Patents by Inventor Robert M. Burk

Robert M. Burk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prostamide-containing intraocular implant
    Patent number: 9889142
    Abstract: Prostamide-containing biodegradable intraocular implants, prostamide compounds, prostamide-containing pharmaceutical compositions, and methods for making and using such implants and compositions for the immediate and sustained reduction of intraocular pressure and treatment of glaucoma in an eye of a patient are described.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: February 13, 2018
    Assignee: Allergan, Inc.
    Inventors: Patrick M. Hughes, Jie Shen, Michael R. Robinson, David F. Woodward, Robert M. Burk, Hui Liu, Jinping Wan, Chandrasekar Durairaj, Gyorgy F. Ambrus, Ke Wu, Danny T. Dinh
  • Prostamides for the treatment of glaucoma and related diseases
    Patent number: 9890118
    Abstract: Disclosed herein are compositions comprising an amide related to a prostaglandin and a biogenic amine. Other aspects relate to certain chemical compounds, pharmaceutical compositions, and methods of treating glaucoma.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: February 13, 2018
    Assignee: ALLERGAN, INC.
    Inventors: David F. Woodward, Robert M. Burk
  • Methods for fat reduction
    Patent number: 9795615
    Abstract: Disclosed herein are methods, compounds, and compositions for fat reduction, and in particular fat reduction without significant hair growth and/or additional hair growth.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: October 24, 2017
    Assignee: ALLERGAN, INC.
    Inventors: Neil J. Poloso, Jenny Wang, David F. Woodward, Robert M. Burk
  • ESTER PRODRUGS OF GAMMA-LACTAMS AND THEIR USE
    Publication number: 20170298050
    Abstract: Described herein are ester prodrugs of gamma-lactam compounds of Formula (I): or pharmaceutically acceptable salt thereof, and methods of use of such compounds for the treatment of ocular diseases including, among other things, glaucoma and macular degeneration.
    Type: Application
    Filed: October 2, 2015
    Publication date: October 19, 2017
    Inventors: Robert M. Burk, Wha Bin Im
  • NOVEL PROSTAMIDES FOR THE TREATMENT OF GLAUCOMA AND RELATED DISEASES
    Publication number: 20170152224
    Abstract: Disclosed herein are compositions comprising an amide related to a prostaglandin and a biogenic amine. Other aspects relate to certain chemical compounds, pharmaceutical compositions, and methods of treating glaucoma.
    Type: Application
    Filed: July 5, 2016
    Publication date: June 1, 2017
    Inventors: David F. Woodward, Robert M. Burk
  • SKIN WOUND HEALING AND SCAR REDUCTION WITH PROSTAGLANDIN EP4 AGONIST COMBINATIONS
    Publication number: 20170151261
    Abstract: A combination of a prostaglandin EP4 agonist and an effective amount of: a prostaglandin EP2 agonist, a skin growth factor, a small peptide, a small inhibitory RNA targeting excess chronic inflammation or fibrosis, a cytokine with beneficial anti-inflammatory activity, an adenosine A2a receptor agonist, an anti-oxidant, or a combination thereof, may be used to treat skin wounds or scars.
    Type: Application
    Filed: July 1, 2016
    Publication date: June 1, 2017
    Inventors: Guang Liang Jiang, Robert M. Burk, Wha-Bin Im, Larry A. Wheeler
  • COMPOUNDS AND METHODS FOR SKIN REPAIR
    Publication number: 20170143733
    Abstract: The disclosure provides compositions and methods for wound healing and scar reduction. The compositions and methods of the invention include at least one mixed EP2/EP4 agonist set forth herein. Wounds and or scars that can be treated by the compositions and methods of the invention can arise from events such as surgery, trauma, disease, mechanical injury, burn, radiation, poisoning, and the like.
    Type: Application
    Filed: June 23, 2016
    Publication date: May 25, 2017
    Inventors: Robert M. Burk, Wha-Bin Im
  • QUATERNARY AMMONIUM ALKYL ESTERS AS STABLE PRODRUGS
    Publication number: 20170081304
    Abstract: Disclosed herein are compounds according to Formulas 1-12, compositions comprising these compounds, and methods of lowering intraocular pressure (IOP) or causing hair growth, and methods of using the same.
    Type: Application
    Filed: May 12, 2015
    Publication date: March 23, 2017
    Inventors: Robert M. Burk, David W. Old, Wha Bin Im, Richard S. Graham, Mu-Lan Lee
  • Amidoalkylenyl and amidoaryl esters, compositions thereof, and methods for their use
    Patent number: 9573926
    Abstract: The invention provides ester compounds for treating ophthalmic diseases. The esters of the invention are particularly advantageous due to their stability in aqueous solutions.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: February 21, 2017
    Assignee: ALLERGAN, INC.
    Inventors: Robert M. Burk, Yariv Donde, Jeremiah H. Nguyen
  • 15-aryl prostaglandins as EP4 agonists, and methods of use thereof
    Patent number: 9540357
    Abstract: The invention provides compositions and methods for reducing healing wounds and reducing scars and blemishes. The compositions and methods of the invention include at least one EP4 agonist set forth herein. Wounds and or scars that can be treated by the compositions and methods of the invention can arise from events such as surgery, trauma, disease, mechanical injury, burn, radiation, poisoning, and the like.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: January 10, 2017
    Assignee: Allergan, Inc.
    Inventors: Vinh X. Ngo, David W. Old, Robert M. Burk
  • Substituted cyclopentanes for inducing hair growth
    Patent number: 9499478
    Abstract: Provided herein, inter alia, are, methods of using esters of bimatoprost with the Formula (I):
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: November 22, 2016
    Assignee: ALLERGAN, INC.
    Inventors: David F. Woodward, Jenny W. Wang, Neil J. Poloso, Todd S. Gac, Robert M. Burk, Michael E. Garst
  • METHODS FOR FAT REDUCTION
    Publication number: 20160317550
    Abstract: Disclosed herein are methods, compounds, and compositions for fat reduction, and in particular fat reduction without significant hair growth and/or additional hair growth.
    Type: Application
    Filed: April 29, 2016
    Publication date: November 3, 2016
    Inventors: Neil J. Poloso, Jenny Wang, David F. Woodward, Robert M. Burk
  • PROSTAMIDES FOR ENHANCEMENT OF LEPTIN PRODUCTION
    Publication number: 20160310505
    Abstract: Prostamides such as bimatoprost and its pro-drugs for enhancement of leptin production and appetite suppression.
    Type: Application
    Filed: November 25, 2015
    Publication date: October 27, 2016
    Inventors: Neil J. Poloso, David F. Woodward, Timothy J. Maziasz, Suzanne Kanaly, Grantley Charles, Michael Garst, Robert M. Burk
  • Prostamides for the treatment of glaucoma and related diseases
    Patent number: 9433627
    Abstract: Disclosed herein are compositions comprising an amide related to a prostaglandin and a biogenic amine. Other aspects relate to certain chemical compounds, pharmaceutical compositions, and methods of treating glaucoma.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: September 6, 2016
    Assignee: Allergan, Inc.
    Inventors: David F. Woodward, Robert M. Burk
  • Reduced central corneal thickening by use of hydrophilic ester prodrugs of beta-chlorocyclopentanes
    Patent number: 9427401
    Abstract: Compositions and methods for treating glaucoma are provided. In particular hydrophilic ester prodrugs and their use to reduce central corneal thickening is provided.
    Type: Grant
    Filed: April 13, 2015
    Date of Patent: August 30, 2016
    Assignee: ALLERGAN, INC.
    Inventors: Wha-Bin Im, Robert M. Burk
  • STABLE AQUEOUS COMPOSITIONS OF PROSTGLANDIN AGONIST PRODRUGS AND METHODS FOR USE THEREOF
    Publication number: 20160220677
    Abstract: The present invention is based on the discovery that a marked increase in aqueous stability (and thereby shelf life) of prostanoid agonist prodrug compositions is achieved by incorporating into the compositions certain well-defined carboxylic acids, and thereafter adjusting the pH of the compositions from about 4.0 to about 8.0. As a result, the compositions and methods of the invention provide the aqueous stability required for marketable topical drug treatments of a wide variety of ocular disorders.
    Type: Application
    Filed: August 26, 2015
    Publication date: August 4, 2016
    Inventors: Robert M. Burk, Wha-Bin Im
  • PROSTAMIDE-CONTAINING INTRAOCULAR IMPLANT
    Publication number: 20160199387
    Abstract: Prostamide-containing biodegradable intraocular implants, prostamide compounds, prostamide-containing pharmaceutical compositions, and methods for making and using such implants and compositions for the immediate and sustained reduction of intraocular pressure and treatment of glaucoma in an eye of a patient are described.
    Type: Application
    Filed: March 21, 2016
    Publication date: July 14, 2016
    Inventors: Patrick M. Hughes, Jie Shen, Michael R. Robinson, David F. Woodward, Robert M. Burk, Hui Liu, Jinping Wan, Chandrasekar Durairaj, Gyorgy F. Ambrus, Ke Wu, Danny T. Dinh
  • Compounds and methods for treating ocular diseases
    Patent number: 9340534
    Abstract: Described herein are compounds of formula I compositions and methods for the treatment of diseases affecting the eye, including glaucoma or ocular hypertension.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: May 17, 2016
    Assignee: ALLERGAN, INC.
    Inventors: Robert M. Burk, Todd S. Gac
  • Therapeutic cyclopentanols, compositions thereof, and methods for use thereof
    Patent number: 9315486
    Abstract: Described herein are well-defined cyclopentanols useful for treating glaucoma and ocular hypertension.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: April 19, 2016
    Assignee: ALLERGAN, INC.
    Inventors: Robert M. Burk, Todd S. Gac
  • Prostamide-containing intraocular implant
    Patent number: 9289413
    Abstract: Prostamide-containing biodegradable intraocular implants, prostamide compounds, prostamide-containing pharmaceutical compositions, and methods for making and using such implants and compositions for the immediate and sustained reduction of intraocular pressure and treatment of glaucoma in an eye of a patient are described.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 22, 2016
    Assignee: Allergan, Inc.
    Inventors: Patrick M. Hughes, Jie Shen, Michael R. Robinson, David F. Woodward, Robert M. Burk, Hui Liu, Jinping Wan, Chandrasekar Durairaj, Gyorgy F. Ambrus, Ke Wu, Danny T. Dinh