Patents by Inventor Robert M. Burk

Robert M. Burk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND METHODS FOR TREATING OCULAR DISEASES
    Publication number: 20160024068
    Abstract: Described herein are compounds of formula I compositions and methods for the treatment of diseases affecting the eye, including glaucoma or ocular hypertension.
    Type: Application
    Filed: July 27, 2015
    Publication date: January 28, 2016
    Inventors: Robert M. Burk, Todd S. Gac
  • AMIDOALKYLENYL AND AMIDOARYL ESTERS, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE
    Publication number: 20150336924
    Abstract: The invention provides ester compounds for treating ophthalmic diseases. The esters of the invention are particularly advantageous due to their stability in aqueous solutions.
    Type: Application
    Filed: May 22, 2015
    Publication date: November 26, 2015
    Inventors: Robert M. Burk, Yariv Donde, Jeremiah H. Nguyen
  • REDUCED CENTRAL CORNEAL THICKENING BY USE OF HYDROPHILIC ESTER PRODRUGS OF BETA-CHLOROCYCLOPENTANES
    Publication number: 20150322036
    Abstract: Compositions and methods for treating glaucoma are provided. In particular hydrophilic ester prodrugs and their use to reduce central corneal thickening is provided.
    Type: Application
    Filed: April 13, 2015
    Publication date: November 12, 2015
    Inventors: Wha-Bin Im, Robert M. Burk
  • THERAPEUTIC LACTAMS
    Publication number: 20150274658
    Abstract: Disclosed herein is a compound having a structure Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
    Type: Application
    Filed: March 27, 2014
    Publication date: October 1, 2015
    Applicant: Allergan, Inc.
    Inventors: David W. Old, Robert M. Burk
  • Reduced central corneal thickening by use of hydrophilic ester prodrugs of beta-chlorocyclopentanes
    Patent number: 9090595
    Abstract: Compositions and methods for treating glaucoma are provided. In particular hydrophilic ester prodrugs and their use to reduce central corneal thickening is provided.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: July 28, 2015
    Assignee: Allergan, Inc.
    Inventors: Robert M. Burk, Wha Bin Im
  • Reduced central corneal thickening by use of hydrophilic ester prodrugs of beta-chlorocyclopentanes
    Patent number: 9024042
    Abstract: Compositions and methods for treating glaucoma are provided. In particular hydrophilic ester prodrugs and their use to reduce central corneal thickening is provided.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: May 5, 2015
    Assignee: Allergan, Inc.
    Inventors: Wha-Bin Im, Robert M. Burk
  • THERAPEUTIC CYCLOPENTANOLS, COMPOSITIONS THEREOF, AND METHODS FOR USE THEREOF
    Publication number: 20150119454
    Abstract: Described herein are well-defined cyclopentanols useful for treating glaucoma and ocular hypertension.
    Type: Application
    Filed: October 29, 2014
    Publication date: April 30, 2015
    Inventors: Robert M. Burk, Todd S. Gac
  • Phosphate Esters of Bimatoprost and the Prostamides
    Publication number: 20150119367
    Abstract: Provided herein, inter alia, are prodrugs of bimatoprost, methods of using the same and compositions including the same.
    Type: Application
    Filed: October 29, 2013
    Publication date: April 30, 2015
    Applicant: Allergan, Inc.
    Inventors: David F. Woodward, Jenny W. Wang, Neil J. Poloso, Todd S. Gac, Robert M. Burk, Michael E. Garst
  • Substituted cyclopentanes having prostaglandin activity
    Patent number: 9006464
    Abstract: Disclosed herein are compounds having a formula: Therapeutic methods, medicaments, and compositions related thereto are also disclosed.
    Type: Grant
    Filed: November 5, 2008
    Date of Patent: April 14, 2015
    Assignee: Allergan, Inc.
    Inventors: Yariv Donde, Jeremiah H. Nguyen, Robert M. Burk
  • ESTER DERIVATIVES OF BIMATOPROST COMPOSITIONS AND METHODS
    Publication number: 20150005377
    Abstract: Provided herein, inter alia, are prodrugs of bimatoprost, methods of using the same and compositions including the same.
    Type: Application
    Filed: September 16, 2014
    Publication date: January 1, 2015
    Inventors: David F. Woodward, Jenny W. Wang, Neil J. Poloso, Todd S. Gac, Robert M. Burk, Michael E. Garst
  • Ester derivatives of bimatoprost compositions and methods
    Patent number: 8865766
    Abstract: Provided herein, inter alia, are prodrugs of bimatoprost, methods of using the same and compositions including the same.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: October 21, 2014
    Assignee: Allergan, Inc.
    Inventors: David F. Woodward, Jenny W. Wang, Neil J. Poloso, Todd Gac, Robert M. Burk, Michael E. Garst
  • PROSTAMIDE-CONTAINING INTRAOCULAR IMPLANT
    Publication number: 20140271780
    Abstract: Prostamide-containing biodegradable intraocular implants, prostamide compounds, prostamide-containing pharmaceutical compositions, and methods for making and using such implants and compositions for the immediate and sustained reduction of intraocular pressure and treatment of glaucoma in an eye of a patient are described.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: Allergan, Inc.
    Inventors: Patrick M. Hughes, Jie Shen, Michael R. Robinson, David F. Woodward, Robert M. Burk, Hui Liu, Jinping Wan, Chandrasekar Durairaj, Gyorgy F. Ambrus, Ke Wu, Danny T. Dinh
  • PROSTAMIDES FOR ENHANCEMENT OF LEPTIN PRODUCTION
    Publication number: 20140275272
    Abstract: Prostamides such as bimatoprost and its pro-drugs for enhancement of leptin production and appetite suppression.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: ALLERGAN, INC.
    Inventors: Neil J. POLOSO, David F. WOODWARD, Timothy J. MAZIASZ, Suzanne KANALY, Grantley CHARLES, Michael GARST, Robert M. BURK
  • Combination therapy for glaucoma
    Publication number: 20140235681
    Abstract: Disclosed herein is method of treating glaucoma or ocular hypertension comprising administering a prostaglandin agonist and a second therapeutically active agent to a mammal in need thereof, wherein said second therapeutically active agent is selected from: ?-Blockers, Adrenergic Agonists, non-selective adrenergic agonists, ?2-selective adrenergic agonists, Carbonic Anhydrase Inhibitors, Cholinergic Agonists, direct acting cholinergic agonists, chlolinesterase inhibitors, Glutamate Antagonists, Ca2+ channel blockers, Prostamides, Prostaglandins, Cannabinoids, and combinations thereof. Compositions and medicaments containing a combination of these two active agents are also disclosed.
    Type: Application
    Filed: December 6, 2013
    Publication date: August 21, 2014
    Applicant: ALLERGAN, INC.
    Inventors: SCOTT M. WHITCUP, ROBERT M. BURK, DAVID W. OLD, YARIV DONDE, WHA-BIN IM, MARK A. HOLOBOSKI
  • REDUCED CENTRAL CORNEAL THICKENING BY USE OF HYDROPHILIC ESTER PRODRUGS OF BETA-CHLOROCYCLOPENTANES
    Publication number: 20140171661
    Abstract: Compositions and methods for treating glaucoma are provided. In particular hydrophilic ester prodrugs and their use to reduce central corneal thickening is provided.
    Type: Application
    Filed: February 20, 2014
    Publication date: June 19, 2014
    Applicant: Allergan, Inc.
    Inventors: Robert M. Burk, Wha Bin Im
  • COMPOUNDS AND METHODS FOR SKIN REPAIR
    Publication number: 20140142092
    Abstract: The disclosure provides compositions and methods for wound healing and scar reduction. The compositions and methods of the invention include at least one mixed EP2/EP4 agonist set forth herein. Wounds and or scars that can be treated by the compositions and methods of the invention can arise from events such as surgery, trauma, disease, mechanical injury, burn, radiation, poisoning, and the like.
    Type: Application
    Filed: November 13, 2013
    Publication date: May 22, 2014
    Applicant: Allergan, Inc.
    Inventors: Robert M. Burk, Wha-Bin Im
  • SKIN WOUND HEALING AND SCAR REDUCTION WITH PROSTAGLANDIN EP4 AGONIST COMBINATIONS
    Publication number: 20140142042
    Abstract: A combination of a prostaglandin EP4 agonist and an effective amount of: a prostaglandin EP2 agonist, a skin growth factor, a small peptide, a small inhibitory RNA targeting excess chronic inflammation or fibrosis, a cytokine with beneficial anti-inflammatory activity, an adenosine A2a receptor agonist, an anti-oxidant, or a combination thereof, may be used to treat skin wounds or scars.
    Type: Application
    Filed: November 13, 2013
    Publication date: May 22, 2014
    Applicant: Allergan, Inc.
    Inventors: Guang L. Jiang, Robert M. Burk, Wha-Bin Im, Larry A. Wheeler
  • NOVEL PROSTAMIDES FOR THE TREATMENT OF GLAUCOMA AND RELATED DISEASES
    Publication number: 20140107124
    Abstract: Disclosed herein are compositions comprising an amide related to a prostaglandin and a biogenic amine. Other aspects relate to certain chemical compounds, pharmaceutical compositions, and methods of treating glaucoma.
    Type: Application
    Filed: December 20, 2013
    Publication date: April 17, 2014
    Applicant: Allergan, Inc.
    Inventors: David F. Woodward, Robert M. Burk
  • Therapeutic lactams
    Patent number: 8686025
    Abstract: Disclosed herein is a compound having a structure Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
    Type: Grant
    Filed: December 15, 2008
    Date of Patent: April 1, 2014
    Assignee: Allergan, Inc.
    Inventors: David W. Old, Robert M. Burk
  • REDUCED CENTRAL CORNEAL THICKENING BY USE OF HYDROPHILIC ESTER PRODRUGS OF BETA-CHLOROCYCLOPENTANES
    Publication number: 20140057975
    Abstract: Compositions and methods for treating glaucoma are provided. In particular hydrophilic ester prodrugs and their use to reduce central corneal thickening is provided.
    Type: Application
    Filed: August 23, 2013
    Publication date: February 27, 2014
    Applicant: ALLERGAN, INC.
    Inventors: Wha-Bin Im, Robert M. Burk