Patents by Inventor Robert E. Cohen

Robert E. Cohen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sensors and assays for ubiquitin or ubiquitin-like proteins
    Patent number: 11630109
    Abstract: The present invention provides compositions comprising chimeric polypeptides that bind to free ubiquitin proteins or free ubiquitin-like proteins with high affinity, as well as chimeric polypeptides that bind to both free and conjugated ubiquitin proteins or free and conjugated ubiquitin-like proteins, and methods of using the chimeric polypeptides to determine the amount of free or total ubiquitin or free or total ubiquitin-like proteins in various types of samples.
    Type: Grant
    Filed: April 22, 2021
    Date of Patent: April 18, 2023
    Assignee: Colorado State University Research Foundation
    Inventors: Robert E. Cohen, Yun-Seok Choi
  • Synthetically functionalized living cells for targeted drug delivery
    Patent number: 11400114
    Abstract: Uniform, functional polymer patches can be attached to a fraction of the surface area of living individual cells. These surface-modified cells can cross the blood-brain barrier while remaining viable after attachment of the functional patch. Functional payloads carried by the patch can include a drug. The patch can include one or more polyelectrolyte multilayers (PEMs).
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: August 2, 2022
    Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Roberta Polak, Robert E. Cohen, Michael F. Rubner, Elena V. Batrakova, Matthew J. Haney, Natalia L. Klyachko, Yuling Zhao
  • Spray-coating method with particle alignment control
    Patent number: 11149154
    Abstract: A simple spray coating process can be utilized to create epoxy/HNT nanocomposites with vertically aligned nanotubes. Important mechanical properties such as modulus and hardness values can be optimized and enhanced by controlling the level of nanotube dispersion during processing and the final orientation of the nanotubes. Thus, a technologically relevant processing scheme can be used to fabricate HNT nanocomposites with a high level of control over nanotube alignment and the resulting mechanical properties.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: October 19, 2021
    Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, KHALIFA UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Robert E. Cohen, Michael F. Rubner, Dayong Chen, Roberta Polak, Kenan Song, Khalid Askar
  • SENSORS AND ASSAYS FOR UBIQUITIN OR UBIQUITIN-LIKE PROTEINS
    Publication number: 20210318329
    Abstract: The present invention provides compositions comprising chimeric polypeptides that bind to free ubiquitin proteins or free ubiquitin-like proteins with high affinity, as well as chimeric polypeptides that bind to both free and conjugated ubiquitin proteins or free and conjugated ubiquitin-like proteins, and methods of using the chimeric polypeptides to determine the amount of free or total ubiquitin or free or total ubiquitin-like proteins in various types of samples.
    Type: Application
    Filed: April 22, 2021
    Publication date: October 14, 2021
    Applicants: Colorado State University Research Foundation, Colorado State University Research Foundation
    Inventors: Robert E. COHEN, Yun-Seok CHOI
  • Anti-icing coatings
    Patent number: 11015063
    Abstract: An anti-icing coating can include an amphiphilic copolymer on a surface of an article.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: May 25, 2021
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Dayong Chen, Robert E. Cohen, Gareth H. McKinley
  • Sensors and assays for ubiquitin or ubiquitin-like proteins
    Patent number: 11016097
    Abstract: The present invention provides compositions comprising chimeric polypeptides that bind to free ubiquitin proteins or free ubiquitin-like proteins with high affinity, as well as chimeric polypeptides that bind to both free and conjugated ubiquitin proteins or free and conjugated ubiquitin-like proteins, and methods of using the chimeric polypeptides to determine the amount of free or total ubiquitin or free or total ubiquitin-like proteins in various types of samples.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: May 25, 2021
    Assignee: Colorado State University Research Foundation
    Inventors: Robert E. Cohen, Yun-Seok Choi
  • ANTI-ICING COATINGS
    Publication number: 20200131375
    Abstract: An anti-icing coating can include an amphiphlic copolymer o» a surface of an article.
    Type: Application
    Filed: March 21, 2017
    Publication date: April 30, 2020
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Dayong Chen, Robert E. Cohen, Gareth H. McKinley
  • TUNABLE SURFACE
    Publication number: 20190368073
    Abstract: An article can have a surface with selected wetting properties for various liquids.
    Type: Application
    Filed: February 8, 2019
    Publication date: December 5, 2019
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Government of the United States as represented by the Secretary of the Air Force
    Inventors: Anish Tuteja, Wonjae Chol, Gareth H. McKinley, Robert E. Cohen, Joseph Mark Mabry
  • Liquid repellent surfaces
    Patent number: 10479895
    Abstract: A surface can be coated with a liquid repellent coating. Materials for making the liquid repellent coating (e.g., a fingerprint resistant coating) can be selected on the basis of surface energy considerations, such as a receding surface energy. The materials can include a polymer and a liquid repelling material, for example, poly(ethyl methacrylate) and a fluorinated silsesquioxane such as fluorodecyl POSS.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: November 19, 2019
    Assignee: United States of America as represented by the Secretary of the Air Force
    Inventors: Adam J. Meuler, Robert E. Cohen, Gareth H. McKinley, Joseph M. Mabry
  • Anti-fingerprint photocatalytic nanostructure for transparent surfaces
    Patent number: 10478802
    Abstract: Titania-based porous nanoparticle coatings are mechanically robust, with low haze, which exhibit short time scales for decomposition of fingerprint oils under ultraviolet light. The mechanism by which a typical dactylogram is consumed combines wicking of the sebum into the nanoporous titania structure followed by photocatalytic degradation. These TiO2 nanostructured surfaces are also anti-fogging, anti-bacterial, and compatible with flexible glass substrates and remain photocatalytically active in natural sunlight.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: November 19, 2019
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Robert E. Cohen, Michael F. Rubner, Gareth H. McKinley, George Barbastathis, Hyungryul Johnny Choi, Kyu Chul Park, Hyo Min Lee
  • SENSORS AND ASSAYS FOR UBIQUITIN OR UBIQUITIN-LIKE PROTEINS
    Publication number: 20190346453
    Abstract: The present invention provides compositions comprising chimeric polypeptides that bind to free ubiquitin proteins or free ubiquitin-like proteins with high affinity, as well as chimeric polypeptides that bind to both free and conjugated ubiquitin proteins or free and conjugated ubiquitin-like proteins, and methods of using the chimeric polypeptides to determine the amount of free or total ubiquitin or free or total ubiquitin-like proteins in various types of samples.
    Type: Application
    Filed: January 18, 2019
    Publication date: November 14, 2019
    Inventors: Robert E. Cohen, Yun-Seok Choi
  • Articles and methods for reducing hydrate adhesion
    Patent number: 10294756
    Abstract: This invention relates generally to articles, devices, and methods for gas hydrate mitigation in deep-sea drilling applications. In certain embodiments, hydrate-phobic surfaces are provided that ensure passive enhancement of flow assurance and prevention of catastrophic failures in deep-sea oil and gas operations.
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: May 21, 2019
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: J. David Smith, Kripa K. Varanasi, Gareth H. McKinley, Robert E. Cohen, Adam J. Meuler, Harrison L. Bralower
  • Sensors and assays for ubiquitin or ubiquitin-like proteins
    Patent number: 10234459
    Abstract: The present invention provides compositions comprising chimeric polypeptides that bind to free ubiquitin proteins or free ubiquitin-like proteins with high affinity, as well as chimeric polypeptides that bind to both free and conjugated ubiquitin proteins or free and conjugated ubiquitin-like proteins, and methods of using the chimeric polypeptides to determine the amount of free or total ubiquitin or free or total ubiquitin-like proteins in various types of samples.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: March 19, 2019
    Assignee: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Robert E. Cohen, Yun-Seok Choi
  • Tunable surface
    Patent number: 10202711
    Abstract: An article can have a surface with selected wetting properties for various liquids.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: February 12, 2019
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Anish Tuteja, Wonjae Choi, Gareth H. McKinley, Robert E. Cohen, Joseph Mark Mabry
  • LIQUID REPELLENT SURFACES
    Publication number: 20190031883
    Abstract: A surface can be coated with a liquid repellent coating. Materials for making the liquid repellent coating (e.g., a fingerprint resistant coating) can be selected on the basis of surface energy considerations, such as a receding surface energy. The materials can include a polymer and a liquid repelling material, for example, poly(ethyl methacrylate) and a fluorinated silsesquioxane such as fluorodecyl POSS.
    Type: Application
    Filed: April 5, 2017
    Publication date: January 31, 2019
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE
    Inventors: Adam J. Meuler, Robert E. Cohen, Gareth H. McKinley, Joseph M. Mabry
  • SENSORS AND ASSAYS FOR UBIQUITIN OR UBIQUITIN-LIKE PROTEINS
    Publication number: 20180364250
    Abstract: The present invention provides compositions comprising chimeric polypeptides that bind to free ubiquitin proteins or free ubiquitin-like proteins with high affinity, as well as chimeric polypeptides that bind to both free and conjugated ubiquitin proteins or free and conjugated ubiquitin-like proteins, and methods of using the chimeric polypeptides to determine the amount of free or toal ubiquitin or free or total ubiquitin-like proteins in various types of samples.
    Type: Application
    Filed: May 11, 2018
    Publication date: December 20, 2018
    Inventors: Robert E. Cohen, Yun-Seok Choi
  • Superhydrophilic coatings
    Patent number: 10036833
    Abstract: A superhydrophilic coating on a substrate can be antireflective and antifogging. The coating can remain antireflective and antifogging for extended periods. The coating can include oppositely charge inorganic nanoparticles, and can be substantially free of an organic polymer. The coating can be made mechanically robust by a hydrothermal calcination.
    Type: Grant
    Filed: November 30, 2010
    Date of Patent: July 31, 2018
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Zekeriyya Gemici, Michael F. Rubner, Robert E. Cohen
  • Sensors and assays for ubiquitin or ubiquitin-like proteins
    Patent number: 10018634
    Abstract: The present invention provides compositions comprising chimeric polypeptides that bind to free ubiquitin proteins or free ubiquitin-like proteins with high affinity, as well as chimeric polypeptides that bind to both free and conjugated ubiquitin proteins or free and conjugated ubiquitin-like proteins, and methods of using the chimeric polypeptides to determine the amount of free or total ubiquitin or free or total ubiquitin-like proteins in various types of samples.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: July 10, 2018
    Assignee: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Robert E. Cohen, Yun-Seok Choi
  • SPRAY-COATING METHOD WITH PARTICLE ALIGNMENT CONTROL
    Publication number: 20180002550
    Abstract: A simple spray coating process can be utilized to create epoxy/HNT nanocomposites with vertically aligned nanotubes. Important mechanical properties such as modulus and hardness values can be optimized and enhanced by controlling the level of nanotube dispersion during processing and the final orientation of the nanotubes. Thus, a technologically relevant processing scheme can be used to fabricate HNT nanocomposites with a high level of control over nanotube alignment and the resulting mechanical properties.
    Type: Application
    Filed: June 27, 2017
    Publication date: January 4, 2018
    Applicant: Massachusetts Institute of Technology
    Inventors: Robert E. Cohen, Michael F. Rubner, Dayong Chen, Roberta Polak, Kenan Song, Khalid Askar
  • Liquid repellent surfaces
    Patent number: 9650518
    Abstract: A surface can be coated with a liquid repellent coating. Materials for making the liquid repellent coating (e.g., a fingerprint resistant coating) can be selected on the basis of surface energy considerations, such as a receding surface energy. The materials can include a polymer and a liquid repelling material, for example, poly(ethyl methacrylate) and a fluorinated silsesquioxane such as fluorodecyl POSS.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: May 16, 2017
    Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE
    Inventors: Adam J. Meuler, Robert E. Cohen, Gareth H. McKinley, Joseph M. Mabry