Abstract: Described herein are compositions and their use in methods and pharmaceutical compositions for inhibiting the binding between Yes-associated protein and TEA domain. Also, described herein are methods of using said compositions capable of inhibiting the binding between Yes-associated protein and TEA domain to treat cancer, inhibit cell proliferation, cell migration, cell invasiveness and tumor growth.

Abstract: This disclosure addresses the problem of preventing sediment laden water (“sediment slurry”) resulting from hydraulic collection of nodules from the seabed from entering the riser and lift system that carries the nodules to the surface as a slurry. An example includes collecting nodules from the seabed by hydraulic suction, separating the nodules utilizing an inverse hydrocyclone.

Abstract: A method includes positioning a downhole acquisition tool in a wellbore in a geological formation. The method includes operating a pump module to gather information for a fluid outside of the downhole acquisition tool that enters the downhole acquisition tool from a first flowline, a second flowline, or both while the downhole acquisition tool is within the wellbore. Operating the pump module includes controlling a valve assembly to a first valve configuration that enables the fluid to flow into the downhole tool via the first flowline fluidly coupled to a first pump module.

Abstract: A beverage forming method and system arranged to allow a user to adjust a volume and flow rate of liquid provided to a brew chamber so that a dispensed beverage is suitable for mixing with ice, e.g., to form an iced coffee beverage. In some cases, a user may provide input indicating that an iced beverage should be dispensed during a beverage dispensing operation. For example, after a dispensing operation is started to dispense a beverage having a particular volume, a user can adjust the beverage volume to be smaller and suitable for mixing with ice.

Abstract: A method includes positioning a downhole acquisition tool in a wellbore in a geological formation. The method includes operating a pump module to gather information for a fluid outside of the downhole acquisition tool that enters the downhole acquisition tool from a first flowline, a second flowline, or both while the downhole acquisition tool is within the wellbore. Operating the pump module includes controlling a valve assembly to a first valve configuration that enables the fluid to flow into the downhole tool via the first flowline fluidly coupled to a first pump module.

Abstract: A method includes positioning a downhole acquisition tool in a wellbore in a geological formation. The method includes operating a pump module to gather information for a fluid outside of the downhole acquisition tool that enters the downhole acquisition tool from a first flowline, a second flowline, or both while the downhole acquisition tool is within the wellbore. Operating the pump module includes controlling a valve assembly to a first valve configuration that enables the fluid to flow into the downhole tool via the first flowline fluidly coupled to a first pump module.

Abstract: Aspects of the disclosure relate to dynamic message analysis using machine learning. A computing platform may apply a security scoring process to an endpoint relationship to compute a weighted security score for the endpoint relationship. Subsequently, the computing platform may determine a weighted grade for the endpoint relationship based on the weighted security score for the endpoint relationship. Based on identifying that the weighted grade exceeds a predetermined threshold, the computing platform may tag the endpoint relationship as compromised. Subsequently, the computing platform may monitor an electronic messaging server to detect messages corresponding to the compromised endpoint relationship.

Abstract: A refuelling method having instructing a refuelling operator to dispense a quantity of fuel to, and maintaining, during dispensing of the fuel, at least intermittent, substantially real time communication with an officer responsible for the aircraft to advise the officer of the status of the refuelling process. A system having a refuelling module and an officer module, the refuelling module configured to receive instructions to dispense a quantity of fuel to an aircraft, an at least intermittent, substantially real time communications link being maintained between the refuelling module and the officer module during dispensing of fuel to the aircraft, the refuelling module being adapted to transmit to the officer module information relating to the status of the refuelling process, and the officer module being adapted to display to an output indicative of the status of the refuelling process. The method and system permits modification of the instruction during refuelling.

Abstract: A method includes operating a downhole acquisition tool in a wellbore in a geological formation. The wellbore or the geological formation, or both, contains a fluid that includes a native reservoir fluid of the geological formation and a contaminant. The method also includes receiving a portion of the fluid into the downhole acquisition tool, obtaining a measured resistivity, a measured conductivity, or both of the portion of the fluid using the downhole acquisition tool, and using a processor of the downhole acquisition tool to obtain a temperature-corrected resistivity, a temperature-corrected conductivity, or both based on a downhole temperature of the portion of the fluid and the measured resistivity, the measured conductivity, or both.

Abstract: A temperature control system fitted to a system for forming glass product is provided. The temperature control system includes a first plurality of temperature sensors configured to sense a temperature of glass products exiting an annealing lehr. The first plurality of temperature sensors is further configured to generate sensed temperature signals. A second plurality of temperature sensors configured to sense a temperature of glass products exiting a cooling fan bank. The cooling fan bank is positioned downstream from the annealing lehr. The second plurality of temperature sensors is further configured to generate sensed temperature signals. A control module is configured to receive the sensed temperature signals from the first and second plurality of temperature sensors and compare the sensed temperature signals with pre-set parameters. The control module is configured to direct adjustments in a rotational speed of a plurality of cooling fans in response to the sensed temperature signals.

Abstract: A glass product stress evaluation system is provided. The glass product stress evaluation system includes a background light source to selectively transmit light of different wavelengths and illuminates a glass product. An imaging device is mounted in proximity to the glass product and develops digitally encoded representations of internal annealing stresses formed within the glass product. The imaging device converts the digitally encoded internal stress representations into digital signals. A plurality of optical devices provides a converging view of the glass product. A plurality of filters is mounted in proximity to the plurality of optical devices and selectively transmits light of different wavelengths to the optical devices, thereby transforming detected imaged stresses in the glass product into visible colors. A processing unit receives the digital images from the imaging device and converts the digital images into visible images. The digital images can be classified into annealing grades.

Abstract: A method includes operating a downhole acquisition tool in a wellbore in a geological formation. The wellbore or the geological formation, or both, contain a reservoir fluid. The method also includes receiving a portion of the reservoir fluid into the downhole acquisition tool and performing downhole fluid analysis using the downhole acquisition tool in the wellbore to determine at least one measurement associated with the portion of the reservoir fluid. The at least one measurement includes fluid density, optical density, or both. The method also includes using a processor of the downhole acquisition tool to obtain compressibility of the reservoir fluid based at least in part on the fluid density, the optical density, or both and determining a composition of the reservoir fluid based at least in part on the compressibility.

Abstract: A fuelling method is described which comprises the steps of dispensing an initial quantity of fuel to a fuel tank, waiting for a predetermined settling period for the fuel dispensed to the fuel tank to homogenise and settle, after the predetermined settling period has elapsed, taking a fuel quantity reading using a fuel gauge associated with the fuel tank, calculating a differential volume of fuel between the fuel gauge reading and a desired final fuel quantity, and dispensing to the fuel tank a volume of fuel substantially equivalent to the differential volume using a dispensing apparatus including a fuel volume meter.

Abstract: A refuelling method having instructing a refuelling operator to dispense a quantity of fuel to, and maintaining, during dispensing of the fuel, at least intermittent, substantially real time communication with an officer responsible for the aircraft to advise the officer of the status of the refuelling process. A system having a refuelling module and an officer module, the refuelling module configured to receive instructions to dispense a quantity of fuel to an aircraft, an at least intermittent, substantially real time communications link being maintained between the refuelling module and the officer module during dispensing of fuel to the aircraft, the refuelling module being adapted to transmit to the officer module information relating to the status of the refuelling process, and the officer module being adapted to display to an output indicative of the status of the refuelling process. The method and system permits modification of the instruction during refuelling.

Abstract: A temperature control system fitted to a system for forming glass product is provided. The temperature control system includes a first plurality of temperature sensors configured to sense a temperature of glass products exiting an annealing lehr. The first plurality of temperature sensors is further configured to generate sensed temperature signals. A second plurality of temperature sensors configured to sense a temperature of glass products exiting a cooling fan bank. The cooling fan bank is positioned downstream from the annealing lehr. The second plurality of temperature sensors is further configured to generate sensed temperature signals. A control module is configured to receive the sensed temperature signals from the first and second plurality of temperature sensors and compare the sensed temperature signals with pre-set parameters. The control module is configured to direct adjustments in a rotational speed of a plurality of cooling fans in response to the sensed temperature signals.

Abstract: A method includes positioning a downhole acquisition tool in a wellbore in a geological formation. The method includes operating a pump module to gather information for a fluid outside of the downhole acquisition tool that enters the downhole acquisition tool from a first flowline, a second flowline, or both while the downhole acquisition tool is within the wellbore. Operating the pump module includes controlling a valve assembly to a first valve configuration that enables the fluid to flow into the downhole tool via the first flowline fluidly coupled to a first pump module.

Abstract: A method includes operating a downhole acquisition tool in a wellbore in a geological formation. The wellbore or the geological formation, or both, contain a reservoir fluid. The method also includes receiving a portion of the reservoir fluid into the downhole acquisition tool and performing downhole fluid analysis using the downhole acquisition tool in the wellbore to determine at least one measurement associated with the portion of the reservoir fluid. The at least one measurement includes fluid density, optical density, or both. The method also includes using a processor of the downhole acquisition tool to obtain compressibility of the reservoir fluid based at least in part on the fluid density, the optical density, or both and determining a composition of the reservoir fluid based at least in part on the compressibility.

Abstract: A method includes operating a downhole acquisition tool in a wellbore in a geological formation. The wellbore or the geological formation, or both, contains a fluid that includes a native reservoir fluid of the geological formation and a contaminant. The method also includes receiving a portion of the fluid into the downhole acquisition tool, obtaining a measured resistivity, a measured conductivity, or both of the portion of the fluid using the downhole acquisition tool, and using a processor of the downhole acquisition tool to obtain a temperature-corrected resistivity, a temperature-corrected conductivity, or both based on a downhole temperature of the portion of the fluid and the measured resistivity, the measured conductivity, or both.

Abstract: Variable volume systems and methods of use thereof described herein are capable of making calibrated determinations of fluid properties and phase behavior of a fluid sample. The determinations can be calibrated based on one or more calibration functions, such as system volume corrected for pressure and temperature variations. Cross-checking the results of measurements can be used to determine accuracy of the calibration or monitor for leaks or other anomalies of the variable volume systems. The variable volume systems can be implemented in a well logging tool and are capable of being calibrated downhole.

Abstract: An electric current responsive circuit breaker device includes a housing formed from electrically insulating material and the housing has an internal compartment and an open end. The circuit breaker further includes a thermostatic snap-action blade and first and second electrically conductive contacts such that the first contact has a stationary position disposed within the internal compartment and the second contact is disposed on the thermostatic snap-action blade. Further, the first and second contacts are coupled such that electric current flows through the contacts when the temperature of the thermostatic snap-action blade is below a threshold level, and the thermostatic snap-action blade bends to uncouple the second contact from the first contact when the temperature of the thermostatic snap-action blade is at or above the threshold level so that electric current does not flow through the first and second contacts after the first and second contacts are uncoupled.