 2013
    Assignees: Synageva BioPharma Corp., The University of Georgia Research Foundation, Inc.
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
  • Production of exogenous proteins in egg whites of transgenic chickens
    Patent number: 8519214
    Abstract: This invention provides for proteins which are expressed in the avian oviduct, packaged into eggs laid by the avian, then isolated.
    Type: Grant
    Filed: March 15, 2006
    Date of Patent: August 27, 2013
    Assignees: Synageva BioPharma Corp., The University of Georgia Research Foundation, Inc.
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
  • Transgenic chickens producing exogenous protein in eggs
    Patent number: 8507749
    Abstract: This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of a bird and for expressing said exogenous sequences to alter the phenotype of the bird or to produce desired proteins. In particular, transgenic chickens are produced which express exogenous sequences in their oviducts. Eggs which contain exogenous proteins are also produced.
    Type: Grant
    Filed: November 15, 2005
    Date of Patent: August 13, 2013
    Assignees: Synageva BioPharma Corp., The University of Georgia Research Foundation, Inc.
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
  • Antibodies produced in a transgenic avian egg white
    Patent number: 8372956
    Abstract: The invention provides for antibodies produced in transgenic birds as chickens.
    Type: Grant
    Filed: October 15, 2007
    Date of Patent: February 12, 2013
    Assignee: Synageva BioPharma Corp.
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
  • Transgenic avians and protein production
    Publication number: 20120266265
    Abstract: This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of avians in order to express the exogenous sequences to alter the phenotype of the avians or to produce desired proteins. In particular, transgenic avians are produced which express exogenous sequences in their oviducts and which deposit exogenous proteins into their eggs. Avian eggs that contain exogenous proteins are encompassed by this invention. The instant invention further provides novel forms of interferon and erythropoietin which are efficiently expressed in the oviduct of transgenic avians and deposited into avian eggs.
    Type: Application
    Filed: June 24, 2011
    Publication date: October 18, 2012
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
  • Method of producing an exogenous protein in the egg of a chicken
    Patent number: 7875762
    Abstract: This invention provides for proteins which are expressed in the avian oviduct, packaged into eggs laid by the avian and removed from the eggs.
    Type: Grant
    Filed: January 23, 2006
    Date of Patent: January 25, 2011
    Assignees: Synageva BioPharma Corp., University of Georgia Research Foundation, Inc.
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
  • Glycosylated human G-CSF
    Patent number: 7812127
    Abstract: The invention relates to G-CSF molecules having certain O-linked oligosaccharide structures.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: October 12, 2010
    Assignees: Synageva BioPharma Corp., University of Georgia Research Foundation
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
  • Glycosylated interferon alpha
    Patent number: 7803362
    Abstract: The invention relates to interferon-? molecules having certain O-linked oligosaccharide structures.
    Type: Grant
    Filed: July 3, 2008
    Date of Patent: September 28, 2010
    Assignees: Synageva BioPharma Corp., University of GA Research Foundation
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
  • Antibodies produced in a transgenic avian
    Publication number: 20090220494
    Abstract: The invention includes compositions comprising novel forms of glycosylated human interferon-?.
    Type: Application
    Filed: October 15, 2007
    Publication date: September 3, 2009
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
  • Avians expressing heterologous protein
    Patent number: 7534929
    Abstract: This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of avians in order to express the exogenous sequences to alter the phenotype of the avians or to produce desired proteins. In particular, transgenic avians are produced which express exogenous sequences in their oviducts and which deposit exogenous proteins into their eggs. Avian eggs that contain exogenous proteins are encompassed by this invention. The instant invention further provides novel forms of interferon and erythropoietin which are efficiently expressed in the oviduct of transgenic avians and deposited into avian eggs.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: May 19, 2009
    Assignees: Synageva BioPharma Corp., University of Georgia Research Foundation, Inc.
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
  • Glycosylated erythropoietin
    Publication number: 20090105462
    Abstract: The invention relates to erythropoietin having certain O-linked and/or N-linked oligosaccharide structures.
    Type: Application
    Filed: July 11, 2008
    Publication date: April 23, 2009
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
  • Glycosylated interferon alpha
    Publication number: 20090104152
    Abstract: The invention relates to interferon-? molecules having certain O-linked oligosaccharide structures.
    Type: Application
    Filed: July 3, 2008
    Publication date: April 23, 2009
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
  • Transgenic chickens that lay eggs containing exogenous proteins
    Patent number: 7521591
    Abstract: This invention provides eggs which contain exogenous proteins. The invention further provides transgenic chickens which express exogenous sequences in their oviducts, and vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of a bird for expressing said exogenous sequences to alter the phenotype of the bird or to produce desired proteins.
    Type: Grant
    Filed: October 28, 2003
    Date of Patent: April 21, 2009
    Assignees: Synageva BioPharm Corp., University of Georgia Research Foundation
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu
  • Glycosylated G-CSF
    Publication number: 20090099067
    Abstract: The invention relates to G-CSF molecules having certain O-linked oligosaccharide structures.
    Type: Application
    Filed: June 27, 2008
    Publication date: April 16, 2009
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
  • Glycosylated G-CSF obtained from a transgenic chicken
    Patent number: 7511120
    Abstract: Granulocyte colony stimulating factor obtained from eggs laid by transgenic avians having newly described G-CSF glycosylation patterns.
    Type: Grant
    Filed: February 20, 2007
    Date of Patent: March 31, 2009
    Assignees: Synageva BioPharma Corp., University of Georgia Research Foundation
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
  • Avian derived erythropoietin
    Publication number: 20090074718
    Abstract: Erythropoietin obtained from eggs laid by transgenic avians having avian N-linked and O-linked glycosylation patterns.
    Type: Application
    Filed: October 10, 2007
    Publication date: March 19, 2009
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
  • Glycosylated interferon ?
    Patent number: 7445774
    Abstract: This invention provides for human interferon-? which includes novel glycosylation structures.
    Type: Grant
    Filed: February 28, 2006
    Date of Patent: November 4, 2008
    Assignees: AviGenics, Inc., University of Georgia Research Foundation, Inc.
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
  • Glycosylated interferon alpha obtained from a transgenic chicken
    Patent number: 7338654
    Abstract: This invention includes compositions comprising glycosylated human interferon-? derived from a chicken.
    Type: Grant
    Filed: March 8, 2006
    Date of Patent: March 4, 2008
    Assignees: AviGenics, Inc., University of Georgia Research Foundation, Inc.
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
  • Poultry Derived Glycosylated Interferon Alpha 2b
    Patent number: 7129390
    Abstract: This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of avians in order to express the exogenous sequences to alter the phenotype of the avians or to produce desired proteins. In particular, transgenic avians are produced which express exogenous sequences in their oviducts and which deposit exogenous proteins into their eggs. Avian eggs that contain exogenous proteins are encompassed by this invention. The instant invention further provides novel forms of interferon and erythropoietin which are efficiently expressed in the oviduct of transgenic avians and deposited into avian eggs.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: October 31, 2006
    Assignees: AviGenics, Inc, University of Georgia Research Foundation, Inc.
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp