Abstract: Methods for probing multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets, binding at least one fluorescent probe to one or more target present in the sample, and binding at least at least one control probe to one or more target present in the sample. The methods include the steps of observing a signal from the fluorescent probe and a control signal from the control probe and applying to the sample a basic solution containing an oxidizing agent that selectively inactivates the fluorescent probe and not the control probe. The methods further include the steps of binding at least one fluorescent probe to one or more target present in the sample and observing a signal from the fluorescent probe. The methods disclosed herein also provide for multiple iterations of binding, observing, and oxidizing for deriving information about multiple targets in a single sample. An associated kit is also provided.

Abstract: An ultrasound system includes an ultrasound probe configured for sensing and transmitting ultrasound signals. The ultrasound system further includes an optical conduit configured for coupling a light source and an optical detector in an optical path. The optical conduit includes electro-optic modulators configured for modulating optical signals on the optical conduit with at least one of the electrical signals configured to generate corresponding optically modulated analog signals on the optical conduit. In one example, the electro-optic modulators comprise electro-optic polymer modulators.

Abstract: A system for analyzing tissue samples, that generally comprises, a storage device for at least temporarily storing one or more images of one or more cells, wherein the images comprise a plurality of channels; and a processor that is adapted to determine the extent to which a biomarker may have translocated from at least one subcellular region to another subcellular region; and then to generate a score corresponding to the extent of translocation.

Abstract: A system for analyzing tissue samples, comprising: a storage device for at least temporarily storing one or more images of one or more cells, wherein at least one of the images is indicative of one or more channels comprising a receptor tyrosine kinase (RTK); and a processing device that determines an extent to which one or more of the RTKs may have translocated from at least one subcellular region to another subcellular region of one or more of the cells; and generates a score based at least in part on the RTK translocation.

Abstract: A novel micro optical system as a platform technology for electrical and optical interconnections, thermal and mechanical assembly and integration of electronic, optoelectronic, passive and active components. This platform provides optical coupling and chip-to-chip interconnection by microwave electrical, optical guided and unguided waves, and power or bias electrical contacts or interfaces by a novel chip in flexible circuit, rigid or inflexible embodiments.

Abstract: A system for generating a tunable X-ray pulse comprises a first electron beam source configured to direct a first electron pulse of predetermined energy and pulse length towards a first interaction zone, a laser beam source configured to direct a first photon pulse of predetermined energy and pulse length towards the first interaction zone to interact with the first electron pulse. The first interaction produces a substantially monochromatic second photon pulse of higher photon energy directed towards a second interaction zone, and a second electron beam source configured to direct a second electron pulse of predetermined energy and pulse length towards the second interaction zone so that the second interaction produces an X-ray pulse of predetermined energy and pulse length in a cascaded inverse Compton scattering (ICS) configuration.

Abstract: A wavelength multiplexed holographic system includes a wavelength tunable blue-violet laser and a controller for wavelength multiplexing. A method of holographic data recording includes providing a holographic medium, providing a tunable blue-violet laser for wavelength multiplexing, and tuning the laser wavelength to record a hologram at a set wavelength and recording holographic data at the set wavelength on the holographic medium. A method for retrieving holographic data includes providing a holographic medium, providing at least one tunable blue-violet laser, tuning the blue-violet laser to a set wavelength, and retrieving holographic data at the set wavelength.

Abstract: A wireless transceiver for performing ultrasonic measurements includes an uplink transmitter configured to transmit at least one modulated timing pulse signal. Each modulated timing pulse signal is transmitted over a respective uplink wireless channel. The transceiver further includes at least one uplink receiver, which is adapted to receive a respective one of the modulated timing pulse signals from the uplink transmitter and configured to supply an unmodulated timing pulse signal to a respective transducer. The transceiver further includes at least one downlink transmitter, which is adapted to receive an echo signal from the respective transducer, and is configured to extract envelope information from the echo signal and to transmit a modulated echo signal over a respective downlink wireless channel. The transceiver also includes a downlink receiver adapted to receive the modulated echo signals from the respective downlink transmitters.

Abstract: The invention provides a system for generating X-rays via the process of inverse Compton scattering. The system includes a high repetition rate laser adapted to direct high-energy optical pulses in a first direction in a laser cavity and a source of pulsed electron beam adapted to direct electron beam in a second direction opposite to the first direction in the laser cavity. The electron beam interacts with photons in the optical pulses in the laser cavity to produce X-rays in the second direction.

Abstract: A method for remotely monitoring at least one sensor and a measurement system. The method includes making a first measurement using a first sensor of the at least one sensor. The method also includes converting the first measurement into a first data signal; and transmitting the first data signal via a wireless connection to a first processor. The measurement system includes at least one sensor unit having at least one sensor for making a first measurement; and a first wireless transceiver coupled to the at least one sensor for transmitting a data signal based on the first measurement. The measurement system includes a second wireless transceiver arranged for receiving the data signal from the first wireless transceiver, and a first processor coupled to the second wireless transceiver arranged for receiving the data signal from the second wireless transceiver.

Abstract: A novel micro optical system as a platform technology for electrical and optical interconnections, thermal and mechanical assembly and integration of electronic, optoelectronic, passive and active components. This platform provides optical coupling and chip-to-chip interconnection by microwave electrical, optical guided and unguided waves, and power or bias electrical contacts or interfaces by a novel chip in flexible circuit, rigid or inflexible embodiments.

Abstract: A method for remotely monitoring at least one sensor and a measurement system. The method includes making a first measurement using a first sensor of the at least one sensor. The method also includes converting the first measurement into a first data signal; and transmitting the first data signal via a wireless connection to a first processor. The measurement system includes at least one sensor unit having at least one sensor for making a first measurement; and a first wireless transceiver coupled to the at least one sensor for transmitting a data signal based on the first measurement. The measurement system includes a second wireless transceiver arranged for receiving the data signal from the first wireless transceiver, and a first processor coupled to the second wireless transceiver arranged for receiving the data signal from the second wireless transceiver.

Abstract: A technique for achieving quasi phase matching in a photonic band gap structure comprising a first material and a second material is disclosed.

Abstract: A wireless transceiver for performing ultrasonic measurements includes an uplink transmitter configured to transmit at least one modulated timing pulse signal. Each modulated timing pulse signal is transmitted over a respective uplink wireless channel. The transceiver further includes at least one uplink receiver, which is adapted to receive a respective one of the modulated timing pulse signals from the uplink transmitter and configured to supply an unmodulated timing pulse signal to a respective transducer. The transceiver further includes at least one downlink transmitter, which is adapted to receive an echo signal from the respective transducer, and is configured to extract envelope information from the echo signal and to transmit a modulated echo signal over a respective downlink wireless channel. The transceiver also includes a downlink receiver adapted to receive the modulated echo signals from the respective downlink transmitters.

Abstract: A method for determining surface acoustic wave ray paths for an object. The method includes obtaining a representation of the object. A plurality of geodesics from a point on the object are determined and a plurality of surface acoustic wave ray paths are defined in response to the plurality of geodesics. The acoustic wave ray paths are used to determine a plurality of equally spaced surface acoustic wave fronts. In one application the surface acoustic wave fronts may then be used in a synthetic aperture focusing technique to obtain an image of the object.

Abstract: An exemplary inspection apparatus for inspecting an article comprises a flexible sensor for sensing a characteristic of the article, which sensor conforms to a surface of the article, a finger cover which fits over a finger of a user, and an attachment device for removably attaching the sensor to the finger cover. The apparatus allows the user to traverse the sensor over a large range of smoothly varying concave or convex inspection surfaces, for example, while providing the user with direct control of the sensor.

Abstract: An exemplary inspection apparatus for inspecting an article comprises a flexible sensor for sensing a characteristic of the article, which sensor conforms to a surface of the article, a finger cover which fits over a finger of a user, and an attachment device for removably attaching the sensor to the finger cover. The apparatus allows the user to traverse the sensor over a large range of smoothly varying concave or convex inspection surfaces, for example, while providing the user with direct control of the sensor.

Abstract: An eddy current probe which can be moved by hand to a surface to be tested. A toroidal-shaped first resilient member contacts the bottom face of a support member. An elastic membrane extends over the bore of the first resilient member, contacts the bottom lateral surface of the first resilient member, and is unattached to the radially-inward-facing surface of the first resilient member. A more elastic, second resilient member is placed in the bore, is unattached to the first resilient member, and contacts the bottom surface of the elastic membrane. A flexible, surface-conformable, eddy current sensing coil overlies a portion of the bottom side of the second resilient member.