Abstract: The present disclosure relates to a laboratory execution system that provides for automation of laboratory processes. A centralized data management system may be dynamically updated and used to facilitate management of components of the laboratory execution system, such as an automation system and an analytics results management system that may facilitate complex analytical functions, such as synthesizing raw test data. Potential workflows include the detection of specific molecules of interest.

Abstract: A method of treating aqueous, preferably concentrated, waste streams with a unique combination of steps in a way that is easily scalable and able to be used with batch or continuous flows. The method comprises at least the following steps: Adding at least one precipitating agent to the waste water to produce precipitated solids; and removing the precipitated solids from the waste water using a forward flushable membrane to remove the precipitate solids.

Abstract: Systems and methods for controlling an autonomous vehicle are provided. In one example embodiment, a computer-implemented method includes determining vehicle diagnostics information associated with a first autonomous vehicle that is part of a fleet of vehicles controlled by a first entity to provide a vehicle service to a second entity. The method includes determining remote inspection information that includes an assessment of one or more categories pertaining to a third entity, based at least in part on the vehicle diagnostics information. The method includes providing the remote inspection information to the third entity to provide the vehicle service.

Abstract: Methods, apparatus, systems, and articles of manufacture are disclosed to determine total audience ratings. An example apparatus includes metrics generator circuitry to generate a first audience size for media accessed by first devices of a first media platform at a first level of aggregation, the first level of aggregation corresponding to the media accessed on a first television network and on a first website, generate a second audience size for the media accessed by the first devices of the first media platform at a second level of aggregation, the second level of aggregation corresponding to the media accessed on the first television network and accessed on the first website and a second website, comparator circuitry to compare the first audience size to the second audience size, adjustor circuitry to reduce the first audience size based on the second audience size, and audience determination circuitry to determine a total audience size.

Abstract: The specification relates to compounds of Formula (1): and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of cancer.

Abstract: A cutting element assembly includes a cutter support including a cutter bore. A cutting element is in the cutter bore and a resilient element is integral with the cutter support. The resilient element is longitudinally compressible and has a displacement of greater than 0.1 mm and optionally less than 2 mm. Another cutting assembly includes a cutter support coupled to multiple cutting elements. A resilient element of the cutter support is compressible based on a force applied to the cutter support through one or more of the cutting elements. The resilient element can include a slit in the cutter support. A slit may, for instance, extend perpendicular or transverse to an axis of the cutting elements and allow the cutter support to flex and close off or reduce a size of the slit when forces act on one or more of the cutting elements.

Abstract: Methods, apparatus, systems, and articles of manufacture are disclosed to determine total audience ratings. An example apparatus includes metrics generator circuitry to generate a first audience size for media accessed by first devices of a first media platform at a first level of aggregation, the first level of aggregation corresponding to the media accessed on a first television network and on a first website, generate a second audience size for the media accessed by the first devices of the first media platform at a second level of aggregation, the second level of aggregation corresponding to the media accessed on the first television network and accessed on the first website and a second website, comparator circuitry to compare the first audience size to the second audience size, adjustor circuitry to reduce the first audience size based on the second audience size, and audience determination circuitry to determine a total audience size.

Abstract: Disclosed herein are low dielectric constant (low-k) two-dimensional covalent organic framework materials that have a dielectric constant k less than 2.4, optionally less than 1.9, and are comprised of regularly porous, covalently linked, layer structures.

Abstract: The present disclosure relates to methods for detecting unique genetic signatures derived from markers such as, for example, mutations, somatic or germ-line, in nucleic acids obtained from biological samples. The sensitivity of the methods provides for detection of mutations associated with a disease, e.g., cancer mutations, or with inherited disease, e.g., an autosomal recessive disease, in a noninvasive manner at ultra-low proportions of sequences carrying mutations to sequences carrying normal, e.g., non-cancer sequences, or a reference sequence, e.g., a human reference genome.

Abstract: The present invention provides methods for enhancing the efficacy and/or safety of a vaccine. In certain embodiments, the invention provides methods to increase or potentiate the immune response to a vaccine in a subject in need thereof. The methods of the present invention comprise administering to a subject in need thereof an interleukin-4 receptor (IL-4R) antagonist such as an anti-IL-4R antibody in combination with said vaccine. In certain embodiments, the methods of the present invention are used to afford enhanced protection to an infectious disease such as whooping cough.

Abstract: A system for monitoring and optimizing fuel consumption by a genset at an oil rig is described. Gensets require large amounts of fuel to initiate and to maintain in a standby, idling position. The system accesses data in a drill plan to determine the present and future power requirements and initiates gensets if needed; otherwise gensets can be shut down. Excess power can be stored in a power storage unit such as a capacitor, battery, or a liquid air energy storage unit.

Abstract: The present disclosure relates to a laboratory execution system that provides for automation of laboratory processes. A centralized data management system may be dynamically updated and used to facilitate management of components of the laboratory execution system, such as an automation system and an analytics results management system that may facilitate complex analytical functions, such as synthesizing raw test data. Potential workflows include the detection of specific molecules of interest.

Abstract: Systems and methods for providing a vehicle service are provided. In one example embodiment, a computer-implemented method includes receiving data indicative of a service request to provide a vehicle service for an entity with respect to one or more cargo items designated for autonomous transport. The method includes obtaining a first cargo item among the one or more cargo items, from a representative of the entity at a dedicated first transfer hub proximate to a first location associated with the first cargo item. The method includes controlling a first autonomous vehicle to transport the first cargo item from the first transfer hub to a dedicated second transfer hub proximate to a second location associated with the first cargo item. The method includes providing the first cargo item to a representative of the entity at the second transfer hub, to provide the vehicle service.

Abstract: The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and a Toll-like receptor 9 (TLR9) agonist that is a CpG-C type oligonucleotide, and the use of the combination therapies for the treatment of cancer.

Abstract: According to an aspect, an electrochemical cell may include a vessel, at least two instances of an anode assembly, at least two instances of an oxygen evolution electrode (OEE), and a gas diffusion electrode (GDE). In the vessel, the GDE may be disposed between mirrored arrangements of the at least two instances of the OEE and the at least two instances of the anode assembly.

Abstract: One or more clips to be hooked to an item (e.g., belt) and enable a bandage wrapped around an inguinal wound to be secured thereto. The clip(s) act as tie-down point(s) for the bandage to provide most efficient pressure to the wound. The clips include a waist securing member and a bandage retention member. The waist securing member includes first and second legs secured together along a first side (e.g., top) of clip by a first connection piece. A first space is defined between adjacent sides of first and second legs having a first opening along a second side (e.g., bottom) of clip. The bandage retention member includes second and third legs secured together along the second side of the clip by a second connection piece. A second space is defined between adjacent sides of second and third legs having a second opening along the first side of clip.

Abstract: Systems and methods for controlling an autonomous vehicle in response to vehicle instructions from a remote computing system are provided. In one example embodiment, a computer-implemented method includes controlling a first autonomous vehicle to provide a vehicle service, the first autonomous vehicle being associated with a first convoy that includes one or more second autonomous vehicles. The method includes receiving one or more communications from a remote computing system associated with a third-party entity, the one or more communications including one or more vehicle instructions. The method includes coordinating with the one or more second autonomous vehicles to determine one or more vehicle actions to perform in response to receiving the one or more vehicle instructions from the third-party entity. The method includes controlling the first autonomous vehicle to implement the one or more vehicle actions.

Abstract: A system for monitoring and optimizing fuel consumption by a genset at an oil rig is described. Gensets require large amounts of fuel to initiate and to maintain in a standby, idling position. The system accesses data in a drill plan to determine the present and future power requirements and initiates gensets if needed; otherwise gensets can be shut down. Excess power can be stored in a power storage unit such as a capacitor, battery, or a liquid air energy storage unit.

Abstract: A magnetic traction assembly is disclosed for a railcar mover that provides additional downforce to improve traction for a railcar mover when required. The magnetic traction assembly may comprise a frame, an actuator, and a magnetic element positioned underneath a railcar mover. The magnetic element may be lowered to a deployed position, where the magnetic element is positioned near the railroad rails such that the magnetic field from the magnetic element interacts with the railroad rail creating an attraction force that provides additional downforce to the railcar mover.

Abstract: Systems and methods for providing a vehicle service are provided. In one example embodiment, a computer-implemented method includes receiving data indicative of a service request to provide a vehicle service for an entity with respect to one or more cargo items designated for autonomous transport. The method includes obtaining a first cargo item among the one or more cargo items, from a representative of the entity at a dedicated first transfer hub proximate to a first location associated with the first cargo item. The method includes controlling a first autonomous vehicle to transport the first cargo item from the first transfer hub to a dedicated second transfer hub proximate to a second location associated with the first cargo item. The method includes providing the first cargo item to a representative of the entity at the second transfer hub, to provide the vehicle service.