Abstract: Packaging forming system and related methods are provided. A packaging forming system can include a controller and nip rollers in communication with the controller. The nip rollers are positioned on either side of a product pathway on which products being packaged travel. The packaging forming system can include a top sheet material guide system that is configured to feed a top sheet material and a bottom sheet material guide system that is configured to feed a bottom sheet material to the nip rollers to form sides of packages around one or more products traveling along the pathway. The packaging forming system can include an adjustable table in communication with the controller and positioned along the pathway to provide support to the product being packaged such that the height of the table is movable to adjust a height position of each individual product to be packaged relative to the nip rollers.

Abstract: Cross Seal Devices and related methods are provided. A cross seal device for forming ends of packages being formed in a packaging forming system can include an anvil configured to extend transverse to a product pathway of a packaging forming system along which top and bottom sheet materials travel. The cross seal device can also include a track positioned above the anvil transverse to the product pathway. Further, the cross seal device can include a carriage configured to operate along the track. The carriage can include one or more rollers configured to engage the anvil to form a pressure contact between the anvil and the roller so that the top and bottom sheet materials are joined together.

Abstract: Adjustable tables for use in a packaging forming system and related methods are provided. An adjustable table for use in a packaging forming system can include outer side panels and moveable inner side panels moveably connected to the outer side panels with the outer side panels held stationary relative to the moveable inner side panels. The adjustable table can also include a table top secured to the moveable inner side panels. The table top and the inner side panels are configured to move upwardly or downwardly relative to the outer side panels.

Abstract: Disclosed herein are heart pumps that can include a catheter body and an impeller coupled with a distal end of the catheter body. The impeller can include a tip that is resealable or that includes a resealable member. The heart pump can also include a diffuser disposed between the distal end of the catheter body and the impeller, wherein the diffuser includes a flow directing surface.

Abstract: An impeller includes a hub, and a plurality of blades supported by the hub, the blades being arranged in at least two blade rows. The impeller has a deployed configuration in which the blades extend away from the hub, and a stored configuration in which at least one of the blades is radially compressed, for example by folding the blade towards the hub. The impeller may also have an operational configuration in which at least some of the blades are deformed from the deployed configuration upon rotation of the impeller when in the deployed configuration. The outer edge of one or more blades may have a winglet, and the base of the blades may have an associated indentation to facilitate folding of the blades.

Abstract: Disclosed herein is a method of pumping blood in a patient. The method includes inserting an impeller housing and impeller into the patient, the impeller disposed within the impeller housing and having a longitudinal axis, positioning the impeller housing and the impeller at a treatment location in the patient, activating an adjustment device at a proximal end portion of the heart pump outside the patient to provide relative motion between the impeller housing and the impeller along the longitudinal axis, and pumping blood through the impeller housing along the longitudinal axis.

Abstract: An impeller includes a hub and a blade supported by the hub. The impeller has a stored configuration in which the blade is compressed so that its distal end moves towards the hub, and a deployed configuration in which the blade extends away from the hub. The impeller may be part of a pump for pumping fluids, such as blood, and may include a cannula having a proximal portion with a fixed diameter, and a distal portion with an expandable diameter. The impeller may reside in the expandable portion of the cannula. The cannula may have a compressed diameter which allows it to be inserted percutaneously into a patient. Once at a desired location, the expandable portion of the cannula may be expanded and the impeller expanded to the deployed configuration. A flexible drive shaft may extend through the cannula for rotationally driving the impeller within the patient.

Abstract: The present invention provides methods and compositions for detecting Mycoplasma exposure in a subject.

Abstract: An impeller includes a hub, and a plurality of blades supported by the hub, the blades being arranged in at least two blade rows. The impeller has a deployed configuration in which the blades extend away from the hub, and a stored configuration in which at least one of the blades is radially compressed, for example by folding the blade towards the hub. The impeller may also have an operational configuration in which at least some of the blades are deformed from the deployed configuration upon rotation of the impeller when in the deployed configuration. The outer edge of one or more blades may have a winglet, and the base of the blades may have an associated indentation to facilitate folding of the blades.

Abstract: An impeller includes a hub and a blade supported by the hub. The impeller has a stored configuration in which the blade is compressed so that its distal end moves towards the hub, and a deployed configuration in which the blade extends away from the hub. The impeller may be part of a pump for pumping fluids, such as blood, and may include a cannula having a proximal portion with a fixed diameter, and a distal portion with an expandable diameter. The impeller may reside in the expandable portion of the cannula. The cannula may have a compressed diameter which allows it to be inserted percutaneously into a patient. Once at a desired location, the expandable portion of the cannula may be expanded and the impeller expanded to the deployed configuration. A flexible drive shaft may extend through the cannula for rotationally driving the impeller within the patient.

Abstract: Floor underlayments, floor underlayment systems and related methods are provided herein. A floor underlayment sheet can include a middle body portion having first outer face and a second outer face with the middle body portion having a thickness. The floor underlayment sheet can also include a first end portion extending outward from the middle body portion from a first side of the middle body portion. The first end portion can have an outer face that aligns with and is contiguous with the first outer face of the middle body portion and an inner face that is opposite the first end portion outer face. The floor underlayment sheet can further include a second and portion extending outward from the middle body portion from a second side of the middle body portion. The second end portion can have an outer face that aligns with and is contiguous with the second outer face of the middle body portion and an inner face that is opposite the second end portion outer face.

Abstract: Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.

Abstract: Disclosed herein are heart pumps that can include a catheter body and an impeller coupled with a distal end of the catheter body. The impeller can include a tip that is resealable or that includes a resealable member. The heart pump can also include a diffuser disposed between the distal end of the catheter body and the impeller, wherein the diffuser includes a flow directing surface.

Abstract: Packaging forming system and related methods are provided. A packaging forming system can include a controller and nip rollers in communication with the controller. The nip rollers are positioned on either side of a product pathway on which products being packaged travel. The packaging forming system can include a top sheet material guide system that is configured to feed a top sheet material and a bottom sheet material guide system that is configured to feed a bottom sheet material to the nip rollers to form sides of packages around one or more products traveling along the pathway. The packaging forming system can include an adjustable table in communication with the controller and positioned along the pathway to provide support to the product being packaged such that the height of the table is movable to adjust a height position of each individual product to be packaged relative to the nip rollers.

Abstract: Cross Seal Devices and related methods are provided. A cross seal device for forming ends of packages being formed in a packaging forming system can include an anvil configured to extend transverse to a product pathway of a packaging forming system along which top and bottom sheet materials travel. The cross seal device can also include a track positioned above the anvil transverse to the product pathway. Further, the cross seal device can include a carriage configured to operate along the track. The carriage can include one or more rollers configured to engage the anvil to form a pressure contact between the anvil and the roller so that the top and bottom sheet materials are joined together.

Abstract: Adjustable tables for use in a packaging forming system and related methods are provided. An adjustable table for use in a packaging forming system can include outer side panels and moveable inner side panels moveably connected to the outer side panels with the outer side panels held stationary relative to the moveable inner side panels. The adjustable table can also include a table top secured to the moveable inner side panels. The table top and the inner side panels are configured to move upwardly or downwardly relative to the outer side panels.

Abstract: Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.

Abstract: Disclosed herein are heart pumps that can include a catheter body and an impeller coupled with a distal end of the catheter body. The impeller can include a tip that is resealable or that includes a resealable member. The heart pump can also include a diffuser disposed between the distal end of the catheter body and the impeller, wherein the diffuser includes a flow directing surface.

Abstract: An impeller includes a hub and a blade supported by the hub. The impeller has a stored configuration in which the blade is compressed so that its distal end moves towards the hub, and a deployed configuration in which the blade extends away from the hub. The impeller may be part of a pump for pumping fluids, such as blood, and may include a cannula having a proximal portion with a fixed diameter, and a distal portion with an expandable diameter. The impeller may reside in the expandable portion of the cannula. The cannula may have a compressed diameter which allows it to be inserted percutaneously into a patient. Once at a desired location, the expandable portion of the cannula may be expanded and the impeller expanded to the deployed configuration. A flexible drive shaft may extend through the cannula for rotationally driving the impeller within the patient.

Abstract: The present invention provides methods and compositions for detecting Mycoplasma exposure in a subject.